Aliases for TCF7L2 Gene
Aliases for TCF7L2 Gene
External Ids for TCF7L2 Gene
- HGNC: 11641
- Entrez Gene: 6934
- Ensembl: ENSG00000148737
- OMIM: 602228
- UniProtKB: Q9NQB0
Previous HGNC Symbols for TCF7L2 Gene
- TCF4
Previous GeneCards Identifiers for TCF7L2 Gene
- GC10P113605
- GC10P113943
- GC10P114841
- GC10P114374
- GC10P114700
- GC10P108337
- GC10P114710
Summaries for TCF7L2 Gene
-
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
GeneCards Summary for TCF7L2 Gene
TCF7L2 (Transcription Factor 7 Like 2) is a Protein Coding gene. Diseases associated with TCF7L2 include Diabetes Mellitus, Noninsulin-Dependent and Colorectal Cancer. Among its related pathways are Development VEGF signaling via VEGFR2 - generic cascades and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is TCF7L1.
UniProtKB/Swiss-Prot for TCF7L2 Gene
-
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5-CCTTTGATC-3 in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF7L2 Gene
Genomics for TCF7L2 Gene
Regulatory Elements for TCF7L2 Gene
Enhancers for TCF7L2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TCF7L2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TCF7L2 gene promoter:
Regulatory Element Products
Genomic Location for TCF7L2 Gene
- Chromosome:
- 10
- Start:
- 112,950,219 bp from pter
- End:
- 113,167,678 bp from pter
- Size:
- 217,460 bases
- Orientation:
- Plus strand
Genomic View for TCF7L2 Gene
Genes around TCF7L2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q25.2 by Ensembl
- 10q25.2-q25.3 by Entrez Gene
- 10q25.2-q25.3 by HGNC
TCF7L2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TCF7L2 Gene
Proteins for TCF7L2 Gene
-
Protein details for TCF7L2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NQB0-TF7L2_HUMAN
- Recommended name:
- Transcription factor 7-like 2
- Protein Accession:
- Q9NQB0
- B4DRJ8
- B9X074
- C6ZRJ8
- C6ZRK0
- E2GH14
- E2GH19
- E2GH20
- E2GH24
- E2GH25
- E9PFH9
- F8W742
- F8W7T5
- O00185
- Q9NQB1
- Q9NQB2
- Q9NQB3
- Q9NQB4
- Q9NQB5
- Q9NQB6
- Q9NQB7
- Q9ULC2
Protein attributes for TCF7L2 Gene
- Size:
- 619 amino acids
- Molecular mass:
- 67919 Da
- Quaternary structure:
-
- Interacts with TGFB1I1 (By similarity). Interacts with CTNNB1 (via the armadillo repeat); forms stable transcription complex. Interacts with EP300. Interacts with NLK. Interacts with CCDC85B (probably through the HMG box); prevents interaction with CTNNB1. Interacts with TNIK. Interacts with MAD2L2; prevents TCF7L2/TCF4 binding to promZIPK/DAPK3oters, negatively modulating its transcriptional activity. Interacts with ZIPK/DAPK3. Interacts with XIAP/BIRC4 and TLE3. Interacts with DDIT3/CHOP. The CTNNB1 and TCF7L2/TCF4 complex interacts with PML (isoform PML-4). Identified in a complex with CTNNB1 and FERMT2. Interacts with SPIN1.
Protein Expression for TCF7L2 Gene
Post-translational modifications for TCF7L2 Gene
- In vitro, phosphorylated by TNIK.
- Phosphorylated at Thr-201 and/or Thr-212 by NLK. Phosphorylation by NLK at these sites inhibits DNA-binding by TCF7L2/TCF4, thereby preventing transcriptional activation of target genes of the canonical Wnt/beta-catenin signaling pathway.
- Polysumoylated. Sumoylation is enhanced by PIAS family members and desumoylation is enhanced by SENP2. Sumoylation/desumoylation regulates TCF7L2/TCF4 transcription activity in the Wnt/beta-catenin signaling pathway without altering interaction with CTNNB1 nor binding to DNA.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for TCF7L2 Gene
- ENSEMBL proteins:
-
- ENSP00000277945
- ENSP00000298692
- ENSP00000344823
- ENSP00000345640
- ENSP00000347949
- ENSP00000348274
- ENSP00000358393
- ENSP00000358396
- ENSP00000358402
- ENSP00000358404
- ENSP00000435694
- ENSP00000440547
- ENSP00000443626
- ENSP00000443883
- ENSP00000446172
- ENSP00000446238
- ENSP00000486891
- ENSP00000487507
- ENSP00000490004
- ENSP00000490260
- ENSP00000490478
- ENSP00000444972
- REFSEQ proteins:
-
- NP_001139746.1
- NP_001139755.1
- NP_001139756.1
- NP_001139757.1
- NP_001139758.1
- NP_001185454.1
- NP_001185455.1
- NP_001185456.1
- NP_001185457.1
- NP_001185458.1
- NP_001185459.1
- NP_001185460.1
- NP_001336799.1
- NP_001336800.1
- NP_110383.2
- XP_005270128.1
- XP_005270132.1
- XP_005270134.1
- XP_005270135.1
- XP_005270136.1
- XP_005270137.1
- XP_005270141.1
- XP_005270142.1
- XP_005270143.1
- XP_005270145.1
- XP_005270146.1
- XP_005270148.1
- XP_005270149.1
- XP_005270150.1
- XP_005270151.1
- XP_005270152.1
- XP_005270153.1
- XP_005270157.1
- XP_005270158.1
- XP_005270159.1
- XP_005270160.1
- XP_005270161.1
- XP_011538411.1
- XP_011538412.1
- XP_011538413.1
- XP_011538415.1
- XP_011538418.1
- XP_016872073.1
- XP_016872074.1
- XP_016872075.1
- XP_016872076.1
- XP_016872077.1
- XP_016872078.1
- XP_016872079.1
- XP_016872080.1
- XP_016872081.1
- XP_016872082.1
- XP_016872083.1
- XP_016872084.1
- XP_016872085.1
Antibody Products
- Cell Signaling Technology (CST) Antibodies for TCF7L2 (TCF7L2)
-
Custom Antibody ServicesOriGene Antibodies for TCF7L2
- Novus Biologicals Antibodies for TCF7L2
-
Abcam antibodies for TCF7L2
- Invitrogen Antibodies for TCF7L2
- antibodies-online Antibodies for TCF7L2: See all 81
- Search GeneTex for Antibodies for TCF7L2
-
Santa Cruz Biotechnology (SCBT) Antibodies for TCF7L2
Protein Products
-
OriGene Purified Proteins for TCF7L2
- Search Origene for MassSpec and Protein Over-expression Lysates for TCF7L2
- Origene Custom Protein Services for TCF7L2
- antibodies-online Proteins for TCF7L2: See all 10
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TCF7L2
-
Abcam proteins for TCF7L2
No data available for DME Specific Peptides for TCF7L2 Gene
Domains & Families for TCF7L2 Gene
Protein Domains for TCF7L2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TCF7L2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ60833, highly similar to Transcription factor 7-like 2 (B4DRJ8_HUMAN)
- Transcription factor 7-like 2 (B5BU30_HUMAN)
- Transcription factor 7-like 2 isoform (B9X074_HUMAN)
- TCF7L2 isoform pFC8A_TCF7L2_D4,ex1-11-13a-14 (C6ZRJ8_HUMAN)
- Transcription factor 7-like 2 (T-cell specific, HMG-box), isoform CRA_i (C6ZRK5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9NQB0UniProtKB/Swiss-Prot:
TF7L2_HUMAN :- The promoter-specific activation domain interacts with the transcriptional coactivator EP300.
- Belongs to the TCF/LEF family.
- Domain:
-
- The promoter-specific activation domain interacts with the transcriptional coactivator EP300.
- Family:
-
- Belongs to the TCF/LEF family.
No data available for Gene Families for TCF7L2 Gene
Function for TCF7L2 Gene
Molecular function for TCF7L2 Gene
- UniProtKB/Swiss-Prot Function:
- Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5-CCTTTGATC-3 in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IDA | 19443654 |
| GO:0001103 | RNA polymerase II repressing transcription factor binding | IPI | 19443654 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IDA | 9727977 |
| GO:0005515 | protein binding | IPI | 11713475 |
Phenotypes for TCF7L2 Gene
- MGI mutant phenotypes for TCF7L2:
-
inferred from 12 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- muscle phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- digestive/alimentary phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- integument phenotype
- skeleton phenotype
- embryo phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for TCF7L2:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- Increased transferrin (TF) endocytosis
- Increased G1 DNA content
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Downregulation of Wnt pathway after Wnt3A stimulation
- Increased Nanog expression
Animal Models for TCF7L2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TCF7L2
-
- Search ViGene Biosciences for TCF7L2
CRISPR Products
-
OriGene CRISPR knockouts for TCF7L2
-
Applied Biological Materials CRISPR for TCF7L2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCF7L2
- GenScript: Design CRISPR guide RNA sequences for TCF7L2
miRNA for TCF7L2 Gene
- miRTarBase miRNAs that target TCF7L2
-
- hsa-mir-324-5p (MIRT043052)
- hsa-mir-148b-3p (MIRT043583)
- hsa-mir-4698 (MIRT261338)
- hsa-mir-8063 (MIRT261341)
- hsa-mir-513a-3p (MIRT261342)
- hsa-mir-513c-3p (MIRT261347)
- hsa-mir-3606-3p (MIRT261349)
- hsa-mir-3613-3p (MIRT261354)
- hsa-mir-4435 (MIRT505411)
- hsa-mir-1298-5p (MIRT505412)
- hsa-mir-539-3p (MIRT505413)
- hsa-mir-485-3p (MIRT505414)
- hsa-mir-539-5p (MIRT505415)
- hsa-mir-3190-5p (MIRT505416)
- hsa-mir-4793-3p (MIRT505417)
- hsa-mir-3919 (MIRT505418)
- hsa-mir-892b (MIRT505419)
- hsa-mir-6807-3p (MIRT505420)
- hsa-mir-217 (MIRT505421)
- hsa-mir-509-5p (MIRT505422)
- hsa-mir-509-3-5p (MIRT505423)
- hsa-mir-4418 (MIRT505424)
- hsa-mir-1-5p (MIRT505425)
- hsa-mir-193a-3p (MIRT505426)
- hsa-mir-193b-3p (MIRT505427)
- hsa-mir-429 (MIRT505428)
- hsa-mir-200c-3p (MIRT505429)
- hsa-mir-200b-3p (MIRT505430)
- hsa-mir-651-5p (MIRT553690)
- hsa-mir-3117-3p (MIRT553691)
- hsa-mir-891b (MIRT553692)
- hsa-mir-616-5p (MIRT553693)
- hsa-mir-373-5p (MIRT553694)
- hsa-mir-371b-5p (MIRT553695)
- hsa-mir-5193 (MIRT553696)
- hsa-mir-8083 (MIRT553697)
- hsa-mir-4759 (MIRT553698)
- hsa-mir-3169 (MIRT553699)
- hsa-mir-519c-3p (MIRT553700)
- hsa-mir-519b-3p (MIRT553701)
- hsa-mir-519a-3p (MIRT553702)
- hsa-mir-17-5p (MIRT553703)
- hsa-mir-106b-5p (MIRT553704)
- hsa-mir-20a-5p (MIRT553705)
- hsa-mir-20b-5p (MIRT553706)
- hsa-mir-519d-3p (MIRT553707)
- hsa-mir-526b-3p (MIRT553708)
- hsa-mir-93-5p (MIRT553709)
- hsa-mir-106a-5p (MIRT553710)
- hsa-mir-301b-3p (MIRT553711)
- hsa-mir-301a-3p (MIRT553712)
- hsa-mir-3666 (MIRT553713)
- hsa-mir-454-3p (MIRT553714)
- hsa-mir-4295 (MIRT553715)
- hsa-mir-130b-3p (MIRT553716)
- hsa-mir-130a-3p (MIRT553717)
- hsa-mir-384 (MIRT612388)
- hsa-mir-3685 (MIRT612389)
- hsa-mir-155-3p (MIRT612390)
- hsa-mir-32-3p (MIRT612391)
- hsa-mir-1305 (MIRT621858)
- hsa-mir-421 (MIRT621859)
- hsa-mir-7159-5p (MIRT621860)
- hsa-mir-8485 (MIRT621861)
- hsa-mir-505-3p (MIRT621862)
- hsa-mir-5006-3p (MIRT641834)
- hsa-mir-4755-5p (MIRT641835)
- hsa-mir-623 (MIRT641836)
- hsa-mir-6832-3p (MIRT641837)
- hsa-mir-3938 (MIRT641838)
- hsa-mir-4717-5p (MIRT641839)
- hsa-mir-4753-5p (MIRT641840)
- hsa-mir-6768-3p (MIRT641841)
- hsa-mir-211-5p (MIRT641842)
- hsa-mir-204-5p (MIRT641843)
Targeted motifs for TCF7L2 Gene
HOMER Transcription Factor Regulatory Elements motif TCF7L2
- Consensus sequence: ACATCAAAGGGA Submotif: canonical Cell Type: Hct116 GEO ID: SRA012054
miRNA Products
- Search ViGene Biosciences for TCF7L2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TCF7L2
- Browse OriGene Inhibitory RNA Products For TCF7L2
Clone Products
-
OriGene ORF clones in human for TCF7L2
- RG216058
- RC216058L2
- RC216058L1
- RC216058
- RG231252
- RC231252L2
- RC231252L1
- RC231252
- RG231215
- RC231215L2
- RC231215L1
- RC231215
- RG234158
- RC234158
- RG231248
- RC231248L2
- RC231248L1
- RC231248
- RG234152
- RC234152
- RG234477
- RC234477
- RG231262
- RC231262L2
- RC231262L1
- RC231262
- RG228355
- RC228355L2
- RC228355L1
- RC228355
- RG228470
- RC228470L2
- RC228470L1
- RC228470
- RG228906
- RC228906L2
- RC228906L1
- RC228906
- RG228404
- RC228404L2
- RC228404L1
- RC228404
- RG228489
- RC228489L2
- RC228489L1
- RC228489
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for TCF7L2 in any vector
- XM_005270071
- XM_011540109
- XM_005270073
- XM_005270074
- XM_005270075
- XM_005270078
- XM_005270077
- XM_005270079
- XM_005270080
- XM_011540110
- XM_005270082
- XM_005270083
- XM_005270084
- XM_005270085
- XM_005270086
- XM_011540111
- XM_005270088
- XM_005270089
- XM_011540112
- XM_005270091
- XM_011540113
- XM_005270092
- XM_011540114
- XM_011540115
- XM_005270093
- XM_005270094
- XM_011540116
- XM_011540117
- XM_006717956
- XM_005270095
- XM_011540118
- XM_011540119
- XM_005270096
- XM_005270100
- XM_005270101
- XM_005270102
- XM_005270103
- XM_005270104
- NM_001198529
- NM_001198530
- NM_001198531
- NM_001146283
- NM_001146284
- NM_001146285
- NM_001146286
- NM_030756
- NM_001146274
- NM_001198525
- NM_001198526
- NM_001198527
- NM_001198528
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for TCF7L2
- VectorBuilder custom plasmid, inducible vectors for TCF7L2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TCF7L2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TCF7L2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TCF7L2 Gene
Localization for TCF7L2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TCF7L2 Gene
- Nucleus, PML body. Note=Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| extracellular | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | IDA | 19443654 |
| GO:0005634 | nucleus | IDA,IEA | 9065401 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0016605 | PML body | IEA | -- |
| GO:0032993 | protein-DNA complex | IDA | 14661054 |
Pathways & Interactions for TCF7L2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Endometrial cancer | ||
| 2 | CDK-mediated phosphorylation and removal of Cdc6 |
.41
|
|
| 3 | Wnt Signaling Pathways: beta-Catenin-independent Wnt/Ca2+ Signaling and Other Non-canonical Wnt Signaling Pathways |
.39
|
|
| 4 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ||
| 5 | Glioma |
.37
|
.36
|
Pathways by source for TCF7L2 Gene
1 Cell Signaling Technology pathway for TCF7L2 Gene
6 BioSystems pathways for TCF7L2 Gene
18 Reactome pathways for TCF7L2 Gene
13 KEGG pathways for TCF7L2 Gene
8 GeneGo (Thomson Reuters) pathways for TCF7L2 Gene
2 R&D Systems pathways for TCF7L2 Gene
7 Qiagen pathways for TCF7L2 Gene
Interacting Proteins for TCF7L2 Gene
Selected Interacting proteins:
ENSP00000444972
Q9NQB0-TF7L2_HUMAN
for TCF7L2 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IDA | 12799378 |
| GO:0001568 | blood vessel development | IMP | 15578569 |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IDA,IEA | 9727977 |
Drugs & Compounds for TCF7L2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cyclosporine | Approved, Investigational, Vet_approved | Pharma | Antagonist | Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor | 922 | |
| Hydrochlorothiazide | Approved, Vet_approved | Pharma | Inhibition, Inhibitor | 413 | ||
| Repaglinide | Approved, Investigational | Pharma | Kir6 (KATP) channel blocker | 51 | ||
| Sirolimus | Approved, Investigational | Pharma | Kinase Inhibitors, Mammalian target of rapamycin (mTOR) inhibitors | 1940 | ||
| Tacrolimus | Approved, Investigational | Pharma | 1102 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for TCF7L2 Gene
mRNA/cDNA for TCF7L2 Gene
- (55) REFSEQ mRNAs :
- (41) Additional mRNA sequences :
- (176) Selected AceView cDNA sequences:
- (30) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TCF7L2 Gene
- Transcription factor 7-like 2 (T-cell specific, HMG-box):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for TCF7L2
-
Applied Biological Materials CRISPR for TCF7L2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCF7L2
- GenScript: Design CRISPR guide RNA sequences for TCF7L2
miRNA Products
- Search ViGene Biosciences for TCF7L2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TCF7L2
- Browse OriGene Inhibitory RNA Products For TCF7L2
Clone Products
-
OriGene ORF clones in human for TCF7L2
- RG216058
- RC216058L2
- RC216058L1
- RC216058
- RG231252
- RC231252L2
- RC231252L1
- RC231252
- RG231215
- RC231215L2
- RC231215L1
- RC231215
- RG234158
- RC234158
- RG231248
- RC231248L2
- RC231248L1
- RC231248
- RG234152
- RC234152
- RG234477
- RC234477
- RG231262
- RC231262L2
- RC231262L1
- RC231262
- RG228355
- RC228355L2
- RC228355L1
- RC228355
- RG228470
- RC228470L2
- RC228470L1
- RC228470
- RG228906
- RC228906L2
- RC228906L1
- RC228906
- RG228404
- RC228404L2
- RC228404L1
- RC228404
- RG228489
- RC228489L2
- RC228489L1
- RC228489
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
-
GenScript: Next-day shipping of latest version cDNA ORF clones for TCF7L2 in any vector
- XM_005270071
- XM_011540109
- XM_005270073
- XM_005270074
- XM_005270075
- XM_005270078
- XM_005270077
- XM_005270079
- XM_005270080
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for TCF7L2
- VectorBuilder custom plasmid, inducible vectors for TCF7L2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TCF7L2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | · | 13c | · | 13d | ^ | 14 | ^ | 15 | ^ | 16a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - |
| ExUns: | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | · | 20c | · | 20d | · | 20e |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||
| SP2: | - | - | |||||||||||||||
| SP3: | - | - | |||||||||||||||
| SP4: | |||||||||||||||||
| SP5: | |||||||||||||||||
| SP6: | - | - | - | ||||||||||||||
| SP7: | |||||||||||||||||
| SP8: | |||||||||||||||||
| SP9: | |||||||||||||||||
| SP10: |
Expression for TCF7L2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Pre-myelinating Oligodendrocyte Cells Forebrain White Matter
-
Spinal Cord (Nervous System)
- Pre-myelinating Oligodendrocyte Cells Spinal Cord White Matter
This gene is overexpressed in Liver (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCF7L2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TCF7L2 Gene:
TCF7L2SOURCE GeneReport for Unigene cluster for TCF7L2 Gene:
Hs.593995mRNA Expression by UniProt/SwissProt for TCF7L2 Gene:
Q9NQB0-TF7L2_HUMAN
Tissue specificity:
Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom.
Evidence on tissue expression from TISSUES for TCF7L2 Gene
- Nervous system(4.8)
- Intestine(4.5)
- Liver(4.4)
- Pancreas(3.1)
- Blood(2.1)
Primer Products
-
OriGene qPCR primer pairs for TCF7L2
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF7L2 Gene
Orthologs for TCF7L2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TCF7L2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TCF7L2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Tcf7l2 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TCF7L2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TCF7L2 35 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Tcf7l2 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TCFL2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TCF7L2 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tcf7l2 34 |
|
||
| Str.5723 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.11987 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tcf7l2 34 35 |
|
||
| tcf4 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | pan 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | pop-1 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11069 35 |
|
OneToMany |
- Species where no ortholog for TCF7L2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TCF7L2 Gene
(7) SIMAP similar genes for TCF7L2 Gene using alignment to 17 proteins:
Variants for TCF7L2 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_035939 | A colorectal cancer sample | ||||
| rs7903146 | drug-response | 112,998,590(+) | AGATA(C/T)TATAT | intron-variant | |
| rs11196205 | other | 113,047,288(+) | ACTAC(C/G/T)AGCAG | intron-variant | |
| rs12255372 | other | 113,049,143(+) | AGAAT(A/G/T)ACCAT | intron-variant | |
| rs1000006717 | -- | 113,045,628(+) | CTGCA(A/G)AGGGC | intron-variant, downstream-variant-500B |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv286e212 | CNV | loss | 25503493 |
| dgv41e215 | CNV | deletion | 23714750 |
| dgv518n106 | CNV | deletion | 24896259 |
| esv2074123 | CNV | deletion | 18987734 |
| esv2762881 | CNV | loss | 21179565 |
| esv3546869 | CNV | deletion | 23714750 |
| esv3579130 | CNV | loss | 25503493 |
| esv3624589 | CNV | loss | 21293372 |
| nsv1070891 | CNV | deletion | 25765185 |
| nsv1134056 | CNV | deletion | 24896259 |
| nsv24033 | CNV | deletion | 16902084 |
| nsv437693 | CNV | loss | 16327808 |
| nsv476274 | CNV | novel sequence insertion | 20440878 |
| nsv476737 | CNV | novel sequence insertion | 20440878 |
| nsv527837 | CNV | loss | 19592680 |
| nsv7211 | OTHER | inversion | 18451855 |
| nsv7553 | CNV | deletion | 18451855 |
| nsv982900 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.27;
76.41% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TCF7L2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF7L2 Gene
Disorders for TCF7L2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| diabetes mellitus, noninsulin-dependent |
|
|
| colorectal cancer |
|
|
| tropical calcific pancreatitis |
|
|
| acute insulin response |
|
|
| gestational diabetes |
|
Search TCF7L2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TF7L2_HUMAN- Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:16415884, ECO:0000269 PubMed:24390345}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Note=Constitutive activation and subsequent transactivation of target genes may lead to the maintenance of stem-cell characteristics (cycling and longevity) in cells that should normally undergo terminal differentiation and constitute the primary transforming event in colorectal cancer (CRC).
Relevant External Links for TCF7L2
No data available for Genatlas for TCF7L2 Gene
Publications for TCF7L2 Gene
- Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. (PMID: 16415884) Grant S.F.A. … Stefansson K. (Nat. Genet. 2006) 3 4 22 46 64
- Transcription factor 7-like 2-gene polymorphism is related to fasting C peptide in latent autoimmune diabetes in adults (LADA). (PMID: 19533015) Szepietowska B. … Szelachowska M. (Acta Diabetol 2010) 3 22 46 64
- Transcription factor 7-like 2 polymorphism modulates glucose and lipid homeostasis, adipokine profile, and hepatocyte apoptosis in NASH. (PMID: 19105201) Musso G. … Cassader M. (Hepatology 2009) 3 22 46 64
- No effect of cancer-associated SNP rs6983267 in the 8q24 region on co-expression of MYC and TCF7L2 in normal colon tissue. (PMID: 19895682) Prokunina-Olsson L. … Hall J.L. (Mol. Cancer 2009) 3 22 46 64
- Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease. (PMID: 19221600) Koslowski M.J. … Wehkamp J. (PLoS ONE 2009) 3 22 46 64
Products for TCF7L2 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TCF7L2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
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- (5) Ensembl
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- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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