Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]
TCF7 (Transcription Factor 7) is a Protein Coding gene. Diseases associated with TCF7 include Gastric Cardia Adenocarcinoma and Astrocytoma. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Endometrial cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is TCF7L2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 18579517 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001217 | bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding | ISS | -- |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA,IDA | 18579517 |
GO:0005654 | nucleoplasm | IDA,TAS | -- |
GO:0005667 | transcription factor complex | IBA | 21873635 |
GO:0005719 | nuclear euchromatin | IEA | -- |
GO:0016604 | nuclear body | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Endometrial cancer |
Signal transduction PTEN pathway
.44
.36
|
.32
|
2 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.41
|
|
3 | Gastric cancer |
.62
.62
|
|
4 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | ||
5 | Aldosterone synthesis and secretion |
.41
|
.41
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | ISS | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA,TAS | 1569101 |
GO:0006955 | immune response | TAS | 1569101 |
GO:0016055 | Wnt signaling pathway | IEA,IBA | 21873635 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP13: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP14: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP15: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP16: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP17: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP18: |
ExUns: | 13a | · | 13b | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · | 18c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||
SP5: | - | - | - | - | |||||||||||||||||
SP6: | - | - | - | - | |||||||||||||||||
SP7: | |||||||||||||||||||||
SP8: | |||||||||||||||||||||
SP9: | - | ||||||||||||||||||||
SP10: | - | - | - | - | - | ||||||||||||||||
SP11: | |||||||||||||||||||||
SP12: | |||||||||||||||||||||
SP13: | |||||||||||||||||||||
SP14: | |||||||||||||||||||||
SP15: | |||||||||||||||||||||
SP16: | |||||||||||||||||||||
SP17: | |||||||||||||||||||||
SP18: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TCF7 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TCF7 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TCF7 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tcf7 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TCF7 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TCF7 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TCF1 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TCF7 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | tcf7 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | pan 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | pop-1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11069 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2678103 | CNV | deletion | 23128226 |
esv3606842 | CNV | loss | 21293372 |
nsv1073496 | CNV | deletion | 25765185 |
nsv1112885 | CNV | deletion | 24896259 |
nsv1145070 | CNV | deletion | 24896259 |
nsv5011 | CNV | insertion | 18451855 |
nsv599732 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
gastric cardia adenocarcinoma |
|
|
astrocytoma |
|
|
hepatocellular carcinoma |
|
|
lung cancer |
|
|
cleidocranial dysplasia |
|
|