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Aliases for TCP10L2 Gene

Aliases for TCP10L2 Gene

  • T-Complex 10 Like 2 2 3 5
  • T-Complex 10-Like 2 (Mouse) 2
  • T-Complex 10-Like Protein 2 4
  • T-Complex 10-Like 2 2

External Ids for TCP10L2 Gene

Previous GeneCards Identifiers for TCP10L2 Gene

  • GC06P167493
  • GC06U900706
  • GC06P165056
  • GC06P167585
  • GC06P167559

Summaries for TCP10L2 Gene

GeneCards Summary for TCP10L2 Gene

TCP10L2 (T-Complex 10 Like 2) is a Protein Coding gene. An important paralog of this gene is TCP10.

Additional gene information for TCP10L2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP10L2 Gene

Genomics for TCP10L2 Gene

GeneHancer (GH) Regulatory Elements for TCP10L2 Gene

Promoters and enhancers for TCP10L2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I167146 Enhancer 0.7 Ensembl ENCODE 555.9 +0.6 617 1.2 USF1 POLR2A MAX CTBP2 REST TCP10L2 LOC105378124 CCR6 FGFR1OP LOC105378120 RNASET2 ENSG00000249141 GPR31
GH06I167170 Promoter 0.5 EPDnew 550.3 +24.2 24186 0.1 LOC105378123 TCP10L2 PIR32108
GH06I167143 Enhancer 1.1 ENCODE dbSUPER 5.9 -4.2 -4206 1.5 ELF3 FOXA2 RB1 ARID4B IRF4 ZNF48 RAD21 ARID2 ZNF207 ZNF143 CCR6 FGFR1OP LOC105378120 TCP10L2 LOC105378124 LOC105378122
GH06I167233 Enhancer 0.3 ENCODE 6.1 +87.0 87006 0.9 CTCF UNC93A LOC102724220 TCP10L2 ENSG00000280707 LOC102725048
GH06I167150 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 0.4 +6.1 6126 3.4 PKNOX1 SMAD1 BATF KLF5 IRF4 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 GPR31 RNASET2 CCR6 LOC105378120 FGFR1OP ENSG00000249141 UNC93A RPS6KA2-AS1 RPS6KA2 AFDN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCP10L2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCP10L2 gene promoter:

Genomic Locations for TCP10L2 Gene

Genomic Locations for TCP10L2 Gene
50,500 bases
Plus strand

Genomic View for TCP10L2 Gene

Genes around TCP10L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP10L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP10L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP10L2 Gene

Proteins for TCP10L2 Gene

  • Protein details for TCP10L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-complex protein 10A homolog 2
    Protein Accession:

    Protein attributes for TCP10L2 Gene

    353 amino acids
    Molecular mass:
    38357 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCP10L2 Gene

Post-translational modifications for TCP10L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCP10L2 Gene

No data available for DME Specific Peptides for TCP10L2 Gene

Domains & Families for TCP10L2 Gene

Gene Families for TCP10L2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCP10L2 Gene


Suggested Antigen Peptide Sequences for TCP10L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TCP10 family.
  • Belongs to the TCP10 family.
genes like me logo Genes that share domains with TCP10L2: view

Function for TCP10L2 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCP10L2 Gene

Localization for TCP10L2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCP10L2 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TCP10L2 Gene

Pathways & Interactions for TCP10L2 Gene

SuperPathways for TCP10L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCP10L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TCP10L2 Gene

Drugs & Compounds for TCP10L2 Gene

No Compound Related Data Available

Transcripts for TCP10L2 Gene

mRNA/cDNA for TCP10L2 Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCP10L2 Gene

T-complex 10-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCP10L2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: - - - -
SP2: - -
SP3: - - -

Relevant External Links for TCP10L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCP10L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCP10L2 Gene

mRNA differential expression in normal tissues according to GTEx for TCP10L2 Gene

This gene is overexpressed in Testis (x39.9).

Protein differential expression in normal tissues from HIPED for TCP10L2 Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCP10L2 Gene

Protein tissue co-expression partners for TCP10L2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCP10L2 Gene:


SOURCE GeneReport for Unigene cluster for TCP10L2 Gene:

genes like me logo Genes that share expression patterns with TCP10L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCP10L2 Gene

Orthologs for TCP10L2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TCP10L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 95 (a)
Species where no ortholog for TCP10L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCP10L2 Gene

Gene Tree for TCP10L2 (if available)
Gene Tree for TCP10L2 (if available)

Paralogs for TCP10L2 Gene

Paralogs for TCP10L2 Gene

(2) SIMAP similar genes for TCP10L2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TCP10L2: view

Variants for TCP10L2 Gene

Sequence variations from dbSNP and Humsavar for TCP10L2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000385113 -- 167,191,175(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000480087 -- 167,190,953(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000523470 -- 167,184,802(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000712378 -- 167,175,023(+) T/A intron_variant
rs1000743327 -- 167,175,247(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TCP10L2 Gene

Variant ID Type Subtype PubMed ID
dgv1240e214 CNV gain 21293372
dgv6194n100 CNV gain 25217958
esv2759492 CNV gain 17122850
esv3571536 CNV loss 25503493
esv3571537 CNV loss 25503493
esv3611649 CNV gain 21293372
esv3890997 CNV loss 25118596
nsv464141 CNV gain 19166990
nsv469673 CNV loss 16826518
nsv470873 CNV gain 18288195
nsv605338 CNV gain 21841781
nsv7389 OTHER inversion 18451855
nsv8000 CNV gain 18304495
nsv949892 CNV deletion 24416366
nsv965787 CNV duplication 23825009
nsv981207 CNV duplication 23825009

Variation tolerance for TCP10L2 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.93; 79.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCP10L2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP10L2 Gene

Disorders for TCP10L2 Gene

Additional Disease Information for TCP10L2

No disorders were found for TCP10L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCP10L2 Gene

Publications for TCP10L2 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4 58

Products for TCP10L2 Gene

Sources for TCP10L2 Gene

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