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TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008... See more...
Aliases for TCF21 Gene
Aliases for TCF21 Gene
External Ids for TCF21 Gene
- HGNC: 11632
- NCBI Entrez Gene: 6943
- Ensembl: ENSG00000118526
- OMIM®: 603306
- UniProtKB/Swiss-Prot: O43680
Previous GeneCards Identifiers for TCF21 Gene
- GC06P133833
- GC06P134057
- GC06P134190
- GC06P134251
- GC06P131779
Summaries for TCF21 Gene
-
TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCF21 Gene
TCF21 (Transcription Factor 21) is a Protein Coding gene. Diseases associated with TCF21 include Uterine Corpus Endometrial Carcinoma and Pericoronitis. Among its related pathways are TGF-Beta Pathway and CDK-mediated phosphorylation and removal of Cdc6. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is MSC.
UniProtKB/Swiss-Prot Summary for TCF21 Gene
-
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.
Additional gene information for TCF21 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCF21 Gene
Genomics for TCF21 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TCF21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TCF21 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCF21
- Top Transcription factor binding sites by QIAGEN in the TCF21 gene promoter:
-
- MyoD
- NF-kappaB
- NF-kappaB1
Genomic Locations for TCF21 Gene
Latest Assembly
- chr6:133,889,113-133,895,553
- (GRCh38/hg38)
- Size:
- 6,441 bases
- Orientation:
- Plus strand
Previous Assembly
- chr6:134,210,251-134,216,675
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 6,425 bases
- Orientation:
- Plus strand
Genomic View for TCF21 Gene
Genes around TCF21 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q23.2 by HGNC
- 6q23.2 by Entrez Gene
- 6q23.2 by Ensembl
TCF21 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TCF21 Gene
Proteins for TCF21 Gene
-
Protein details for TCF21 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43680-TCF21_HUMAN
- Recommended name:
- Transcription factor 21
- Protein Accession:
- O43680
- E1P581
- O43545
- Q6ICV0
- Q9BZ14
Protein attributes for TCF21 Gene
- Size:
- 179 amino acids
- Molecular mass:
- 19715 Da
- Quaternary structure:
-
- Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3 and binds the E box (5'-CANNTG-3').
Post-translational modifications for TCF21 Gene
Other Protein References for TCF21 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences TCF21 / Epicardin Antibody
- Novus Biologicals Antibodies for TCF21
-
Abcam antibodies for TCF21
- Invitrogen Antibodies for TCF21 (AFLGC-TCF21)
-
Custom Antibody ServicesProSci Antibodies for TCF21
-
Santa Cruz Biotechnology (SCBT) Antibodies for TCF21
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for TCF21
- Origene Custom Protein Services for TCF21
-
Abcam proteins for TCF21
Assay products for research
- antibodies-online: Show 9 available TCF21 Elisa Kits ranked by validation data
- Compare Top TCF21 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for TCF21 Gene
Domains & Families for TCF21 Gene
Gene Families for TCF21 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for TCF21 Gene
- InterPro:
- Blocks:
-
- Basic helix-loop-helix dimerization domain bHLH
Suggested Antigen Peptide Sequences for TCF21 Gene
- GenScript: Design optimal peptide antigens:
-
- Podocyte-expressed 1 (TCF21_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TCF21 Gene
Function for TCF21 Gene
Molecular function for TCF21 Gene
- UniProtKB/Swiss-Prot Function:
- Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.
- GENATLAS Biochemistry:
- transcription factor 21,murine Pod-1 homolog,mesoderm specific,expressed in mesenchymal and glomerular epithelial cells in the developing kidney
Phenotypes From GWAS Catalog for TCF21 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISA | -- |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IEA,IDA | 12493738 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA,ISS | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for TCF21 Gene
- MGI mutant phenotypes for TCF21:
-
inferred from 6 alleles
- normal phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- cardiovascular system phenotype
- immune system phenotype
- respiratory system phenotype
- mortality/aging
- renal/urinary system phenotype
- hematopoietic system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- integument phenotype
- craniofacial phenotype
- GenomeRNAi human phenotypes for TCF21:
Animal Models for TCF21 Gene
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TCF21 - Starting at $85 >
- * TCF21 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TCF21
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TCF21
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCF21
miRNA for TCF21 Gene
- miRTarBase miRNAs that target TCF21
-
- hsa-miR-492 (MIRT006075)
- hsa-miR-21-5p (MIRT007085)
- hsa-miR-181a-5p (MIRT025053)
- hsa-miR-6735-3p (MIRT492081)
- hsa-miR-4721 (MIRT492082)
- hsa-miR-2467-3p (MIRT492083)
- hsa-miR-7107-5p (MIRT492084)
- hsa-miR-1234-3p (MIRT492085)
- hsa-miR-5088-5p (MIRT492086)
- mmu-miR-369-3p (MIRT577581)
- mmu-miR-374b-5p (MIRT577582)
- mmu-miR-410-3p (MIRT577583)
- mmu-miR-344d-3p (MIRT577584)
- mmu-miR-344e-3p (MIRT577585)
- mmu-miR-466p-3p (MIRT577586)
- mmu-miR-466b-3p (MIRT577587)
- mmu-miR-466c-3p (MIRT577588)
Targeted motifs for TCF21 Gene
HOMER Transcription Factor Regulatory Elements motif TCF21
- Consensus sequence: NAACAGCTGG Submotif: canonical Cell Type: ArterySmoothMuscle GEO ID: GSE61369
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TCF21
- Browse OriGene Inhibitory RNA Products For TCF21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCF21
Clone products for research
- Applied Biological Materials (abm): Clones for TCF21 - Starting at $45 >
- * TCF21 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TCF21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TCF21
Cell Lines for research
-
Horizon Cell Lines for TCF21
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for TCF21 Gene
Localization for TCF21 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TCF21 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000785 | chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA,IDA | 12493738 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCF21 Gene
Pathways & Interactions for TCF21 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Human Embryonic Stem Cell Pluripotency |
Factors Promoting Cardiogenesis in Vertebrates
.50
|
Human Embryonic Stem Cell Pluripotency
.50
|
| 2 | ERK Signaling |
MAPK Signaling
.58
|
ILK Signaling
.49
|
| 3 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 4 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
|
| 5 | TGF-Beta Pathway |
JNK Pathway
.51
|
|
Pathways by source for TCF21 Gene
1 Sino Biological pathway for TCF21 Gene
7 Qiagen pathways for TCF21 Gene
- Epithelial Adherens Junctions
- Factors Promoting Cardiogenesis in Vertebrates
- Human Embryonic Stem Cell Pluripotency
- ILK Signaling
- JNK Pathway
Interacting Proteins for TCF21 Gene
Selected Interacting proteins:
O43680-TCF21_HUMAN
ENSP00000356857
for TCF21 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for TCF21
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA,IDA | 12493738 |
| GO:0001657 | ureteric bud development | IEA,ISS | -- |
| GO:0001658 | branching involved in ureteric bud morphogenesis | IEA,ISS | -- |
| GO:0001763 | morphogenesis of a branching structure | IEA,ISS | -- |
| GO:0001822 | kidney development | IEA,ISS | -- |
No data available for SIGNOR curated interactions for TCF21 Gene
Transcripts for TCF21 Gene
mRNA/cDNA for TCF21 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000237316 3010 nts (view in UCSC)
- ENST00000367882 1280 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for TCF21 - Starting at $85 >
- * TCF21 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for TCF21
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TCF21
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCF21
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TCF21
- Browse OriGene Inhibitory RNA Products For TCF21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCF21
Clone products for research
- Applied Biological Materials (abm): Clones for TCF21 - Starting at $45 >
- * TCF21 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for TCF21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TCF21
Relevant External Links for TCF21 Gene
- GeneLoc Exon Structure for
- TCF21
Expression for TCF21 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Paraxial Mesoderm Cells Branchial Arch 2
- Mononuclear Myocytes Hyoid Arch Muscles
- Muscle satellite Cells Extraocular Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Paraxial Mesoderm Cells Branchial Arch 1
-
Kidney (Urinary System)
- Interstitial Stroma Cells Interstitial Stroma
- Cap Mesenchyme Cells Cap Mesenchyme
- Medullary Stroma Cells Interstitial Stroma
- S-shaped Body
- Interstitial Stroma
-
Adipose (Muscoskeletal System)
- Visceral White Preadipocytes Visceral White Adipose
- Subcutaneous White Preadipocytes Body Subcutaneous White Adipose
- Mesenchymal Stem Cells Subcutaneous White Adipose
- Visceral White Adipose
-
Heart (Cardiovascular System)
- Epicardial Progenitors Cells Epicardium
- Proepicardial Progenitor cells Proepicardium
- Endocardial Cells Endocardium
- Vascular Smooth Muscle Cells Coronary Capillary Plexus
-
Head Mesenchyme (Muscoskeletal System)
- Paraxial Mesoderm Cells Branchial Arch 2
- Paraxial Mesoderm Cells Branchial Arch 1
- Paraxial Mesoderm Cells Head Mesenchyme
-
Lung (Respiratory System)
- Distal Mesodermal Progenitor Cells Lung Mesoderm
- Early Lung Mesoderm Cells Lung Mesoderm
- Alveolar type II cells(Wade KC et. al. 2006)
-
Bone (Muscoskeletal System)
- Paraxial Mesoderm Cells Branchial Arch 1
- Paraxial Mesoderm Cells Head Mesenchyme
- Mandibular Process
-
Lateral Plate Mesoderm (Gastrulation Derivatives)
- Proepicardial Progenitor cells Proepicardium
- Coelomic Epithelial Cells Intraembryonic Coelom
- PureStem SM30, NCr-fac & Meso-latp Progenitor
-
Mesoderm (Gastrulation Derivatives)
- Septum Transversum Mesenchyme Cells Septum Transversum
- Septum Transversum
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
-
Mesenchymal Stem Cells
- Mesenchymal Stem Cells Subcutaneous White Adipose
-
Epithelial Cells
- Coelomic Epithelial Cells Intraembryonic Coelom
-
Gonad
- Coelomic Epithelial Cells Intraembryonic Coelom
-
Smooth Muscle (Muscoskeletal System)
- Vascular Smooth Muscle Cells Coronary Capillary Plexus
- Neural Crest (Gastrulation Derivatives)
- NULL (Uncategorized)
mRNA differential expression in normal tissues according to GTEx for TCF21 Gene
This gene is overexpressed in Lung (x7.6), Ovary (x6.3), Spleen (x4.7), and Kidney - Cortex (x4.1).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCF21
SOURCE GeneReport for Unigene cluster for TCF21 Gene:
Hs.78061Evidence on tissue expression from TISSUES for TCF21 Gene
- Pancreas(4.3)
- Kidney(3)
- Lung(2.8)
- Intestine(2.7)
- Heart(2.7)
- Spleen(2.5)
- Muscle(2.5)
- Skin(2.5)
- Blood(2.3)
- Liver(2.3)
- Nervous system(2.1)
Primer products for research
-
OriGene qPCR primer pairs for TCF21
-
OriGene qPCR primer pairs and template standards for TCF21
Gene Expression Assays for research
No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF21 Gene
Orthologs for TCF21 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TCF21 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | TCF21 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TCF21 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TCF21 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tcf21 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Tcf21 29 16 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TCF21 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TCF21 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TCF21 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tcf21 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tcf21 29 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | HLH54F 30 |
|
OneToMany |
- Species where no ortholog for TCF21 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TCF21 Gene
- ENSEMBL:
- Gene Tree for TCF21 (if available)
- TreeFam:
- Gene Tree for TCF21 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TCF21: view image
- Alliance of Genome Resources:
- Additional Orthologs for TCF21
Paralogs for TCF21 Gene
Variants for TCF21 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCF21 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs3777890 | Benign: not provided | 133,889,667(+) |
C/T NM_003206.4(TCF21):c.270C>T (p.Ala90=) |
SYNONYMOUS | |
| rs61729591 | Uncertain Significance: not provided | 133,889,460(+) |
C/G NM_003206.3(TCF21):c.63C>G (p.Asp21Glu) |
MISSENSE | |
| rs78733835 | Benign: not provided | 133,889,838(+) |
G/T NM_003206.4(TCF21):c.441G>T (p.Pro147=) |
SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.51;
64.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TCF21 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF21 Gene
Disorders for TCF21 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| uterine corpus endometrial carcinoma |
|
|
| pericoronitis |
|
|
| paralytic ileus |
|
|
| pain agnosia |
|
|
| subacute lymphocytic thyroiditis |
|
|
Search TCF21 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TCF21
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TCF21 Gene
Publications for TCF21 Gene
- epicardin: A novel basic helix-loop-helix transcription factor gene expressed in epicardium, branchial arch myoblasts, and mesenchyme of developing lung, gut, kidney, and gonads. (PMID: 9733105) Robb L … Harvey RP (Developmental dynamics : an official publication of the American Association of Anatomists 1998) 3 4 22
- Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney. (PMID: 9507058) Quaggin SE … Igarashi P (Mechanisms of development 1998) 2 3 22
- Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H … Samani NJ (Nature genetics 2011) 3 40
- Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 40
- Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. (PMID: 18978678) Vieira AR … Marazita ML (Genetics in medicine : official journal of the American College of Medical Genetics 2008) 3 40
ExternalLinks
Products for TCF21 Gene
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for TCF21
- Abcam proteins for TCF21
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- Browse Primary Antibodies
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- antibodies-online: Show 9 available TCF21 Antibodies ranked by validation data
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- Quality Products:
- antibodies-online: Show 8 available TCF21 Proteins ranked by validation data
- Compare Top TCF21 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for TCF21
- Search Santa Cruz Biotechnology (SCBT) for TCF21 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TCF21
- Horizon Cell Lines for TCF21
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TCF21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TCF21
- Search GeneCopoeia for miRNA 3'UTR Target clone products for TCF21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCF21
Sources for TCF21 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
- (53) R&D Systems
- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
- (127) BRCA Exchange
- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources