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TCF25 is a member of the basic helix-loop-helix (bHLH) family of transcription factors that are important in embryonic development (Steen and Lindholm, 2008 [PubMed 18068114]).[supplied by OMIM, Sep 2008]
TCF25 (Transcription Factor 25) is a Protein Coding gene. Diseases associated with TCF25 include Vulvovaginitis. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Non-Canonical Wnt Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IBA,IDA | 16574069 |
GO:0005515 | protein binding | IEA,IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA,IDA | 16574069 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
2 | Non-Canonical Wnt Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA,IDA | 16574069 |
GO:0007507 | heart development | NAS | 16574069 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d | ^ | 15 | ^ | 16a | · | 16b | ^ | 17a | · |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
ExUns: | 17b | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 |
---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||
SP2: | - | ||||||||
SP3: | |||||||||
SP4: | |||||||||
SP5: | |||||||||
SP6: | - | - | |||||||
SP7: | |||||||||
SP8: | |||||||||
SP9: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TCF25 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TCF25 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tcf25 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tcf25 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TCF25 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TCF25 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TCF25 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TCF25 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TCF25 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tcf25 30 |
|
||
Str.8047 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.23789 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tcf25 30 31 |
|
OneToOne | |
wufc09e07 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5155 30 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005545 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG7927 30 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | K07A12.1 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | -- 31 |
|
OneToOne | |
RQC1 33 |
|
|
|||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT2G46900 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os09g0514900 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC1142.01 30 |
|
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
729643 | Likely Benign: not provided | 89,911,074(+) | C/T | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
vulvovaginitis |
|
|