The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008] See more...

Aliases for TCF15 Gene

Aliases for TCF15 Gene

  • Transcription Factor 15 2 3 4 5
  • BHLHa40 2 3 4
  • Transcription Factor 15 (Basic Helix-Loop-Helix) 2 3
  • Class A Basic Helix-Loop-Helix Protein 40 3 4
  • Protein BHLH-EC2 3 4
  • PARAXIS 2 3
  • TCF-15 3 4
  • EC2 2 3
  • Basic Helix-Loop-Helix Transcription Factor 15 3
  • BHLHA40 4
  • BHLHEC2 4
  • Paraxis 4
  • TCF15 5

External Ids for TCF15 Gene

Previous GeneCards Identifiers for TCF15 Gene

  • GC20M000572
  • GC20M000579
  • GC20M000532
  • GC20M000584

Summaries for TCF15 Gene

Entrez Gene Summary for TCF15 Gene

  • The protein encoded by this gene is found in the nucleus and may be involved in the early transcriptional regulation of patterning of the mesoderm. The encoded basic helix-loop-helix protein requires dimerization with another basic helix-loop-helix protein for efficient DNA binding. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCF15 Gene

TCF15 (Transcription Factor 15) is a Protein Coding gene. Diseases associated with TCF15 include Galactosemia I and Advanced Sleep Phase Syndrome, Familial, 3. Among its related pathways are ERK Signaling and Human Embryonic Stem Cell Pluripotency. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is SCX.

UniProtKB/Swiss-Prot Summary for TCF15 Gene

  • May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCF15 Gene

Genomics for TCF15 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TCF15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J000610 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 600.7 +1.2 1197 4 RFX1 EZH2 GATAD2B NRF1 MTA3 EGR1 CTBP1 RNF2 POLR2A ZKSCAN1 TCF15 SOX12 RF00017-3486 CSNK2A1
GH20J000645 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 12.5 -35.8 -35824 2.3 HNRNPL GATAD2A CTCF TFE3 SOX13 NFKBIZ RCOR2 PRDM1 ZNF143 RBFOX2 SRXN1 TCF15 CSNK2A1 SCRT2 SLC52A3 HSALNG0128051 ENSG00000270299
GH20J000641 Enhancer 1 ENCODE CraniofacialAtlas 12.5 -32.3 -32314 0.7 GATAD2A TFE3 NFKBIZ RCOR2 RBFOX2 RXRB IRF2 ZNF740 ZNF24 GATAD2B LOC107985387 HSALNG0128051 SRXN1 TCF15 CSNK2A1
GH20J000571 Enhancer 1 ENCODE CraniofacialAtlas dbSUPER 12 +37.0 37035 3.9 ATF7 TEAD4 KDM1A PRDM1 ZIC2 SCRT2 JUND CTCF CREB1 SCRT1 CSNK2A1 TCF15 RF00017-3485 lnc-TCF15-1
GH20J000578 Enhancer 0.8 ENCODE 13.2 +32.8 32846 0.2 CREB1 CTCF ATF7 ZNF629 JUND KAT8 HDAC1 YY1 SCRT2 MGA TCF15 CSNK2A1 SRXN1 SCRT2 RF00017-3485 lnc-TCF15-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCF15 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCF15

Top Transcription factor binding sites by QIAGEN in the TCF15 gene promoter:
  • E2F-1
  • FOXO4
  • IRF-1
  • IRF-7A
  • MyoD
  • p300
  • Pax-4a
  • RORalpha1

Genomic Locations for TCF15 Gene

Genomic Locations for TCF15 Gene
chr20:603,797-610,398
(GRCh38/hg38)
Size:
6,602 bases
Orientation:
Minus strand
chr20:584,441-591,042
(GRCh37/hg19)
Size:
6,602 bases
Orientation:
Minus strand

Genomic View for TCF15 Gene

Genes around TCF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCF15 Gene

Proteins for TCF15 Gene

  • Protein details for TCF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12870-TCF15_HUMAN
    Recommended name:
    Transcription factor 15
    Protein Accession:
    Q12870
    Secondary Accessions:
    • Q9NQQ1

    Protein attributes for TCF15 Gene

    Size:
    199 amino acids
    Molecular mass:
    20816 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein.

neXtProt entry for TCF15 Gene

Post-translational modifications for TCF15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCF15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCF15 Gene

Domains & Families for TCF15 Gene

Gene Families for TCF15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TCF15 Gene

InterPro:
Blocks:
  • Basic helix-loop-helix dimerization domain bHLH
ProtoNet:

Suggested Antigen Peptide Sequences for TCF15 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor 15 (Basic helix-loop-helix) (A4LBB6_HUMAN)
  • TCF15 protein (Q6NVX3_HUMAN)
  • Protein bHLH-EC2 (TCF15_HUMAN)
genes like me logo Genes that share domains with TCF15: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TCF15 Gene

Function for TCF15 Gene

Molecular function for TCF15 Gene

UniProtKB/Swiss-Prot Function:
May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.
GENATLAS Biochemistry:
transcription factor 15,expressed in early mesoderma and developing somites in the mouse embryo

Phenotypes From GWAS Catalog for TCF15 Gene

Gene Ontology (GO) - Molecular Function for TCF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TCF15: view
genes like me logo Genes that share phenotypes with TCF15: view

Animal Models for TCF15 Gene

MGI Knock Outs for TCF15:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCF15

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCF15 Gene

Localization for TCF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCF15 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCF15 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
golgi apparatus 2
peroxisome 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0090575 RNA polymerase II transcription factor complex IEA --
genes like me logo Genes that share ontologies with TCF15: view

Pathways & Interactions for TCF15 Gene

PathCards logo

SuperPathways for TCF15 Gene

SuperPathway Contained pathways
1 Human Embryonic Stem Cell Pluripotency
.50
.50
2 ERK Signaling
.58
.49
3 PAK Pathway
.36
4 TGF-Beta Pathway
.51
5 WNT Signaling
-
genes like me logo Genes that share pathways with TCF15: view

Pathways by source for TCF15 Gene

7 Qiagen pathways for TCF15 Gene
  • Epithelial Adherens Junctions
  • Factors Promoting Cardiogenesis in Vertebrates
  • Human Embryonic Stem Cell Pluripotency
  • ILK Signaling
  • JNK Pathway

Gene Ontology (GO) - Biological Process for TCF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001756 somitogenesis IEA --
GO:0003016 respiratory system process IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS,IBA 21873635
GO:0007275 multicellular organism development IEA --
GO:0007498 mesoderm development TAS 8041747
genes like me logo Genes that share ontologies with TCF15: view

No data available for SIGNOR curated interactions for TCF15 Gene

Drugs & Compounds for TCF15 Gene

No Compound Related Data Available

Transcripts for TCF15 Gene

mRNA/cDNA for TCF15 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCF15

Alternative Splicing Database (ASD) splice patterns (SP) for TCF15 Gene

No ASD Table

Relevant External Links for TCF15 Gene

GeneLoc Exon Structure for
TCF15

Expression for TCF15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCF15 Gene

This gene is overexpressed in Heart - Left Ventricle (x12.3), Adipose - Visceral (Omentum) (x4.7), and Heart - Atrial Appendage (x4.6).

Protein differential expression in normal tissues from HIPED for TCF15 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCF15 Gene



Protein tissue co-expression partners for TCF15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCF15

SOURCE GeneReport for Unigene cluster for TCF15 Gene:

Hs.437

Evidence on tissue expression from TISSUES for TCF15 Gene

  • Muscle(3.2)
  • Heart(3)
  • Liver(3)
  • Nervous system(2.8)
  • Skin(2.5)
  • Intestine(2.3)
  • Kidney(2.3)
  • Blood(2.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with TCF15: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCF15 Gene

Orthologs for TCF15 Gene

This gene was present in the common ancestor of animals.

Orthologs for TCF15 Gene

Organism Taxonomy Gene Similarity Type Details
Dog
(Canis familiaris)
Mammalia TCF15 30 31
  • 94.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TCF15 30 31
  • 93.4 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tcf15 30
  • 90.94 (n)
Mouse
(Mus musculus)
Mammalia Tcf15 30 17 31
  • 90.6 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TCF15 31
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TCF15 30 31
  • 77.96 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TCF15 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101733229 30
  • 72.54 (n)
Str.11266 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15926 30
Zebrafish
(Danio rerio)
Actinopterygii par1 30 31
  • 65.17 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG33557 31
  • 39 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea hlh-8 31
  • 25 (a)
OneToMany
Species where no ortholog for TCF15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TCF15 Gene

ENSEMBL:
Gene Tree for TCF15 (if available)
TreeFam:
Gene Tree for TCF15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCF15: view image

Paralogs for TCF15 Gene

(9) SIMAP similar genes for TCF15 Gene using alignment to 3 proteins:

  • TCF15_HUMAN
  • A4LBB6_HUMAN
  • Q6NVX3_HUMAN
genes like me logo Genes that share paralogs with TCF15: view

Variants for TCF15 Gene

Additional dbSNP identifiers (rs#s) for TCF15 Gene

Structural Variations from Database of Genomic Variants (DGV) for TCF15 Gene

Variant ID Type Subtype PubMed ID
dgv7421n54 CNV loss 21841781
dgv7422n54 CNV loss 21841781
esv3644952 CNV gain 21293372
nsv1058681 CNV loss 25217958
nsv1072093 CNV deletion 25765185
nsv458844 CNV loss 19166990
nsv458845 CNV loss 19166990
nsv469833 CNV gain 16826518
nsv585172 CNV gain 21841781
nsv585173 CNV loss 21841781
nsv585176 CNV loss 21841781
nsv585179 CNV loss 21841781
nsv828661 CNV gain 20364138
nsv833891 CNV gain+loss 17160897

Variation tolerance for TCF15 Gene

Gene Damage Index Score: 2.91; 48.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCF15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCF15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCF15 Gene

Disorders for TCF15 Gene

MalaCards: The human disease database

(6) MalaCards diseases for TCF15 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search TCF15 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with TCF15: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCF15 Gene

Publications for TCF15 Gene

  1. Genomic organization and chromosomal localization of the gene TCF15 encoding the early mesodermal basic helix-loop-helix factor bHLH-EC2. (PMID: 8825648) Hidai H … Quertermous T (Genomics 1995) 2 3 23
  2. Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites. (PMID: 8041747) Quertermous EE … Quertermous T (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
  4. Meox2/Tcf15 heterodimers program the heart capillary endothelium for cardiac fatty acid uptake. (PMID: 25561514) Coppiello G … Luttun A (Circulation 2015) 3
  5. Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population. (PMID: 26428460) Yang WY … Staessen JA (BMC genetics 2015) 3

Products for TCF15 Gene

Sources for TCF15 Gene