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This gene encodes a protein that contains a PHD-type zinc finger domain and likely functions as a transcription factor. The encoded protein plays a role proliferation and apoptosis of pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
TCF19 (Transcription Factor 19) is a Protein Coding gene. Diseases associated with TCF19 include Psoriasis 8 and Psoriasis 7. Among its related pathways are ERK Signaling and Human Embryonic Stem Cell Pluripotency. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
GO:0005515 | protein binding | IEA,IPI | 21516116 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Human Embryonic Stem Cell Pluripotency |
Factors Promoting Cardiogenesis in Vertebrates
.50
|
Human Embryonic Stem Cell Pluripotency
.50
|
2 | ERK Signaling |
MAPK Signaling
.58
|
ILK Signaling
.49
|
3 | PAK Pathway |
Epithelial Adherens Junctions
.36
|
|
4 | TGF-Beta Pathway |
JNK Pathway
.51
|
|
5 | WNT Signaling |
WNT Signaling
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0010468 | regulation of gene expression | IEA,IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Nevirapine | Approved | Pharma | 231 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||
SP6: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TCF19 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TCF19 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TCF19 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tcf19 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tcf19 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TCF19 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TCF19 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tcf19 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tcf19l 30 31 |
|
OneToOne |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1174e214 | CNV | gain | 21293372 |
esv2731791 | CNV | deletion | 23290073 |
esv2759414 | CNV | gain+loss | 17122850 |
esv3411275 | CNV | duplication | 20981092 |
esv3608531 | CNV | loss | 21293372 |
esv3608532 | CNV | gain | 21293372 |
nsv1074389 | CNV | deletion | 25765185 |
nsv1122126 | CNV | deletion | 24896259 |
nsv1144137 | CNV | deletion | 24896259 |
nsv428140 | CNV | gain+loss | 18775914 |
nsv524061 | CNV | loss | 19592680 |
nsv525933 | CNV | loss | 19592680 |
nsv601264 | CNV | loss | 21841781 |
nsv601481 | CNV | loss | 21841781 |
nsv970105 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
psoriasis 8 |
|
|
psoriasis 7 |
|
|
peeling skin syndrome |
|
|
psoriasis 9 |
|
|
psoriasis 1 |
|
|