Aliases for TCP11L2 Gene

Aliases for TCP11L2 Gene

  • T-Complex 11 Like 2 2 3 5
  • T-Complex 11, Testis-Specific-Like 2 2 3
  • T-Complex Protein 11-Like Protein 2 3 4
  • T-Complex 11 (Mouse) Like 2 2
  • T-Complex 11 (Mouse)-Like 2 2

External Ids for TCP11L2 Gene

Previous GeneCards Identifiers for TCP11L2 Gene

  • GC12P105200
  • GC12P106696
  • GC12P103756
  • GC12P106698
  • GC12P106702
  • GC12P106705

Summaries for TCP11L2 Gene

GeneCards Summary for TCP11L2 Gene

TCP11L2 (T-Complex 11 Like 2) is a Protein Coding gene. An important paralog of this gene is TCP11L1.

Additional gene information for TCP11L2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCP11L2 Gene

Genomics for TCP11L2 Gene

GeneHancer (GH) Regulatory Elements for TCP11L2 Gene

Promoters and enhancers for TCP11L2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCP11L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCP11L2 gene promoter:
  • AREB6
  • FOXO1
  • FOXO1a
  • NF-1
  • NF-1/L
  • Nkx2-5
  • Nkx5-1
  • Pax-4a
  • POU2F1
  • POU2F1a

Genomic Locations for TCP11L2 Gene

Genomic Locations for TCP11L2 Gene
chr12:106,301,929-106,347,587
(GRCh38/hg38)
Size:
45,659 bases
Orientation:
Plus strand
chr12:106,695,707-106,740,793
(GRCh37/hg19)
Size:
45,087 bases
Orientation:
Plus strand

Genomic View for TCP11L2 Gene

Genes around TCP11L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP11L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP11L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP11L2 Gene

Proteins for TCP11L2 Gene

  • Protein details for TCP11L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4U5-T11L2_HUMAN
    Recommended name:
    T-complex protein 11-like protein 2
    Protein Accession:
    Q8N4U5
    Secondary Accessions:
    • B2RA65
    • G3V1Y9

    Protein attributes for TCP11L2 Gene

    Size:
    519 amino acids
    Molecular mass:
    58091 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCP11L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCP11L2 Gene

Post-translational modifications for TCP11L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCP11L2 Gene

Domains & Families for TCP11L2 Gene

Gene Families for TCP11L2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for TCP11L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCP11L2 Gene

GenScript: Design optimal peptide antigens:
  • T-complex protein 11-like protein 2 (T11L2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N4U5

UniProtKB/Swiss-Prot:

T11L2_HUMAN :
  • Belongs to the TCP11 family.
Family:
  • Belongs to the TCP11 family.
genes like me logo Genes that share domains with TCP11L2: view

Function for TCP11L2 Gene

Phenotypes From GWAS Catalog for TCP11L2 Gene

genes like me logo Genes that share phenotypes with TCP11L2: view

Animal Model Products

CRISPR Products

miRNA for TCP11L2 Gene

miRTarBase miRNAs that target TCP11L2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCP11L2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCP11L2 Gene

Localization for TCP11L2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCP11L2 gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCP11L2 Gene

Pathways & Interactions for TCP11L2 Gene

PathCards logo

SuperPathways for TCP11L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCP11L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCP11L2 Gene

Drugs & Compounds for TCP11L2 Gene

No Compound Related Data Available

Transcripts for TCP11L2 Gene

mRNA/cDNA for TCP11L2 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCP11L2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCP11L2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - -
SP7:
SP8: - -

Relevant External Links for TCP11L2 Gene

GeneLoc Exon Structure for
TCP11L2
ECgene alternative splicing isoforms for
TCP11L2

Expression for TCP11L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCP11L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCP11L2 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for TCP11L2 Gene

This gene is overexpressed in Hair follicle (56.6) and Cervix (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TCP11L2 Gene



Protein tissue co-expression partners for TCP11L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCP11L2 Gene:

TCP11L2

SOURCE GeneReport for Unigene cluster for TCP11L2 Gene:

Hs.696047
genes like me logo Genes that share expression patterns with TCP11L2: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCP11L2 Gene

Orthologs for TCP11L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCP11L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCP11L2 33 32
  • 99.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TCP11L2 33 32
  • 92.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TCP11L2 33 32
  • 89.66 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tcp11l2 17 33 32
  • 83.43 (n)
rat
(Rattus norvegicus)
Mammalia Tcp11l2 32
  • 83.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCP11L2 33
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCP11L2 33
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCP11L2 33 32
  • 72.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCP11L2 33
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcp11l2 32
  • 63.87 (n)
Str.3807 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.20084 32
zebrafish
(Danio rerio)
Actinopterygii tcp11l2 33 32
  • 59.12 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16721 33
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M05D6.2 33
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOK1 35 33
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 20 (a)
OneToMany
Species where no ortholog for TCP11L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCP11L2 Gene

ENSEMBL:
Gene Tree for TCP11L2 (if available)
TreeFam:
Gene Tree for TCP11L2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCP11L2: view image

Paralogs for TCP11L2 Gene

Paralogs for TCP11L2 Gene

(4) SIMAP similar genes for TCP11L2 Gene using alignment to 9 proteins:

  • T11L2_HUMAN
  • F8VRQ3_HUMAN
  • F8VU20_HUMAN
  • F8VW27_HUMAN
  • F8W0R5_HUMAN
  • F8W1M6_HUMAN
  • G3V1Y9_HUMAN
  • G3V1Z2_HUMAN
  • L8E978_HUMAN
genes like me logo Genes that share paralogs with TCP11L2: view

Variants for TCP11L2 Gene

Sequence variations from dbSNP and Humsavar for TCP11L2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000005201 -- 106,327,459(+) C/T intron_variant
rs1000105350 -- 106,335,662(+) T/C coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000195425 -- 106,323,329(+) A/G intron_variant
rs1000285752 -- 106,328,949(+) C/T intron_variant
rs1000297254 -- 106,317,157(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TCP11L2 Gene

Variant ID Type Subtype PubMed ID
esv2746335 CNV deletion 23290073
esv2746336 CNV deletion 23290073

Variation tolerance for TCP11L2 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCP11L2 Gene

Human Gene Mutation Database (HGMD)
TCP11L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCP11L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP11L2 Gene

Disorders for TCP11L2 Gene

Additional Disease Information for TCP11L2

No disorders were found for TCP11L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCP11L2 Gene

Publications for TCP11L2 Gene

  1. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 56
  2. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 56
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 56

Products for TCP11L2 Gene

Sources for TCP11L2 Gene