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Aliases for TCP11L2 Gene

Aliases for TCP11L2 Gene

  • T-Complex 11 Like 2 2 3 5
  • T-Complex 11, Testis-Specific-Like 2 2 3
  • T-Complex Protein 11-Like Protein 2 3 4
  • T-Complex 11 (Mouse) Like 2 2
  • T-Complex 11 (Mouse)-Like 2 2

External Ids for TCP11L2 Gene

Previous GeneCards Identifiers for TCP11L2 Gene

  • GC12P105200
  • GC12P106696
  • GC12P103756
  • GC12P106698
  • GC12P106702
  • GC12P106705

Summaries for TCP11L2 Gene

GeneCards Summary for TCP11L2 Gene

TCP11L2 (T-Complex 11 Like 2) is a Protein Coding gene. An important paralog of this gene is TCP11L1.

Additional gene information for TCP11L2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP11L2 Gene

Genomics for TCP11L2 Gene

GeneHancer (GH) Regulatory Elements for TCP11L2 Gene

Promoters and enhancers for TCP11L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J106299 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 609.6 +0.4 428 5.7 SP1 ZFX CC2D1A ZKSCAN8 MNT SIX5 CBFA2T2 ZNF148 NKRF GTF2F1 TCP11L2 CKAP4 ENSG00000260329 POLR3B MTERF2 TMEM263
GH12J106295 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 608 -5.0 -4985 2.5 MNT MAFK FOSL2 CREB1 POLR2A GATAD2A RXRB ZNF316 SOX13 JUN TCP11L2 GC12P106296 POLR3B CKAP4
GH12J106357 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.9 +56.5 56519 2.6 SP1 CC2D1A ZFX ELF3 CTCF ZKSCAN8 MNT SIX5 CBFA2T2 NKRF POLR3B GC12M106356 TCP11L2 GC12P106417
GH12J106226 Enhancer 1.3 FANTOM5 Ensembl ENCODE 16.4 -72.6 -72649 5 CC2D1A CTCF CEBPG MAFK SP1 RAD21 RXRA ARID2 CEBPA GATAD2A TCP11L2 RNU7-94P POLR3B GC12M106238 PIR51001
GH12J106280 Enhancer 1.4 FANTOM5 Ensembl ENCODE 15.2 -21.5 -21528 5.6 ZNF652 ELF3 CTCF CEBPG RERE TFE3 SP7 SP1 PPARG HNF1A TCP11L2 POLR3B MTERF2 RNU7-94P CKAP4 ENSG00000277715
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCP11L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCP11L2 gene promoter:
  • AREB6
  • FOXO1
  • FOXO1a
  • NF-1
  • NF-1/L
  • Nkx2-5
  • Nkx5-1
  • Pax-4a
  • POU2F1
  • POU2F1a

Genomic Locations for TCP11L2 Gene

Genomic Locations for TCP11L2 Gene
45,659 bases
Plus strand
45,087 bases
Plus strand

Genomic View for TCP11L2 Gene

Genes around TCP11L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP11L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP11L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP11L2 Gene

Proteins for TCP11L2 Gene

  • Protein details for TCP11L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-complex protein 11-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RA65
    • G3V1Y9

    Protein attributes for TCP11L2 Gene

    519 amino acids
    Molecular mass:
    58091 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCP11L2 Gene


neXtProt entry for TCP11L2 Gene

Post-translational modifications for TCP11L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCP11L2 Gene

Domains & Families for TCP11L2 Gene

Gene Families for TCP11L2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for TCP11L2 Gene


Suggested Antigen Peptide Sequences for TCP11L2 Gene

GenScript: Design optimal peptide antigens:
  • T-complex protein 11-like protein 2 (T11L2_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TCP11 family.
  • Belongs to the TCP11 family.
genes like me logo Genes that share domains with TCP11L2: view

Function for TCP11L2 Gene

Phenotypes From GWAS Catalog for TCP11L2 Gene

genes like me logo Genes that share phenotypes with TCP11L2: view

Animal Model Products

CRISPR Products

miRNA for TCP11L2 Gene

miRTarBase miRNAs that target TCP11L2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCP11L2

Clone Products

  • Applied Biological Materials (abm): Clones for TCP11L2 - Now 50% OFF >
  • * TCP11L2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TCP11L2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCP11L2 Gene

Localization for TCP11L2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCP11L2 gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCP11L2 Gene

Pathways & Interactions for TCP11L2 Gene

PathCards logo

SuperPathways for TCP11L2 Gene

No Data Available

Interacting Proteins for TCP11L2 Gene

Gene Ontology (GO) - Biological Process for TCP11L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TCP11L2 Gene

Drugs & Compounds for TCP11L2 Gene

No Compound Related Data Available

Transcripts for TCP11L2 Gene

mRNA/cDNA for TCP11L2 Gene

Unigene Clusters for TCP11L2 Gene

T-complex 11, testis-specific-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCP11L2

Clone Products

  • Applied Biological Materials (abm): Clones for TCP11L2 - Now 50% OFF >
  • * TCP11L2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * TCP11L2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for TCP11L2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - -
SP8: - -

Relevant External Links for TCP11L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCP11L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCP11L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCP11L2 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for TCP11L2 Gene

This gene is overexpressed in Hair follicle (56.6) and Cervix (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TCP11L2 Gene

Protein tissue co-expression partners for TCP11L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCP11L2 Gene:


SOURCE GeneReport for Unigene cluster for TCP11L2 Gene:

genes like me logo Genes that share expression patterns with TCP11L2: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCP11L2 Gene

Orthologs for TCP11L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCP11L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TCP11L2 35 34
  • 99.36 (n)
(Canis familiaris)
Mammalia TCP11L2 35 34
  • 92.3 (n)
(Bos Taurus)
Mammalia TCP11L2 35 34
  • 89.66 (n)
(Mus musculus)
Mammalia Tcp11l2 17 35 34
  • 83.43 (n)
(Rattus norvegicus)
Mammalia Tcp11l2 34
  • 83.17 (n)
(Ornithorhynchus anatinus)
Mammalia TCP11L2 35
  • 82 (a)
(Monodelphis domestica)
Mammalia TCP11L2 35
  • 80 (a)
(Gallus gallus)
Aves TCP11L2 35 34
  • 72.83 (n)
(Anolis carolinensis)
Reptilia TCP11L2 35
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tcp11l2 34
  • 63.87 (n)
Str.3807 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.20084 34
(Danio rerio)
Actinopterygii tcp11l2 35 34
  • 59.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG16721 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea M05D6.2 35
  • 23 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOK1 37 35
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
Species where no ortholog for TCP11L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCP11L2 Gene

Gene Tree for TCP11L2 (if available)
Gene Tree for TCP11L2 (if available)
Evolutionary constrained regions (ECRs) for TCP11L2: view image

Paralogs for TCP11L2 Gene

Paralogs for TCP11L2 Gene

(4) SIMAP similar genes for TCP11L2 Gene using alignment to 9 proteins:

  • T11L2_HUMAN
  • F8VU20_HUMAN
  • F8VW27_HUMAN
  • F8W0R5_HUMAN
  • F8W1M6_HUMAN
  • G3V1Y9_HUMAN
  • G3V1Z2_HUMAN
  • L8E978_HUMAN
genes like me logo Genes that share paralogs with TCP11L2: view

Variants for TCP11L2 Gene

Sequence variations from dbSNP and Humsavar for TCP11L2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005201 -- 106,327,459(+) C/T intron_variant
rs1000105350 -- 106,335,662(+) T/C coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000195425 -- 106,323,329(+) A/G intron_variant
rs1000285752 -- 106,328,949(+) C/T intron_variant
rs1000297254 -- 106,317,157(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TCP11L2 Gene

Variant ID Type Subtype PubMed ID
esv2746335 CNV deletion 23290073
esv2746336 CNV deletion 23290073

Variation tolerance for TCP11L2 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCP11L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP11L2 Gene

Disorders for TCP11L2 Gene

Additional Disease Information for TCP11L2

No disorders were found for TCP11L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCP11L2 Gene

Publications for TCP11L2 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E … Raught B (Molecular & cellular proteomics : MCP 2015) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  5. Genome-wide association study of Tourette's syndrome. (PMID: 22889924) Scharf JM … Pauls DL (Molecular psychiatry 2013) 3 58

Products for TCP11L2 Gene

Sources for TCP11L2 Gene

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