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This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/... See more...
Aliases for TCF7 Gene
Aliases for TCF7 Gene
External Ids for TCF7 Gene
- HGNC: 11639
- Entrez Gene: 6932
- Ensembl: ENSG00000081059
- OMIM: 189908
- UniProtKB: P36402
Previous GeneCards Identifiers for TCF7 Gene
- GC05P133100
- GC05P133965
- GC05P133481
- GC05P133526
- GC05P133478
- GC05P128635
Summaries for TCF7 Gene
-
This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]
GeneCards Summary for TCF7 Gene
TCF7 (Transcription Factor 7) is a Protein Coding gene. Diseases associated with TCF7 include Gastric Cardia Adenocarcinoma and Astrocytoma. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Endometrial cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is TCF7L2.
UniProtKB/Swiss-Prot Summary for TCF7 Gene
-
Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.
Additional gene information for TCF7 Gene
- HGNC(11639)
- Entrez Gene(6932)
- Ensembl(ENSG00000081059)
- OMIM(189908)
- UniProtKB(P36402)
- Open Targets Platform(ENSG00000081059)
- Monarch Initiative
- Search for TCF7 at DataMed
- Search for TCF7 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCF7 Gene
Genomics for TCF7 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TCF7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TCF7 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCF7
- Top Transcription factor binding sites by QIAGEN in the TCF7 gene promoter:
-
- HNF-4alpha1
Genomic Locations for TCF7 Gene
Genomic Locations for TCF7 Gene
- chr5:134,114,681-134,151,865
- (GRCh38/hg38)
- Size:
- 37,185 bases
- Orientation:
- Plus strand
- chr5:133,450,402-133,487,556
- (GRCh37/hg19)
- Size:
- 37,155 bases
- Orientation:
- Plus strand
Genomic View for TCF7 Gene
Genes around TCF7 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.1 by HGNC
- 5q31.1 by Entrez Gene
- 5q31.1 by Ensembl
TCF7 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TCF7 Gene
Proteins for TCF7 Gene
-
Protein details for TCF7 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P36402-TCF7_HUMAN
- Recommended name:
- Transcription factor 7
- Protein Accession:
- P36402
- B3KSH3
- Q86WR9
- Q9UKI4
Protein attributes for TCF7 Gene
- Size:
- 384 amino acids
- Molecular mass:
- 41642 Da
- Quaternary structure:
-
- Binds the armadillo repeat of CTNNB1 and forms a stable complex (PubMed:9488439 PubMed:9783587). Interacts with TLE5, TLE1, TLE2, TLE3 and TLE4 (PubMed:9783587, PubMed:11266540). Interacts with MLLT11 (PubMed:26079538). Long isoform interacts (via N-terminus) with SOX13; inhibits WNT-mediated transcriptional activity (PubMed:17218525, PubMed:20028982).
- SequenceCaution:
-
- Sequence=CAA87441.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 1L]: Produced by alternative splicing of isoform 4L.
- [Isoform 1S]: Produced by alternative splicing of isoform 4S.
- [Isoform 5L]: Produced by alternative splicing of isoform 4L.
- [Isoform 5S]: Produced by alternative splicing of isoform 4S.
- [Isoform 6L]: Produced by alternative splicing of isoform 4L.
- [Isoform 6S]: Produced by alternative splicing of isoform 4S.
- [Isoform 7L]: Produced by alternative splicing of isoform 4L.
- [Isoform 7S]: Produced by alternative splicing of isoform 4S.
- [Isoform 8L]: Produced by alternative splicing of isoform 4L.
- [Isoform 8S]: Produced by alternative splicing of isoform 4S.
- [Isoform 2L]: Produced by alternative splicing of isoform 4L.
- [Isoform 2S]: Produced by alternative splicing of isoform 4S.
- [Isoform 3L]: Produced by alternative splicing of isoform 4L.
- [Isoform 3S]: Produced by alternative splicing of isoform 4S.
Protein Expression for TCF7 Gene
Post-translational modifications for TCF7 Gene
Other Protein References for TCF7 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_006714741.1
- XP_006714742.1
- XP_006714745.1
- XP_006714747.1
- XP_006714748.1
- XP_006714749.1
- XP_011541906.1
- XP_011541908.1
- XP_011541909.1
- XP_011541910.1
- XP_011541911.1
- XP_011541915.1
- XP_016865279.1
- NP_001128323.2
- NP_001333354.1
- NP_001333379.1
- NP_001353431.1
- NP_003193.2
- NP_963963.1
- NP_963965.1
- NP_998813.1
Antibody Products
- LifeSpan BioSciences TCF7 Antibody
- Creative Diagnostics Anti-TCF7 (aa 287-384) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for TCF7
- Novus Biologicals Antibodies for TCF7
-
Abcam antibodies for TCF7
- Invitrogen Antibodies for TCF7 (AFLGC-TCF7)
-
Biorbyt antibodies for TCF7
-
Santa Cruz Biotechnology (SCBT) Antibodies for TCF7
Protein Products
-
OriGene Purified Proteins for TCF7
- Search Origene for MassSpec and Protein Over-expression Lysates for TCF7
- Origene Custom Protein Services for TCF7
-
Abcam proteins for TCF7
Assay Products
- Creative Diagnostics Human TCF7 ELISA Matched Antibody Pair
- antibodies-online: Search results for available TCF7 related products ranked by validation data
No data available for DME Specific Peptides for TCF7 Gene
Domains & Families for TCF7 Gene
Gene Families for TCF7 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for TCF7 Gene
- InterPro:
- Blocks:
-
- CTNNB1 binding, N-teminal
- ProtoNet:
Suggested Antigen Peptide Sequences for TCF7 Gene
- GenScript: Design optimal peptide antigens:
-
- T-cell-specific transcription factor 1 (TCF7_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P36402- Family:
-
- Belongs to the TCF/LEF family.
Function for TCF7 Gene
Molecular function for TCF7 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.
- UniProtKB/Swiss-Prot Induction:
- By TCF7L2 and CTNNB1.
- GENATLAS Biochemistry:
- transcription factor 7,T cell specific
Phenotypes From GWAS Catalog for TCF7 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 18579517 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001217 | bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding | ISS | -- |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA | -- |
Phenotypes for TCF7 Gene
- GenomeRNAi human phenotypes for TCF7:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- no effect
- Decreased vaccinia virus (VACV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability
- Downregulation of Wnt pathway after Wnt3A stimulation
- Increased shRNA abundance (Z-score > 2)
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased shRNA abundance (Z-score < -2)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TCF7 - Select products 50% OFF >
- * TCF7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TCF7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TCF7
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCF7
miRNA for TCF7 Gene
- miRTarBase miRNAs that target TCF7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TCF7
- Browse OriGene Inhibitory RNA Products For TCF7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCF7
Clone Products
- Applied Biological Materials (abm): Clones for TCF7 - Select products 50% OFF >
- * TCF7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226713
- MR226713
- MR226713L1
- MR226713L2
- MR226713L3
- MR226713L4
- RC207918
- RC207918L3
- RC207918L4
- RC219450
- RC219450L3
- RC219450L4
- RC224290
- RC224290L1
- RC224290L2
- RC224290L3
- RC224290L4
- RC224338
- RC224338L3
- RC224338L4
- RC225556
- RC225556L3
- RC225556L4
- RG207918
- RG219450
- RG224290
- RG224338
- RG225556
- MR226713L1V
- MR226713L2V
- MR226713L3V
- MR226713L4V
- RC207918L3V
- RC207918L4V
- RC219450L3V
- RC219450L4V
- RC224290L1V
- RC224290L2V
- RC224290L3V
- RC224290L4V
- RC224338L3V
- RC224338L4V
- RC225556L3V
- RC225556L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TCF7
- Addgene plasmids for TCF7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TCF7
Cell Line Products
-
Horizon Cell Lines for TCF7
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCF7 Gene
Localization for TCF7 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TCF7 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 18579517 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005667 | transcription factor complex | IBA | 21873635 |
| GO:0005719 | nuclear euchromatin | IEA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for TCF7 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Endometrial cancer |
Signal transduction PTEN pathway
.44
.36
|
.32
|
| 2 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.41
|
|
| 3 | Gastric cancer |
.62
.62
|
|
| 4 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ||
| 5 | Aldosterone synthesis and secretion |
.41
|
.41
|
Pathways by source for TCF7 Gene
6 BioSystems pathways for TCF7 Gene
10 Reactome pathways for TCF7 Gene
19 KEGG pathways for TCF7 Gene
3 GeneGo (Thomson Reuters) pathways for TCF7 Gene
- Cell adhesion Tight junctions
- Cytoskeleton remodeling Integrin outside-in signaling
- Signal transduction PTEN pathway
1 R&D Systems pathway for TCF7 Gene
9 Qiagen pathways for TCF7 Gene
- Epithelial Adherens Junctions
- Factors Promoting Cardiogenesis in Vertebrates
- GSK3 Signaling
- Human Embryonic Stem Cell Pluripotency
- ILK Signaling
1 Cell Signaling Technology pathway for TCF7 Gene
Interacting Proteins for TCF7 Gene
Selected Interacting proteins:
P36402-TCF7_HUMAN
ENSP00000340347
for TCF7 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TCF7
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | ISS | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,TAS | 1569101 |
| GO:0006955 | immune response | TAS | 1569101 |
| GO:0016055 | Wnt signaling pathway | IEA,IBA | 21873635 |
Transcripts for TCF7 Gene
mRNA/cDNA for TCF7 Gene
- 9 REFSEQ mRNAs :
- 26 NCBI additional mRNA sequence :
- 24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000342854 3288 nts (view in UCSC)
- ENST00000378560 2929 nts (view in UCSC)
- ENST00000395023 2815 nts (view in UCSC)
- ENST00000395029 3330 nts (view in UCSC)
- ENST00000517478 572 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TCF7 - Select products 50% OFF >
- * TCF7 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TCF7
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TCF7
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCF7
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TCF7
- Browse OriGene Inhibitory RNA Products For TCF7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCF7
Clone Products
- Applied Biological Materials (abm): Clones for TCF7 - Select products 50% OFF >
- * TCF7 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226713
- MR226713
- MR226713L1
- MR226713L2
- MR226713L3
- MR226713L4
- RC207918
- RC207918L3
- RC207918L4
- RC219450
- RC219450L3
- RC219450L4
- RC224290
- RC224290L1
- RC224290L2
- RC224290L3
- RC224290L4
- RC224338
- RC224338L3
- RC224338L4
- RC225556
- RC225556L3
- RC225556L4
- RG207918
- RG219450
- RG224290
- RG224338
- RG225556
- MR226713L1V
- MR226713L2V
- MR226713L3V
- MR226713L4V
- RC207918L3V
- RC207918L4V
- RC219450L3V
- RC219450L4V
- RC224290L1V
- RC224290L2V
- RC224290L3V
- RC224290L4V
- RC224338L3V
- RC224338L4V
- RC225556L3V
- RC225556L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TCF7
- Addgene plasmids for TCF7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TCF7
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: |
| ExUns: | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||
| SP5: | - | - | - | - | |||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||
| SP10: | - | - | - | - | - | ||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: | |||||||||||||||||||||
| SP13: | |||||||||||||||||||||
| SP14: | |||||||||||||||||||||
| SP15: | |||||||||||||||||||||
| SP16: | |||||||||||||||||||||
| SP17: | |||||||||||||||||||||
| SP18: |
Relevant External Links for TCF7 Gene
- GeneLoc Exon Structure for
- TCF7
Expression for TCF7 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- T Helper Cells Peripheral Blood
- Double Negative 2 Thymocytes Thymus
- Hematopoietic Bone Marrow
-
Thymus (Hematopoietic System)
- Double Negative 2 Thymocytes Thymus
- Ovary (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for TCF7 Gene
This gene is overexpressed in Whole Blood (x13.3).
This gene is overexpressed in Serum (32.7), CD8 Tcells (14.2), CD4 Tcells (9.8), and Peripheral blood mononuclear cells (7.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TCF7 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCF7
SOURCE GeneReport for Unigene cluster for TCF7 Gene:
Hs.573153mRNA Expression by UniProt/SwissProt for TCF7 Gene:
P36402-TCF7_HUMAN
Tissue specificity:
Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.
Evidence on tissue expression from TISSUES for TCF7 Gene
- Blood(4.6)
- Liver(4.5)
- Skin(4.4)
- Lymph node(3.1)
- Intestine(3)
- Spleen(2.9)
- Bone marrow(2.5)
- Heart(2.3)
- Nervous system(2.1)
Primer Products
-
OriGene qPCR primer pairs for TCF7
-
OriGene qPCR primer pairs and template standards for TCF7
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF7 Gene
Orthologs for TCF7 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TCF7 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TCF7 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TCF7 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Tcf7 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TCF7 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TCF7 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TCF1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TCF7 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | tcf7 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | pan 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | pop-1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11069 31 |
|
OneToMany |
- Species where no ortholog for TCF7 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for TCF7 Gene
- ENSEMBL:
- Gene Tree for TCF7 (if available)
- TreeFam:
- Gene Tree for TCF7 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TCF7: view image
Paralogs for TCF7 Gene
(6) SIMAP similar genes for TCF7 Gene using alignment to 13 proteins:
- TCF7_HUMAN
- B7WNT5_HUMAN
- D4PHA3_HUMAN
- E5RG34_HUMAN
- E5RG75_HUMAN
- E5RGJ5_HUMAN
- E5RGQ1_HUMAN
- E5RHL1_HUMAN
- E5RJ51_HUMAN
- H0YAR8_HUMAN
- H0YBC8_HUMAN
- H0YBM1_HUMAN
- H0YBP2_HUMAN
Variants for TCF7 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2678103 | CNV | deletion | 23128226 |
| esv3606842 | CNV | loss | 21293372 |
| nsv1073496 | CNV | deletion | 25765185 |
| nsv1112885 | CNV | deletion | 24896259 |
| nsv1145070 | CNV | deletion | 24896259 |
| nsv5011 | CNV | insertion | 18451855 |
| nsv599732 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.42;
54.50% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TCF7 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCF7 Gene
Disorders for TCF7 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| gastric cardia adenocarcinoma |
|
|
| astrocytoma |
|
|
| hepatocellular carcinoma |
|
|
| lung cancer |
|
|
| cleidocranial dysplasia |
|
|
Search TCF7 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TCF7
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TCF7 Gene
Publications for TCF7 Gene
- A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. (PMID: 12765974) Noble JA … Erlich HA (Diabetes 2003) 3 23 41
- The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. (PMID: 1569101) van de Wetering M … Clevers H (The Journal of biological chemistry 1992) 3 4 23
- AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. (PMID: 26079538) Park J … Tse W (Oncotarget 2015) 3 4
- SLUG: a new target of lymphoid enhancer factor-1 in human osteoblasts. (PMID: 20128911) Lambertini E … Piva R (BMC molecular biology 2010) 3 23
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
ExternalLinks
Products for TCF7 Gene
- Custom Antibody ServicesOriGene Antibodies for TCF7
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TCF7
- Search Origene for MassSpec and Protein Over-expression Lysates for TCF7
- Origene Custom Protein Services for TCF7
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TCF7
- Browse OriGene Inhibitory RNA Products For TCF7
- OriGene qPCR primer pairs for TCF7
- OriGene qPCR primer pairs and template standards for TCF7
- OriGene CRISPR knockouts for TCF7
- MG226713
- MR226713
- MR226713L1
- MR226713L2
- MR226713L3
- MR226713L4
- RC207918
- RC207918L3
- RC207918L4
- RC219450
- RC219450L3
- RC219450L4
- RC224290
- RC224290L1
- RC224290L2
- RC224290L3
- RC224290L4
- RC224338
- RC224338L3
- RC224338L4
- RC225556
- RC225556L3
- RC225556L4
- RG207918
- RG219450
- RG224290
- RG224338
- RG225556
- MR226713L1V
- MR226713L2V
- MR226713L3V
- MR226713L4V
- RC207918L3V
- RC207918L4V
- RC219450L3V
- RC219450L4V
- RC224290L1V
- RC224290L2V
- RC224290L3V
- RC224290L4V
- RC224338L3V
- RC224338L4V
- RC225556L3V
- RC225556L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TCF7
- Sino Biological Human cDNA Clone for TCF7
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for TCF7
- Novus Biologicals proteins and lysates for TCF7
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TCF7
- Abcam proteins for TCF7
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for TCF7 (AFLGC-TCF7)
- VectorBuilder Custom and pre-made DNA vectors for TCF7 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for TCF7 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for TCF7 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for TCF7 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for TCF7
- Addgene plasmids for TCF7
- antibodies-online: Show 49 available TCF7 Antibodies ranked by validation data
- Compare Top TCF7 Antibodies
- antibodies-online: Search results for available TCF7 related products ranked by validation data
- antibodies-online: Show 4 available TCF7 Proteins ranked by validation data
- Compare Top TCF7 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TCF7
- Search Santa Cruz Biotechnology (SCBT) for TCF7 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TCF7
- Horizon Cell Lines for TCF7
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TCF7
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TCF7
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TCF7
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCF7
- Biorbyt antibodies for TCF7
Sources for TCF7 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB