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Aliases for TCTEX1D4 Gene

Aliases for TCTEX1D4 Gene

  • Tctex1 Domain Containing 4 2 3 5
  • Novel Tctex-1 Family Domain-Containing Protein 2 3
  • Protein N22.1 3 4
  • Tctex-2-Beta 3 4
  • Tctex1 Domain-Containing Protein 4 3
  • Tctex2 Beta 3

External Ids for TCTEX1D4 Gene

Previous GeneCards Identifiers for TCTEX1D4 Gene

  • GC01M045045
  • GC01M045271
  • GC01M043385

Summaries for TCTEX1D4 Gene

GeneCards Summary for TCTEX1D4 Gene

TCTEX1D4 (Tctex1 Domain Containing 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein phosphatase 1 binding. An important paralog of this gene is TCTE3.

Additional gene information for TCTEX1D4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCTEX1D4 Gene

Genomics for TCTEX1D4 Gene

GeneHancer (GH) Regulatory Elements for TCTEX1D4 Gene

Promoters and enhancers for TCTEX1D4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J044830 Enhancer 0.7 dbSUPER 12.9 -23.7 -23655 1.4 CTCF KLF1 NFRKB ZNF384 ZIC2 RAD21 ZNF335 TCF12 POLR2A BRD9 TCTEX1D4 BTBD19 PLK3 RPS8 BEST4 RNU5D-1 KIF2C PPIAP35 EIF2B3 UROD
GH01J044924 Enhancer 0.8 Ensembl ENCODE 10.1 -118.3 -118279 3.1 MEIS2 CTCF PKNOX1 SAP130 JUN ERF RAD21 FOSL1 JUND EGR1 BTBD19 UROD EIF2B3 PPIAP35 BEST4 ENSG00000226499 PTCH2 TCTEX1D4 PLK3 RNA5SP47
GH01J044834 Enhancer 0.6 Ensembl 12.9 -26.9 -26859 0.2 HDAC1 L3MBTL2 IKZF1 NBN MNT DPF2 ZFX ZKSCAN1 BTBD19 TCTEX1D4 PLK3 UROD BEST4 RNU5D-1 KIF2C EIF2B3 PPIAP35 PTCH2
GH01J045272 Enhancer 0.9 FANTOM5 Ensembl ENCODE 7.5 -465.8 -465796 1.5 CEBPB ZNF24 FOS PLK3 ZSWIM5 TCTEX1D4 IPP BEST4 BTBD19 LOC105378691 GC01P045223
GH01J044746 Promoter 0.5 EPDnew 11.2 +61.0 61048 0.1 KIF2C RPS8 ENSG00000225721 SNORD38A SNORD46 RNU5F-1 PLK3 BTBD19 TCTEX1D4 ARMH1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCTEX1D4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCTEX1D4 gene promoter:
  • Nkx2-5
  • LyF-1
  • Pax-4a
  • GR
  • FOXO1a
  • FOXO1
  • GR-alpha
  • ATF
  • Cart-1
  • Zic3

Genomic Locations for TCTEX1D4 Gene

Genomic Locations for TCTEX1D4 Gene
chr1:44,805,908-44,807,442
(GRCh38/hg38)
Size:
1,535 bases
Orientation:
Minus strand
chr1:45,271,580-45,272,957
(GRCh37/hg19)
Size:
1,378 bases
Orientation:
Minus strand

Genomic View for TCTEX1D4 Gene

Genes around TCTEX1D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCTEX1D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCTEX1D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTEX1D4 Gene

Proteins for TCTEX1D4 Gene

  • Protein details for TCTEX1D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JR98-TC1D4_HUMAN
    Recommended name:
    Tctex1 domain-containing protein 4
    Protein Accession:
    Q5JR98

    Protein attributes for TCTEX1D4 Gene

    Size:
    221 amino acids
    Molecular mass:
    23353 Da
    Quaternary structure:
    • Interacts with ENG/endoglin, TGFBR2 and TGFBR3.

neXtProt entry for TCTEX1D4 Gene

Post-translational modifications for TCTEX1D4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCTEX1D4 Gene

Antibody Products

  • Boster Bio Antibodies for TCTEX1D4

No data available for DME Specific Peptides for TCTEX1D4 Gene

Domains & Families for TCTEX1D4 Gene

Gene Families for TCTEX1D4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCTEX1D4 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCTEX1D4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JR98

UniProtKB/Swiss-Prot:

TC1D4_HUMAN :
  • Belongs to the dynein light chain Tctex-type family.
Family:
  • Belongs to the dynein light chain Tctex-type family.
genes like me logo Genes that share domains with TCTEX1D4: view

Function for TCTEX1D4 Gene

Gene Ontology (GO) - Molecular Function for TCTEX1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21382349
GO:0008157 protein phosphatase 1 binding IDA 23789093
genes like me logo Genes that share ontologies with TCTEX1D4: view

Phenotypes for TCTEX1D4 Gene

genes like me logo Genes that share phenotypes with TCTEX1D4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TCTEX1D4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCTEX1D4 Gene

Localization for TCTEX1D4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCTEX1D4 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TCTEX1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005930 axoneme IEA --
genes like me logo Genes that share ontologies with TCTEX1D4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TCTEX1D4 Gene

Pathways & Interactions for TCTEX1D4 Gene

SuperPathways for TCTEX1D4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCTEX1D4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCTEX1D4 Gene

Drugs & Compounds for TCTEX1D4 Gene

No Compound Related Data Available

Transcripts for TCTEX1D4 Gene

mRNA/cDNA for TCTEX1D4 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCTEX1D4 Gene

Tctex1 domain containing 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCTEX1D4 Gene

No ASD Table

Relevant External Links for TCTEX1D4 Gene

GeneLoc Exon Structure for
TCTEX1D4
ECgene alternative splicing isoforms for
TCTEX1D4

Expression for TCTEX1D4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCTEX1D4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCTEX1D4 Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for TCTEX1D4 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCTEX1D4 Gene



Protein tissue co-expression partners for TCTEX1D4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCTEX1D4 Gene:

TCTEX1D4

SOURCE GeneReport for Unigene cluster for TCTEX1D4 Gene:

Hs.585137

mRNA Expression by UniProt/SwissProt for TCTEX1D4 Gene:

Q5JR98-TC1D4_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with TCTEX1D4: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCTEX1D4 Gene

Orthologs for TCTEX1D4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCTEX1D4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCTEX1D4 34 33
  • 99.1 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TCTEX1D4 34 33
  • 82.95 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TCTEX1D4 34 33
  • 81.43 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tctex1d4 16 34 33
  • 74.43 (n)
rat
(Rattus norvegicus)
Mammalia LOC102551208 33
  • 74.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCTEX1D4 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCTEX1D4 34 33
  • 57.43 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCTEX1D4 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tctex1d4 33
  • 46.55 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC793976 33
  • 47.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5359 34
  • 28 (a)
ManyToMany
CG7276 34
  • 20 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dylt-2 34
  • 22 (a)
OneToMany
Species where no ortholog for TCTEX1D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCTEX1D4 Gene

ENSEMBL:
Gene Tree for TCTEX1D4 (if available)
TreeFam:
Gene Tree for TCTEX1D4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCTEX1D4: view image

Paralogs for TCTEX1D4 Gene

Paralogs for TCTEX1D4 Gene

(1) SIMAP similar genes for TCTEX1D4 Gene using alignment to 1 proteins:

  • TC1D4_HUMAN
genes like me logo Genes that share paralogs with TCTEX1D4: view

Variants for TCTEX1D4 Gene

Sequence variations from dbSNP and Humsavar for TCTEX1D4 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000516764 -- 44,806,329(-) G/A coding_sequence_variant, missense_variant
rs1001246064 -- 44,808,235(-) TTTT/TTT upstream_transcript_variant
rs1001294697 -- 44,807,241(-) C/G 5_prime_UTR_variant, intron_variant
rs1001842731 -- 44,808,455(-) CC/CCC upstream_transcript_variant
rs1002966543 -- 44,808,518(-) C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TCTEX1D4 Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV loss 19166990
nsv546145 CNV loss 21841781
nsv546146 CNV loss 21841781
nsv950705 CNV deletion 24416366

Variation tolerance for TCTEX1D4 Gene

Gene Damage Index Score: 1.53; 29.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCTEX1D4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCTEX1D4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCTEX1D4 Gene

Disorders for TCTEX1D4 Gene

Additional Disease Information for TCTEX1D4

No disorders were found for TCTEX1D4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCTEX1D4 Gene

Publications for TCTEX1D4 Gene

  1. Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors. (PMID: 16982625) Meng Q … Garland JM (The Journal of biological chemistry 2006) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. TCTEX1D4 interactome in human testis: unraveling the function of dynein light chain in spermatozoa. (PMID: 24606217) Freitas MJ … Fardilha M (Omics : a journal of integrative biology 2014) 3 58
  4. TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network. (PMID: 23789093) Korrodi-Gregório L … da Cruz E Silva EF (Biology open 2013) 3 58
  5. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M … da Cruz e Silva EF (Biochemical pharmacology 2011) 3 58

Products for TCTEX1D4 Gene

Sources for TCTEX1D4 Gene

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