Aliases for TCF21 Gene
External Ids for TCF21 Gene
Previous GeneCards Identifiers for TCF21 Gene
TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCF21 Gene
TCF21 (Transcription Factor 21) is a Protein Coding gene. Diseases associated with TCF21 include Uterine Corpus Endometrial Carcinoma and Pericoronitis. Among its related pathways are ERK Signaling and Human Embryonic Stem Cell Pluripotency. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific. An important paralog of this gene is MSC.
UniProtKB/Swiss-Prot Summary for TCF21 Gene
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types.