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Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in C... See more...
Aliases for TCL1A Gene
Aliases for TCL1A Gene
External Ids for TCL1A Gene
- HGNC: 11648
- NCBI Entrez Gene: 8115
- Ensembl: ENSG00000100721
- OMIM®: 186960
- UniProtKB/Swiss-Prot: P56279
Previous GeneCards Identifiers for TCL1A Gene
- GC14M093687
- GC14M089992
- GC14M094166
- GC14M095246
- GC14M096177
- GC14M076361
Summaries for TCL1A Gene
-
Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]
GeneCards Summary for TCL1A Gene
TCL1A (TCL1 Family AKT Coactivator A) is a Protein Coding gene. Diseases associated with TCL1A include Precursor T-Cell Acute Lymphoblastic Leukemia and Leukemia. Among its related pathways are PI3K-Akt signaling pathway and PI3K / Akt Signaling. An important paralog of this gene is MTCP1.
UniProtKB/Swiss-Prot Summary for TCL1A Gene
-
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
Additional gene information for TCL1A Gene
- HGNC (11648)
- NCBI Entrez Gene (8115)
- Ensembl (ENSG00000100721)
- OMIM® (186960)
- UniProtKB/Swiss-Prot (P56279)
- Open Targets Platform(ENSG00000100721)
- Monarch Initiative
- Search for TCL1A at DataMed
- Search for TCL1A at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCL1A Gene
Genomics for TCL1A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TCL1A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TCL1A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCL1A
- Top Transcription factor binding sites by QIAGEN in the TCL1A gene promoter:
-
- GATA-3
- HSF2
- LyF-1
- NF-AT
- NF-AT1
- NF-AT2
- NF-AT3
- NF-AT4
- S8
- STAT5A
Genomic Locations for TCL1A Gene
Latest Assembly
- chr14:95,694,160-95,714,196
- (GRCh38/hg38)
- Size:
- 20,037 bases
- Orientation:
- Minus strand
Previous Assembly
- chr14:96,176,284-96,180,462
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 4,179 bases
- Orientation:
- Minus strand
- chr14:96,176,304-96,180,533
- (GRCh37/hg19 by Ensembl)
- Size:
- 4,230 bases
- Orientation:
- Minus strand
Genomic View for TCL1A Gene
Genes around TCL1A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.13 by HGNC
- 14q32.13 by Entrez Gene
- 14q32.13 by Ensembl
TCL1A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TCL1A Gene
Proteins for TCL1A Gene
-
Protein details for TCL1A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P56279-TCL1A_HUMAN
- Recommended name:
- T-cell leukemia/lymphoma protein 1A
- Protein Accession:
- P56279
- Q6IBK7
Protein attributes for TCL1A Gene
- Size:
- 114 amino acids
- Molecular mass:
- 13460 Da
- Quaternary structure:
-
- Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.
Protein Expression for TCL1A Gene
Post-translational modifications for TCL1A Gene
Other Protein References for TCL1A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ TCL1 (AS1A19) monoclonal antibody and Immunotag™ TCL1A Antibody
- NSJ Bioreagents TCL1 Antibody (Protein Microarray-Validated Monoclonal)
- BioLegend TCL1 Antibody (330508) and TCL1 Antibody (330506)
-
Custom Antibody ServicesOriGene Antibodies for TCL1A
- Novus Biologicals Antibodies for TCL1A
-
Abcam antibodies for TCL1A
- Invitrogen Antibodies for TCL1A (AFLGC-TCL1A)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TCL1A
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for TCL1A
- Origene Custom Protein Services for TCL1A
- Sino Biological Recombinant Proteins for TCL1A
- Browse Sino Biological Cell Lysates
- ProSpec Recombinant Proteins for TCL1A
-
Abcam proteins for TCL1A
Assay products for research
- G Biosciences Immunotag™ T-cell leukemia/lymphoma protein 1A ELISA Kit
- antibodies-online: Show 3 available TCL1A Elisa Kits ranked by validation data
- Compare Top TCL1A Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TCL1A Gene
Domains & Families for TCL1A Gene
Gene Families for TCL1A Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for TCL1A Gene
- InterPro:
- Blocks:
-
- TCL1/MTCP1 family
- ProtoNet:
Suggested Antigen Peptide Sequences for TCL1A Gene
- GenScript: Design optimal peptide antigens:
-
- Protein p14 TCL1 (TCL1A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P56279- Family:
-
- Belongs to the TCL1 family.
Function for TCL1A Gene
Molecular function for TCL1A Gene
- UniProtKB/Swiss-Prot Function:
- Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
- GENATLAS Biochemistry:
- T cell leukemia,transcript 1a,14kDa,normally expressed in pre-B cells and immature IgM expressing B cells and in early T cell progenitors with very low levels in bone marrow and peripheral lymphocytes activated in T cell leukemia and lymphoma by rearrangements of the 14q32.1 region
Phenotypes From GWAS Catalog for TCL1A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16189514 |
| GO:0019901 | protein kinase binding | IPI | 10983986 |
| GO:0042802 | identical protein binding | IPI | 25416956 |
| GO:0043539 | protein serine/threonine kinase activator activity | IBA,IMP | 10983986 |
Phenotypes for TCL1A Gene
- MGI mutant phenotypes for TCL1A:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TCL1A:
-
- Increased gamma-H2AX phosphorylation
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Decreased viability in ovarian lineage
- Decreased POU5F1-GFP protein expression
- Increased shRNA abundance (Z-score > 2)
- Decreased OCT4 protein expression
- Decreased NANOG protein expression
- Decreased shRNA abundance (Z-score < -2)
Animal Models for TCL1A Gene
- MGI Knock Outs for TCL1A:
-
- Tcl1 Tcl1<tm1Rso>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TCL1A - Starting at $85 >
- * TCL1A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TCL1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TCL1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCL1A
miRNA for TCL1A Gene
- miRTarBase miRNAs that target TCL1A
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TCL1A
- Browse OriGene Inhibitory RNA Products For TCL1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCL1A
Clone products for research
- Applied Biological Materials (abm): Clones for TCL1A - Starting at $45 >
- * TCL1A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TCL1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TCL1A
Cell Lines for research
-
Horizon Cell Lines for TCL1A
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCL1A Gene
Localization for TCL1A Gene
Subcellular locations from UniProtKB/Swiss-Prot for TCL1A Gene
- Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Note=Microsomal fraction.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| endoplasmic reticulum | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| mitochondrion | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
- Endoplasmic reticulum (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IDA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for TCL1A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | PI3K / Akt Signaling | ||
| 2 | PI3K-Akt signaling pathway | ||
Pathways by source for TCL1A Gene
1 KEGG pathway for TCL1A Gene
1 Cell Signaling Technology pathway for TCL1A Gene
Interacting Proteins for TCL1A Gene
Selected Interacting proteins:
P56279-TCL1A_HUMAN
ENSP00000385036
for TCL1A Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TCL1A
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | TAS | 7809072 |
| GO:0008284 | positive regulation of cell proliferation | IDA | 10983986 |
| GO:0010918 | positive regulation of mitochondrial membrane potential | IDA | 10983986 |
| GO:0031334 | positive regulation of protein complex assembly | IDA | 10983986 |
| GO:0033138 | positive regulation of peptidyl-serine phosphorylation | IBA,IMP | 10983986 |
Transcripts for TCL1A Gene
mRNA/cDNA for TCL1A Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000402399 1345 nts (view in UCSC)
- ENST00000553467 368 nts (view in UCSC)
- ENST00000554012 1391 nts (view in UCSC)
- ENST00000554119 913 nts (view in UCSC)
- ENST00000555202 717 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TCL1A - Starting at $85 >
- * TCL1A CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TCL1A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TCL1A
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCL1A
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TCL1A
- Browse OriGene Inhibitory RNA Products For TCL1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCL1A
Clone products for research
- Applied Biological Materials (abm): Clones for TCL1A - Starting at $45 >
- * TCL1A as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TCL1A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TCL1A
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||
| SP4: | - | - | - | - | - | - | |||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||
| SP7: |
Relevant External Links for TCL1A Gene
- GeneLoc Exon Structure for
- TCL1A
Expression for TCL1A Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
- Plasmacytoid Dendritic cells Peripheral Blood
- Mature B-Cells Peripheral Blood
- Hematopoietic Bone Marrow
-
Ovary (Reproductive System)
- Secondary Oocyte Antral Follicle
- Secondary follicles
-
Gonad
- Secondary Oocyte Antral Follicle
- Primordial Germ Cells Allantois
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
- Inner Cell Mass (Early Embryonic Tissues)
-
Spleen (Hematopoietic System)
-
Tonsil (Hematopoietic System)
-
Lymph (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for TCL1A Gene
This gene is overexpressed in Spleen (x7.9) and Whole Blood (x7.4).
This gene is overexpressed in Peripheral blood mononuclear cells (34.5) and Blymphocyte (23.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCL1A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCL1A
SOURCE GeneReport for Unigene cluster for TCL1A Gene:
Hs.2484mRNA Expression by UniProt/SwissProt for TCL1A Gene:
P56279-TCL1A_HUMAN
Tissue specificity:
Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
Evidence on tissue expression from TISSUES for TCL1A Gene
- Lymph node(3.4)
- Blood(3.3)
- Spleen(3.2)
- Bone marrow(2.6)
- Intestine(2.5)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TCL1A Gene
Germ Layers:
- mesoderm
Systems:
- cardiovascular
- immune
- lymphatic
Regions:
General:
- blood
- bone marrow
- white blood cell
Primer products for research
-
OriGene qPCR primer pairs for TCL1A
-
OriGene qPCR primer pairs and template standards for TCL1A
Gene Expression Assays for research
Orthologs for TCL1A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TCL1A 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TCL1A 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tcl1a 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tcl1 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TCL1A 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany |
- Species where no ortholog for TCL1A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Evolution for TCL1A Gene
- ENSEMBL:
- Gene Tree for TCL1A (if available)
- TreeFam:
- Gene Tree for TCL1A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TCL1A: view image
Paralogs for TCL1A Gene
Variants for TCL1A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCL1A Gene
| SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs75353825 | Benign: not provided | 95,714,036(-) |
C/T NM_021966.3(TCL1A):c.31G>A (p.Val11Ile) |
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT | |
| rs17093294 | - |
p.Val56Ile |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1046191 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.88;
35.20% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TCL1A Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCL1A Gene
Disorders for TCL1A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| precursor t-cell acute lymphoblastic leukemia |
|
|
| leukemia |
|
|
| prolymphocytic leukemia |
|
|
| lymphoma |
|
|
| t-cell prolymphocytic leukemia |
|
|
Search TCL1A in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TCL1A_HUMAN- Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
Genatlas disease for TCL1A Gene
chronic lymphocytic leukemia (T-CLL) associated breakpoint 1,with inversion inv(14) (q11;q32) and translocations t(14;14)(q11;q32),t(7;14)(q35;q32)
Additional Disease Information for TCL1A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
Publications for TCL1A Gene
- Identification of the TCL1 gene involved in T-cell malignancies. (PMID: 7809072) Virgilio L … Russo G (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 23
- Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PMID: 11707444) Laine J … Noguchi M (The Journal of biological chemistry 2002) 3 4 23
- The protooncogene TCL1 is an Akt kinase coactivator. (PMID: 10983986) Laine J … Noguchi M (Molecular cell 2000) 3 4 23
- Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. (PMID: 9519406) Hoh F … van Tilbeurgh H (Structure (London, England : 1993) 1998) 3 4 23
- TCL1 protein expression in testicular germ cell tumors. (PMID: 20395523) Lau SK … Chu PG (American journal of clinical pathology 2010) 3 23
ExternalLinks
Products for TCL1A Gene
- Custom Antibody ServicesOriGene Antibodies for TCL1A
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- Search Origene for MassSpec and Protein Over-expression Lysates for TCL1A
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- OriGene qPCR primer pairs for TCL1A
- OriGene qPCR primer pairs and template standards for TCL1A
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- Sino Biological Human cDNA Clone for TCL1A
- Sino Biological Recombinant Proteins for TCL1A
- Browse Sino Biological Cell Lysates
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TCL1A
- Novus Biologicals proteins and lysates for TCL1A
- Browse Antibodies
- Browse Peptides and Proteins
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- Browse Primary Antibodies
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- Browse Secondary Antibodies
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- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for TCL1A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TCL1A (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Stable cell line generation for TCL1A
- antibodies-online: Show 9 available TCL1A Antibodies ranked by validation data
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- antibodies-online: Show 3 available TCL1A Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 16 available TCL1A Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for TCL1A
- Search Santa Cruz Biotechnology (SCBT) for TCL1A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TCL1A
- Horizon Cell Lines for TCL1A
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TCL1A
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for TCL1A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCL1A
Sources for TCL1A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB