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TCL1B (TCL1 Family AKT Coactivator B) is a Protein Coding gene. Diseases associated with TCL1B include T-Cell Lymphoblastic Leukemia/Lymphoma and Leukemia. Among its related pathways are PI3K-Akt signaling pathway. An important paralog of this gene is TCL1A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 32296183 |
GO:0019901 | protein kinase binding | IPI | 10983986 |
GO:0043539 | protein serine/threonine kinase activator activity | IBA,IDA | 10983986 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0032991 | protein-containing complex | IDA | 10983986 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | PI3K-Akt signaling pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0033138 | positive regulation of peptidyl-serine phosphorylation | IBA,IDA | 10983986 |
GO:0071902 | positive regulation of protein serine/threonine kinase activity | IDA | 10983986 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TCL1B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TCL1B 30 |
|
||
Cow (Bos Taurus) |
Mammalia | TCL1B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tcl1b1 31 |
|
OneToMany | |
Tcl1b4 31 |
|
OneToMany | |||
Tcl1b3 31 |
|
OneToMany | |||
Tcl1b5 31 |
|
OneToMany | |||
Tcl1b2 31 |
|
OneToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1064017 | - |
p.Gly93Arg |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3635406 | CNV | loss | 21293372 |
nsv1046191 | CNV | gain | 25217958 |
Disorder | Aliases | PubMed IDs |
---|---|---|
t-cell lymphoblastic leukemia/lymphoma |
|
|
leukemia |
|
|
lymphoma |
|
|
splenic manifestation of leukemia |
|
|
ovary sarcoma |
|
|