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Aliases for TCEAL6 Gene

Aliases for TCEAL6 Gene

  • Transcription Elongation Factor A Like 6 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 6 3 4
  • Transcription Elongation Factor A (SII)-Like 6 2 3
  • TCEA-Like Protein 6 3 4
  • Transcription Elongation Factor A Protein-Like 6 3
  • Transcription Elongation Factor A (SII)-Like 3 3
  • Tceal3 3
  • WEX2 3

External Ids for TCEAL6 Gene

Previous GeneCards Identifiers for TCEAL6 Gene

  • GC0XM101202
  • GC0XM101281
  • GC0XM101394
  • GC0XM091203

Summaries for TCEAL6 Gene

GeneCards Summary for TCEAL6 Gene

TCEAL6 (Transcription Elongation Factor A Like 6) is a Protein Coding gene. An important paralog of this gene is TCEAL3.

UniProtKB/Swiss-Prot for TCEAL6 Gene

  • May be involved in transcriptional regulation.

Additional gene information for TCEAL6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL6 Gene

Genomics for TCEAL6 Gene

GeneHancer (GH) Regulatory Elements for TCEAL6 Gene

Promoters and enhancers for TCEAL6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI102142 Promoter 0.6 EPDnew 550.8 +0.5 504 0.1 EZH2 GC0XM102141 LOC105373299 TCEAL6
GH0XI101930 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 3.9 +211.3 211294 2.1 ATF1 ZNF48 YY1 ATF7 SP3 NFYC REST ZNF592 ATF4 GMEB1 ZMAT1 BEX5 TCEAL6 RNU6-345P
GH0XI102154 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 0.4 -12.7 -12709 1.8 HDGF CTCF ATF1 SP2 MTA1 POLR2A CREB1 CREM BEX5 NXF2 NXF2B TCEAL6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCEAL6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCEAL6 gene promoter:

Genomic Locations for TCEAL6 Gene

Genomic Locations for TCEAL6 Gene
3,010 bases
Minus strand

Genomic View for TCEAL6 Gene

Genes around TCEAL6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL6 Gene

Proteins for TCEAL6 Gene

  • Protein details for TCEAL6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcription elongation factor A protein-like 6
    Protein Accession:
    Secondary Accessions:
    • Q5H9J8

    Protein attributes for TCEAL6 Gene

    200 amino acids
    Molecular mass:
    22298 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCEAL6 Gene


neXtProt entry for TCEAL6 Gene

Post-translational modifications for TCEAL6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEAL6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEAL6 Gene

Domains & Families for TCEAL6 Gene

Gene Families for TCEAL6 Gene

Protein Domains for TCEAL6 Gene


Suggested Antigen Peptide Sequences for TCEAL6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TFS-II family. TFA subfamily.
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL6: view

Function for TCEAL6 Gene

Molecular function for TCEAL6 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for TCEAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050699 WW domain binding IBA --
genes like me logo Genes that share ontologies with TCEAL6: view

Phenotypes for TCEAL6 Gene

GenomeRNAi human phenotypes for TCEAL6:
genes like me logo Genes that share phenotypes with TCEAL6: view

Animal Model Products

CRISPR Products

miRNA for TCEAL6 Gene

miRTarBase miRNAs that target TCEAL6

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL6 Gene

Localization for TCEAL6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL6 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TCEAL6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCEAL6 Gene

Pathways & Interactions for TCEAL6 Gene

SuperPathways for TCEAL6 Gene

No Data Available

Interacting Proteins for TCEAL6 Gene

Selected Interacting proteins: Q6IPX3-TCAL6_HUMAN for TCEAL6 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TCEAL6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0006414 translational elongation IEA --
genes like me logo Genes that share ontologies with TCEAL6: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL6 Gene

Drugs & Compounds for TCEAL6 Gene

No Compound Related Data Available

Transcripts for TCEAL6 Gene

mRNA/cDNA for TCEAL6 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCEAL6 Gene

Transcription elongation factor A (SII)-like 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL6 Gene

No ASD Table

Relevant External Links for TCEAL6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCEAL6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCEAL6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCEAL6 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.1), Brain - Cerebellar Hemisphere (x4.9), Brain - Hypothalamus (x4.8), Pituitary (x4.6), Brain - Cortex (x4.6), and Brain - Anterior cingulate cortex (BA24) (x4.4).

Protein differential expression in normal tissues from HIPED for TCEAL6 Gene

This gene is overexpressed in Adrenal (38.4) and Heart (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCEAL6 Gene

Protein tissue co-expression partners for TCEAL6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCEAL6 Gene:


SOURCE GeneReport for Unigene cluster for TCEAL6 Gene:


Evidence on tissue expression from TISSUES for TCEAL6 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TCEAL6: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL6 Gene

Orthologs for TCEAL6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TCEAL3 33
  • 96.15 (n)
  • 87 (a)
(Mus musculus)
Mammalia Tceal3 33 34
  • 79.26 (n)
Tceal6 16 34
  • 62 (a)
Tceal5 34
  • 60 (a)
(Canis familiaris)
Mammalia -- 34
  • 73 (a)
-- 34
  • 72 (a)
-- 34
  • 69 (a)
-- 34
  • 68 (a)
Species where no ortholog for TCEAL6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL6 Gene

Gene Tree for TCEAL6 (if available)
Gene Tree for TCEAL6 (if available)

Paralogs for TCEAL6 Gene

Paralogs for TCEAL6 Gene

(7) SIMAP similar genes for TCEAL6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEAL6: view

Variants for TCEAL6 Gene

Sequence variations from dbSNP and Humsavar for TCEAL6 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1003094769 -- 102,144,155(-) T/C upstream_transcript_variant
rs1006282966 -- 102,144,134(-) A/G upstream_transcript_variant
rs1007411663 -- 102,143,383(-) C/T upstream_transcript_variant
rs1007918859 -- 102,143,683(-) G/A upstream_transcript_variant
rs1010822725 -- 102,140,278(-) G/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TCEAL6 Gene

Variant ID Type Subtype PubMed ID
nsv1076269 CNV deletion 25765185
nsv469670 CNV loss 16826518

Variation tolerance for TCEAL6 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCEAL6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEAL6 Gene

Disorders for TCEAL6 Gene

Additional Disease Information for TCEAL6

No disorders were found for TCEAL6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL6 Gene

Publications for TCEAL6 Gene

  1. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening. (PMID: 22379092) Shamay M … Hayward SD (Journal of virology 2012) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TCEAL6 Gene

Sources for TCEAL6 Gene

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