Aliases for TCTE1 Gene

Aliases for TCTE1 Gene

  • T-Complex-Associated-Testis-Expressed 1 2 3 5
  • DRC5 2 3 4
  • T-Complex-Associated Testis-Expressed Protein 1 3 4
  • Dynein Regulatory Complex Subunit 5 3 4
  • FAP155 2 3
  • Tcte-1 3 4
  • D6S46 2 3
  • MGC33600 2
  • TCTE1 5

External Ids for TCTE1 Gene

Previous GeneCards Identifiers for TCTE1 Gene

  • GC06U990121
  • GC06M158967
  • GC06M044357
  • GC06M044246
  • GC06M043969

Summaries for TCTE1 Gene

GeneCards Summary for TCTE1 Gene

TCTE1 (T-Complex-Associated-Testis-Expressed 1) is a Protein Coding gene. Diseases associated with TCTE1 include Meningocele and Rigid Spine Muscular Dystrophy 1.

UniProtKB/Swiss-Prot Summary for TCTE1 Gene

  • Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility.

Additional gene information for TCTE1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCTE1 Gene

Genomics for TCTE1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TCTE1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCTE1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCTE1

Top Transcription factor binding sites by QIAGEN in the TCTE1 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • E47
  • Lmo2
  • POU2F1
  • Tal-1beta

Genomic Locations for TCTE1 Gene

Genomic Locations for TCTE1 Gene
chr6:44,278,734-44,297,805
(GRCh38/hg38)
Size:
19,072 bases
Orientation:
Minus strand
chr6:44,246,480-44,265,458
(GRCh37/hg19)
Size:
18,979 bases
Orientation:
Minus strand

Genomic View for TCTE1 Gene

Genes around TCTE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCTE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCTE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTE1 Gene

Proteins for TCTE1 Gene

  • Protein details for TCTE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JU00-DRC5_HUMAN
    Recommended name:
    Dynein regulatory complex subunit 5
    Protein Accession:
    Q5JU00
    Secondary Accessions:
    • B4DX59
    • Q8IYS6

    Protein attributes for TCTE1 Gene

    Size:
    501 amino acids
    Molecular mass:
    55632 Da
    Quaternary structure:
    • Component of the nexin-dynein regulatory complex (N-DRC). Interacts with FBXL13/DRC6, DRC3 and DRC7.

neXtProt entry for TCTE1 Gene

Post-translational modifications for TCTE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCTE1 Gene

Domains & Families for TCTE1 Gene

Gene Families for TCTE1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCTE1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCTE1 Gene

GenScript: Design optimal peptide antigens:
  • T-complex-associated testis-expressed protein 1 (TCTE1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5JU00

UniProtKB/Swiss-Prot:

DRC5_HUMAN :
  • Belongs to the DRC5 family.
Family:
  • Belongs to the DRC5 family.
genes like me logo Genes that share domains with TCTE1: view

Function for TCTE1 Gene

Molecular function for TCTE1 Gene

UniProtKB/Swiss-Prot Function:
Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. May play a role in the assembly of N-DRC. May be required for sperm motility.
GENATLAS Biochemistry:
t-complex associated,testis expressed 1 (formerly D6S46)

Phenotypes From GWAS Catalog for TCTE1 Gene

Gene Ontology (GO) - Molecular Function for TCTE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with TCTE1: view
genes like me logo Genes that share phenotypes with TCTE1: view

Animal Models for TCTE1 Gene

MGI Knock Outs for TCTE1:
  • Tcte1 Tcte1<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCTE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCTE1 Gene

Localization for TCTE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCTE1 Gene

Cell projection, cilium, flagellum. Cytoplasm, cytoskeleton, flagellum axoneme. Note=Detected along the length of the sperm flagellum. {ECO:0000250 UniProtKB:A6H639}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCTE1 gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TCTE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005929 cilium IEA --
GO:0031514 motile cilium IEA --
GO:0036126 sperm flagellum IEA,ISS --
genes like me logo Genes that share ontologies with TCTE1: view

Pathways & Interactions for TCTE1 Gene

PathCards logo

SuperPathways for TCTE1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCTE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030317 flagellated sperm motility IEA,ISS --
genes like me logo Genes that share ontologies with TCTE1: view

No data available for Pathways by source and SIGNOR curated interactions for TCTE1 Gene

Drugs & Compounds for TCTE1 Gene

No Compound Related Data Available

Transcripts for TCTE1 Gene

mRNA/cDNA for TCTE1 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCTE1

Alternative Splicing Database (ASD) splice patterns (SP) for TCTE1 Gene

No ASD Table

Relevant External Links for TCTE1 Gene

GeneLoc Exon Structure for
TCTE1

Expression for TCTE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCTE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCTE1 Gene

This gene is overexpressed in Testis (x29.0).

Protein differential expression in normal tissues from HIPED for TCTE1 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCTE1 Gene



Protein tissue co-expression partners for TCTE1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCTE1

SOURCE GeneReport for Unigene cluster for TCTE1 Gene:

Hs.189183
genes like me logo Genes that share expression patterns with TCTE1: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCTE1 Gene

Orthologs for TCTE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCTE1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TCTE1 30 31
  • 99.2 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TCTE1 30 31
  • 87.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TCTE1 30
  • 80.3 (n)
Rat
(Rattus norvegicus)
Mammalia Tcte1 30
  • 78.05 (n)
Mouse
(Mus musculus)
Mammalia Tcte1 30 17 31
  • 77.46 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TCTE1 31
  • 69 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TCTE1 31
  • 64 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TCTE1 30 31
  • 66.83 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TCTE1 31
  • 62 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tcte1 30
  • 63.52 (n)
Zebrafish
(Danio rerio)
Actinopterygii tcte1 30 31
  • 60.98 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002751 30
  • 45.54 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG14325 30 31
  • 43.6 (n)
OneToMany
Species where no ortholog for TCTE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TCTE1 Gene

ENSEMBL:
Gene Tree for TCTE1 (if available)
TreeFam:
Gene Tree for TCTE1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCTE1: view image

Paralogs for TCTE1 Gene

No data available for Paralogs for TCTE1 Gene

Variants for TCTE1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCTE1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs17853373 - p.His53Arg
rs2297336 - p.Phe261Ser
rs324146 - p.Pro35Leu

Additional dbSNP identifiers (rs#s) for TCTE1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TCTE1 Gene

Variant ID Type Subtype PubMed ID
dgv10641n54 CNV loss 21841781
dgv3507e59 CNV insertion 20981092
esv3408956 CNV insertion 20981092
esv3571032 CNV loss 25503493
nsv462936 CNV loss 19166990
nsv524398 CNV loss 19592680
nsv603003 CNV gain 21841781

Variation tolerance for TCTE1 Gene

Residual Variation Intolerance Score: 78% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.38; 85.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCTE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCTE1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCTE1 Gene

Disorders for TCTE1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TCTE1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
meningocele
  • spinal meningocele
rigid spine muscular dystrophy 1
  • rss
primary ciliary dyskinesia
  • pcd
- elite association - COSMIC cancer census association via MalaCards
Search TCTE1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TCTE1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with TCTE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCTE1 Gene

Publications for TCTE1 Gene

  1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 41
  2. A mouse chromosome 17 gene encodes a testes-specific transcript with unusual properties. (PMID: 2568335) Sarvetnick N … Silver LM (Immunogenetics 1989) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4

Products for TCTE1 Gene

Sources for TCTE1 Gene