Aliases for TCP11L2 Gene

Aliases for TCP11L2 Gene

  • T-Complex 11 Like 2 2 3 5
  • T-Complex 11, Testis-Specific-Like 2 2 3
  • T-Complex Protein 11-Like Protein 2 3 4
  • T-Complex 11 (Mouse) Like 2 2
  • T-Complex 11 (Mouse)-Like 2 2

External Ids for TCP11L2 Gene

Previous GeneCards Identifiers for TCP11L2 Gene

  • GC12P105200
  • GC12P106696
  • GC12P103756
  • GC12P106698
  • GC12P106702
  • GC12P106705

Summaries for TCP11L2 Gene

GeneCards Summary for TCP11L2 Gene

TCP11L2 (T-Complex 11 Like 2) is a Protein Coding gene. An important paralog of this gene is TCP11L1.

Additional gene information for TCP11L2 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCP11L2 Gene

Genomics for TCP11L2 Gene

GeneHancer (GH) Regulatory Elements for TCP11L2 Gene

Promoters and enhancers for TCP11L2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J106299 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 509.6 +0.4 428 5.7 EP300 FOXK2 ZNF217 SIN3A TCF12 POLR2G SP1 BCLAF1 NONO PHF8 TCP11L2 CKAP4 NONHSAG012173.2 lnc-NUAK1-7 ENSG00000260329 POLR3B MTERF2 TMEM263
GH12J106295 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 508 -5.0 -4985 2.5 TCF12 JUND FOS CLOCK RFX1 CUX1 TEAD1 TBX3 ESRRA FOXA2 TCP11L2 piR-60140-004 POLR3B CKAP4 lnc-NUAK1-7
GH12J106357 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 10.9 +56.4 56448 2.8 RXRA EP300 ZBTB40 ZNF217 CTCF SIN3A TCF12 NRF1 POLR2G SP1 POLR3B lnc-CKAP4-1 TCP11L2 RF00017-1242
GH12J106280 Enhancer 1.3 FANTOM5 Ensembl ENCODE 15.2 -21.5 -21529 5.6 EP300 FOXK2 ZNF217 CTCF NCOR1 KDM6A TCF7 FOXA1 REST CUX1 TCP11L2 POLR3B MTERF2 RF00066-052 RNU7-94P CKAP4 lnc-NUAK1-7 ENSG00000277715
GH12J106226 Enhancer 1.2 FANTOM5 Ensembl ENCODE 16.4 -73.0 -73028 5.4 CTCF USF1 POLR2A ZNF623 REST KLF4 RAD21 TRIM22 TEAD1 SMC3 TCP11L2 RNU7-94P POLR3B piR-53063-049 piR-57002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCP11L2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCP11L2

Top Transcription factor binding sites by QIAGEN in the TCP11L2 gene promoter:
  • AREB6
  • FOXO1
  • FOXO1a
  • NF-1
  • NF-1/L
  • Nkx2-5
  • Nkx5-1
  • Pax-4a
  • POU2F1
  • POU2F1a

Genomic Locations for TCP11L2 Gene

Genomic Locations for TCP11L2 Gene
chr12:106,301,929-106,347,587
(GRCh38/hg38)
Size:
45,659 bases
Orientation:
Plus strand
chr12:106,695,707-106,740,793
(GRCh37/hg19)
Size:
45,087 bases
Orientation:
Plus strand

Genomic View for TCP11L2 Gene

Genes around TCP11L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP11L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP11L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP11L2 Gene

Proteins for TCP11L2 Gene

  • Protein details for TCP11L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4U5-T11L2_HUMAN
    Recommended name:
    T-complex protein 11-like protein 2
    Protein Accession:
    Q8N4U5
    Secondary Accessions:
    • B2RA65
    • G3V1Y9

    Protein attributes for TCP11L2 Gene

    Size:
    519 amino acids
    Molecular mass:
    58091 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCP11L2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCP11L2 Gene

Post-translational modifications for TCP11L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCP11L2 Gene

Domains & Families for TCP11L2 Gene

Gene Families for TCP11L2 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for TCP11L2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCP11L2 Gene

GenScript: Design optimal peptide antigens:
  • T-complex protein 11-like protein 2 (T11L2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N4U5

UniProtKB/Swiss-Prot:

T11L2_HUMAN :
  • Belongs to the TCP11 family.
Family:
  • Belongs to the TCP11 family.
genes like me logo Genes that share domains with TCP11L2: view

Function for TCP11L2 Gene

Phenotypes From GWAS Catalog for TCP11L2 Gene

Gene Ontology (GO) - Molecular Function for TCP11L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 28514442
genes like me logo Genes that share ontologies with TCP11L2: view
genes like me logo Genes that share phenotypes with TCP11L2: view

Animal Model Products

CRISPR Products

miRNA for TCP11L2 Gene

miRTarBase miRNAs that target TCP11L2

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCP11L2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCP11L2 Gene

Localization for TCP11L2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCP11L2 gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TCP11L2 Gene

Pathways & Interactions for TCP11L2 Gene

PathCards logo

SuperPathways for TCP11L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCP11L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCP11L2 Gene

Drugs & Compounds for TCP11L2 Gene

No Compound Related Data Available

Transcripts for TCP11L2 Gene

mRNA/cDNA for TCP11L2 Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCP11L2

Alternative Splicing Database (ASD) splice patterns (SP) for TCP11L2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: -
SP5: - - - - -
SP6: - - - - -
SP7:
SP8: - -

Relevant External Links for TCP11L2 Gene

GeneLoc Exon Structure for
TCP11L2

Expression for TCP11L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCP11L2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCP11L2 Gene

This gene is overexpressed in Whole Blood (x5.3).

Protein differential expression in normal tissues from HIPED for TCP11L2 Gene

This gene is overexpressed in Hair follicle (56.6) and Cervix (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TCP11L2 Gene



Protein tissue co-expression partners for TCP11L2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCP11L2

SOURCE GeneReport for Unigene cluster for TCP11L2 Gene:

Hs.696047
genes like me logo Genes that share expression patterns with TCP11L2: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCP11L2 Gene

Orthologs for TCP11L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCP11L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCP11L2 31 30
  • 99.36 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TCP11L2 31 30
  • 92.3 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TCP11L2 31 30
  • 89.66 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tcp11l2 17 31 30
  • 83.43 (n)
rat
(Rattus norvegicus)
Mammalia Tcp11l2 30
  • 83.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCP11L2 31
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCP11L2 31
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCP11L2 31 30
  • 72.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCP11L2 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcp11l2 30
  • 63.87 (n)
Str.3807 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.20084 30
zebrafish
(Danio rerio)
Actinopterygii tcp11l2 31 30
  • 59.12 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG16721 31
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M05D6.2 31
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOK1 33 31
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 20 (a)
OneToMany
Species where no ortholog for TCP11L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCP11L2 Gene

ENSEMBL:
Gene Tree for TCP11L2 (if available)
TreeFam:
Gene Tree for TCP11L2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCP11L2: view image

Paralogs for TCP11L2 Gene

Paralogs for TCP11L2 Gene

(4) SIMAP similar genes for TCP11L2 Gene using alignment to 9 proteins:

  • T11L2_HUMAN
  • F8VRQ3_HUMAN
  • F8VU20_HUMAN
  • F8VW27_HUMAN
  • F8W0R5_HUMAN
  • F8W1M6_HUMAN
  • G3V1Y9_HUMAN
  • G3V1Z2_HUMAN
  • L8E978_HUMAN
genes like me logo Genes that share paralogs with TCP11L2: view

Variants for TCP11L2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCP11L2 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs11837375 - p.Ala82Ser
rs17218950 - p.Asp261Asn
rs4964460 - p.Ala41Thr

Additional dbSNP identifiers (rs#s) for TCP11L2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TCP11L2 Gene

Variant ID Type Subtype PubMed ID
esv2746335 CNV deletion 23290073
esv2746336 CNV deletion 23290073

Variation tolerance for TCP11L2 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.99% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCP11L2 Gene

Human Gene Mutation Database (HGMD)
TCP11L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCP11L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP11L2 Gene

Disorders for TCP11L2 Gene

Additional Disease Information for TCP11L2

No disorders were found for TCP11L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCP11L2 Gene

Publications for TCP11L2 Gene

  1. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3 54
  2. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 54

Products for TCP11L2 Gene

Sources for TCP11L2 Gene