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Aliases for TCL6 Gene
Data sources for TCL6 Gene:
Subcategory (RNA class) for TCL6 Gene
misc_RNA
Aliases for TCL6 Gene
- T Cell Leukemia/Lymphoma 6 (HGNC, NCBI Entrez Gene, Ensembl)
- T Cell Leukemia/Lymphoma 6 (Non-Protein Coding) (HGNC, NCBI Entrez Gene)
- TNG1 (HGNC, NCBI Entrez Gene)
- TNG2 (HGNC, NCBI Entrez Gene)
- TCL6 (Ensembl, LNCipedia)
- T-Cell Leukemia/Lymphoma 6 (Non-Protein Coding) (HGNC)
- T-Cell Leukemia/Lymphoma 6, Isoform CRA_b (UniProtKB/TrEMBL)
- T-Cell Leukemia/Lymphoma 6, Isoform CRA_c (UniProtKB/TrEMBL)
- T-Cell Leukemia/Lymphoma 6, Isoform CRA_d (UniProtKB/TrEMBL)
- T-Cell Leukemia/Lymphoma 6, Isoform CRA_a (UniProtKB/TrEMBL)
- T-Cell Leukemia/Lymphoma 6 (HGNC)
- TCL1-Neighboring Gene 1 (NCBI Entrez Gene)
- TCL1-Neighboring Gene 2 (NCBI Entrez Gene)
- NONHSAG015801.2 (NONCODE)
- HSALNG0103448 (LncBook)
- TCL6e1 (HGNC)
External Ids for TCL6 Gene
- HGNC: 13463
- NCBI Entrez Gene: 27004
- Ensembl: ENSG00000187621
- OMIM®: 604412
- UniProtKB/TrEMBL: A0A024R6G0
- UniProtKB/TrEMBL: A0A024R6L9
- UniProtKB/TrEMBL: A0A024R6J2
- UniProtKB/TrEMBL: A0A024R6J5
Previous GeneCards Identifiers for TCL6 Gene
- GC14U990093
- GC14P089934
- GC14P094106
- GC14P094107
- GC14P095187
- GC14P096116
- GC14P076303
Summaries for TCL6 Gene
GeneCards Summary for TCL6 Gene
TCL6 (T Cell Leukemia/Lymphoma 6) is an RNA Gene, and is affiliated with the misc_RNA class. Diseases associated with TCL6 include Lymphoma and Renal Cell Carcinoma, Nonpapillary.
Rfam classification for TCL6 Gene
Additional gene information for TCL6 Gene
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for TCL6 Gene
Genomics for TCL6 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TCL6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TCL6 on the GeneHancer Hub at the UCSC Golden Path
- Top Transcription factor binding sites by QIAGEN in the TCL6 gene promoter:
-
- Evi-1
- FAC1
- MyoD
- MZF-1
- Nkx2-5
- Pax-6
- RORalpha1
- RSRFC4
Genomic Locations for TCL6 Gene
Latest Assembly
- chr14:95,650,498-95,679,833
- (GRCh38/hg38)
- Size:
- 29,336 bases
- Orientation:
- Plus strand
Previous Assembly
- chr14:96,118,434-96,139,789
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 21,356 bases
- Orientation:
- Plus strand
- chr14:96,116,835-96,146,170
- (GRCh37/hg19 by Ensembl)
- Size:
- 29,336 bases
- Orientation:
- Plus strand
Genomic View for TCL6 Gene
Genes around TCL6 on UCSC Golden Path with GeneCards custom track
TCL6 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
- Cytogenetic band:
-
- 14q32.13 by HGNC
- 14q32.13 by Entrez Gene
- 14q32.13 by Ensembl
TCL6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TCL6 Gene
Proteins for TCL6 Gene
-
Protein details for TCL6 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A024R6G0-A0A024R6G0_HUMAN
- Recommended name:
- T-cell leukemia/lymphoma 6, isoform CRA_b
- Protein Accession:
- A0A024R6G0
Protein attributes for TCL6 Gene
- Size:
- 141 amino acids
- Molecular mass:
- 15855 Da
- Quaternary structure:
- No Data Available
-
Protein details for TCL6 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A024R6L9-A0A024R6L9_HUMAN
- Recommended name:
- T-cell leukemia/lymphoma 6, isoform CRA_c
- Protein Accession:
- A0A024R6L9
Protein attributes for TCL6 Gene
- Size:
- 103 amino acids
- Molecular mass:
- 12064 Da
- Quaternary structure:
- No Data Available
-
Protein details for TCL6 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A024R6J2-A0A024R6J2_HUMAN
- Recommended name:
- T-cell leukemia/lymphoma 6, isoform CRA_d
- Protein Accession:
- A0A024R6J2
Protein attributes for TCL6 Gene
- Size:
- 163 amino acids
- Molecular mass:
- 18579 Da
- Quaternary structure:
- No Data Available
-
Protein details for TCL6 Gene (UniProtKB/TrEMBL)
- Protein Symbol:
- A0A024R6J5-A0A024R6J5_HUMAN
- Recommended name:
- T-cell leukemia/lymphoma 6, isoform CRA_a
- Protein Accession:
- A0A024R6J5
Protein attributes for TCL6 Gene
- Size:
- 119 amino acids
- Molecular mass:
- 13961 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for TCL6 Gene
No Post-translational modifications
Antibodies for research
- Invitrogen Antibodies for TCL6 (AFLGC-TCL6)
- antibodies-online: Show 10 available TCL6 Antibodies ranked by validation data
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for TCL6
- Origene Custom Protein Services for TCL6
- Novus Biologicals lysates for TCL6
- antibodies-online: Search results for available TCL6 related products ranked by validation data
Assay products for research
- antibodies-online: Search results for available TCL6 related products ranked by validation data
No data available for DME Specific Peptides for TCL6 Gene
Domains & Families for TCL6 Gene
Gene Families for TCL6 Gene
Protein Domains for TCL6 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for TCL6 Gene
- GenScript: Design optimal peptide antigens:
-
- T-cell leukemia/lymphoma 6 ORF163 (Q9P2S0_HUMAN)
- TCL1 neighboring gene 1 protein (TCL6_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TCL6 Gene
Function for TCL6 Gene
Phenotypes From GWAS Catalog for TCL6 Gene
Phenotypes for TCL6 Gene
- GenomeRNAi human phenotypes for TCL6:
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TCL6 - Starting at $85 >
- * TCL6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TCL6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TCL6
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TCL6
- Browse OriGene Inhibitory RNA Products For TCL6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCL6
Clone products for research
- Applied Biological Materials (abm): Clones for TCL6 - Starting at $45 >
- * TCL6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
OriGene ORF clones in human for TCL6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TCL6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TCL6
Cell Lines for research
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCL6 Gene
Localization for TCL6 Gene
| Compartment | Confidence |
|---|---|
| plasma membrane | 1 |
| extracellular | 1 |
| nucleus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TCL6 Gene
Transcripts for TCL6 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for TCL6 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00009C5443_9606 | lncRNA | 1947 | 4 |
Ensembl: ENST00000619182 (view in UCSC) , LncBook: HSALNT0215257, LNCipedia: TCL6:24, NONCODE: NONHSAT168856.1, |
| URS00008C2BD0_9606 | lncRNA | 915 | 4 |
Ensembl: ENST00000460130 (view in UCSC) , LncBook: HSALNT0215239, LNCipedia: TCL6:5, NONCODE: NONHSAT039469.2, |
| URS00008B5A2D_9606 | lncRNA | 789 | 4 |
Ensembl: ENST00000495696 (view in UCSC) , LncBook: HSALNT0215259, LNCipedia: TCL6:25, NONCODE: NONHSAT039486.2, |
| URS00008B96F1_9606 | lncRNA | 3668 | 3 |
Ensembl: ENST00000467865 (view in UCSC) , LNCipedia: TCL6:12, NONCODE: NONHSAT039477.2, |
| URS00009B5612_9606 | lncRNA | 3398 | 3 |
Ensembl: ENST00000352367 (view in UCSC) , LNCipedia: TCL6:13, NONCODE: NONHSAT039475.2, |
TCL6 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for TCL6 Gene
- 6 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000357168 1939 nts (view in UCSC)
- ENST00000465501 2078 nts (view in UCSC)
- ENST00000484207 3780 nts (view in UCSC)
- ENST00000486671 2504 nts (view in UCSC)
- ENST00000497248 4232 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TCL6 - Starting at $85 >
- * TCL6 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TCL6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TCL6
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TCL6
- Browse OriGene Inhibitory RNA Products For TCL6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCL6
Clone products for research
- Applied Biological Materials (abm): Clones for TCL6 - Starting at $45 >
- * TCL6 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
OriGene ORF clones in human for TCL6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TCL6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TCL6
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||
| SP9: |
Relevant External Links for TCL6 Gene
- GeneLoc Exon Structure for
- TCL6
Expression for TCL6 Gene
mRNA differential expression in normal tissues according to GTEx for TCL6 Gene
This gene is overexpressed in Kidney - Cortex (x15.2), Whole Blood (x9.1), and Spleen (x6.5).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCL6
SOURCE GeneReport for Unigene cluster for TCL6 Gene:
Hs.510368Primer products for research
-
OriGene qPCR primer pairs for TCL6
-
OriGene qPCR primer pairs and template standards for TCL6
Gene Expression Assays for research
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCL6 Gene
Orthologs for TCL6 Gene
No data available for Orthologs for TCL6 Gene
Paralogs for TCL6 Gene
No data available for Paralogs for TCL6 Gene
Variants for TCL6 Gene
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv89e55 | CNV | gain | 17911159 |
| esv3635403 | CNV | gain | 21293372 |
| esv3635404 | CNV | gain | 21293372 |
| esv3635405 | CNV | loss | 21293372 |
| nsv1042858 | CNV | gain | 25217958 |
| nsv1046191 | CNV | gain | 25217958 |
| nsv1047138 | CNV | loss | 25217958 |
| nsv456410 | CNV | loss | 19166990 |
| nsv565631 | CNV | gain | 21841781 |
| nsv565644 | CNV | loss | 21841781 |
| nsv565645 | CNV | loss | 21841781 |
Additional Variant Information for TCL6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TCL6
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for TCL6 Gene
Disorders for TCL6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphoma |
|
|
| renal cell carcinoma, nonpapillary |
|
|
| precursor t-cell acute lymphoblastic leukemia |
|
|
| leukemia |
|
|
| plummer's disease |
|
|
Search TCL6 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TCL6
- Genetic Association Database
- (GAD)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TCL6 Gene
Publications for TCL6 Gene
- Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. (PMID: 10851082) Saitou M … Isobe M (Oncogene 2000) 2 3 74
- Decreased TCL6 expression is associated with poor prognosis in patients with clear cell renal cell carcinoma. (PMID: 27494890) Su H … Ye D (Oncotarget 2017) 3 74
- A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PMID: 20031603) Marroni F … EUROSPAN Consortium (Circulation. Cardiovascular genetics 2009) 3 41
- Molecular basis of mature T-cell leukemia. (PMID: 11710897) Pekarsky Y … Croce CM (JAMA 2001) 3 23
- Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes. (PMID: 10588720) Hallas C … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3
ExternalLinks
Products for TCL6 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for TCL6
- Origene Custom Protein Services for TCL6
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TCL6
- Browse OriGene Inhibitory RNA Products For TCL6
- OriGene qPCR primer pairs for TCL6
- OriGene qPCR primer pairs and template standards for TCL6
- OriGene CRISPR knockouts for TCL6
- OriGene ORF clones in human for TCL6
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TCL6
- Sino Biological Human cDNA Clone for TCL6
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals lysates for TCL6
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for TCL6 (AFLGC-TCL6)
- antibodies-online: Show 10 available TCL6 Antibodies ranked by validation data
- antibodies-online: Search results for available TCL6 related products ranked by validation data
- antibodies-online: Search results for available TCL6 related products ranked by validation data
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TCL6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TCL6
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TCL6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCL6
Sources for TCL6 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB