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Aliases for TCTA Gene

Aliases for TCTA Gene

  • T Cell Leukemia Translocation Altered 2 3
  • T-Cell Leukemia Translocation Altered 2 5
  • T-Cell Leukemia Translocation-Associated Gene Protein 4
  • T-Cell Leukemia Translocation Altered Gene 2

External Ids for TCTA Gene

Previous GeneCards Identifiers for TCTA Gene

  • GC03M048875
  • GC03M048951
  • GC03P049304
  • GC03P049408
  • GC03P049424

Summaries for TCTA Gene

GeneCards Summary for TCTA Gene

TCTA (T Cell Leukemia Translocation Altered) is a Protein Coding gene. Diseases associated with TCTA include T-Cell Leukemia and Leukemia.

UniProtKB/Swiss-Prot for TCTA Gene

  • May be required for cellular fusion during osteoclastogenesis.

Additional gene information for TCTA Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCTA Gene

Genomics for TCTA Gene

GeneHancer (GH) Regulatory Elements for TCTA Gene

Promoters and enhancers for TCTA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I049409 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.6 1601 8.9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 RHOA TCTA AMT CCDC71 WDR6 SEMA3F-AS1 QRICH1 FAM212A RBM5 DAG1
GH03I049338 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12 -66.2 -66156 14.7 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A USP4 AMT QRICH1 ENSG00000235236 RBM6 ATRIP RBM5 WDR6 IP6K2 ENSG00000230454
GH03I049265 Enhancer 0.7 Ensembl ENCODE 10.5 -145.9 -145875 2.6 PRDM12 ZFP64 ZC3H11A ZNF781 ZNF518A ZNF697 WDR6 QRICH1 AMT RBM5 RBM6 SEMA3F-AS1 NME6 IP6K2 USP19 ATRIP
GH03I049269 Enhancer 0.4 ENCODE 10.5 -141.6 -141550 3.3 ATF2 ZIC2 ENSG00000199546 AMT WDR6 CCDC36 C3orf84 KLHDC8B CCDC71 DAG1 RNA5SP130 LAMB2
GH03I049408 Enhancer 0.7 ENCODE dbSUPER 0.8 -3.2 -3153 0.1 ZNF121 ZNF384 ZBTB33 MLLT1 USP4 C3orf62 CCDC71 KLHDC8B TCTA RHOA RHOA-IT1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCTA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCTA gene promoter:

Genomic Locations for TCTA Gene

Genomic Locations for TCTA Gene
chr3:49,412,206-49,416,476
(GRCh38/hg38)
Size:
4,271 bases
Orientation:
Plus strand
chr3:49,449,639-49,453,909
(GRCh37/hg19)

Genomic View for TCTA Gene

Genes around TCTA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCTA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCTA Gene

Proteins for TCTA Gene

  • Protein details for TCTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57738-TCTA_HUMAN
    Recommended name:
    T-cell leukemia translocation-altered gene protein
    Protein Accession:
    P57738
    Secondary Accessions:
    • B2R4I4
    • Q6I9U4
    • Q9BSB0

    Protein attributes for TCTA Gene

    Size:
    103 amino acids
    Molecular mass:
    11341 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCTA Gene

Post-translational modifications for TCTA Gene

Other Protein References for TCTA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCTA Gene

Domains & Families for TCTA Gene

Gene Families for TCTA Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted membrane proteins

Protein Domains for TCTA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCTA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57738

UniProtKB/Swiss-Prot:

TCTA_HUMAN :
  • Belongs to the TCTA family.
Family:
  • Belongs to the TCTA family.
genes like me logo Genes that share domains with TCTA: view

Function for TCTA Gene

Molecular function for TCTA Gene

GENATLAS Biochemistry:
T cell leukemia translocation-associated gene,involved in t(1;3)(p34;p21);see SCL,TAL1
UniProtKB/Swiss-Prot Function:
May be required for cellular fusion during osteoclastogenesis.

Phenotypes From GWAS Catalog for TCTA Gene

Gene Ontology (GO) - Molecular Function for TCTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TCTA: view
genes like me logo Genes that share phenotypes with TCTA: view

Animal Model Products

CRISPR Products

miRNA for TCTA Gene

miRTarBase miRNAs that target TCTA

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCTA Gene

Localization for TCTA Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCTA Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCTA gene
Compartment Confidence
cytosol 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TCTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 19560569
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TCTA: view

Pathways & Interactions for TCTA Gene

No Data Available

Interacting Proteins for TCTA Gene

Selected Interacting proteins: P57738-TCTA_HUMAN for TCTA Gene via IID MINT

Gene Ontology (GO) - Biological Process for TCTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045671 negative regulation of osteoclast differentiation IDA 19560569
GO:0072675 osteoclast fusion IDA 19560569
genes like me logo Genes that share ontologies with TCTA: view

No data available for Pathways by source and SIGNOR curated interactions for TCTA Gene

Drugs & Compounds for TCTA Gene

No Compound Related Data Available

Transcripts for TCTA Gene

Unigene Clusters for TCTA Gene

T-cell leukemia translocation altered:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCTA Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g · 1h ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: -
SP8: - - -
SP9: -

Relevant External Links for TCTA Gene

GeneLoc Exon Structure for
TCTA
ECgene alternative splicing isoforms for
TCTA

Expression for TCTA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCTA Gene

NURSA nuclear receptor signaling pathways regulating expression of TCTA Gene:

TCTA

SOURCE GeneReport for Unigene cluster for TCTA Gene:

Hs.517962

mRNA Expression by UniProt/SwissProt for TCTA Gene:

P57738-TCTA_HUMAN
Tissue specificity: Ubiquitous. Highest level of expression in kidney. Present in monocytes, osteoclasts, macrophages, synoviocytes and synovial lining cells (at protein level).

Evidence on tissue expression from TISSUES for TCTA Gene

  • Nervous system(4.3)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TCTA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCTA Gene

Orthologs for TCTA Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCTA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCTA 33 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia TCTA 33 34
  • 92.23 (n)
dog
(Canis familiaris)
Mammalia TCTA 33 34
  • 90.85 (n)
rat
(Rattus norvegicus)
Mammalia Tcta 33
  • 89.97 (n)
mouse
(Mus musculus)
Mammalia Tcta 33 16 34
  • 89 (n)
oppossum
(Monodelphis domestica)
Mammalia TCTA 34
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCTA 34
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcta 33
  • 57.76 (n)
zebrafish
(Danio rerio)
Actinopterygii tcta 33 34
  • 58 (n)
Species where no ortholog for TCTA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCTA Gene

ENSEMBL:
Gene Tree for TCTA (if available)
TreeFam:
Gene Tree for TCTA (if available)

Paralogs for TCTA Gene

No data available for Paralogs for TCTA Gene

Variants for TCTA Gene

Sequence variations from dbSNP and Humsavar for TCTA Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs10640 benign, Non-ketotic hyperglycinemia 49,416,844(+) G/A/C/T downstream_transcript_variant
rs779703869 uncertain-significance, Non-ketotic hyperglycinemia 49,416,862(+) G/C/T downstream_transcript_variant
rs1000203507 -- 49,412,305(+) C/T 5_prime_UTR_variant
rs1000291791 -- 49,411,270(+) T/A upstream_transcript_variant
rs1000322619 -- 49,411,534(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TCTA Gene

Variant ID Type Subtype PubMed ID
nsv834687 CNV loss 17160897

Variation tolerance for TCTA Gene

Residual Variation Intolerance Score: 78.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.57; 30.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCTA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCTA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCTA Gene

Disorders for TCTA Gene

MalaCards: The human disease database

(2) MalaCards diseases for TCTA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
leukemia
- elite association - COSMIC cancer census association via MalaCards
Search TCTA in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TCTA_HUMAN
  • Note=A chromosomal aberration involving TCTA is associated with T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(1;3)(p34;p21).

Additional Disease Information for TCTA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TCTA: view

No data available for Genatlas for TCTA Gene

Publications for TCTA Gene

  1. Cloning and characterization of TCTA, a gene located at the site of a t(1;3) translocation. (PMID: 7728759) Aplan PD … Kirsch IR (Cancer research 1995) 2 3 4 22 58
  2. T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. (PMID: 19560569) Kotake S … Yamanaka H (Bone 2009) 3 4 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
  5. [Role of T-cell leukemia translocation-associated gene (TCTA) protein in human osteoclastogenesis]. (PMID: 20046013) Kotake S … Nanke Y (Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2009) 3 22 58

Products for TCTA Gene

Sources for TCTA Gene

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