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Aliases for TCF15 Gene

Aliases for TCF15 Gene

  • Transcription Factor 15 2 3 5
  • Transcription Factor 15 (Basic Helix-Loop-Helix) 2 3
  • Class A Basic Helix-Loop-Helix Protein 40 3 4
  • Protein BHLH-EC2 3 4
  • PARAXIS 3 4
  • BHLHa40 3 4
  • TCF-15 3 4
  • Basic Helix-Loop-Helix Transcription Factor 15 3
  • BHLHEC2 4
  • EC2 3

External Ids for TCF15 Gene

Previous GeneCards Identifiers for TCF15 Gene

  • GC20M000572
  • GC20M000579
  • GC20M000532
  • GC20M000584

Summaries for TCF15 Gene

Entrez Gene Summary for TCF15 Gene

  • The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCF15 Gene

TCF15 (Transcription Factor 15) is a Protein Coding gene. Among its related pathways are PAK Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein dimerization activity. An important paralog of this gene is SCX.

UniProtKB/Swiss-Prot for TCF15 Gene

  • May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.

Additional gene information for TCF15 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCF15 Gene

Genomics for TCF15 Gene

GeneHancer (GH) Regulatory Elements for TCF15 Gene

Promoters and enhancers for TCF15 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I000610 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 550.8 +0.0 26 0.2 RB1 L3MBTL2 BHLHE40 MAX GTF2A2 ZNF395 SP1 CCNT2 CTBP1 MTA3 TCF15 GC20M000594
GH20I000645 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.5 -35.8 -35824 2.3 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 ETS1 SLC30A9 POLR2B SRXN1 TCF15 SOX12 CSNK2A1 SCRT2 NRSN2 SLC52A3 GC20M000621 GC20M000631 ENSG00000270299
GH20I000641 Enhancer 1.1 Ensembl ENCODE 12.5 -32.2 -32165 2 PKNOX1 ATF1 ARID4B DMAP1 ZNF48 ATF7 SP5 NFYC PPARG KAT8 SRXN1 TCF15 CSNK2A1 GC20M000621 GC20M000631
GH20I000571 Enhancer 1.1 Ensembl ENCODE dbSUPER 12 +37.0 37035 3.9 TFAP4 KLF1 ATF1 KLF17 SIN3A ZIC2 POLR2A SCRT2 VEZF1 ATF7 CSNK2A1 TCF15 GC20M000594
GH20I000577 Enhancer 0.8 ENCODE 13.2 +33.1 33123 0.1 HDAC1 CTCF ATF1 NFRKB MAX CTBP1 ZNF766 MTA3 DIDO1 CBFA2T2 TCF15 CSNK2A1 SRXN1 SCRT2 GC20M000594
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCF15 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCF15 gene promoter:

Genomic Locations for TCF15 Gene

Genomic Locations for TCF15 Gene
6,602 bases
Minus strand

Genomic View for TCF15 Gene

Genes around TCF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF15 Gene

Proteins for TCF15 Gene

  • Protein details for TCF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription factor 15
    Protein Accession:
    Secondary Accessions:
    • Q9NQQ1

    Protein attributes for TCF15 Gene

    199 amino acids
    Molecular mass:
    20816 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for TCF15 Gene

Post-translational modifications for TCF15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCF15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCF15 Gene

Domains & Families for TCF15 Gene

Gene Families for TCF15 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TCF15 Gene

Suggested Antigen Peptide Sequences for TCF15 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TCF15: view

No data available for UniProtKB/Swiss-Prot for TCF15 Gene

Function for TCF15 Gene

Molecular function for TCF15 Gene

GENATLAS Biochemistry:
transcription factor 15,expressed in early mesoderma and developing somites in the mouse embryo
UniProtKB/Swiss-Prot Function:
May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.

Phenotypes From GWAS Catalog for TCF15 Gene

Gene Ontology (GO) - Molecular Function for TCF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 8041747
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with TCF15: view
genes like me logo Genes that share phenotypes with TCF15: view

Animal Models for TCF15 Gene

MGI Knock Outs for TCF15:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCF15 Gene

Localization for TCF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF15 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCF15 gene
Compartment Confidence
nucleus 4
extracellular 2
cytosol 2
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0090575 RNA polymerase II transcription factor complex IEA --
genes like me logo Genes that share ontologies with TCF15: view

Pathways & Interactions for TCF15 Gene

genes like me logo Genes that share pathways with TCF15: view

Gene Ontology (GO) - Biological Process for TCF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001756 somitogenesis IEA --
GO:0003016 respiratory system process IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 8825648
genes like me logo Genes that share ontologies with TCF15: view

No data available for SIGNOR curated interactions for TCF15 Gene

Drugs & Compounds for TCF15 Gene

No Compound Related Data Available

Transcripts for TCF15 Gene

mRNA/cDNA for TCF15 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCF15 Gene

Transcription factor 15 (basic helix-loop-helix):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCF15 Gene

No ASD Table

Relevant External Links for TCF15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCF15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF15 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.3), Adipose - Visceral (Omentum) (x4.7), and Heart - Atrial Appendage (x4.6).

Protein differential expression in normal tissues from HIPED for TCF15 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCF15 Gene

Protein tissue co-expression partners for TCF15 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCF15 Gene:


SOURCE GeneReport for Unigene cluster for TCF15 Gene:


Evidence on tissue expression from TISSUES for TCF15 Gene

  • Muscle(2.6)
  • Heart(2.3)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with TCF15: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF15 Gene

Orthologs for TCF15 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF15 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia TCF15 33 34
  • 94.64 (n)
(Bos Taurus)
Mammalia TCF15 33 34
  • 93.4 (n)
(Rattus norvegicus)
Mammalia Tcf15 33
  • 90.94 (n)
(Mus musculus)
Mammalia Tcf15 33 16 34
  • 90.6 (n)
(Monodelphis domestica)
Mammalia TCF15 34
  • 74 (a)
(Gallus gallus)
Aves TCF15 33 34
  • 77.96 (n)
(Anolis carolinensis)
Reptilia TCF15 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101733229 33
  • 72.54 (n)
Str.11266 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15926 33
(Danio rerio)
Actinopterygii par1 33 34
  • 65.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG33557 34
  • 39 (a)
(Caenorhabditis elegans)
Secernentea hlh-8 34
  • 25 (a)
Species where no ortholog for TCF15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCF15 Gene

Gene Tree for TCF15 (if available)
Gene Tree for TCF15 (if available)

Paralogs for TCF15 Gene

Paralogs for TCF15 Gene

(9) SIMAP similar genes for TCF15 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TCF15: view

Variants for TCF15 Gene

Sequence variations from dbSNP and Humsavar for TCF15 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000633007 -- 607,028(-) G/T intron_variant
rs1000858149 -- 606,797(-) G/A intron_variant
rs1000910486 -- 607,132(-) T/C intron_variant
rs1001191637 -- 608,516(-) C/A intron_variant
rs1001237846 -- 608,491(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TCF15 Gene

Variant ID Type Subtype PubMed ID
dgv7421n54 CNV loss 21841781
dgv7422n54 CNV loss 21841781
esv3644952 CNV gain 21293372
nsv1058681 CNV loss 25217958
nsv1072093 CNV deletion 25765185
nsv458844 CNV loss 19166990
nsv458845 CNV loss 19166990
nsv469833 CNV gain 16826518
nsv585172 CNV gain 21841781
nsv585173 CNV loss 21841781
nsv585176 CNV loss 21841781
nsv585179 CNV loss 21841781
nsv828661 CNV gain 20364138
nsv833891 CNV gain+loss 17160897

Variation tolerance for TCF15 Gene

Gene Damage Index Score: 2.91; 48.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCF15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCF15 Gene

Disorders for TCF15 Gene

Additional Disease Information for TCF15

No disorders were found for TCF15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCF15 Gene

Publications for TCF15 Gene

  1. Genomic organization and chromosomal localization of the gene TCF15 encoding the early mesodermal basic helix-loop-helix factor bHLH-EC2. (PMID: 8825648) Hidai H … Quertermous T (Genomics 1995) 2 3 22 58
  2. Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites. (PMID: 8041747) Quertermous EE … Quertermous T (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake. (PMID: 25561514) Coppiello G … Luttun A (Circulation 2015) 3 58
  5. Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population. (PMID: 26428460) Yang WY … Staessen JA (BMC genetics 2015) 3 58

Products for TCF15 Gene

Sources for TCF15 Gene

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