TCL1B Gene (Protein Coding)

TCL1 Family AKT Coactivator B

GC14P095686
GIFtS:
37
See more...

Aliases for TCL1B Gene

Aliases for TCL1B Gene

  • TCL1 Family AKT Coactivator B 2 3 5
  • Syncytiotrophoblast-Specific Protein 3 4
  • T-Cell Leukemia/Lymphoma Protein 1B 3 4
  • T Cell Leukemia/Lymphoma 1B 2 3
  • Oncogene TCL-1B 3 4
  • SYN-1 3 4
  • TML1 2 3
  • T-Cell Lymphoma/Leukemia 1B 3
  • TCL1/MTCP1-Like Protein 1 4
  • TCL1/ MTCP1-Like 1 3
  • TCL1/MTCP1-Like 1 2
  • Oncogene TCL1B 4
  • TCL1B 5
  • TCL1 4

External Ids for TCL1B Gene

Previous GeneCards Identifiers for TCL1B Gene

  • GC14P093628
  • GC14P089969
  • GC14P094118
  • GC14P094142
  • GC14P095198
  • GC14P095222
  • GC14P096152
  • GC14P076338

Summaries for TCL1B Gene

GeneCards Summary for TCL1B Gene

TCL1B (TCL1 Family AKT Coactivator B) is a Protein Coding gene. Diseases associated with TCL1B include T-Cell Lymphoblastic Leukemia/Lymphoma and Leukemia. Among its related pathways are PI3K-Akt signaling pathway. An important paralog of this gene is TCL1A.

UniProtKB/Swiss-Prot Summary for TCL1B Gene

Gene Wiki entry for TCL1B Gene

Additional gene information for TCL1B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCL1B Gene

Genomics for TCL1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TCL1B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH14J095686 Promoter/Enhancer 0.8 EPDnew Ensembl 269.4 0.0 -25 2.4 SIX4 VEZF1 NRF1 L3MBTL2 ZFP3 OSR2 MNT TCL1B TCL1A lnc-TCL1B-4 ENSG00000259084 GLRX5
GH14J095670 Promoter/Enhancer 0.5 EPDnew Ensembl 263.9 -15.8 -15826 0.4 TCL1B ENSG00000277468 TCL1A ENSG00000259084 lnc-TCL1B-4 TCL6 GLRX5
GH14J095698 Enhancer 1 Ensembl ENCODE dbSUPER 9.7 +12.5 12505 2.5 PRDM6 TAF1 ZNF362 IKZF1 MTA3 GLIS1 ZNF561 ZXDB SPI1 TARDBP TCL1B piR-30481 lnc-SYNE3-5 TCL1A
GH14J095725 Enhancer 0.8 ENCODE dbSUPER 10.9 +39.7 39675 1.5 EBF1 CBFB BHLHE40 IKZF1 NR2F1 BACH1 TCF12 TARDBP ZNF687 MTA2 TCL1B piR-30350-026 ENSG00000257275 TCL1A LOC107984703 C14orf132
GH14J095659 Enhancer 1.2 FANTOM5 Ensembl ENCODE 6.6 -23.3 -23285 7.5 SP1 BCL11A ZIC2 CTCF IRF4 ZNF341 EBF1 SMARCA5 CBFB USF2 ENSG00000275033 ENSG00000259084 TCL1A TCL6 ENSG00000258927 TCL1B GLRX5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCL1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCL1B

Top Transcription factor binding sites by QIAGEN in the TCL1B gene promoter:
  • AML1a
  • AP-2rep
  • MZF-1
  • Nkx2-5
  • Nkx5-1
  • p53
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • S8

Genomic Locations for TCL1B Gene

Latest Assembly
chr14:95,686,426-95,692,628
(GRCh38/hg38)
Size:
6,203 bases
Orientation:
Plus strand

Previous Assembly
chr14:96,152,763-96,158,965
(GRCh37/hg19 by Entrez Gene)
Size:
6,203 bases
Orientation:
Plus strand

chr14:96,152,754-96,158,980
(GRCh37/hg19 by Ensembl)
Size:
6,227 bases
Orientation:
Plus strand

Genomic View for TCL1B Gene

Genes around TCL1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCL1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCL1B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TCL1B Gene

Proteins for TCL1B Gene

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  • Protein details for TCL1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95988-TCL1B_HUMAN
    Recommended name:
    T-cell leukemia/lymphoma protein 1B
    Protein Accession:
    O95988
    Secondary Accessions:
    • A6NEK7
    • Q6IAR7
    • Q9UBQ4

    Protein attributes for TCL1B Gene

    Size:
    128 amino acids
    Molecular mass:
    14846 Da
    Quaternary structure:
    • Interacts with AKT1 and AKT2 (via PH domain). Does not interact with AKT3.
    Miscellaneous:
    • Activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region.

neXtProt entry for TCL1B Gene

Post-translational modifications for TCL1B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCL1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCL1B Gene

Domains & Families for TCL1B Gene

Gene Families for TCL1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCL1B Gene

InterPro:
Blocks:
  • TCL1/MTCP1 family
ProtoNet:

Suggested Antigen Peptide Sequences for TCL1B Gene

GenScript: Design optimal peptide antigens:
  • TCL1/MTCP1-like protein 1 (TCL1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O95988

UniProtKB/Swiss-Prot:

TCL1B_HUMAN :
  • Belongs to the TCL1 family.
Family:
  • Belongs to the TCL1 family.
genes like me logo Genes that share domains with TCL1B: view

Function for TCL1B Gene

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  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for TCL1B Gene

UniProtKB/Swiss-Prot Function:
Enhances the phosphorylation and activation of AKT1 and AKT2.
GENATLAS Biochemistry:
T cell leukemia transcript 1b,14kDa,highly similar to TCL1A,with the same pattern of low expression in normal bone marrow and peripheral lymphocytes but activated in T cell leukemias by rearrangements of 14q32.1 region

Phenotypes From GWAS Catalog for TCL1B Gene

Gene Ontology (GO) - Molecular Function for TCL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
GO:0019901 protein kinase binding IPI 10983986
GO:0043539 protein serine/threonine kinase activator activity IBA,IDA 10983986
genes like me logo Genes that share ontologies with TCL1B: view
genes like me logo Genes that share phenotypes with TCL1B: view

Animal Models for research

miRNA for TCL1B Gene

miRTarBase miRNAs that target TCL1B

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCL1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCL1B Gene

Localization for TCL1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCL1B gene
Compartment Confidence
nucleus 3
plasma membrane 2
extracellular 2
mitochondrion 2
cytosol 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032991 protein-containing complex IDA 10983986
genes like me logo Genes that share ontologies with TCL1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TCL1B Gene

Pathways & Interactions for TCL1B Gene

PathCards logo

SuperPathways for TCL1B Gene

SuperPathway Contained pathways
1 PI3K-Akt signaling pathway
PI3K-Akt signaling pathway
.30
genes like me logo Genes that share pathways with TCL1B: view

Pathways by source for TCL1B Gene

1 KEGG pathway for TCL1B Gene

SIGNOR curated interactions for TCL1B Gene

Activates:

Gene Ontology (GO) - Biological Process for TCL1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033138 positive regulation of peptidyl-serine phosphorylation IBA,IDA 10983986
GO:0071902 positive regulation of protein serine/threonine kinase activity IDA 10983986
genes like me logo Genes that share ontologies with TCL1B: view

Drugs & Compounds for TCL1B Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for TCL1B Gene

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mRNA/cDNA for TCL1B Gene

2 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCL1B

Alternative Splicing Database (ASD) splice patterns (SP) for TCL1B Gene

No ASD Table

Relevant External Links for TCL1B Gene

GeneLoc Exon Structure for
TCL1B

Expression for TCL1B Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCL1B Gene

mRNA expression in normal human tissues for TCL1B Gene
mRNA expression by BioGPS for TCL1B GenemRNA expression by GTEx for TCL1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCL1B Gene

This gene is overexpressed in Testis (x21.1), Whole Blood (x9.2), and Spleen (x7.6).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCL1B

SOURCE GeneReport for Unigene cluster for TCL1B Gene:

Hs.632346

mRNA Expression by UniProt/SwissProt for TCL1B Gene:

O95988-TCL1B_HUMAN
Tissue specificity: Expressed in a variety of tissues including placenta and testis.

Evidence on tissue expression from TISSUES for TCL1B Gene

  • Spleen(2.3)
  • Bone marrow(2.3)
  • Blood(2.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with TCL1B: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCL1B Gene

Orthologs for TCL1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCL1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TCL1B 30 31
  • 99.22 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TCL1B 30
  • 72.92 (n)
Cow
(Bos Taurus)
 Mammalia TCL1B 30 31
  • 68.2 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Tcl1b1 31
  • 34 (a)
 OneToMany
Tcl1b4 31
  • 32 (a)
 OneToMany
Tcl1b3 31
  • 30 (a)
 OneToMany
Tcl1b5 31
  • 28 (a)
 OneToMany
Tcl1b2 31
  • 28 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 29 (a)
 OneToMany
Species where no ortholog for TCL1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TCL1B Gene

ENSEMBL:
Gene Tree for TCL1B (if available)
TreeFam:
Gene Tree for TCL1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCL1B: view image

Paralogs for TCL1B Gene

Paralogs for TCL1B Gene

(2) SIMAP similar genes for TCL1B Gene using alignment to 1 proteins:

  • TCL1B_HUMAN

Pseudogenes.org Pseudogenes for TCL1B Gene

genes like me logo Genes that share paralogs with TCL1B: view

Variants for TCL1B Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCL1B Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs1064017 - p.Gly93Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TCL1B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TCL1B Gene

Variant ID Type Subtype PubMed ID
esv3635406 CNV loss 21293372
nsv1046191 CNV gain 25217958

Variation tolerance for TCL1B Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.57; 88.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCL1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCL1B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCL1B Gene

Disorders for TCL1B Gene

MalaCards: The human disease database

(7) MalaCards diseases for TCL1B Gene - From: COP and GCD

Disorder Aliases PubMed IDs
t-cell lymphoblastic leukemia/lymphoma
  • t-cell leukemia
leukemia
  • leukemias
lymphoma
  • lymphoid cancer
splenic manifestation of leukemia
  • splenic leukemia
ovary sarcoma
  • sarcoma of ovary
- elite association - COSMIC cancer census association via MalaCards
Search TCL1B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TCL1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TCL1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCL1B Gene

Publications for TCL1B Gene

  1. Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. (PMID: 10077617) Pekarsky Y … Croce CM (Proceedings of the National Academy of Sciences of the United States of America 1999) 2 3 4 23
  2. Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus. (PMID: 10344735) Sugimoto J … Isobe M (Cancer research 1999) 2 3 4 23
  3. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PMID: 11707444) Laine J … Noguchi M (The Journal of biological chemistry 2002) 3 4 23
  4. The protooncogene TCL1 is an Akt kinase coactivator. (PMID: 10983986) Laine J … Noguchi M (Molecular cell 2000) 3 4 23
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41

ExternalLinks

View latest publications for TCL1B gene in Mastermind

Products for TCL1B Gene

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