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Aliases for TCEAL3 Gene

Aliases for TCEAL3 Gene

  • Transcription Elongation Factor A Like 3 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 3 3 4
  • Transcription Elongation Factor A (SII)-Like 3 2 3
  • TCEA-Like Protein 3 3 4
  • Transcription Elongation Factor A Protein-Like 3 3
  • WEX8 3

External Ids for TCEAL3 Gene

Previous GeneCards Identifiers for TCEAL3 Gene

  • GC0XP102668
  • GC0XP102862
  • GC0XP092518

Summaries for TCEAL3 Gene

Entrez Gene Summary for TCEAL3 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL3 Gene

TCEAL3 (Transcription Elongation Factor A Like 3) is a Protein Coding gene. An important paralog of this gene is TCEAL5.

UniProtKB/Swiss-Prot for TCEAL3 Gene

  • May be involved in transcriptional regulation.

Additional gene information for TCEAL3 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL3 Gene

Genomics for TCEAL3 Gene

GeneHancer (GH) Regulatory Elements for TCEAL3 Gene

Promoters and enhancers for TCEAL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI103607 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 550.8 +0.8 802 1.9 PKNOX1 KLF1 USF1 ZNF507 ZNF335 ZFHX2 GLIS2 POLR2A PATZ1 ZBTB20 GC0XM103601 TCEAL3 BEX3 TCEAL3-AS1 LOC105373302
GH0XI103151 Enhancer 1.2 Ensembl ENCODE 23.2 -455.1 -455142 1.3 ARNT NEUROD1 FEZF1 GLI4 BRCA1 ZNF2 ZBTB7B TCF12 ZNF121 GLIS2 GPRASP1 BEX4 TCEAL3 ELF2P1 TMSB15B ZCCHC18 GPRASP2 BEX3 TCEAL7 TCEAL1
GH0XI103584 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 13.9 -21.6 -21630 2.5 HDGF USF1 MLX SIN3A YY1 ZNF507 HIC1 ZNF335 ZFHX2 GLIS2 TCEAL4 LOC105373300 TCEAL3 TCEAL1 TCEAL3-AS1 BEX4 ENSG00000279894
GH0XI103655 Enhancer 1 Ensembl ENCODE 13.2 +50.2 50235 4.2 NCOA3 SOX13 FOXA2 JUN MAX BRCA1 RFX5 ZFHX2 CTBP1 GATA3 MORF4L2-AS1 MORF4L2 TCEAL3 TCEAL1 TCEAL3-AS1 PLP1 BEX4 BEX2 RAB40A LOC100130176
GH0XI103637 Enhancer 0.7 Ensembl ENCODE 13.6 +31.1 31076 2.2 RFX1 RFX3 MYNN FOSL2 FOS ZIC2 ZBTB17 TCEAL3 TCEAL4 PLP1 BEX4 BEX2 LOC105373302 LOC100130176
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCEAL3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCEAL3 gene promoter:

Genomic Locations for TCEAL3 Gene

Genomic Locations for TCEAL3 Gene
chrX:103,607,451-103,629,690
(GRCh38/hg38)
Size:
22,240 bases
Orientation:
Plus strand
chrX:102,862,379-102,884,618
(GRCh37/hg19)

Genomic View for TCEAL3 Gene

Genes around TCEAL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL3 Gene

Proteins for TCEAL3 Gene

  • Protein details for TCEAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969E4-TCAL3_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 3
    Protein Accession:
    Q969E4
    Secondary Accessions:
    • D3DXA4

    Protein attributes for TCEAL3 Gene

    Size:
    200 amino acids
    Molecular mass:
    22502 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL3 Gene

Post-translational modifications for TCEAL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TCEAL3 Gene

No data available for DME Specific Peptides for TCEAL3 Gene

Domains & Families for TCEAL3 Gene

Gene Families for TCEAL3 Gene

Protein Domains for TCEAL3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969E4

UniProtKB/Swiss-Prot:

TCAL3_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL3: view

Function for TCEAL3 Gene

Molecular function for TCEAL3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for TCEAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050699 WW domain binding IBA --
genes like me logo Genes that share ontologies with TCEAL3: view

Phenotypes for TCEAL3 Gene

genes like me logo Genes that share phenotypes with TCEAL3: view

Animal Model Products

miRNA for TCEAL3 Gene

miRTarBase miRNAs that target TCEAL3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL3 Gene

Localization for TCEAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL3 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TCEAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TCEAL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCEAL3 Gene

Pathways & Interactions for TCEAL3 Gene

SuperPathways for TCEAL3 Gene

No Data Available

Interacting Proteins for TCEAL3 Gene

Selected Interacting proteins: Q969E4-TCAL3_HUMAN for TCEAL3 Gene via IID

Gene Ontology (GO) - Biological Process for TCEAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with TCEAL3: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL3 Gene

Drugs & Compounds for TCEAL3 Gene

No Compound Related Data Available

Transcripts for TCEAL3 Gene

Unigene Clusters for TCEAL3 Gene

Transcription elongation factor A (SII)-like 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2:
SP3:
SP4: -

Relevant External Links for TCEAL3 Gene

GeneLoc Exon Structure for
TCEAL3
ECgene alternative splicing isoforms for
TCEAL3

Expression for TCEAL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCEAL3 Gene

Protein differential expression in normal tissues from HIPED for TCEAL3 Gene

This gene is overexpressed in Adrenal (19.6), Uterus (7.4), and Skin (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TCEAL3 Gene



Protein tissue co-expression partners for TCEAL3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCEAL3 Gene:

TCEAL3

SOURCE GeneReport for Unigene cluster for TCEAL3 Gene:

Hs.311776

Evidence on tissue expression from TISSUES for TCEAL3 Gene

  • Eye(4.3)
  • Skin(4.2)
  • Stomach(4.2)
  • Nervous system(2.6)
  • Heart(2.3)
  • Spleen(2.3)
  • Kidney(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with TCEAL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL3 Gene

Orthologs for TCEAL3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL3 33 34
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 85 (a)
ManyToMany
-- 34
  • 83 (a)
ManyToMany
-- 34
  • 77 (a)
ManyToMany
-- 34
  • 77 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tceal6 33
  • 79.29 (n)
mouse
(Mus musculus)
Mammalia Tceal6 34
  • 74 (a)
ManyToMany
Tceal3 34
  • 73 (a)
ManyToMany
Tceal5 34
  • 69 (a)
ManyToMany
Species where no ortholog for TCEAL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL3 Gene

ENSEMBL:
Gene Tree for TCEAL3 (if available)
TreeFam:
Gene Tree for TCEAL3 (if available)

Paralogs for TCEAL3 Gene

Paralogs for TCEAL3 Gene

(5) SIMAP similar genes for TCEAL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEAL3: view

Variants for TCEAL3 Gene

Sequence variations from dbSNP and Humsavar for TCEAL3 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000217403 -- 103,606,100(+) A/G upstream_transcript_variant
rs1001408916 -- 103,606,646(+) T/C upstream_transcript_variant
rs1002526248 -- 103,608,639(+) A/C 5_prime_UTR_variant
rs1003079255 -- 103,609,118(+) A/G coding_sequence_variant, synonymous_variant
rs1005537597 -- 103,606,711(+) A/T upstream_transcript_variant

Variation tolerance for TCEAL3 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.28; 6.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCEAL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL3 Gene

Disorders for TCEAL3 Gene

Additional Disease Information for TCEAL3

No disorders were found for TCEAL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL3 Gene

Publications for TCEAL3 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TCEAL3 Gene

Sources for TCEAL3 Gene

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