Aliases for TCL6 Gene

Subcategory (RNA class) for TCL6 Gene

misc_RNA

Aliases for TCL6 Gene

External Ids for TCL6 Gene

Previous GeneCards Identifiers for TCL6 Gene

  • GC14U990093
  • GC14P089934
  • GC14P094106
  • GC14P094107
  • GC14P095187
  • GC14P096116
  • GC14P076303

Summaries for TCL6 Gene

GeneCards Summary for TCL6 Gene

TCL6 (T Cell Leukemia/Lymphoma 6) is an RNA Gene, and is affiliated with the misc_RNA class. Diseases associated with TCL6 include Lymphoma and Renal Cell Carcinoma, Nonpapillary.

Rfam classification for TCL6 Gene

  • T-cell leukemia/lymphoma 6 conserved region 1
  • T-cell leukemia/lymphoma 6 conserved region 2
  • T-cell leukemia/lymphoma 6 conserved region 3

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for TCL6 Gene

Genomics for TCL6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TCL6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J095620 Promoter 0.9 Ensembl 20.2 -29.4 -29398 1 BHLHE40 ZNF395 GABPA HCFC1 ELF1 POLR2A EHMT2 ZEB2 TFDP1 DIDO1 ENSG00000258927 TCL6 TCL1A ENSG00000270038 TCL1B GLRX5
GH14J095659 Enhancer 1.2 FANTOM5 Ensembl ENCODE 12.2 +12.6 12643 7.5 SP1 BCL11A ZIC2 CTCF IRF4 ZNF341 EBF1 SMARCA5 CBFB USF2 ENSG00000275033 ENSG00000259084 TCL1A TCL6 ENSG00000258927 TCL1B GLRX5
GH14J095597 Enhancer 0.7 ENCODE 13 -52.5 -52489 1.3 ZIC2 PAX8 ZNF24 ZNF189 CBLL2 GLIS1 SP7 ZNF561 TRIM28 L3MBTL2 piR-60794-007 TCL6 ENSG00000258927 ENSG00000270038 GLRX5 lnc-GLRX5-3 TCL1B
GH14J095576 Enhancer 0.8 Ensembl ENCODE 8.8 -74.0 -73998 2.2 TRIM22 BHLHE40 ASH2L IKZF1 NR2F1 ZNF217 POU5F1 ARID3A ATF7 TBL1XR1 piR-38583-005 TCL6 GLRX5 LINC02318 piR-36588-166 TCL1B
GH14J095543 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.1 -104.2 -104211 5.4 CEBPA THAP11 ZNF395 CUX1 FOXA2 SMAD4 SAP130 TAL1 ETV4 TAF9B GLRX5 ENSG00000258572 TCL6 HSALNG0103444 SNHG10 TCL1B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCL6 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the TCL6 gene promoter:
  • Evi-1
  • FAC1
  • MyoD
  • MZF-1
  • Nkx2-5
  • Pax-6
  • RORalpha1
  • RSRFC4

Genomic Locations for TCL6 Gene

Latest Assembly
chr14:95,650,498-95,679,833
(GRCh38/hg38)
Size:
29,336 bases
Orientation:
Plus strand

Previous Assembly
chr14:96,118,434-96,139,789
(GRCh37/hg19 by Entrez Gene)
Size:
21,356 bases
Orientation:
Plus strand

chr14:96,116,835-96,146,170
(GRCh37/hg19 by Ensembl)
Size:
29,336 bases
Orientation:
Plus strand

Genomic View for TCL6 Gene

Genes around TCL6 on UCSC Golden Path with GeneCards custom track
TCL6 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
TCL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCL6 Gene

Proteins for TCL6 Gene

  • Protein details for TCL6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R6G0-A0A024R6G0_HUMAN
    Recommended name:
    T-cell leukemia/lymphoma 6, isoform CRA_b
    Protein Accession:
    A0A024R6G0

    Protein attributes for TCL6 Gene

    Size:
    141 amino acids
    Molecular mass:
    15855 Da
    Quaternary structure:
    No Data Available
  • Protein details for TCL6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R6L9-A0A024R6L9_HUMAN
    Recommended name:
    T-cell leukemia/lymphoma 6, isoform CRA_c
    Protein Accession:
    A0A024R6L9

    Protein attributes for TCL6 Gene

    Size:
    103 amino acids
    Molecular mass:
    12064 Da
    Quaternary structure:
    No Data Available
  • Protein details for TCL6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R6J2-A0A024R6J2_HUMAN
    Recommended name:
    T-cell leukemia/lymphoma 6, isoform CRA_d
    Protein Accession:
    A0A024R6J2

    Protein attributes for TCL6 Gene

    Size:
    163 amino acids
    Molecular mass:
    18579 Da
    Quaternary structure:
    No Data Available
  • Protein details for TCL6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A024R6J5-A0A024R6J5_HUMAN
    Recommended name:
    T-cell leukemia/lymphoma 6, isoform CRA_a
    Protein Accession:
    A0A024R6J5

    Protein attributes for TCL6 Gene

    Size:
    119 amino acids
    Molecular mass:
    13961 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCL6 Gene

Post-translational modifications for TCL6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TCL6 Gene

Domains & Families for TCL6 Gene

Gene Families for TCL6 Gene

Protein Domains for TCL6 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TCL6 Gene

GenScript: Design optimal peptide antigens:
  • T-cell leukemia/lymphoma 6 ORF163 (Q9P2S0_HUMAN)
  • TCL1 neighboring gene 1 protein (TCL6_HUMAN)
genes like me logo Genes that share domains with TCL6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TCL6 Gene

Function for TCL6 Gene

Phenotypes From GWAS Catalog for TCL6 Gene

Phenotypes for TCL6 Gene

genes like me logo Genes that share phenotypes with TCL6: view

CRISPR products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCL6 Gene

Localization for TCL6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCL6 gene
Compartment Confidence
plasma membrane 1
extracellular 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TCL6 Gene

Pathways & Interactions for TCL6 Gene

PathCards logo

SuperPathways for TCL6 Gene

No Data Available

Interacting Proteins for TCL6 Gene

Selected Interacting proteins: A0A024R6G0-A0A024R6G0_HUMAN for TCL6 Gene via UniProtKB

Symbol External ID(s) Details
MEOX2
  • EBI-10173366, EBI-748397

Gene Ontology (GO) - Biological Process for TCL6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCL6 Gene

Drugs & Compounds for TCL6 Gene

No Compound Related Data Available

Transcripts for TCL6 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for TCL6 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00009C5443_9606 lncRNA 1947 4

Ensembl: ENST00000619182 (view in UCSC) ,

LncBook: HSALNT0215257,

LNCipedia: TCL6:24,

NONCODE: NONHSAT168856.1,

URS00008C2BD0_9606 lncRNA 915 4

Ensembl: ENST00000460130 (view in UCSC) ,

LncBook: HSALNT0215239,

LNCipedia: TCL6:5,

NONCODE: NONHSAT039469.2,

URS00008B5A2D_9606 lncRNA 789 4

Ensembl: ENST00000495696 (view in UCSC) ,

LncBook: HSALNT0215259,

LNCipedia: TCL6:25,

NONCODE: NONHSAT039486.2,

URS00008B96F1_9606 lncRNA 3668 3

Ensembl: ENST00000467865 (view in UCSC) ,

LNCipedia: TCL6:12,

NONCODE: NONHSAT039477.2,

URS00009B5612_9606 lncRNA 3398 3

Ensembl: ENST00000352367 (view in UCSC) ,

LNCipedia: TCL6:13,

NONCODE: NONHSAT039475.2,

TCL6 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for TCL6 Gene

6 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR products for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCL6

Alternative Splicing Database (ASD) splice patterns (SP) for TCL6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - -
SP5: - - -
SP6: -
SP7: - - -
SP8:
SP9:

Relevant External Links for TCL6 Gene

GeneLoc Exon Structure for
TCL6

Expression for TCL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCL6 Gene

mRNA differential expression in normal tissues according to GTEx for TCL6 Gene

This gene is overexpressed in Kidney - Cortex (x15.2), Whole Blood (x9.1), and Spleen (x6.5).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCL6

SOURCE GeneReport for Unigene cluster for TCL6 Gene:

Hs.510368
genes like me logo Genes that share expression patterns with TCL6: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCL6 Gene

Orthologs for TCL6 Gene

Evolution for TCL6 Gene

ENSEMBL:
Gene Tree for TCL6 (if available)
TreeFam:
Gene Tree for TCL6 (if available)

No data available for Orthologs for TCL6 Gene

Paralogs for TCL6 Gene

No data available for Paralogs for TCL6 Gene

Variants for TCL6 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TCL6 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TCL6 Gene

Variant ID Type Subtype PubMed ID
dgv89e55 CNV gain 17911159
esv3635403 CNV gain 21293372
esv3635404 CNV gain 21293372
esv3635405 CNV loss 21293372
nsv1042858 CNV gain 25217958
nsv1046191 CNV gain 25217958
nsv1047138 CNV loss 25217958
nsv456410 CNV loss 19166990
nsv565631 CNV gain 21841781
nsv565644 CNV loss 21841781
nsv565645 CNV loss 21841781

Additional Variant Information for TCL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCL6

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for TCL6 Gene

Disorders for TCL6 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TCL6 Gene - From: LNC, COP, and GCD

Disorder Aliases PubMed IDs
lymphoma
  • lymphoid cancer
renal cell carcinoma, nonpapillary
  • rcc
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
leukemia
  • leukemias
plummer's disease
  • plummer disease
- elite association - COSMIC cancer census association via MalaCards
Search TCL6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TCL6

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TCL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCL6 Gene

Publications for TCL6 Gene

  1. Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. (PMID: 10851082) Saitou M … Isobe M (Oncogene 2000) 2 3 74
  2. Decreased TCL6 expression is associated with poor prognosis in patients with clear cell renal cell carcinoma. (PMID: 27494890) Su H … Ye D (Oncotarget 2017) 3 74
  3. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PMID: 20031603) Marroni F … EUROSPAN Consortium (Circulation. Cardiovascular genetics 2009) 3 41
  4. Molecular basis of mature T-cell leukemia. (PMID: 11710897) Pekarsky Y … Croce CM (JAMA 2001) 3 23
  5. Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes. (PMID: 10588720) Hallas C … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3

Products for TCL6 Gene

Sources for TCL6 Gene