Aliases for TCP10L Gene

Aliases for TCP10L Gene

  • T-Complex 10 Like 2 3 5
  • T-Complex Protein 10A Homolog 1 3 4
  • T-Complex Protein 10A-1 3 4
  • TCP10-Like 3 4
  • TCP10A-1 3 4
  • PRED77 2 3
  • T-Complex 10 (A Murine Tcp Homolog)-Like 2
  • T-Complex Protein 10A Homolog 2 3
  • T-Complex 10 (Mouse)-Like 2
  • T-Complex Protein 10A-2 3
  • C21orf77 3
  • TCP10A-2 3
  • TCP10L 5

External Ids for TCP10L Gene

Previous GeneCards Identifiers for TCP10L Gene

  • GC21U990032
  • GC21M030609
  • GC21M032869
  • GC21M032870
  • GC21M033947
  • GC21M019356
  • GC21M032574

Summaries for TCP10L Gene

GeneCards Summary for TCP10L Gene

TCP10L (T-Complex 10 Like) is a Protein Coding gene. Diseases associated with TCP10L include Hepatocellular Carcinoma. Gene Ontology (GO) annotations related to this gene include identical protein binding and repressing transcription factor binding. An important paralog of this gene is TCP10L2.

UniProtKB/Swiss-Prot Summary for TCP10L Gene

  • May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.

Gene Wiki entry for TCP10L Gene

Additional gene information for TCP10L Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCP10L Gene

Genomics for TCP10L Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TCP10L Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J032603 Promoter/Enhancer 0.8 EPDnew Ensembl 600.4 -15.9 -15914 0.6 ZIC2 POLR2A GLIS1 SMARCA4 TCP10L EVA1C URB1 URB1-AS1 CFAP298-TCP10L SNORA80A ENSG00000252045 CFAP298 lnc-EVA1C-5
GH21J032585 Promoter 0.6 EPDnew 622 +1.8 1830 0.1 ZFP91 HNF4A RNF2 TCP10L LOC105372782 HSALNG0132702 lnc-C21orf59-1 CFAP298-TCP10L EVA1C
GH21J032545 Enhancer 1 Ensembl ENCODE 25.4 +41.7 41672 4.2 PRDM10 LEF1 IKZF1 JUND ZNF24 BRD9 DPF2 HDAC1 SOX6 GATAD2B lnc-EVA1C-2 TCP10L SCAF4 PAXBP1 SON EVA1C URB1 URB1-AS1 piR-47675-074 CFAP298-TCP10L
GH21J032562 Enhancer 0.8 Ensembl ENCODE 31.3 +25.7 25662 3 CTCF PKNOX1 REST NFE2 USF1 NFIC TBP POLR3A MNT GTF3C2 RF00001-202 RNA5SP490 piR-49782-002 TCP10L CFAP298 ENSG00000252045 EVA1C PAXBP1 URB1 URB1-AS1
GH21J032519 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 16.3 +65.0 65041 6.5 CREB1 ZNF629 IKZF1 JUND ZNF300 FOXA1 ZNF776 ZSCAN4 SP1 ZNF341 FJ601684-288 PAXBP1 TMEM50B SCAF4 EVA1C TCP10L CFAP298 MIS18A SNORA80A lnc-EVA1C-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCP10L on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCP10L

Top Transcription factor binding sites by QIAGEN in the TCP10L gene promoter:
  • AML1a
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for TCP10L Gene

Genomic Locations for TCP10L Gene
chr21:32,497,967-32,587,373
(GRCh38/hg38)
Size:
89,407 bases
Orientation:
Minus strand
chr21:33,947,151-33,959,683
(GRCh37/hg19)
Size:
12,533 bases
Orientation:
Minus strand

Genomic View for TCP10L Gene

Genes around TCP10L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP10L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP10L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP10L Gene

Proteins for TCP10L Gene

  • Protein details for TCP10L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDR4-TCP1L_HUMAN
    Recommended name:
    T-complex protein 10A homolog 1
    Protein Accession:
    Q8TDR4
    Secondary Accessions:
    • Q53EW0
    • Q96LN5

    Protein attributes for TCP10L Gene

    Size:
    215 amino acids
    Molecular mass:
    23863 Da
    Quaternary structure:
    • Self-associates (via leucine zipper). Interacts (via leucine zipper) with ZIPK/DAPK3 (via leucine zipper). Interacts with MAD4.

neXtProt entry for TCP10L Gene

Post-translational modifications for TCP10L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCP10L Gene

No data available for DME Specific Peptides for TCP10L Gene

Domains & Families for TCP10L Gene

Gene Families for TCP10L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCP10L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCP10L Gene

GenScript: Design optimal peptide antigens:
  • TCP10-like (TCP1L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TDR4

UniProtKB/Swiss-Prot:

TCP1L_HUMAN :
  • Belongs to the TCP10 family.
Family:
  • Belongs to the TCP10 family.
genes like me logo Genes that share domains with TCP10L: view

Function for TCP10L Gene

Molecular function for TCP10L Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Has in vitro transcription inhibition activity. Acts as a tumor suppressor in hepatocellular carcinoma (HCC) cells.

Phenotypes From GWAS Catalog for TCP10L Gene

Gene Ontology (GO) - Molecular Function for TCP10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IDA 14586771
GO:0005515 protein binding IPI 15469726
GO:0042802 identical protein binding IPI 17377852
GO:0043621 protein self-association IDA 17377852
GO:0070491 repressing transcription factor binding IDA 15469726
genes like me logo Genes that share ontologies with TCP10L: view
genes like me logo Genes that share phenotypes with TCP10L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCP10L

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCP10L Gene

Localization for TCP10L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCP10L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCP10L gene
Compartment Confidence
nucleus 5
cytoskeleton 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TCP10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 14586771
GO:0005814 centriole IBA 21873635
genes like me logo Genes that share ontologies with TCP10L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCP10L Gene

Pathways & Interactions for TCP10L Gene

PathCards logo

SuperPathways for TCP10L Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCP10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 14586771
genes like me logo Genes that share ontologies with TCP10L: view

No data available for Pathways by source and SIGNOR curated interactions for TCP10L Gene

Drugs & Compounds for TCP10L Gene

No Compound Related Data Available

Transcripts for TCP10L Gene

mRNA/cDNA for TCP10L Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCP10L

Alternative Splicing Database (ASD) splice patterns (SP) for TCP10L Gene

No ASD Table

Relevant External Links for TCP10L Gene

GeneLoc Exon Structure for
TCP10L

Expression for TCP10L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCP10L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for TCP10L Gene

This gene is overexpressed in Testis (x36.7).

Protein differential expression in normal tissues from HIPED for TCP10L Gene

This gene is overexpressed in Testis (45.1) and Heart (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCP10L Gene



Protein tissue co-expression partners for TCP10L Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCP10L

SOURCE GeneReport for Unigene cluster for TCP10L Gene:

Hs.728804

mRNA Expression by UniProt/SwissProt for TCP10L Gene:

Q8TDR4-TCP1L_HUMAN
Tissue specificity: Expressed in liver and testis. Expressed in the seminiferous tubules (at protein level).

Evidence on tissue expression from TISSUES for TCP10L Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TCP10L: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TCP10L Gene

Orthologs for TCP10L Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TCP10L Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TCP10L 30 31
  • 86.76 (n)
OneToOne
Species where no ortholog for TCP10L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TCP10L Gene

ENSEMBL:
Gene Tree for TCP10L (if available)
TreeFam:
Gene Tree for TCP10L (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCP10L: view image

Paralogs for TCP10L Gene

Paralogs for TCP10L Gene

(2) SIMAP similar genes for TCP10L Gene using alignment to 4 proteins:

  • TCP1L_HUMAN
  • J3KTL9_HUMAN
  • V9GY77_HUMAN
  • V9GYF3_HUMAN
genes like me logo Genes that share paralogs with TCP10L: view

Variants for TCP10L Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCP10L Gene

SNP ID Clinical significance and condition Chr 21 pos Variation AA Info Type
724391 Benign: not provided 32,576,780(-) A/AC FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT
rs16989521 - p.Arg194His
rs9622 - p.His145Arg

Additional dbSNP identifiers (rs#s) for TCP10L Gene

Structural Variations from Database of Genomic Variants (DGV) for TCP10L Gene

Variant ID Type Subtype PubMed ID
esv2671062 CNV deletion 23128226
esv3557645 CNV deletion 23714750
esv3646886 CNV gain 21293372
esv3646888 CNV loss 21293372
esv3646889 CNV loss 21293372
esv3893405 CNV gain 25118596
nsv1063676 CNV gain 25217958
nsv1066657 CNV gain 25217958
nsv438321 CNV loss 16468122

Variation tolerance for TCP10L Gene

Residual Variation Intolerance Score: 62.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCP10L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCP10L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP10L Gene

Disorders for TCP10L Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCP10L Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with TCP10L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCP10L Gene

Publications for TCP10L Gene

  1. Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity. (PMID: 14586771) Chen Z … Zhao S (Journal of human genetics 2003) 3 4 23
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M … Chromosome 21 mapping and sequencing consortium (Nature 2000) 2 3 4
  3. TCP10L acts as a tumor suppressor by inhibiting cell proliferation in hepatocellular carcinoma. (PMID: 24565846) Zuo J … Yu L (Biochemical and biophysical research communications 2014) 3 4
  4. Identification of TCP10L as primate-specific gene derived via segmental duplication and homodimerization of TCP10L through the leucine zipper motif. (PMID: 17377852) Zhong Z … Yu L (Molecular biology reports 2008) 3 4
  5. TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3. (PMID: 15910542) Yu H … Yu L (International journal of andrology 2005) 3 4

Products for TCP10L Gene

Sources for TCP10L Gene