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Aliases for TCL6 Gene

Subcategory (RNA class) for TCL6 Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for TCL6 Gene

  • T Cell Leukemia/Lymphoma 6 (Non-Protein Coding) 2 3
  • T-Cell Leukemia/Lymphoma 6 (Non-Protein Coding) 2 5
  • T-Cell Leukemia/Lymphoma 6 2 3
  • TCL1-Neighboring Gene 1 3
  • TCL1-Neighboring Gene 2 3
  • TNG1 3
  • TNG2 3

External Ids for TCL6 Gene

Previous GeneCards Identifiers for TCL6 Gene

  • GC14U990093
  • GC14P089934
  • GC14P094106
  • GC14P094107
  • GC14P095187
  • GC14P096116
  • GC14P076303

Summaries for TCL6 Gene

GeneCards Summary for TCL6 Gene

TCL6 (T Cell Leukemia/Lymphoma 6 (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with TCL6 include T-Cell Leukemia.

Additional gene information for TCL6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCL6 Gene

Genomics for TCL6 Gene

GeneHancer (GH) Regulatory Elements for TCL6 Gene

Promoters and enhancers for TCL6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I095650 Enhancer 0.7 Ensembl ENCODE 550.8 +1.9 1851 3.1 SCRT1 PKNOX1 SCRT2 SPI1 TCL6 GLRX5 ENSG00000275033
GH14I095597 Enhancer 1 Ensembl ENCODE 13 -52.5 -52489 1.3 GLIS2 ZNF366 ZSCAN5C ZNF207 ZNF114 ZIK1 USF2 ZNF645 GLIS1 ZNF24 TCL6 ENSG00000258927 ENSG00000270038 GLRX5 LOC105370643
GH14I095660 Enhancer 0.8 ENCODE 12.1 +12.9 12881 7 PKNOX1 BMI1 BATF KLF5 IRF4 SCRT2 ZNF143 ATF7 FOS IKZF2 ENSG00000259084 ENSG00000275033 TCL6 TCL1A TCL1B ENSG00000258927 GLRX5 ENSG00000277468
GH14I095543 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 5.1 -104.2 -104211 5.4 ATF1 FOXA2 ARID4B NEUROD1 ZNF48 TCF12 ZNF766 GATA2 ATF7 FOS GLRX5 LOC101929107 TCL6 GC14M095530 LINC02318
GH14I095577 Enhancer 0.6 ENCODE 8.3 -73.2 -73199 0.2 SRF PKNOX1 NR2F1 TRIM22 PAX8 RELA ZNF217 TARDBP IKZF1 NBN TCL6 GLRX5 LINC02318 LOC105370643
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCL6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCL6 gene promoter:

Genomic Locations for TCL6 Gene

Genomic Locations for TCL6 Gene
29,336 bases
Plus strand

Genomic View for TCL6 Gene

Genes around TCL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCL6 Gene

Proteins for TCL6 Gene

  • Protein details for TCL6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    T-cell leukemia/lymphoma 6, isoform CRA_b
    Protein Accession:

    Protein attributes for TCL6 Gene

    141 amino acids
    Molecular mass:
    15855 Da
    Quaternary structure:
    No Data Available
  • Protein details for TCL6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    T-cell leukemia/lymphoma 6, isoform CRA_d
    Protein Accession:

    Protein attributes for TCL6 Gene

    163 amino acids
    Molecular mass:
    18579 Da
    Quaternary structure:
    No Data Available
  • Protein details for TCL6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    T-cell leukemia/lymphoma 6, isoform CRA_a
    Protein Accession:

    Protein attributes for TCL6 Gene

    119 amino acids
    Molecular mass:
    13961 Da
    Quaternary structure:
    No Data Available
  • Protein details for TCL6 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    T-cell leukemia/lymphoma 6, isoform CRA_c
    Protein Accession:

    Protein attributes for TCL6 Gene

    103 amino acids
    Molecular mass:
    12064 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCL6 Gene

Post-translational modifications for TCL6 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TCL6 Gene

Domains & Families for TCL6 Gene

Protein Domains for TCL6 Gene


Suggested Antigen Peptide Sequences for TCL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TCL6: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TCL6 Gene

Function for TCL6 Gene

Phenotypes From GWAS Catalog for TCL6 Gene

Phenotypes for TCL6 Gene

GenomeRNAi human phenotypes for TCL6:
genes like me logo Genes that share phenotypes with TCL6: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCL6 Gene

Localization for TCL6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCL6 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TCL6 Gene

Pathways & Interactions for TCL6 Gene

No Data Available

Interacting Proteins for TCL6 Gene

Gene Ontology (GO) - Biological Process for TCL6 Gene


No data available for Pathways by source and SIGNOR curated interactions for TCL6 Gene

Drugs & Compounds for TCL6 Gene

No Compound Related Data Available

Transcripts for TCL6 Gene

Unigene Clusters for TCL6 Gene

T-cell leukemia/lymphoma 6 (non-protein coding):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCL6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - -
SP5: - - -
SP6: -
SP7: - - -

Relevant External Links for TCL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCL6 Gene

mRNA differential expression in normal tissues according to GTEx for TCL6 Gene

This gene is overexpressed in Kidney - Cortex (x15.2), Whole Blood (x9.1), and Spleen (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of TCL6 Gene:


SOURCE GeneReport for Unigene cluster for TCL6 Gene:

genes like me logo Genes that share expression patterns with TCL6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCL6 Gene

Orthologs for TCL6 Gene

Evolution for TCL6 Gene

Gene Tree for TCL6 (if available)
Gene Tree for TCL6 (if available)

No data available for Orthologs for TCL6 Gene

Paralogs for TCL6 Gene

No data available for Paralogs for TCL6 Gene

Variants for TCL6 Gene

Sequence variations from dbSNP and Humsavar for TCL6 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000037689 -- 95,652,673(+) A/C intron_variant
rs1000192101 -- 95,673,759(+) A/G downstream_transcript_variant
rs1000247841 -- 95,667,700(+) T/ intron_variant
rs1000351523 -- 95,664,798(+) C/A intron_variant
rs1000703088 -- 95,667,498(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TCL6 Gene

Variant ID Type Subtype PubMed ID
nsv565645 CNV loss 21841781
nsv565644 CNV loss 21841781
nsv565631 CNV gain 21841781
nsv456410 CNV loss 19166990
nsv1047138 CNV loss 25217958
nsv1046191 CNV gain 25217958
nsv1042858 CNV gain 25217958
esv3635405 CNV loss 21293372
esv3635404 CNV gain 21293372
esv3635403 CNV gain 21293372
dgv89e55 CNV gain 17911159

Additional Variant Information for TCL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TCL6 Gene

Disorders for TCL6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCL6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
- elite association - COSMIC cancer census association via MalaCards
Search TCL6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TCL6

genes like me logo Genes that share disorders with TCL6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCL6 Gene

Publications for TCL6 Gene

  1. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. (PMID: 20031603) Marroni F … EUROSPAN Consortium (Circulation. Cardiovascular genetics 2009) 3 44 58
  2. Molecular basis of mature T-cell leukemia. (PMID: 11710897) Pekarsky Y … Croce CM (JAMA 2001) 3 22 58
  3. Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia. (PMID: 10851082) Saitou M … Isobe M (Oncogene 2000) 2 3 58
  4. Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes. (PMID: 10588720) Hallas C … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 58
  5. Decreased TCL6 expression is associated with poor prognosis in patients with clear cell renal cell carcinoma. (PMID: 27494890) Su H … Ye D (Oncotarget 2017) 3 58

Products for TCL6 Gene

Sources for TCL6 Gene

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