Aliases for TCTEX1D4 Gene

Aliases for TCTEX1D4 Gene

  • Tctex1 Domain Containing 4 2 3 5
  • Novel Tctex-1 Family Domain-Containing Protein 2 3
  • Tctex1 Domain-Containing Protein 4 3 4
  • Protein N22.1 3 4
  • Tctex-2-Beta 3 4
  • Tctex2 Beta 3

External Ids for TCTEX1D4 Gene

Previous GeneCards Identifiers for TCTEX1D4 Gene

  • GC01M045045
  • GC01M045271
  • GC01M043385

Summaries for TCTEX1D4 Gene

GeneCards Summary for TCTEX1D4 Gene

TCTEX1D4 (Tctex1 Domain Containing 4) is a Protein Coding gene. Diseases associated with TCTEX1D4 include Bardet-Biedl Syndrome 7 and Retinitis Pigmentosa 3. Gene Ontology (GO) annotations related to this gene include protein phosphatase 1 binding. An important paralog of this gene is TCTEX1D1.

Additional gene information for TCTEX1D4 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCTEX1D4 Gene

Genomics for TCTEX1D4 Gene

GeneHancer (GH) Regulatory Elements for TCTEX1D4 Gene

Promoters and enhancers for TCTEX1D4 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J044830 Enhancer 0.7 dbSUPER 12.9 -23.7 -23655 1.4 CTCF ZIC2 ZNF423 MYC ZNF341 NFRKB RELA NFIC ZBTB17 ZNF592 BTBD19 TCTEX1D4 PLK3 RPS8 BEST4 RNU5D-1 KIF2C EIF2B3 PPIAP35 UROD
GH01J044924 Enhancer 0.8 Ensembl ENCODE 10.1 -118.7 -118654 3.8 CTCF TCF12 JUND FOS RAD21 SAP130 FOSL2 PBX2 JUN FOSL1 BTBD19 UROD EIF2B3 PPIAP35 BEST4 ENSG00000226499 PTCH2 TCTEX1D4 PLK3 RNA5SP47
GH01J045270 Enhancer 1 FANTOM5 Ensembl ENCODE 7.5 -463.7 -463659 5.8 FOS CEBPB HOMEZ NFE2 MITF GATA2 TFAP4 PRDM4 L3MBTL2 SOX5 PLK3 ZSWIM5 TCTEX1D4 IPP BEST4 BTBD19 piR-30048-001 piR-58308-004 lnc-ZSWIM5-1
GH01J044848 Enhancer 0.5 Ensembl 11.8 -41.8 -41759 2.4 RARA TFAP4 NFIA SOX5 PRDM10 ZBTB20 SOX13 BTBD19 TCTEX1D4 PLK3 EIF2B3 PPIAP35 UROD ENSG00000226499 RF00017-191
GH01J045372 Enhancer 0.6 Ensembl 9.9 -567.1 -567058 3 CTCF NFIC IRF1 MEF2B ZNF189 PRDM6 ZNF664 ZBTB12 ZNF770 ZNF121 PRDX1 TESK2 MUTYH TOE1 HMGB1P48 PLK3 BTBD19 TCTEX1D4 EIF2B3 PPIAP35
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCTEX1D4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCTEX1D4

Top Transcription factor binding sites by QIAGEN in the TCTEX1D4 gene promoter:
  • ATF
  • Cart-1
  • FOXO1
  • FOXO1a
  • GR
  • GR-alpha
  • LyF-1
  • Nkx2-5
  • Pax-4a
  • Zic3

Genomic Locations for TCTEX1D4 Gene

Genomic Locations for TCTEX1D4 Gene
1,535 bases
Minus strand
1,378 bases
Minus strand

Genomic View for TCTEX1D4 Gene

Genes around TCTEX1D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCTEX1D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCTEX1D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTEX1D4 Gene

Proteins for TCTEX1D4 Gene

  • Protein details for TCTEX1D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tctex1 domain-containing protein 4
    Protein Accession:

    Protein attributes for TCTEX1D4 Gene

    221 amino acids
    Molecular mass:
    23353 Da
    Quaternary structure:
    • Interacts with ENG/endoglin, TGFBR2 and TGFBR3.

neXtProt entry for TCTEX1D4 Gene

Post-translational modifications for TCTEX1D4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCTEX1D4 Gene

No data available for DME Specific Peptides for TCTEX1D4 Gene

Domains & Families for TCTEX1D4 Gene

Gene Families for TCTEX1D4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCTEX1D4 Gene

  • Tctex-1 family

Suggested Antigen Peptide Sequences for TCTEX1D4 Gene

GenScript: Design optimal peptide antigens:
  • Tctex-2-beta (TC1D4_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the dynein light chain Tctex-type family.
  • Belongs to the dynein light chain Tctex-type family.
genes like me logo Genes that share domains with TCTEX1D4: view

Function for TCTEX1D4 Gene

Phenotypes From GWAS Catalog for TCTEX1D4 Gene

Gene Ontology (GO) - Molecular Function for TCTEX1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21382349
GO:0008157 protein phosphatase 1 binding IDA 23789093
genes like me logo Genes that share ontologies with TCTEX1D4: view

Phenotypes for TCTEX1D4 Gene

genes like me logo Genes that share phenotypes with TCTEX1D4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TCTEX1D4

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCTEX1D4 Gene

Localization for TCTEX1D4 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCTEX1D4 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TCTEX1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005930 axoneme IEA --
genes like me logo Genes that share ontologies with TCTEX1D4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TCTEX1D4 Gene

Pathways & Interactions for TCTEX1D4 Gene

PathCards logo

SuperPathways for TCTEX1D4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCTEX1D4 Gene


No data available for Pathways by source and SIGNOR curated interactions for TCTEX1D4 Gene

Drugs & Compounds for TCTEX1D4 Gene

No Compound Related Data Available

Transcripts for TCTEX1D4 Gene

mRNA/cDNA for TCTEX1D4 Gene

2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCTEX1D4 Gene

No ASD Table

Relevant External Links for TCTEX1D4 Gene

GeneLoc Exon Structure for

Expression for TCTEX1D4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCTEX1D4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCTEX1D4 Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for TCTEX1D4 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCTEX1D4 Gene

Protein tissue co-expression partners for TCTEX1D4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCTEX1D4

SOURCE GeneReport for Unigene cluster for TCTEX1D4 Gene:


mRNA Expression by UniProt/SwissProt for TCTEX1D4 Gene:

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with TCTEX1D4: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCTEX1D4 Gene

Orthologs for TCTEX1D4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCTEX1D4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TCTEX1D4 31 30
  • 99.1 (n)
(Bos Taurus)
Mammalia TCTEX1D4 31 30
  • 82.95 (n)
(Canis familiaris)
Mammalia TCTEX1D4 31 30
  • 81.43 (n)
(Mus musculus)
Mammalia Tctex1d4 17 31 30
  • 74.43 (n)
(Rattus norvegicus)
Mammalia LOC102551208 30
  • 74.43 (n)
(Ornithorhynchus anatinus)
Mammalia TCTEX1D4 31
  • 69 (a)
(Gallus gallus)
Aves TCTEX1D4 31 30
  • 57.43 (n)
(Anolis carolinensis)
Reptilia TCTEX1D4 31
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tctex1d4 30
  • 46.55 (n)
(Danio rerio)
Actinopterygii LOC793976 30
  • 47.18 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5359 31
  • 28 (a)
CG7276 31
  • 20 (a)
(Caenorhabditis elegans)
Secernentea dylt-2 31
  • 22 (a)
Species where no ortholog for TCTEX1D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCTEX1D4 Gene

Gene Tree for TCTEX1D4 (if available)
Gene Tree for TCTEX1D4 (if available)
Evolutionary constrained regions (ECRs) for TCTEX1D4: view image

Paralogs for TCTEX1D4 Gene

Paralogs for TCTEX1D4 Gene

(1) SIMAP similar genes for TCTEX1D4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCTEX1D4: view

Variants for TCTEX1D4 Gene

Additional dbSNP identifiers (rs#s) for TCTEX1D4 Gene

Structural Variations from Database of Genomic Variants (DGV) for TCTEX1D4 Gene

Variant ID Type Subtype PubMed ID
nsv461406 CNV loss 19166990
nsv546145 CNV loss 21841781
nsv546146 CNV loss 21841781
nsv950705 CNV deletion 24416366

Variation tolerance for TCTEX1D4 Gene

Gene Damage Index Score: 1.53; 29.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCTEX1D4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCTEX1D4 Gene

Disorders for TCTEX1D4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TCTEX1D4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bardet-biedl syndrome 7
  • bbs7
retinitis pigmentosa 3
  • rp3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TCTEX1D4

genes like me logo Genes that share disorders with TCTEX1D4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCTEX1D4 Gene

Publications for TCTEX1D4 Gene

  1. TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network. (PMID: 23789093) Korrodi-Gregório L … da Cruz E Silva EF (Biology open 2013) 2 3 54
  2. Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors. (PMID: 16982625) Meng Q … Garland JM (The Journal of biological chemistry 2006) 3 4 54
  3. TCTEX1D4 interactome in human testis: unraveling the function of dynein light chain in spermatozoa. (PMID: 24606217) Freitas MJ … Fardilha M (Omics : a journal of integrative biology 2014) 3 54
  4. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M … da Cruz e Silva EF (Biochemical pharmacology 2011) 3 54
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 54

Products for TCTEX1D4 Gene

Sources for TCTEX1D4 Gene