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Aliases for TCTE3 Gene

Aliases for TCTE3 Gene

  • T-Complex-Associated-Testis-Expressed 3 2 3 5
  • T-Complex-Associated Testis-Expressed Protein 3 3 4
  • T-Complex Testis-Specific Protein 3 3 4
  • Tctex1 Domain Containing 3 2 3
  • TCTEX1D3 3 4
  • Tctex1 Domain-Containing Protein 3 3
  • Tcte-3 4

External Ids for TCTE3 Gene

Previous GeneCards Identifiers for TCTE3 Gene

  • GC06U990122
  • GC06M169715
  • GC06M169896
  • GC06M169957
  • GC06M170140
  • GC06M167559

Summaries for TCTE3 Gene

GeneCards Summary for TCTE3 Gene

TCTE3 (T-Complex-Associated-Testis-Expressed 3) is a Protein Coding gene. Diseases associated with TCTE3 include Primary Ciliary Dyskinesia and Kartagener Syndrome. Among its related pathways are Organelle biogenesis and maintenance and Intraflagellar transport. Gene Ontology (GO) annotations related to this gene include motor activity. An important paralog of this gene is TCTEX1D4.

UniProtKB/Swiss-Prot for TCTE3 Gene

  • May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity).

Additional gene information for TCTE3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCTE3 Gene

Genomics for TCTE3 Gene

GeneHancer (GH) Regulatory Elements for TCTE3 Gene

Promoters and enhancers for TCTE3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I169750 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 -0.2 -247 3.3 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ERMARD TCTE3 GC06M169749 WDR27 ENSG00000266896 PDCD2 TBP FAM120B PSMB1 ENSG00000236173
GH06I169721 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.2 +27.4 27421 4.7 PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ENSG00000227704 PHF10 ENSG00000232640 ERMARD WDR27 C6orf120 ENSG00000266896 TCTE3 ENSG00000236173
GH06I170400 Enhancer 0.9 ENCODE 26.7 -648.9 -648881 0.5 HDGF FOXA2 ARNT NEUROD1 YBX1 TCF12 ZNF207 ATF7 ZNF548 NCOA1 WDR27 TBP ENSG00000266896 FAM120B ERMARD PDCD2 TCTE3 ENSG00000272848 PHF10 ENSG00000232640
GH06I169371 Enhancer 0.7 ENCODE 15 +379.8 379835 1.1 ZNF146 ZSCAN4 CHD4 ZNF76 GLI4 CDC5L ZNF2 TCF12 PHF20 ZNF547 WDR27 ERMARD FAM120B TCTE3 ENSG00000232640 PHF10 ENSG00000266896 LINC02519 PIR40323
GH06I169861 Enhancer 0.6 ENCODE 16.5 -110.9 -110864 2.3 HDGF ZNF473 HLF NR2F2 NONO ARHGAP35 ZNF184 TARDBP TBP ENSG00000266896 TCTE3 WDR27 PDCD2 ERMARD LOC105378149 ENSG00000236173
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCTE3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCTE3 gene promoter:

Genomic Locations for TCTE3 Gene

Genomic Locations for TCTE3 Gene
chr6:169,725,090-169,751,587
(GRCh38/hg38)
Size:
26,498 bases
Orientation:
Minus strand
chr6:170,140,210-170,151,655
(GRCh37/hg19)

Genomic View for TCTE3 Gene

Genes around TCTE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCTE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCTE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTE3 Gene

Proteins for TCTE3 Gene

  • Protein details for TCTE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZS6-TC1D3_HUMAN
    Recommended name:
    Tctex1 domain-containing protein 3
    Protein Accession:
    Q8IZS6

    Protein attributes for TCTE3 Gene

    Size:
    198 amino acids
    Molecular mass:
    23176 Da
    Quaternary structure:
    • Interacts with CSNK2B.

neXtProt entry for TCTE3 Gene

Post-translational modifications for TCTE3 Gene

No Post-translational modifications

Other Protein References for TCTE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCTE3 Gene

Domains & Families for TCTE3 Gene

Gene Families for TCTE3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCTE3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TCTE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZS6

UniProtKB/Swiss-Prot:

TC1D3_HUMAN :
  • Belongs to the dynein light chain Tctex-type family.
Family:
  • Belongs to the dynein light chain Tctex-type family.
genes like me logo Genes that share domains with TCTE3: view

Function for TCTE3 Gene

Molecular function for TCTE3 Gene

GENATLAS Biochemistry:
t-complex associated,testis expressed 3,murine homolog
UniProtKB/Swiss-Prot Function:
May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity).

Phenotypes From GWAS Catalog for TCTE3 Gene

Gene Ontology (GO) - Molecular Function for TCTE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003774 motor activity IEA --
genes like me logo Genes that share ontologies with TCTE3: view
genes like me logo Genes that share phenotypes with TCTE3: view

Animal Models for TCTE3 Gene

MGI Knock Outs for TCTE3:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TCTE3 Gene

Localization for TCTE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCTE3 Gene

Cytoplasm, cytoskeleton. Cytoplasmic granule. Membrane; Peripheral membrane protein. Note=Found on the surface of sperm tail. Stored in cytoplasmic granules during spermatogenesis (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCTE3 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TCTE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0016020 membrane IEA --
GO:0030286 dynein complex IEA --
genes like me logo Genes that share ontologies with TCTE3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCTE3 Gene

Pathways & Interactions for TCTE3 Gene

genes like me logo Genes that share pathways with TCTE3: view

Pathways by source for TCTE3 Gene

Interacting Proteins for TCTE3 Gene

Gene Ontology (GO) - Biological Process for TCTE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with TCTE3: view

No data available for SIGNOR curated interactions for TCTE3 Gene

Drugs & Compounds for TCTE3 Gene

No Compound Related Data Available

Transcripts for TCTE3 Gene

Unigene Clusters for TCTE3 Gene

T-complex-associated-testis-expressed 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCTE3 Gene

No ASD Table

Relevant External Links for TCTE3 Gene

GeneLoc Exon Structure for
TCTE3
ECgene alternative splicing isoforms for
TCTE3

Expression for TCTE3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCTE3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCTE3 Gene

This gene is overexpressed in Testis (x20.8).

Protein differential expression in normal tissues from HIPED for TCTE3 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCTE3 Gene



Protein tissue co-expression partners for TCTE3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCTE3 Gene:

TCTE3

SOURCE GeneReport for Unigene cluster for TCTE3 Gene:

Hs.733746

mRNA Expression by UniProt/SwissProt for TCTE3 Gene:

Q8IZS6-TC1D3_HUMAN
Tissue specificity: Expressed predominantly in testis. Also expressed in brain, lung and trachea.
genes like me logo Genes that share expression patterns with TCTE3: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCTE3 Gene

Orthologs for TCTE3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCTE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCTE3 33 34
  • 99.49 (n)
cow
(Bos Taurus)
Mammalia TCTE3 33 34
  • 87.63 (n)
mouse
(Mus musculus)
Mammalia Gm3448 33 34
  • 85.34 (n)
Tcte3 16 34
  • 82 (a)
Gm3417 34
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TCTE3 34
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCTE3 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCTE3 34
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCTE3 33 34
  • 65 (n)
lizard
(Anolis carolinensis)
Reptilia TCTE3 34
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7276 34
  • 23 (a)
ManyToMany
CG5359 34
  • 21 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea dylt-2 34
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
OneToMany
CSA.4501 34
  • 27 (a)
OneToMany
Species where no ortholog for TCTE3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TCTE3 Gene

ENSEMBL:
Gene Tree for TCTE3 (if available)
TreeFam:
Gene Tree for TCTE3 (if available)

Paralogs for TCTE3 Gene

Paralogs for TCTE3 Gene

genes like me logo Genes that share paralogs with TCTE3: view

Variants for TCTE3 Gene

Sequence variations from dbSNP and Humsavar for TCTE3 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs182293452 likely-benign, not specified 169,751,645(-) G/A/C upstream_transcript_variant
rs773523861 likely-benign, not specified 169,751,629(-) A/T upstream_transcript_variant
rs3749882 benign, not specified 169,751,670(-) C/A/T upstream_transcript_variant
rs1000078260 -- 169,737,011(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000126669 -- 169,744,535(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TCTE3 Gene

Variant ID Type Subtype PubMed ID
nsv1032232 CNV loss 25217958
nsv605499 CNV gain 21841781
nsv830872 CNV loss 17160897

Variation tolerance for TCTE3 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.52; 85.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCTE3 Gene

Human Gene Mutation Database (HGMD)
TCTE3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCTE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCTE3 Gene

Disorders for TCTE3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TCTE3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
primary ciliary dyskinesia
  • ciliary motility disorder
kartagener syndrome
  • kartagener's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TCTE3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TCTE3

genes like me logo Genes that share disorders with TCTE3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCTE3 Gene

Publications for TCTE3 Gene

  1. Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia. (PMID: 12584439) Neesen J … Omran H (Cytogenetic and genome research 2002) 2 3 4 58
  2. Assignment of the human homologue of the mouse t-complex gene TCTE3 to human chromosome 6q27. (PMID: 1505969) Rappold GA … Lichter P (Genomics 1992) 2 3 58
  3. Search for Rare Copy-Number Variants in Congenital Heart Defects Identifies Novel Candidate Genes and a Potential Role for FOXC1 in Patients With Coarctation of the Aorta. (PMID: 26643481) Sanchez-Castro M … Le Caignec C (Circulation. Cardiovascular genetics 2016) 3 58
  4. Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array. (PMID: 21085971) Teshiba R … Yamamoto K (Pediatric surgery international 2011) 3 58
  5. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield JP … Hakonarson H (PLoS genetics 2011) 3 58

Products for TCTE3 Gene

Sources for TCTE3 Gene

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