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TCF19 Gene(Protein Coding)

Transcription Factor 19

GCID:
GC06P031297
GIFtS:
44
Genes Participants
UDN Logo

Aliases for TCF19 Gene

Aliases for TCF19 Gene

  • Transcription Factor 19 2 3 5
  • Transcription Factor SC1 3 4
  • TCF-19 3 4
  • SC1 3 4

External Ids for TCF19 Gene

Previous GeneCards Identifiers for TCF19 Gene

  • GC06P031182
  • GC06P030897
  • GC06P031232
  • GC06P031234
  • GC06P031126
  • GC06P031159
  • GC06P031162
  • GC06P031295

Summaries for TCF19 Gene

Entrez Gene Summary for TCF19 Gene

  • This gene encodes a protein that contains a PHD-type zinc finger domain and likely functions as a transcription factor. The encoded protein plays a role proliferation and apoptosis of pancreatic beta cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GeneCards Summary for TCF19 Gene

TCF19 (Transcription Factor 19) is a Protein Coding gene. Diseases associated with TCF19 include Peeling Skin Syndrome. Among its related pathways are PAK Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for TCF19 Gene

  • Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.

Gene Wiki entry for TCF19 Gene

Additional gene information for TCF19 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF19 Gene

Genomics for TCF19 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for TCF19 Gene

Promoters and enhancers for TCF19 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06I031157 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 570.3 +0.2 214 3 HDGF PKNOX1 ZFP64 ARID4B SIN3A YY1 POLR2B E2F8 ZNF207 ZNF143 CCHCR1 TCF19 MDC1 DHX16 TRIM39 ABCF1 DDX39B LSM2 BAG6 GPANK1
GH06I031538 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 63.3 +382.6 382613 4.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 DDX39B DDX39B-AS1 GC06M031542 GC06M031543 GC06M031550 GC06M031555 GC06M031573 GC06M031962 GC06M031965 GC06M031970
GH06I031733 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 41.5 +578.9 578929 8.5 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 MSH5 CLIC1 DDX39B LY6G5B ATF6B LSM2 CSNK2B SKIV2L GPANK1 BAG6
GH06I031545 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 45.9 +389.0 389006 3.2 CLOCK MLX YBX1 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 NFKBIL1 ATP6V1G2 ATP6V1G2-DDX39B DDX39B DHX16 ATF6B LY6G5B LSM2 MDC1 TCF19
GH06I030715 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 39.8 -439.0 -439000 7.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 MDC1 TUBB DDX39B TRIM39 DHX16 LY6G5B PPP1R10 ZNRD1 PAIP1P1 NRM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCF19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCF19 gene promoter:

Genomic Locations for TCF19 Gene

Genomic Locations for TCF19 Gene
chr6:31,158,526-31,167,159
(GRCh38/hg38)
Size:
8,634 bases
Orientation:
Plus strand
chr6:31,126,303-31,134,936
(GRCh37/hg19)

Genomic View for TCF19 Gene

Genes around TCF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF19 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TCF19 Gene

Proteins for TCF19 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for TCF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y242-TCF19_HUMAN
    Recommended name:
    Transcription factor 19
    Protein Accession:
    Q9Y242
    Secondary Accessions:
    • A6NCT8
    • B0UY11
    • Q0EFA8
    • Q13176
    • Q15967
    • Q5SQ89
    • Q5STD6
    • Q5STF5
    • Q9BUM2
    • Q9UBH7

    Protein attributes for TCF19 Gene

    Size:
    345 amino acids
    Molecular mass:
    37184 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB60363.1; Type=Frameshift; Positions=288, 290, 291; Evidence={ECO:0000305}; Sequence=AAB60363.1; Type=Frameshift; Positions=288; Evidence={ECO:0000305};

neXtProt entry for TCF19 Gene

Post-translational modifications for TCF19 Gene

No Post-translational modifications

Other Protein References for TCF19 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCF19 Gene

Domains & Families for TCF19 Gene

Gene Families for TCF19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCF19 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TCF19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TCF19: view

No data available for UniProtKB/Swiss-Prot for TCF19 Gene

Function for TCF19 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for TCF19 Gene

GENATLAS Biochemistry:
transcription factor 19,SC1,late growth-regulated gene
UniProtKB/Swiss-Prot Function:
Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.

Phenotypes From GWAS Catalog for TCF19 Gene

Gene Ontology (GO) - Molecular Function for TCF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity TAS 1868030
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TCF19: view
genes like me logo Genes that share phenotypes with TCF19: view

Animal Models for TCF19 Gene

MGI Knock Outs for TCF19:

Animal Model Products

miRNA for TCF19 Gene

miRTarBase miRNAs that target TCF19

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCF19 Gene

Localization for TCF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF19 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCF19 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TCF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCF19: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCF19 Gene

Pathways & Interactions for TCF19 Gene

genes like me logo Genes that share pathways with TCF19: view

Gene Ontology (GO) - Biological Process for TCF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 1868030
GO:0008283 cell proliferation TAS 1868030
genes like me logo Genes that share ontologies with TCF19: view

No data available for SIGNOR curated interactions for TCF19 Gene

Drugs & Compounds for TCF19 Gene

Products:

  1. Drug

(1) Drugs for TCF19 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nevirapine Approved Pharma 224
genes like me logo Genes that share compounds with TCF19: view

Transcripts for TCF19 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for TCF19 Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(143) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCF19 Gene

Transcription factor 19:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCF19 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5:
SP6: -

Relevant External Links for TCF19 Gene

GeneLoc Exon Structure for
TCF19
ECgene alternative splicing isoforms for
TCF19

Expression for TCF19 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCF19 Gene

mRNA expression in normal human tissues for TCF19 Gene
mRNA expression by BioGPS for TCF19 GenemRNA expression by GTEx for TCF19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TCF19 Gene:

TCF19

SOURCE GeneReport for Unigene cluster for TCF19 Gene:

Hs.584807

Evidence on tissue expression from TISSUES for TCF19 Gene

  • Skin(4.3)
  • Intestine(4.2)
  • Blood(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with TCF19: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF19 Gene

Orthologs for TCF19 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCF19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia TCF19 33 34
  • 98.94 (n)
cow
(Bos Taurus)
 Mammalia TCF19 33 34
  • 86.63 (n)
dog
(Canis familiaris)
 Mammalia TCF19 33 34
  • 85.27 (n)
rat
(Rattus norvegicus)
 Mammalia Tcf19 33
  • 82.58 (n)
mouse
(Mus musculus)
 Mammalia Tcf19 33 16 34
  • 81.3 (n)
oppossum
(Monodelphis domestica)
 Mammalia TCF19 34
  • 72 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia TCF19 34
  • 54 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia tcf19 33
  • 51.53 (n)
zebrafish
(Danio rerio)
 Actinopterygii tcf19l 33 34
  • 54.36 (n)
Species where no ortholog for TCF19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCF19 Gene

ENSEMBL:
Gene Tree for TCF19 (if available)
TreeFam:
Gene Tree for TCF19 (if available)

Paralogs for TCF19 Gene

Pseudogenes.org Pseudogenes for TCF19 Gene

genes like me logo Genes that share paralogs with TCF19: view

No data available for Paralogs for TCF19 Gene

Variants for TCF19 Gene

Sequence variations from dbSNP and Humsavar for TCF19 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000226564 -- 31,158,753(+) G/C intron_variant
rs1000507363 -- 31,158,499(+) C/G/T upstream_transcript_variant
rs1000615578 -- 31,164,140(+) A/G 3_prime_UTR_variant
rs1000654068 -- 31,158,477(+) T/A upstream_transcript_variant
rs1001481045 -- 31,157,529(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TCF19 Gene

Variant ID Type Subtype PubMed ID
nsv970105 CNV duplication 23825009
nsv601481 CNV loss 21841781
nsv601264 CNV loss 21841781
nsv525933 CNV loss 19592680
nsv524061 CNV loss 19592680
nsv428140 CNV gain+loss 18775914
nsv1144137 CNV deletion 24896259
nsv1122126 CNV deletion 24896259
nsv1074389 CNV deletion 25765185
esv3608532 CNV gain 21293372
esv3608531 CNV loss 21293372
esv3411275 CNV duplication 20981092
esv2759414 CNV gain+loss 17122850
esv2731791 CNV deletion 23290073
dgv1174e214 CNV gain 21293372

Variation tolerance for TCF19 Gene

Residual Variation Intolerance Score: 55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCF19 Gene

Human Gene Mutation Database (HGMD)
TCF19
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF19 Gene

Disorders for TCF19 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCF19 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
peeling skin syndrome
  • exfoliation syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TCF19 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TCF19

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TCF19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCF19 Gene

Publications for TCF19 Gene

  1. Genetic polymorphisms in the cell growth regulated gene, SC1 telomeric of the HLA-C gene and lack of association of psoriasis vulgaris. (PMID: 10777095) Teraoka Y … Inoko H (Tissue antigens 2000) 3 4 22 44 58
  2. A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. (PMID: 1868030) Ku DH … Baserga R (Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1991) 2 3 4 22 58
  3. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E … Dorak MT (Molecular human reproduction 2010) 3 44 58
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  5. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PMID: 16702430) Shiina T … Bahram S (Genetics 2006) 3 4 58

Products for TCF19 Gene

Sources for TCF19 Gene

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