Aliases for TCEANC2 Gene

Aliases for TCEANC2 Gene

  • Transcription Elongation Factor A N-Terminal And Central Domain Containing 2 2 3 5
  • Transcription Elongation Factor A N-Terminal And Central Domain-Containing Protein 2 3 4
  • Transcription Elongation Factor A (SII) N-Terminal And Central Domain Containing 2 2 3
  • C1orf83 3 4
  • Chromosome 1 Open Reading Frame 83 2
  • FLJ32112 2
  • TCEANC2 5

External Ids for TCEANC2 Gene

Previous HGNC Symbols for TCEANC2 Gene

  • C1orf83

Previous GeneCards Identifiers for TCEANC2 Gene

  • GC01P054520

Summaries for TCEANC2 Gene

GeneCards Summary for TCEANC2 Gene

TCEANC2 (Transcription Elongation Factor A N-Terminal And Central Domain Containing 2) is a Protein Coding gene. Diseases associated with TCEANC2 include Breast Adenoid Cystic Carcinoma and Breast Secretory Carcinoma.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCEANC2 Gene

Genomics for TCEANC2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TCEANC2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCEANC2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCEANC2

Genomic Locations for TCEANC2 Gene

Latest Assembly
chr1:54,053,584-54,112,520
(GRCh38/hg38)
Size:
58,937 bases
Orientation:
Plus strand

Previous Assembly
chr1:54,519,281-54,578,193
(GRCh37/hg19 by Entrez Gene)
Size:
58,913 bases
Orientation:
Plus strand

chr1:54,519,260-54,578,192
(GRCh37/hg19 by Ensembl)
Size:
58,933 bases
Orientation:
Plus strand

Genomic View for TCEANC2 Gene

Genes around TCEANC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEANC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEANC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEANC2 Gene

Proteins for TCEANC2 Gene

  • Protein details for TCEANC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MN5-TEAN2_HUMAN
    Recommended name:
    Transcription elongation factor A N-terminal and central domain-containing protein 2
    Protein Accession:
    Q96MN5
    Secondary Accessions:
    • Q5T702
    • Q8N8N2

    Protein attributes for TCEANC2 Gene

    Size:
    208 amino acids
    Molecular mass:
    24150 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCEANC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEANC2 Gene

Post-translational modifications for TCEANC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEANC2 Gene

No data available for DME Specific Peptides for TCEANC2 Gene

Domains & Families for TCEANC2 Gene

Gene Families for TCEANC2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TCEANC2 Gene

Suggested Antigen Peptide Sequences for TCEANC2 Gene

GenScript: Design optimal peptide antigens:
  • Transcription elongation factor A N-terminal and central domain-containing protein 2 (TEAN2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96MN5

UniProtKB/Swiss-Prot:

TEAN2_HUMAN :
  • Belongs to the TCEANC2 family.
Family:
  • Belongs to the TCEANC2 family.
genes like me logo Genes that share domains with TCEANC2: view

Function for TCEANC2 Gene

Phenotypes From GWAS Catalog for TCEANC2 Gene

Gene Ontology (GO) - Molecular Function for TCEANC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TCEANC2: view
genes like me logo Genes that share phenotypes with TCEANC2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCEANC2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEANC2 Gene

Localization for TCEANC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEANC2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEANC2 gene
Compartment Confidence
nucleus 4
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCEANC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCEANC2: view

Pathways & Interactions for TCEANC2 Gene

PathCards logo

SuperPathways for TCEANC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEANC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEANC2: view

No data available for Pathways by source and SIGNOR curated interactions for TCEANC2 Gene

Drugs & Compounds for TCEANC2 Gene

No Compound Related Data Available

Transcripts for TCEANC2 Gene

mRNA/cDNA for TCEANC2 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCEANC2

Alternative Splicing Database (ASD) splice patterns (SP) for TCEANC2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for TCEANC2 Gene

GeneLoc Exon Structure for
TCEANC2

Expression for TCEANC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCEANC2 Gene

Protein differential expression in normal tissues from HIPED for TCEANC2 Gene

This gene is overexpressed in Lung (64.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCEANC2 Gene



Protein tissue co-expression partners for TCEANC2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCEANC2

SOURCE GeneReport for Unigene cluster for TCEANC2 Gene:

Hs.558618

Evidence on tissue expression from TISSUES for TCEANC2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TCEANC2: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEANC2 Gene

Orthologs for TCEANC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCEANC2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TCEANC2 29 30
  • 99.68 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TCEANC2 29 30
  • 93.11 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TCEANC2 29 30
  • 92.95 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tceanc2 29 16 30
  • 88.89 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tceanc2 29
  • 86.47 (n)
Oppossum
(Monodelphis domestica)
Mammalia TCEANC2 30
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TCEANC2 30
  • 63 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TCEANC2 29 30
  • 70.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TCEANC2 30
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5187 29
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.17785 29
Zebrafish
(Danio rerio)
Actinopterygii tceanc2 29 30
  • 63.93 (n)
OneToOne
Species where no ortholog for TCEANC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TCEANC2 Gene

ENSEMBL:
Gene Tree for TCEANC2 (if available)
TreeFam:
Gene Tree for TCEANC2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCEANC2: view image
Alliance of Genome Resources:
Additional Orthologs for TCEANC2

Paralogs for TCEANC2 Gene

No data available for Paralogs for TCEANC2 Gene

Variants for TCEANC2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TCEANC2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TCEANC2 Gene

Variant ID Type Subtype PubMed ID
nsv1011262 CNV gain 25217958
nsv475184 CNV novel sequence insertion 20440878
nsv945957 CNV duplication 23825009

Variation tolerance for TCEANC2 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCEANC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEANC2
Leiden Open Variation Database (LOVD)
TCEANC2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCEANC2 Gene

Disorders for TCEANC2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TCEANC2 Gene - From: COP

Disorder Aliases PubMed IDs
breast adenoid cystic carcinoma
  • adenoid cystic carcinoma of breast
breast secretory carcinoma
  • juvenile breast carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TCEANC2

genes like me logo Genes that share disorders with TCEANC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCEANC2 Gene

Publications for TCEANC2 Gene

  1. Prenatal mercury concentration is associated with changes in DNA methylation at TCEANC2 in newborns. (PMID: 25906783) Bakulski KM … Fallin MD (International journal of epidemiology 2015) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. (PMID: 30196744) Arbogast F … Gros F (Autophagy 2019) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

Products for TCEANC2 Gene

Sources for TCEANC2 Gene