TCF7 Gene (Protein Coding)

Transcription Factor 7

GC05P134114
GIFtS:
45
This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/... See more...

Aliases for TCF7 Gene

Aliases for TCF7 Gene

  • Transcription Factor 7 2 3 4 5
  • TCF-1 2 3 4
  • Transcription Factor 7 (T-Cell Specific, HMG-Box) 2 3
  • T-Cell-Specific Transcription Factor 1 3 4
  • T-Cell-Factor-7 2 3
  • T-Cell Factor 1 4
  • TCF-7 4
  • TCF7 5
  • TCF1 4

External Ids for TCF7 Gene

Previous GeneCards Identifiers for TCF7 Gene

  • GC05P133100
  • GC05P133965
  • GC05P133481
  • GC05P133526
  • GC05P133478
  • GC05P128635

Summaries for TCF7 Gene

Entrez Gene Summary for TCF7 Gene

  • This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]

GeneCards Summary for TCF7 Gene

TCF7 (Transcription Factor 7) is a Protein Coding gene. Diseases associated with TCF7 include Gastric Cardia Adenocarcinoma and Hepatocellular Carcinoma. Among its related pathways are Adherens junction and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is TCF7L2.

UniProtKB/Swiss-Prot Summary for TCF7 Gene

  • Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.

Gene Wiki entry for TCF7 Gene

Additional gene information for TCF7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCF7 Gene

Genomics for TCF7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TCF7 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH05J134111 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 277.7 +14.8 14791 36.3 BCLAF1 SP1 ZNF654 ZNF207 NCOR1 ZNF600 IKZF1 MYC POLR2A ZIC2 TCF7 VDAC1 SKP1 CDKL3 MTND4LP30 JADE2 CDKN2AIPNL SAR1B UBE2B PPP2CA
GH05J134098 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -14.4 -14402 4 BCLAF1 SP1 ZMYM3 POLR2A CEBPA ATF3 ZIC2 YY1 BCL11A CTCF JADE2 TCF7 CAMLG CDKL3 PPP2CA RF00017-4421 LOC105379185 RF00017-4420 VDAC1
GH05J134149 Enhancer 1.1 Ensembl ENCODE dbSUPER 12.7 +36.8 36764 5.1 ZNF600 ATF2 POLR2A CEBPA FOXA2 SAP130 RARA TEAD3 JUND BCL6 HSALNG0044948 TCF7 SKP1 piR-35560
GH05J134062 Enhancer 0.6 Ensembl dbSUPER 20.5 -51.2 -51180 0.2 FOXA2 RFX5 USF2 PRDM10 WT1 TCF7 HSALNG0044941 RF00017-4416 VDAC1 C5orf15
GH05J134048 Enhancer 1 ENCODE dbSUPER 11.4 -67.5 -67466 0.2 SSRP1 ZIC2 CHD4 KDM6A SMAD4 SAP130 ETV4 RARA TEAD3 THRB VDAC1 TCF7 HSALNG0044940 RF00017-4416 RF00017-4419 C5orf15
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCF7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCF7

Top Transcription factor binding sites by QIAGEN in the TCF7 gene promoter:
  • HNF-4alpha1

Genomic Locations for TCF7 Gene

Latest Assembly
chr5:134,114,681-134,151,865
(GRCh38/hg38)
Size:
37,185 bases
Orientation:
Plus strand

Previous Assembly
chr5:133,450,372-133,483,901
(GRCh37/hg19 by Entrez Gene)
Size:
33,530 bases
Orientation:
Plus strand

chr5:133,450,402-133,487,556
(GRCh37/hg19 by Ensembl)
Size:
37,155 bases
Orientation:
Plus strand

Genomic View for TCF7 Gene

Genes around TCF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF7 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TCF7 Gene

Proteins for TCF7 Gene

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  • Protein details for TCF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36402-TCF7_HUMAN
    Recommended name:
    Transcription factor 7
    Protein Accession:
    P36402
    Secondary Accessions:
    • B3KSH3
    • Q86WR9
    • Q9UKI4

    Protein attributes for TCF7 Gene

    Size:
    384 amino acids
    Molecular mass:
    41642 Da
    Quaternary structure:
    • Binds the armadillo repeat of CTNNB1 and forms a stable complex (PubMed:9488439 PubMed:9783587). Interacts with TLE5, TLE1, TLE2, TLE3 and TLE4 (PubMed:9783587, PubMed:11266540). Interacts with MLLT11 (PubMed:26079538). Long isoform interacts (via N-terminus) with SOX13; inhibits WNT-mediated transcriptional activity (PubMed:17218525, PubMed:20028982).
    SequenceCaution:
    • Sequence=CAA87441.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 1L]: Produced by alternative splicing of isoform 4L.
    • [Isoform 1S]: Produced by alternative splicing of isoform 4S.
    • [Isoform 5L]: Produced by alternative splicing of isoform 4L.
    • [Isoform 5S]: Produced by alternative splicing of isoform 4S.
    • [Isoform 6L]: Produced by alternative splicing of isoform 4L.
    • [Isoform 6S]: Produced by alternative splicing of isoform 4S.
    • [Isoform 7L]: Produced by alternative splicing of isoform 4L.
    • [Isoform 7S]: Produced by alternative splicing of isoform 4S.
    • [Isoform 8L]: Produced by alternative splicing of isoform 4L.
    • [Isoform 8S]: Produced by alternative splicing of isoform 4S.
    • [Isoform 2L]: Produced by alternative splicing of isoform 4L.
    • [Isoform 2S]: Produced by alternative splicing of isoform 4S.
    • [Isoform 3L]: Produced by alternative splicing of isoform 4L.
    • [Isoform 3S]: Produced by alternative splicing of isoform 4S.

    Alternative splice isoforms for TCF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCF7 Gene

Protein Expression for TCF7 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TCF7 Gene

  • Ubiquitination at Lys52, Lys253, and Lys294
  • Modification sites at PhosphoSitePlus

Other Protein References for TCF7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for TCF7

No data available for DME Specific Peptides for TCF7 Gene

Domains & Families for TCF7 Gene

Gene Families for TCF7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TCF7 Gene

InterPro:
Blocks:
  • CTNNB1 binding, N-teminal

Suggested Antigen Peptide Sequences for TCF7 Gene

GenScript: Design optimal peptide antigens:
  • T-cell-specific transcription factor 1 (TCF7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P36402

UniProtKB/Swiss-Prot:

TCF7_HUMAN :
  • Belongs to the TCF/LEF family.
Family:
  • Belongs to the TCF/LEF family.
genes like me logo Genes that share domains with TCF7: view

Function for TCF7 Gene

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  6. Cell Lines for research

Molecular function for TCF7 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.
UniProtKB/Swiss-Prot Induction:
By TCF7L2 and CTNNB1.
GENATLAS Biochemistry:
transcription factor 7,T cell specific

Phenotypes From GWAS Catalog for TCF7 Gene

Gene Ontology (GO) - Molecular Function for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 18579517
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0001217 bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding ISS --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TCF7: view
genes like me logo Genes that share phenotypes with TCF7: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCF7

Clone products for research

  • Addgene plasmids for TCF7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCF7 Gene

Localization for TCF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF7 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCF7 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005634 nucleus IEA,IDA 18579517
GO:0005654 nucleoplasm IDA,TAS --
GO:0016604 nuclear body IDA --
GO:1990907 beta-catenin-TCF complex IBA 21873635
genes like me logo Genes that share ontologies with TCF7: view

Pathways & Interactions for TCF7 Gene

genes like me logo Genes that share pathways with TCF7: view

Pathways by source for TCF7 Gene

3 GeneGo (Thomson Reuters) pathways for TCF7 Gene
  • Cell adhesion Tight junctions
  • Cytoskeleton remodeling Integrin outside-in signaling
  • Signal transduction PTEN pathway
9 Qiagen pathways for TCF7 Gene
  • Epithelial Adherens Junctions
  • Factors Promoting Cardiogenesis in Vertebrates
  • GSK3 Signaling
  • Human Embryonic Stem Cell Pluripotency
  • ILK Signaling
1 Cell Signaling Technology pathway for TCF7 Gene

SIGNOR curated interactions for TCF7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA 21873635
GO:0006955 immune response TAS 1569101
GO:0016055 Wnt signaling pathway IEA --
GO:0033153 T cell receptor V(D)J recombination IEA --
genes like me logo Genes that share ontologies with TCF7: view

Drugs & Compounds for TCF7 Gene

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No Compound Related Data Available

Transcripts for TCF7 Gene

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mRNA/cDNA for TCF7 Gene

9 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCF7

Clone products for research

  • Addgene plasmids for TCF7

Alternative Splicing Database (ASD) splice patterns (SP) for TCF7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - -
SP13: - - - -
SP14: - - - - - - -
SP15: -
SP16: -
SP17: - - -
SP18:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7:
SP8:
SP9: -
SP10: - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for TCF7 Gene

GeneLoc Exon Structure for
TCF7

Expression for TCF7 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCF7 Gene

mRNA expression in normal human tissues for TCF7 Gene
mRNA expression by GTEx for TCF7 GenemRNA expression by BioGPS for TCF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF7 Gene

This gene is overexpressed in Whole Blood (x13.3).

Protein differential expression in normal tissues from HIPED for TCF7 Gene

This gene is overexpressed in Serum (32.7), CD8 Tcells (14.2), CD4 Tcells (9.8), and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TCF7 Gene



Protein tissue co-expression partners for TCF7 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCF7

SOURCE GeneReport for Unigene cluster for TCF7 Gene:

Hs.573153

mRNA Expression by UniProt/SwissProt for TCF7 Gene:

P36402-TCF7_HUMAN
Tissue specificity: Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.

Evidence on tissue expression from TISSUES for TCF7 Gene

  • Blood(4.5)
  • Liver(4.4)
  • Skin(4.4)
  • Lymph node(2.9)
  • Intestine(2.9)
  • Spleen(2.7)
  • Bone marrow(2.4)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with TCF7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF7 Gene

Orthologs for TCF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TCF7 29 30
  • 99.73 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TCF7 29 30
  • 91.78 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TCF7 29 30
  • 91.41 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Tcf7 30
  • 85 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia TCF7 30
  • 76 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia TCF7 30
  • 65 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves TCF1 30
  • 58 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia TCF7 30
  • 64 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii tcf7 30
  • 59 (a)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta pan 30 31
  • 10 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea pop-1 30
  • 19 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.11069 30
  • 25 (a)
 OneToMany
Species where no ortholog for TCF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TCF7 Gene

ENSEMBL:
Gene Tree for TCF7 (if available)
TreeFam:
Gene Tree for TCF7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCF7: view image
Alliance of Genome Resources:
Additional Orthologs for TCF7

Paralogs for TCF7 Gene

Paralogs for TCF7 Gene

(6) SIMAP similar genes for TCF7 Gene using alignment to 13 proteins:

  • TCF7_HUMAN
  • B7WNT5_HUMAN
  • D4PHA3_HUMAN
  • E5RG34_HUMAN
  • E5RG75_HUMAN
  • E5RGJ5_HUMAN
  • E5RGQ1_HUMAN
  • E5RHL1_HUMAN
  • E5RJ51_HUMAN
  • H0YAR8_HUMAN
  • H0YBC8_HUMAN
  • H0YBM1_HUMAN
  • H0YBP2_HUMAN
genes like me logo Genes that share paralogs with TCF7: view

Variants for TCF7 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TCF7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TCF7 Gene

Variant ID Type Subtype PubMed ID
esv2678103 CNV deletion 23128226
esv3606842 CNV loss 21293372
nsv1073496 CNV deletion 25765185
nsv1112885 CNV deletion 24896259
nsv1145070 CNV deletion 24896259
nsv5011 CNV insertion 18451855
nsv599732 CNV loss 21841781

Variation tolerance for TCF7 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCF7 Gene

Human Gene Mutation Database (HGMD)
TCF7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF7
Leiden Open Variation Database (LOVD)
TCF7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCF7 Gene

Disorders for TCF7 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TCF7 Gene - From: LNC, COP, and GCD

Disorder Aliases PubMed IDs
gastric cardia adenocarcinoma
  • adenocarcinoma of cardia of stomach
hepatocellular carcinoma
  • hcc
lung cancer
  • lung cancer, susceptibility to
cleidocranial dysplasia
  • ccd
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search TCF7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TCF7

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TCF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCF7 Gene

Publications for TCF7 Gene

  1. A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. (PMID: 12765974) Noble JA … Erlich HA (Diabetes 2003) 3 22 40
  2. The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. (PMID: 1569101) van de Wetering M … Clevers H (The Journal of biological chemistry 1992) 3 4 22
  3. Long noncoding RNA TCF7 promotes invasiveness and self-renewal of human non-small cell lung cancer cells. (PMID: 27766570) Wu J … Wang D (Human cell 2017) 3 72
  4. AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. (PMID: 26079538) Park J … Tse W (Oncotarget 2015) 3 4
  5. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. (PMID: 25842979) Wang Y … Fan Z (Cell stem cell 2015) 3 72

ExternalLinks

View latest publications for TCF7 gene in Mastermind

Products for TCF7 Gene

  • Addgene plasmids for TCF7

Sources for TCF7 Gene