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Aliases for TCERG1 Gene

Aliases for TCERG1 Gene

  • Transcription Elongation Regulator 1 2 3 5
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, S, 150kD 2 2 3
  • TATA Box-Binding Protein-Associated Factor 2S 2 3 4
  • Transcription Factor CA150 2 3 4
  • Co-Activator Of 150 KDa 2 3
  • TAF2S 3 4
  • CA150 3 4
  • Urn1 3

External Ids for TCERG1 Gene

Previous HGNC Symbols for TCERG1 Gene

  • TAF2S

Previous GeneCards Identifiers for TCERG1 Gene

  • GC05P145795
  • GC05P145855
  • GC05P145807
  • GC05P141093

Summaries for TCERG1 Gene

Entrez Gene Summary for TCERG1 Gene

  • This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCERG1 Gene

TCERG1 (Transcription Elongation Regulator 1) is a Protein Coding gene. Diseases associated with TCERG1 include Huntington Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include RNA polymerase II repressing transcription factor binding. An important paralog of this gene is TCERG1L.

UniProtKB/Swiss-Prot for TCERG1 Gene

  • Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.

Gene Wiki entry for TCERG1 Gene

Additional gene information for TCERG1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCERG1 Gene

Genomics for TCERG1 Gene

GeneHancer (GH) Regulatory Elements for TCERG1 Gene

Promoters and enhancers for TCERG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I146446 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 561.9 +0.5 516 2.5 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 TCERG1 RBM27 LARS GPR151 ENSG00000277568
GH05I145974 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 37.7 -468.1 -468065 9.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B NEUROD1 FEZF1 ZNF2 YY1 ZNF213 TCERG1 RBM27 SH3RF2 LARS GRXCR2 GC05P145976 LOC100431175
GH05I146181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.3 -264.9 -264877 2.5 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 LARS RBM27 TCERG1 GC05M146120
GH05I145833 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.9 -612.0 -612004 3.8 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B PRELID2 GRXCR2 LARS TCERG1 GC05M145704
GH05I146877 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 11.3 +431.2 431208 1.4 MXI1 ZNF449 ZNF223 ZNF2 ZNF335 ZFHX2 GLIS2 POLR2A ZBTB48 PATZ1 PPP2R2B RBM27 TCERG1 GC05P146882 GC05P146800
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCERG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCERG1 gene promoter:

Genomic Locations for TCERG1 Gene

Genomic Locations for TCERG1 Gene
chr5:146,447,310-146,511,961
(GRCh38/hg38)
Size:
64,652 bases
Orientation:
Plus strand
chr5:145,826,873-145,891,524
(GRCh37/hg19)

Genomic View for TCERG1 Gene

Genes around TCERG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCERG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCERG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCERG1 Gene

Proteins for TCERG1 Gene

  • Protein details for TCERG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14776-TCRG1_HUMAN
    Recommended name:
    Transcription elongation regulator 1
    Protein Accession:
    O14776
    Secondary Accessions:
    • Q2NKN2
    • Q59EA1

    Protein attributes for TCERG1 Gene

    Size:
    1098 amino acids
    Molecular mass:
    123901 Da
    Quaternary structure:
    • Binds formin (By similarity). Interacts (via the second WW domain) with TREX1 (via proline-rich region) (By similarity). Binds RNA polymerase II, HD and SF1.
    SequenceCaution:
    • Sequence=BAD93147.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TCERG1 Gene

    Alternative splice isoforms for TCERG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCERG1 Gene

Post-translational modifications for TCERG1 Gene

No data available for DME Specific Peptides for TCERG1 Gene

Domains & Families for TCERG1 Gene

Gene Families for TCERG1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TCERG1 Gene

Suggested Antigen Peptide Sequences for TCERG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14776

UniProtKB/Swiss-Prot:

TCRG1_HUMAN :
  • The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5).
Domain:
  • The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5).
  • The WW domains bind Pro-rich domains.
genes like me logo Genes that share domains with TCERG1: view

Function for TCERG1 Gene

Molecular function for TCERG1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.
UniProtKB/Swiss-Prot Induction:
Up-regulated in brain tissue from patients with Huntington disease.

Gene Ontology (GO) - Molecular Function for TCERG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001103 RNA polymerase II repressing transcription factor binding IPI 20956529
GO:0001106 RNA polymerase II transcription corepressor activity IDA 20956529
GO:0003713 transcription coactivator activity TAS 9315662
GO:0003723 RNA binding HDA,IDA 22658674
GO:0005515 protein binding IPI 15383276
genes like me logo Genes that share ontologies with TCERG1: view
genes like me logo Genes that share phenotypes with TCERG1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCERG1 Gene

Localization for TCERG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCERG1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCERG1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TCERG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 9315662
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TCERG1: view

Pathways & Interactions for TCERG1 Gene

SuperPathways for TCERG1 Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with TCERG1: view

Pathways by source for TCERG1 Gene

1 KEGG pathway for TCERG1 Gene

Gene Ontology (GO) - Biological Process for TCERG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 20956529
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 9315662
genes like me logo Genes that share ontologies with TCERG1: view

No data available for SIGNOR curated interactions for TCERG1 Gene

Drugs & Compounds for TCERG1 Gene

(1) Drugs for TCERG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TCERG1: view

Transcripts for TCERG1 Gene

Unigene Clusters for TCERG1 Gene

Transcription elongation regulator 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCERG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a ·
SP1: -
SP2:
SP3:
SP4: -
SP5: -
SP6:
SP7: - -
SP8: - -
SP9:
SP10:
SP11:
SP12: - -
SP13: - - - -
SP14:
SP15:
SP16:

ExUns: 15b · 15c · 15d ^ 16a · 16b ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b
SP1:
SP2: - - -
SP3: - -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for TCERG1 Gene

GeneLoc Exon Structure for
TCERG1
ECgene alternative splicing isoforms for
TCERG1

Expression for TCERG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCERG1 Gene

Protein differential expression in normal tissues from HIPED for TCERG1 Gene

This gene is overexpressed in Lymph node (19.0) and Peripheral blood mononuclear cells (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCERG1 Gene



Protein tissue co-expression partners for TCERG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCERG1 Gene:

TCERG1

SOURCE GeneReport for Unigene cluster for TCERG1 Gene:

Hs.443465

mRNA Expression by UniProt/SwissProt for TCERG1 Gene:

O14776-TCRG1_HUMAN
Tissue specificity: Detected in brain neurons.

Evidence on tissue expression from TISSUES for TCERG1 Gene

  • Nervous system(3.8)
  • Muscle(2)
genes like me logo Genes that share expression patterns with TCERG1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCERG1 Gene

Orthologs for TCERG1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCERG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCERG1 33 34
  • 99.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCERG1 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TCERG1 33 34
  • 95.8 (n)
cow
(Bos Taurus)
Mammalia TCERG1 33 34
  • 95.33 (n)
rat
(Rattus norvegicus)
Mammalia Tcerg1 33
  • 92.87 (n)
mouse
(Mus musculus)
Mammalia Tcerg1 33 16 34
  • 91.91 (n)
oppossum
(Monodelphis domestica)
Mammalia TCERG1 34
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves TCERG1 33 34
  • 82.41 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 84 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tcerg1 33
  • 75.18 (n)
Str.3267 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.5868 33
zebrafish
(Danio rerio)
Actinopterygii tcerg1a 33 34
  • 67.92 (n)
si:ch211-177d9.1 34
  • 20 (a)
ManyToMany
tcerg1 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10117 33
worm
(Caenorhabditis elegans)
Secernentea tcer-1 33 34
  • 51.72 (n)
ZK1127.6 35 34
  • 37 (a)
ZK1127.9a 35
  • 36 (a)
ZK1127.9b 35
  • 36 (a)
ZK1127.9c 35
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRP40 34
  • 20 (a)
OneToMany
Species where no ortholog for TCERG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCERG1 Gene

ENSEMBL:
Gene Tree for TCERG1 (if available)
TreeFam:
Gene Tree for TCERG1 (if available)

Paralogs for TCERG1 Gene

Paralogs for TCERG1 Gene

(1) SIMAP similar genes for TCERG1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TCERG1 Gene

genes like me logo Genes that share paralogs with TCERG1: view

Variants for TCERG1 Gene

Sequence variations from dbSNP and Humsavar for TCERG1 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000018874 -- 146,445,389(+) G/A upstream_transcript_variant
rs1000053478 -- 146,452,657(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000079418 -- 146,496,666(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000083994 -- 146,452,871(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000159995 -- 146,479,563(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TCERG1 Gene

Variant ID Type Subtype PubMed ID
esv3607077 CNV loss 21293372
esv2730879 CNV deletion 23290073
esv2677262 CNV deletion 23128226

Variation tolerance for TCERG1 Gene

Residual Variation Intolerance Score: 2.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCERG1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCERG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCERG1 Gene

Disorders for TCERG1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TCERG1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
huntington disease
  • hd
human immunodeficiency virus type 1
  • human immunodeficiency virus type 1, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TCERG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TCERG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCERG1 Gene

Publications for TCERG1 Gene

  1. CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription. (PMID: 9315662) Suñé C … Garcia-Blanco MA (Molecular and cellular biology 1997) 2 3 4 22 58
  2. General structural motifs of amyloid protofilaments. (PMID: 17060612) Ferguson N … Fersht AR (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 22 58
  3. FF domains of CA150 bind transcription and splicing factors through multiple weak interactions. (PMID: 15485897) Smith MJ … Pawson T (Molecular and cellular biology 2004) 3 4 22 58
  4. The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. (PMID: 11604498) Goldstrohm AC … Garcia-Blanco MA (Molecular and cellular biology 2001) 3 4 22 58
  5. The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. (PMID: 11172033) Holbert S … Néri C (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 22 58

Products for TCERG1 Gene

Sources for TCERG1 Gene

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