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Aliases for TCEAL5 Gene

Aliases for TCEAL5 Gene

  • Transcription Elongation Factor A Like 5 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 5 3 4
  • Transcription Elongation Factor A (SII)-Like 5 2 3
  • TCEA-Like Protein 5 3 4
  • Transcription Elongation Factor A Protein-Like 5 3
  • WEX4 3

External Ids for TCEAL5 Gene

Previous GeneCards Identifiers for TCEAL5 Gene

  • GC0XM102334
  • GC0XM102415
  • GC0XM102528
  • GC0XM092191

Summaries for TCEAL5 Gene

Entrez Gene Summary for TCEAL5 Gene

  • This gene, which is located on the X chromosome, encodes a protein which contains a BEX (brain expressed X-liked like family) domain. This domain is found in proteins encoded by the TCEAL elongation factor (transcription elongation factor A (SII)-like) gene family also located on the X chromosome. The coding region for this gene is located entirely in the terminal exon. [provided by RefSeq, Sep 2011]

GeneCards Summary for TCEAL5 Gene

TCEAL5 (Transcription Elongation Factor A Like 5) is a Protein Coding gene. An important paralog of this gene is TCEAL3.

UniProtKB/Swiss-Prot for TCEAL5 Gene

  • May be involved in transcriptional regulation.

Additional gene information for TCEAL5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL5 Gene

Genomics for TCEAL5 Gene

GeneHancer (GH) Regulatory Elements for TCEAL5 Gene

Promoters and enhancers for TCEAL5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI103276 Promoter/Enhancer 0.9 EPDnew ENCODE 550.8 +0.1 51 0.2 PKNOX1 EZH2 TCEAL5 LOC100420653
GH0XI103403 Promoter/Enhancer 1.4 Ensembl ENCODE 12.2 -127.9 -127925 1.6 HDAC1 ATF1 SIN3A BMI1 ZBTB40 YY1 ZNF335 ATF7 CREM SMAD5 LL0XNC01-250H12.3 ENSG00000281091 BEX4 TCEAL5 BEX3 PIR37216
GH0XI103151 Enhancer 1.2 Ensembl ENCODE 11.2 +124.6 124563 1.3 ARNT NEUROD1 FEZF1 GLI4 BRCA1 ZNF2 ZBTB7B TCF12 ZNF121 GLIS2 GPRASP1 BEX4 TCEAL3 ELF2P1 TMSB15B ZCCHC18 GPRASP2 BEX3 TCEAL7 TCEAL1
GH0XI103251 Enhancer 0.7 ENCODE 12.5 +25.7 25684 0.2 MEIS2 ATF1 ETV1 TEAD4 TAL1 JUN ZBTB40 TCF12 GATA3 CTBP1 TCEAL5 TCEAL8 GC0XM103234
GH0XI103310 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 0.3 -34.0 -34039 1.4 HDAC1 ATF1 SIN3A POLR2B GLIS2 EGR1 ZNF366 ATF7 CREM EGR2 BEX2 BEX4 BEX1 GPRASP2 TCEAL5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCEAL5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCEAL5 gene promoter:

Genomic Locations for TCEAL5 Gene

Genomic Locations for TCEAL5 Gene
chrX:103,273,690-103,276,872
(GRCh38/hg38)
Size:
3,183 bases
Orientation:
Minus strand
chrX:102,528,618-102,531,800
(GRCh37/hg19)

Genomic View for TCEAL5 Gene

Genes around TCEAL5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL5 Gene

Proteins for TCEAL5 Gene

  • Protein details for TCEAL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H9L2-TCAL5_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 5
    Protein Accession:
    Q5H9L2
    Secondary Accessions:
    • A2RUJ4

    Protein attributes for TCEAL5 Gene

    Size:
    206 amino acids
    Molecular mass:
    23307 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL5 Gene

Post-translational modifications for TCEAL5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEAL5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEAL5 Gene

Domains & Families for TCEAL5 Gene

Gene Families for TCEAL5 Gene

Protein Domains for TCEAL5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5H9L2

UniProtKB/Swiss-Prot:

TCAL5_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL5: view

Function for TCEAL5 Gene

Molecular function for TCEAL5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for TCEAL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0050699 WW domain binding IBA --
genes like me logo Genes that share ontologies with TCEAL5: view

Phenotypes for TCEAL5 Gene

MGI mutant phenotypes for TCEAL5:
inferred from 1 alleles
GenomeRNAi human phenotypes for TCEAL5:
genes like me logo Genes that share phenotypes with TCEAL5: view

Animal Models for TCEAL5 Gene

MGI Knock Outs for TCEAL5:

miRNA for TCEAL5 Gene

miRTarBase miRNAs that target TCEAL5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCEAL5 Gene

Localization for TCEAL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL5 gene
Compartment Confidence
nucleus 4
mitochondrion 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCEAL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TCEAL5: view

Pathways & Interactions for TCEAL5 Gene

SuperPathways for TCEAL5 Gene

No Data Available

Interacting Proteins for TCEAL5 Gene

Gene Ontology (GO) - Biological Process for TCEAL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with TCEAL5: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL5 Gene

Drugs & Compounds for TCEAL5 Gene

No Compound Related Data Available

Transcripts for TCEAL5 Gene

mRNA/cDNA for TCEAL5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TCEAL5 Gene

Transcription elongation factor A (SII)-like 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL5 Gene

No ASD Table

Relevant External Links for TCEAL5 Gene

GeneLoc Exon Structure for
TCEAL5
ECgene alternative splicing isoforms for
TCEAL5

Expression for TCEAL5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCEAL5 Gene

mRNA differential expression in normal tissues according to GTEx for TCEAL5 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.4), Brain - Anterior cingulate cortex (BA24) (x4.3), and Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for TCEAL5 Gene

This gene is overexpressed in Adrenal (32.1) and Testis (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCEAL5 Gene



Protein tissue co-expression partners for TCEAL5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCEAL5 Gene:

TCEAL5

SOURCE GeneReport for Unigene cluster for TCEAL5 Gene:

Hs.403462

Evidence on tissue expression from TISSUES for TCEAL5 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with TCEAL5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL5 Gene

Orthologs for TCEAL5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL5 33 34
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia TCEAL5 33
  • 86.08 (n)
-- 34
  • 83 (a)
ManyToMany
-- 34
  • 82 (a)
ManyToMany
-- 34
  • 80 (a)
ManyToMany
-- 34
  • 80 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia TCEAL3 33
  • 83.73 (n)
mouse
(Mus musculus)
Mammalia Tceal5 33 16 34
  • 79.73 (n)
Tceal6 34
  • 70 (a)
ManyToMany
Tceal3 34
  • 69 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tceal5 33
  • 79.23 (n)
Species where no ortholog for TCEAL5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL5 Gene

ENSEMBL:
Gene Tree for TCEAL5 (if available)
TreeFam:
Gene Tree for TCEAL5 (if available)

Paralogs for TCEAL5 Gene

Paralogs for TCEAL5 Gene

(7) SIMAP similar genes for TCEAL5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEAL5: view

Variants for TCEAL5 Gene

Sequence variations from dbSNP and Humsavar for TCEAL5 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000146119 -- 103,274,871(-) A/G intron_variant
rs1002614609 -- 103,277,747(-) T/C upstream_transcript_variant
rs1003618018 -- 103,275,571(-) G/A intron_variant
rs1003808938 -- 103,276,344(-) G/A intron_variant
rs1005868285 -- 103,278,162(-) C/A upstream_transcript_variant

Variation tolerance for TCEAL5 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.37; 70.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCEAL5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL5 Gene

Disorders for TCEAL5 Gene

Additional Disease Information for TCEAL5

No disorders were found for TCEAL5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL5 Gene

Publications for TCEAL5 Gene

  1. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. A comprehensive resource of interacting protein regions for refining human transcription factor networks. (PMID: 20195357) Miyamoto-Sato E … Yanagawa H (PloS one 2010) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TCEAL5 Gene

Sources for TCEAL5 Gene

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