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TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
TCF21 (Transcription Factor 21) is a Protein Coding gene. Diseases associated with TCF21 include Uterine Corpus Endometrial Carcinoma and Pericoronitis. Among its related pathways are ERK Signaling and Human Embryonic Stem Cell Pluripotency. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is MSC.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 12493738 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | ISS | -- |
GO:0003677 | DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA,IDA | 12493738 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Human Embryonic Stem Cell Pluripotency |
Factors Promoting Cardiogenesis in Vertebrates
.50
|
Human Embryonic Stem Cell Pluripotency
.50
|
2 | ERK Signaling |
MAPK Signaling
.58
|
ILK Signaling
.49
|
3 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
4 | Non-Canonical Wnt Pathway | ||
5 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 12493738 |
GO:0001657 | ureteric bud development | ISS | -- |
GO:0001658 | branching involved in ureteric bud morphogenesis | ISS | -- |
GO:0001763 | morphogenesis of a branching structure | ISS | -- |
GO:0001822 | kidney development | ISS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TCF21 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TCF21 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TCF21 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TCF21 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tcf21 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tcf21 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TCF21 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TCF21 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TCF21 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tcf21 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tcf21 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | HLH54F 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
731660 | Benign: not provided | 133,889,838(+) | G/T | SYNONYMOUS_VARIANT | |
769693 | Benign: not provided | 133,889,667(+) | C/T | SYNONYMOUS_VARIANT | |
rs61729591 | Uncertain Significance: not provided | 133,889,460(+) | C/G | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
uterine corpus endometrial carcinoma |
|
|
pericoronitis |
|
|
paralytic ileus |
|
|
subacute lymphocytic thyroiditis |
|
|
pain agnosia |
|
|