This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/... See more...

Aliases for TCF7 Gene

Aliases for TCF7 Gene

  • Transcription Factor 7 2 3 4 5
  • Transcription Factor 7 (T-Cell Specific, HMG-Box) 2 3
  • T-Cell-Specific Transcription Factor 1 3 4
  • T-Cell-Factor-7 2 3
  • TCF-1 3 4
  • T-Cell Factor 1 4
  • TCF-7 4
  • TCF1 4

External Ids for TCF7 Gene

Previous GeneCards Identifiers for TCF7 Gene

  • GC05P133100
  • GC05P133965
  • GC05P133481
  • GC05P133526
  • GC05P133478
  • GC05P128635

Summaries for TCF7 Gene

Entrez Gene Summary for TCF7 Gene

  • This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]

GeneCards Summary for TCF7 Gene

TCF7 (Transcription Factor 7) is a Protein Coding gene. Diseases associated with TCF7 include Gastric Cardia Adenocarcinoma and Hepatocellular Carcinoma. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Endometrial cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is TCF7L2.

UniProtKB/Swiss-Prot Summary for TCF7 Gene

  • Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.

Gene Wiki entry for TCF7 Gene

Additional gene information for TCF7 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCF7 Gene

Genomics for TCF7 Gene

GeneHancer (GH) Regulatory Elements for TCF7 Gene

Promoters and enhancers for TCF7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J134111 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 777.7 +14.8 14786 36.2 SP1 CTCF RBPJ TCF7L2 NR2F6 JUND CC2D1A ETV6 RELA HLF TCF7 DDX46 SEC24A VDAC1 C5orf15 SKP1 CDKL3 MTND4LP30 JADE2 CDKN2AIPNL
GH05J134098 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -14.4 -14402 4 SP1 CTCF FOXA1 MLX RBPJ NR2F1 NR2F6 CREB1 MIXL1 ETV6 TCF7 JADE2 CDKL3 PPP2CA RF00017-4890 LOC105379185 RF00017-4889
GH05J134148 Enhancer 1.1 Ensembl ENCODE dbSUPER 13 +36.3 36319 6 LCORL CREB1 ZNF362 HLF BCL6B SP1 CEBPG ZNF384 ZBED1 CEBPA TCF7 SKP1 piR-35560 piR-38075
GH05J134062 Enhancer 0.7 Ensembl dbSUPER 20.4 -51.1 -51080 0.4 USF2 PRDM10 FOXA2 POLR2A WT1 RFX5 TCF7 VDAC1 RF00017-4885 ENSG00000271128
GH05J134048 Enhancer 1 ENCODE dbSUPER 11.4 -67.5 -67466 0.2 RBPJ NR2F1 NR2F6 CREB1 POU5F1 SP1 RERE ELF3 CEBPG PPARG TCF7 VDAC1 RF00017-4885 RF00017-4888 RF00017-4887
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCF7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCF7 gene promoter:
  • HNF-4alpha1

Genomic Locations for TCF7 Gene

Genomic Locations for TCF7 Gene
chr5:134,114,681-134,151,865
(GRCh38/hg38)
Size:
37,185 bases
Orientation:
Plus strand
chr5:133,450,402-133,487,556
(GRCh37/hg19)
Size:
37,155 bases
Orientation:
Plus strand

Genomic View for TCF7 Gene

Genes around TCF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF7 Gene

Proteins for TCF7 Gene

  • Protein details for TCF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36402-TCF7_HUMAN
    Recommended name:
    Transcription factor 7
    Protein Accession:
    P36402
    Secondary Accessions:
    • B3KSH3
    • Q86WR9
    • Q9UKI4

    Protein attributes for TCF7 Gene

    Size:
    384 amino acids
    Molecular mass:
    41642 Da
    Quaternary structure:
    • Binds the armadillo repeat of CTNNB1 and forms a stable complex (PubMed:9488439 PubMed:9783587). Interacts with TLE5, TLE1, TLE2, TLE3 and TLE4 (PubMed:9783587, PubMed:11266540). Interacts with MLLT11 (PubMed:26079538).
    SequenceCaution:
    • Sequence=CAA87441.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for TCF7 Gene

Post-translational modifications for TCF7 Gene

  • Ubiquitination at Lys52, Lys253, and Lys294
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for TCF7
  • Boster Bio Antibodies for TCF7

No data available for DME Specific Peptides for TCF7 Gene

Domains & Families for TCF7 Gene

Gene Families for TCF7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TCF7 Gene

Suggested Antigen Peptide Sequences for TCF7 Gene

GenScript: Design optimal peptide antigens:
  • T-cell-specific transcription factor 1 (TCF7_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P36402

UniProtKB/Swiss-Prot:

TCF7_HUMAN :
  • Belongs to the TCF/LEF family.
Family:
  • Belongs to the TCF/LEF family.
genes like me logo Genes that share domains with TCF7: view

Function for TCF7 Gene

Molecular function for TCF7 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
UniProtKB/Swiss-Prot Induction:
By TCF7L2 and CTNNB1.
GENATLAS Biochemistry:
transcription factor 7,T cell specific

Phenotypes From GWAS Catalog for TCF7 Gene

Gene Ontology (GO) - Molecular Function for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
genes like me logo Genes that share ontologies with TCF7: view
genes like me logo Genes that share phenotypes with TCF7: view

Animal Model Products

CRISPR Products

miRNA for TCF7 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCF7

Clone Products

  • Addgene plasmids for TCF7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCF7 Gene

Localization for TCF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCF7 gene
Compartment Confidence
nucleus 5
extracellular 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 18579517
GO:0005654 nucleoplasm IDA,TAS --
GO:0005667 transcription factor complex IBA 21873635
GO:0005719 nuclear euchromatin IEA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with TCF7: view

Pathways & Interactions for TCF7 Gene

genes like me logo Genes that share pathways with TCF7: view

SIGNOR curated interactions for TCF7 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TCF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II IEA,IBA 21873635
GO:0006955 immune response TAS 1569101
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with TCF7: view

Drugs & Compounds for TCF7 Gene

No Compound Related Data Available

Transcripts for TCF7 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCF7

Clone Products

  • Addgene plasmids for TCF7

Alternative Splicing Database (ASD) splice patterns (SP) for TCF7 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - -
SP9: - -
SP10:
SP11: - - - -
SP12: - -
SP13: - - - -
SP14: - - - - - - -
SP15: -
SP16: -
SP17: - - -
SP18:

ExUns: 13a · 13b ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7:
SP8:
SP9: -
SP10: - - - - -
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for TCF7 Gene

GeneLoc Exon Structure for
TCF7
ECgene alternative splicing isoforms for
TCF7

Expression for TCF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF7 Gene

This gene is overexpressed in Whole Blood (x13.3).

Protein differential expression in normal tissues from HIPED for TCF7 Gene

This gene is overexpressed in Serum (32.7), CD8 Tcells (14.2), CD4 Tcells (9.8), and Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TCF7 Gene



Protein tissue co-expression partners for TCF7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCF7 Gene:

TCF7

SOURCE GeneReport for Unigene cluster for TCF7 Gene:

Hs.573153

mRNA Expression by UniProt/SwissProt for TCF7 Gene:

P36402-TCF7_HUMAN
Tissue specificity: Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.

Evidence on tissue expression from TISSUES for TCF7 Gene

  • Blood(4.4)
  • Liver(4.1)
  • Skin(4.1)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with TCF7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF7 Gene

Orthologs for TCF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCF7 33 32
  • 99.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TCF7 33 32
  • 91.78 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TCF7 33 32
  • 91.41 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tcf7 33
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TCF7 33
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCF7 33
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCF1 33
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCF7 33
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tcf7 33
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pan 33 34
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pop-1 33
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11069 33
  • 25 (a)
OneToMany
Species where no ortholog for TCF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TCF7 Gene

ENSEMBL:
Gene Tree for TCF7 (if available)
TreeFam:
Gene Tree for TCF7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCF7: view image

Paralogs for TCF7 Gene

Paralogs for TCF7 Gene

(6) SIMAP similar genes for TCF7 Gene using alignment to 13 proteins:

  • TCF7_HUMAN
  • B7WNT5_HUMAN
  • D4PHA3_HUMAN
  • E5RG34_HUMAN
  • E5RG75_HUMAN
  • E5RGJ5_HUMAN
  • E5RGQ1_HUMAN
  • E5RHL1_HUMAN
  • E5RJ51_HUMAN
  • H0YAR8_HUMAN
  • H0YBC8_HUMAN
  • H0YBM1_HUMAN
  • H0YBP2_HUMAN
genes like me logo Genes that share paralogs with TCF7: view

Variants for TCF7 Gene

Sequence variations from dbSNP and Humsavar for TCF7 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000002889 -- 134,132,755(+) G/A/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000005993 -- 134,128,273(+) T/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000100201 -- 134,128,496(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000100827 -- 134,142,445(+) G/C/T intron_variant
rs1000188656 -- 134,115,247(+) GCG/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TCF7 Gene

Variant ID Type Subtype PubMed ID
esv2678103 CNV deletion 23128226
esv3606842 CNV loss 21293372
nsv1073496 CNV deletion 25765185
nsv1112885 CNV deletion 24896259
nsv1145070 CNV deletion 24896259
nsv5011 CNV insertion 18451855
nsv599732 CNV loss 21841781

Variation tolerance for TCF7 Gene

Residual Variation Intolerance Score: 38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCF7 Gene

Human Gene Mutation Database (HGMD)
TCF7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF7

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF7 Gene

Disorders for TCF7 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TCF7 Gene - From: LncRNADisease, HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastric cardia adenocarcinoma
  • adenocarcinoma of cardia of stomach
hepatocellular carcinoma
  • hcc
lung cancer
  • adenocarcinoma of lung
cleidocranial dysplasia
  • ccd
colorectal cancer
  • crc
- elite association - COSMIC cancer census association via MalaCards
Search TCF7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TCF7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TCF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCF7 Gene

Publications for TCF7 Gene

  1. A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. (PMID: 12765974) Noble JA … Erlich HA (Diabetes 2003) 3 23 43 56
  2. The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. (PMID: 1569101) van de Wetering M … Clevers H (The Journal of biological chemistry 1992) 3 4 23 56
  3. AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. (PMID: 26079538) Park J … Tse W (Oncotarget 2015) 3 4 56
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 43 56
  5. Identification of type 2 diabetes-associated combination of SNPs using support vector machine. (PMID: 20416077) Ban HJ … Park KJ (BMC genetics 2010) 3 43 56

Products for TCF7 Gene

Sources for TCF7 Gene