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Aliases for TCL1B Gene

Aliases for TCL1B Gene

  • T Cell Leukemia/Lymphoma 1B 2 3
  • Syncytiotrophoblast-Specific Protein 3 4
  • T-Cell Leukemia/Lymphoma 1B 2 5
  • Oncogene TCL-1B 3 4
  • SYN-1 3 4
  • T-Cell Leukemia/Lymphoma Protein 1B 3
  • T-Cell Lymphoma/Leukemia 1B 3
  • TCL1/MTCP1-Like Protein 1 4
  • TCL1/ MTCP1-Like 1 3
  • Oncogene TCL1B 4
  • TCL1 4
  • TML1 3

External Ids for TCL1B Gene

Previous GeneCards Identifiers for TCL1B Gene

  • GC14P093628
  • GC14P089969
  • GC14P094118
  • GC14P094142
  • GC14P095198
  • GC14P095222
  • GC14P096152
  • GC14P076338

Summaries for TCL1B Gene

GeneCards Summary for TCL1B Gene

TCL1B (T Cell Leukemia/Lymphoma 1B) is a Protein Coding gene. Diseases associated with TCL1B include T-Cell Leukemia and Leukemia. Among its related pathways are PI3K-Akt signaling pathway. An important paralog of this gene is MTCP1.

UniProtKB/Swiss-Prot for TCL1B Gene

  • Enhances the phosphorylation and activation of AKT1 and AKT2.

Gene Wiki entry for TCL1B Gene

Additional gene information for TCL1B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCL1B Gene

Genomics for TCL1B Gene

GeneHancer (GH) Regulatory Elements for TCL1B Gene

Promoters and enhancers for TCL1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I095686 Promoter/Enhancer 1 EPDnew Ensembl 568.8 +0.2 156 0.9 SIX4 ZNF263 ZFP3 L3MBTL2 VEZF1 NRF1 TCL1B TCL1A PIR31480 ENSG00000259084
GH14I095725 Enhancer 0.8 ENCODE dbSUPER 10.9 +39.7 39684 1.5 ZNF687 CBFB NR2F1 BACH1 EBF1 DPF2 RELA TARDBP NBN MLLT1 TCL1B ENSG00000257275 TCL1A LOC105370644
GH14I095698 Enhancer 0.8 ENCODE dbSUPER 9.7 +13.1 13143 1.2 SRF ZNF687 MAZ ZNF362 TSHZ1 RELA PRDM6 POLR2A GLIS1 ZXDB TCL1B PIR31480 GC14M095710 GC14M095711
GH14I095613 Enhancer 0.6 ENCODE 11.1 -71.7 -71673 1.5 CTCF RAD21 FOSL1 MITF GATA3 ZNF366 CREB1 FOS TCL1A TCL1B ENSG00000270038 GLRX5 ENSG00000258927 LOC105370643
GH14I095660 Enhancer 0.8 ENCODE 6.6 -23.0 -23038 7 PKNOX1 BMI1 BATF KLF5 IRF4 SCRT2 ZNF143 ATF7 FOS IKZF2 ENSG00000259084 ENSG00000275033 TCL6 TCL1A TCL1B ENSG00000258927 GLRX5 ENSG00000277468
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCL1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCL1B gene promoter:

Genomic Locations for TCL1B Gene

Genomic Locations for TCL1B Gene
chr14:95,686,417-95,692,643
(GRCh38/hg38)
Size:
6,227 bases
Orientation:
Plus strand
chr14:96,152,754-96,158,980
(GRCh37/hg19)

Genomic View for TCL1B Gene

Genes around TCL1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCL1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCL1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCL1B Gene

Proteins for TCL1B Gene

  • Protein details for TCL1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95988-TCL1B_HUMAN
    Recommended name:
    T-cell leukemia/lymphoma protein 1B
    Protein Accession:
    O95988
    Secondary Accessions:
    • A6NEK7
    • Q6IAR7
    • Q9UBQ4

    Protein attributes for TCL1B Gene

    Size:
    128 amino acids
    Molecular mass:
    14846 Da
    Quaternary structure:
    • Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3.
    Miscellaneous:
    • Activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region.

neXtProt entry for TCL1B Gene

Post-translational modifications for TCL1B Gene

No Post-translational modifications

Other Protein References for TCL1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCL1B Gene

Domains & Families for TCL1B Gene

Gene Families for TCL1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCL1B Gene

Suggested Antigen Peptide Sequences for TCL1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95988

UniProtKB/Swiss-Prot:

TCL1B_HUMAN :
  • Belongs to the TCL1 family.
Family:
  • Belongs to the TCL1 family.
genes like me logo Genes that share domains with TCL1B: view

Function for TCL1B Gene

Molecular function for TCL1B Gene

GENATLAS Biochemistry:
T cell leukemia transcript 1b,14kDa,highly similar to TCL1A,with the same pattern of low expression in normal bone marrow and peripheral lymphocytes but activated in T cell leukemias by rearrangements of 14q32.1 region
UniProtKB/Swiss-Prot Function:
Enhances the phosphorylation and activation of AKT1 and AKT2.

Gene Ontology (GO) - Molecular Function for TCL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019901 protein kinase binding IPI 10983986
GO:0043539 protein serine/threonine kinase activator activity IDA 10983986
genes like me logo Genes that share ontologies with TCL1B: view
genes like me logo Genes that share phenotypes with TCL1B: view

miRNA for TCL1B Gene

miRTarBase miRNAs that target TCL1B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCL1B Gene

Localization for TCL1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCL1B gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TCL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043234 protein complex IDA 10983986
genes like me logo Genes that share ontologies with TCL1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TCL1B Gene

Pathways & Interactions for TCL1B Gene

SuperPathways for TCL1B Gene

SuperPathway Contained pathways
1 PI3K-Akt signaling pathway
genes like me logo Genes that share pathways with TCL1B: view

Pathways by source for TCL1B Gene

1 KEGG pathway for TCL1B Gene

SIGNOR curated interactions for TCL1B Gene

Activates:

Gene Ontology (GO) - Biological Process for TCL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033138 positive regulation of peptidyl-serine phosphorylation IDA 10983986
GO:0071902 positive regulation of protein serine/threonine kinase activity IDA 10983986
genes like me logo Genes that share ontologies with TCL1B: view

Drugs & Compounds for TCL1B Gene

No Compound Related Data Available

Transcripts for TCL1B Gene

Unigene Clusters for TCL1B Gene

T-cell leukemia/lymphoma 1B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCL1B Gene

No ASD Table

Relevant External Links for TCL1B Gene

GeneLoc Exon Structure for
TCL1B
ECgene alternative splicing isoforms for
TCL1B

Expression for TCL1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCL1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCL1B Gene

This gene is overexpressed in Testis (x21.1), Whole Blood (x9.2), and Spleen (x7.6).

NURSA nuclear receptor signaling pathways regulating expression of TCL1B Gene:

TCL1B

SOURCE GeneReport for Unigene cluster for TCL1B Gene:

Hs.632346

mRNA Expression by UniProt/SwissProt for TCL1B Gene:

O95988-TCL1B_HUMAN
Tissue specificity: Expressed in a variety of tissues including placenta and testis.
genes like me logo Genes that share expression patterns with TCL1B: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCL1B Gene

Orthologs for TCL1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCL1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCL1B 33 34
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia TCL1B 33
  • 72.92 (n)
cow
(Bos Taurus)
Mammalia TCL1B 33 34
  • 68.2 (n)
mouse
(Mus musculus)
Mammalia Tcl1b1 34
  • 34 (a)
OneToMany
Tcl1b4 34
  • 32 (a)
OneToMany
Tcl1b3 34
  • 30 (a)
OneToMany
Tcl1b2 34
  • 28 (a)
OneToMany
Tcl1b5 34
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
OneToMany
Species where no ortholog for TCL1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCL1B Gene

ENSEMBL:
Gene Tree for TCL1B (if available)
TreeFam:
Gene Tree for TCL1B (if available)

Paralogs for TCL1B Gene

Paralogs for TCL1B Gene

(2) SIMAP similar genes for TCL1B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TCL1B Gene

genes like me logo Genes that share paralogs with TCL1B: view

Variants for TCL1B Gene

Sequence variations from dbSNP and Humsavar for TCL1B Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000018427 -- 95,691,683(+) G/A intron_variant
rs1000206699 -- 95,692,300(+) A/G 3_prime_UTR_variant
rs1000507741 -- 95,686,219(+) C/A upstream_transcript_variant
rs1000540314 -- 95,686,068(+) G/C upstream_transcript_variant
rs1000977308 -- 95,690,673(+) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TCL1B Gene

Variant ID Type Subtype PubMed ID
esv3635406 CNV loss 21293372
nsv1046191 CNV gain 25217958

Variation tolerance for TCL1B Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.57; 88.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCL1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCL1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCL1B Gene

Disorders for TCL1B Gene

MalaCards: The human disease database

(3) MalaCards diseases for TCL1B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
leukemia
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards
Search TCL1B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TCL1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TCL1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCL1B Gene

Publications for TCL1B Gene

  1. Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. (PMID: 10077617) Pekarsky Y … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 22 58
  2. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PMID: 11707444) Laine J … Noguchi M (The Journal of biological chemistry 2002) 3 4 22 58
  3. The protooncogene TCL1 is an Akt kinase coactivator. (PMID: 10983986) Laine J … Noguchi M (Molecular cell 2000) 3 4 22 58
  4. Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus. (PMID: 10344735) Sugimoto J … Isobe M (Cancer research 1999) 3 4 22 58
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58

Products for TCL1B Gene

Sources for TCL1B Gene

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