Aliases for TCEANC Gene

Aliases for TCEANC Gene

  • Transcription Elongation Factor A N-Terminal And Central Domain Containing 2 3 5
  • Transcription Elongation Factor A N-Terminal And Central Domain-Containing Protein 3 4
  • Transcription Elongation Factor A (SII) N-Terminal And Central Domain Containing 2 3
  • TFIIS Central Domain-Containing Protein 1 3 4
  • TFS2-M Domain-Containing Protein 1 3
  • MGC17403 2
  • TCEANC 5

External Ids for TCEANC Gene

Previous GeneCards Identifiers for TCEANC Gene

  • GC0XP013582
  • GC0XP013584
  • GC0XP013671
  • GC0XP011429

Summaries for TCEANC Gene

GeneCards Summary for TCEANC Gene

TCEANC (Transcription Elongation Factor A N-Terminal And Central Domain Containing) is a Protein Coding gene. Diseases associated with TCEANC include Simpson-Golabi-Behmel Syndrome, Type 2 and Orofaciodigital Syndrome Vi. An important paralog of this gene is TCEA3.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCEANC Gene

Genomics for TCEANC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TCEANC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ013651 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas 267 0.0 -38 3.6 TBP SP1 FEZF1 MNT IKZF1 SMAD5 IRF2 BHLHE40 ELF1 ZIC2 TCEANC LOC107985657 lnc-TRAPPC2-1 EGFL6
GH0XJ013646 Enhancer 1.4 FANTOM5 Ensembl ENCODE 19.3 -4.7 -4672 5.3 MNT IKZF1 HES1 MBD2 CTCF BHLHE40 NONO ZIC2 ARNT ZNF395 GEMIN8 TCEANC RAB9A lnc-TRAPPC2-1 piR-32214-704 EGFL6
GH0XJ013687 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 10.9 +38.4 38410 7.1 TBP MNT IKZF1 SMAD5 BHLHE40 CTCF ZIC2 CEBPB SIN3A ZNF639 OFD1 RAB9A GPM6B TCEANC GLRA2 TRAPPC2 ATXN3L HSALNG0136723 HSALNG0136724
GH0XJ013658 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 17.3 +5.9 5875 1.5 CEBPA CTCF CEBPB REST TRIM22 EP300 SMC3 RAD21 RFX5 SMARCA5 TCEANC RAB9A LOC107985657 LOC107985656
GH0XJ013667 Enhancer 1.2 FANTOM5 ENCODE 15.5 +16.1 16051 2.9 SP1 BCL11A FEZF1 NR2C1 MNT IKZF1 IRF2 ZNF217 BRCA1 BHLHE40 lnc-RAB9A-2 TCEANC RAB9A LOC107985656 lnc-RAB9A-3 piR-61101-703
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCEANC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCEANC

Top Transcription factor binding sites by QIAGEN in the TCEANC gene promoter:
  • aMEF-2
  • C/EBPalpha
  • E47
  • Hand1
  • HOXA9
  • HOXA9B
  • MEF-2A
  • Meis-1
  • Meis-1b
  • SEF-1 (1)

Genomic Locations for TCEANC Gene

Latest Assembly
chrX:13,653,110-13,681,964
(GRCh38/hg38)
Size:
28,855 bases
Orientation:
Plus strand

Previous Assembly
chrX:13,671,260-13,683,528
(GRCh37/hg19 by Entrez Gene)
Size:
12,269 bases
Orientation:
Plus strand

chrX:13,671,225-13,700,083
(GRCh37/hg19 by Ensembl)
Size:
28,859 bases
Orientation:
Plus strand

Genomic View for TCEANC Gene

Genes around TCEANC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEANC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEANC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEANC Gene

Proteins for TCEANC Gene

  • Protein details for TCEANC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8B7-TEANC_HUMAN
    Recommended name:
    Transcription elongation factor A N-terminal and central domain-containing protein
    Protein Accession:
    Q8N8B7
    Secondary Accessions:
    • A6NI06
    • B2RDM3

    Protein attributes for TCEANC Gene

    Size:
    351 amino acids
    Molecular mass:
    40245 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04930.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TCEANC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEANC Gene

Post-translational modifications for TCEANC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCEANC Gene

Domains & Families for TCEANC Gene

Gene Families for TCEANC Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCEANC Gene

Suggested Antigen Peptide Sequences for TCEANC Gene

GenScript: Design optimal peptide antigens:
  • TFIIS central domain-containing protein 1 (TEANC_HUMAN)
genes like me logo Genes that share domains with TCEANC: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TCEANC Gene

Function for TCEANC Gene

Gene Ontology (GO) - Molecular Function for TCEANC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TCEANC: view
genes like me logo Genes that share phenotypes with TCEANC: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCEANC

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEANC Gene

Localization for TCEANC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEANC gene
Compartment Confidence
nucleus 4
mitochondrion 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCEANC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TCEANC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TCEANC Gene

Pathways & Interactions for TCEANC Gene

PathCards logo

SuperPathways for TCEANC Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEANC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TCEANC: view

No data available for Pathways by source and SIGNOR curated interactions for TCEANC Gene

Drugs & Compounds for TCEANC Gene

No Compound Related Data Available

Transcripts for TCEANC Gene

mRNA/cDNA for TCEANC Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCEANC

Alternative Splicing Database (ASD) splice patterns (SP) for TCEANC Gene

No ASD Table

Relevant External Links for TCEANC Gene

GeneLoc Exon Structure for
TCEANC

Expression for TCEANC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCEANC Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCEANC

SOURCE GeneReport for Unigene cluster for TCEANC Gene:

Hs.222855

Evidence on tissue expression from TISSUES for TCEANC Gene

  • Intestine(4.1)
  • Skin(4)
genes like me logo Genes that share expression patterns with TCEANC: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEANC Gene

Orthologs for TCEANC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCEANC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TCEANC 30 31
  • 99.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TCEANC 30 31
  • 84.3 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tceanc 30
  • 80.27 (n)
Mouse
(Mus musculus)
Mammalia Tceanc 30 17 31
  • 79.75 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TCEANC 30
  • 75.58 (n)
-- 31
  • 65 (a)
OneToMany
-- 31
  • 63 (a)
OneToMany
Chicken
(Gallus gallus)
Aves TCEANC 30 31
  • 62.74 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TCEANC 31
  • 42 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tceanc 30
  • 58.15 (n)
Str.12985 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.17490 30
Zebrafish
(Danio rerio)
Actinopterygii LOC100150588 30
  • 52.99 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG8117 31
  • 38 (a)
ManyToMany
TfIIS 31
  • 27 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea T24H10.1 31
  • 24 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DST1 31
  • 19 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2769 31
  • 24 (a)
OneToMany
Species where no ortholog for TCEANC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TCEANC Gene

ENSEMBL:
Gene Tree for TCEANC (if available)
TreeFam:
Gene Tree for TCEANC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCEANC: view image

Paralogs for TCEANC Gene

Paralogs for TCEANC Gene

(3) SIMAP similar genes for TCEANC Gene using alignment to 2 proteins:

  • TEANC_HUMAN
  • H0YF26_HUMAN
genes like me logo Genes that share paralogs with TCEANC: view

Variants for TCEANC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCEANC Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs2361159 - p.Ser163Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TCEANC Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for TCEANC Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCEANC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEANC

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEANC Gene

Disorders for TCEANC Gene

MalaCards: The human disease database

(3) MalaCards diseases for TCEANC Gene - From: COP

Disorder Aliases PubMed IDs
simpson-golabi-behmel syndrome, type 2
  • sgbs2
orofaciodigital syndrome vi
  • ofd6
kallmann syndrome
  • familial hypogonadism with anosmia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TCEANC

genes like me logo Genes that share disorders with TCEANC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCEANC Gene

Publications for TCEANC Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3

Products for TCEANC Gene

Sources for TCEANC Gene