Aliases for TCF20 Gene
External Ids for TCF20 Gene
Previous GeneCards Identifiers for TCF20 Gene
This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
GeneCards Summary for TCF20 Gene
TCF20 (Transcription Factor 20) is a Protein Coding gene. Diseases associated with TCF20 include Developmental Delay With Variable Intellectual Impairment And Behavioral Abnormalities and Pectus Excavatum. Among its related pathways are TGF-Beta Pathway and WNT Signaling. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity. An important paralog of this gene is RAI1.
UniProtKB/Swiss-Prot Summary for TCF20 Gene
Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.