Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TCL1A Gene

Aliases for TCL1A Gene

  • T Cell Leukemia/Lymphoma 1A 2 3
  • T-Cell Leukemia/Lymphoma 1A 2 5
  • Protein P14 TCL1 3 4
  • Oncogene TCL-1 3 4
  • Oncogene TCL1 3 4
  • TCL1 3 4
  • T-Cell Leukemia/Lymphoma Protein 1A 3
  • T-Cell Lymphoma-1 3

External Ids for TCL1A Gene

Previous GeneCards Identifiers for TCL1A Gene

  • GC14M093687
  • GC14M089992
  • GC14M094166
  • GC14M095246
  • GC14M096177
  • GC14M076361

Summaries for TCL1A Gene

Entrez Gene Summary for TCL1A Gene

  • Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).[supplied by OMIM, Jul 2010]

GeneCards Summary for TCL1A Gene

TCL1A (T Cell Leukemia/Lymphoma 1A) is a Protein Coding gene. Diseases associated with TCL1A include T-Cell Leukemia and Precursor T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are PI3K-Akt signaling pathway and PI3K / Akt Signaling. An important paralog of this gene is MTCP1.

UniProtKB/Swiss-Prot for TCL1A Gene

  • Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.

Gene Wiki entry for TCL1A Gene

Additional gene information for TCL1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCL1A Gene

Genomics for TCL1A Gene

GeneHancer (GH) Regulatory Elements for TCL1A Gene

Promoters and enhancers for TCL1A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I095711 Promoter/Enhancer 1.3 EPDnew ENCODE dbSUPER 550.8 +1.2 1157 3.2 CTCF ZNF687 SMAD5 CBFB FOXA1 ZFP3 POLR2A IKZF1 ZNF143 RUNX3 ENSG00000257275 TCL1A
GH14I095740 Enhancer 1.1 ENCODE dbSUPER 11.5 -27.0 -26960 1.6 PKNOX1 CLOCK NFIB INSM2 NEUROD1 SIN3A FEZF1 RFX5 GLIS2 ZNF302 TCL1A ENSG00000257275 LOC105370644
GH14I095686 Promoter/Enhancer 1 EPDnew Ensembl 11.6 +27.6 27623 0.9 SIX4 ZNF263 ZFP3 L3MBTL2 VEZF1 NRF1 TCL1B TCL1A PIR31480 ENSG00000259084
GH14I095660 Enhancer 0.8 ENCODE 11.2 +50.8 50817 7 PKNOX1 BMI1 BATF KLF5 IRF4 SCRT2 ZNF143 ATF7 FOS IKZF2 ENSG00000259084 ENSG00000275033 TCL6 TCL1A TCL1B ENSG00000258927 GLRX5 ENSG00000277468
GH14I095613 Enhancer 0.6 ENCODE 11.2 +99.5 99452 1.5 CTCF RAD21 FOSL1 MITF GATA3 ZNF366 CREB1 FOS TCL1A TCL1B ENSG00000270038 GLRX5 ENSG00000258927 LOC105370643
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCL1A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCL1A gene promoter:

Genomic Locations for TCL1A Gene

Genomic Locations for TCL1A Gene
4,230 bases
Minus strand

Genomic View for TCL1A Gene

Genes around TCL1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCL1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCL1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCL1A Gene

Proteins for TCL1A Gene

  • Protein details for TCL1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell leukemia/lymphoma protein 1A
    Protein Accession:
    Secondary Accessions:
    • Q6IBK7

    Protein attributes for TCL1A Gene

    114 amino acids
    Molecular mass:
    13460 Da
    Quaternary structure:
    • Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity.

    Three dimensional structures from OCA and Proteopedia for TCL1A Gene

neXtProt entry for TCL1A Gene

Post-translational modifications for TCL1A Gene

No Post-translational modifications

No data available for DME Specific Peptides for TCL1A Gene

Domains & Families for TCL1A Gene

Gene Families for TCL1A Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TCL1A Gene

Suggested Antigen Peptide Sequences for TCL1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TCL1 family.
  • Belongs to the TCL1 family.
genes like me logo Genes that share domains with TCL1A: view

Function for TCL1A Gene

Molecular function for TCL1A Gene

GENATLAS Biochemistry:
T cell leukemia,transcript 1a,14kDa,normally expressed in pre-B cells and immature IgM expressing B cells and in early T cell progenitors with very low levels in bone marrow and peripheral lymphocytes activated in T cell leukemia and lymphoma by rearrangements of the 14q32.1 region
UniProtKB/Swiss-Prot Function:
Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.

Phenotypes From GWAS Catalog for TCL1A Gene

Gene Ontology (GO) - Molecular Function for TCL1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019901 protein kinase binding IPI 10983986
GO:0042802 identical protein binding IDA,IPI 25416956
GO:0043539 protein serine/threonine kinase activator activity IMP 10983986
genes like me logo Genes that share ontologies with TCL1A: view
genes like me logo Genes that share phenotypes with TCL1A: view

Animal Models for TCL1A Gene

MGI Knock Outs for TCL1A:

Animal Model Products

CRISPR Products

miRNA for TCL1A Gene

miRTarBase miRNAs that target TCL1A

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCL1A Gene

Localization for TCL1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCL1A Gene

Cytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Note=Microsomal fraction.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCL1A gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 3
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TCL1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0043231 intracellular membrane-bounded organelle IEA --
GO:0043234 protein complex IMP 10983986
genes like me logo Genes that share ontologies with TCL1A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCL1A Gene

Pathways & Interactions for TCL1A Gene

genes like me logo Genes that share pathways with TCL1A: view

Pathways by source for TCL1A Gene

1 Cell Signaling Technology pathway for TCL1A Gene
1 KEGG pathway for TCL1A Gene

SIGNOR curated interactions for TCL1A Gene


Gene Ontology (GO) - Biological Process for TCL1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS 7809072
GO:0008284 positive regulation of cell proliferation IDA 10983986
GO:0010918 positive regulation of mitochondrial membrane potential IDA 10983986
GO:0032461 positive regulation of protein oligomerization IDA 10983986
GO:0033138 positive regulation of peptidyl-serine phosphorylation IMP 10983986
genes like me logo Genes that share ontologies with TCL1A: view

Drugs & Compounds for TCL1A Gene

(2) Drugs for TCL1A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TCL1A: view

Transcripts for TCL1A Gene

Unigene Clusters for TCL1A Gene

T-cell leukemia/lymphoma 1A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCL1A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: - - - -
SP3: - - - -
SP4: - - - - - -
SP5: - -
SP6: - - -

Relevant External Links for TCL1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCL1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCL1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCL1A Gene

This gene is overexpressed in Spleen (x7.9) and Whole Blood (x7.4).

Protein differential expression in normal tissues from HIPED for TCL1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.5) and Blymphocyte (23.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCL1A Gene

Protein tissue co-expression partners for TCL1A Gene

NURSA nuclear receptor signaling pathways regulating expression of TCL1A Gene:


SOURCE GeneReport for Unigene cluster for TCL1A Gene:


mRNA Expression by UniProt/SwissProt for TCL1A Gene:

Tissue specificity: Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.

Evidence on tissue expression from TISSUES for TCL1A Gene

  • Lymph node(3)
  • Blood(2.8)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TCL1A Gene

Germ Layers:
  • mesoderm
  • cardiovascular
  • immune
  • lymphatic
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with TCL1A: view

Primer Products

Orthologs for TCL1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCL1A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TCL1A 33 34
  • 99.12 (n)
(Bos Taurus)
Mammalia TCL1A 33 34
  • 77.18 (n)
(Rattus norvegicus)
Mammalia Tcl1a 33
  • 69.44 (n)
(Mus musculus)
Mammalia Tcl1 33 16 34
  • 69.1 (n)
(Canis familiaris)
Mammalia TCL1A 34
  • 59 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
Species where no ortholog for TCL1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCL1A Gene

Gene Tree for TCL1A (if available)
Gene Tree for TCL1A (if available)

Paralogs for TCL1A Gene

Paralogs for TCL1A Gene

(2) SIMAP similar genes for TCL1A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TCL1A: view

Variants for TCL1A Gene

Sequence variations from dbSNP and Humsavar for TCL1A Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000073439 -- 95,709,597(-) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000220700 -- 95,709,051(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000258714 -- 95,707,833(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000815623 -- 95,696,274(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000842835 -- 95,712,895(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TCL1A Gene

Variant ID Type Subtype PubMed ID
nsv1046191 CNV gain 25217958

Variation tolerance for TCL1A Gene

Residual Variation Intolerance Score: 50% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCL1A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCL1A Gene

Disorders for TCL1A Gene

MalaCards: The human disease database

(12) MalaCards diseases for TCL1A Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
  • lymphoid cancer
prolymphocytic leukemia
  • leukemia prolymphocytic
- elite association - COSMIC cancer census association via MalaCards
Search TCL1A in MalaCards View complete list of genes associated with diseases


  • Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.

Genatlas disease for TCL1A Gene

chronic lymphocytic leukemia (T-CLL) associated breakpoint 1,with inversion inv(14) (q11;q32) and translocations t(14;14)(q11;q32),t(7;14)(q35;q32)

Additional Disease Information for TCL1A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TCL1A: view

Publications for TCL1A Gene

  1. Identification of the TCL1 gene involved in T-cell malignancies. (PMID: 7809072) Virgilio L … Russo G (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 22 58
  2. Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. (PMID: 11707444) Laine J … Noguchi M (The Journal of biological chemistry 2002) 3 4 22 58
  3. The protooncogene TCL1 is an Akt kinase coactivator. (PMID: 10983986) Laine J … Noguchi M (Molecular cell 2000) 3 4 22 58
  4. Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology. (PMID: 9519406) Hoh F … van Tilbeurgh H (Structure (London, England : 1993) 1998) 3 4 22 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for TCL1A Gene

Sources for TCL1A Gene

Loading form....