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Aliases for TCEAL2 Gene

Aliases for TCEAL2 Gene

  • Transcription Elongation Factor A Like 2 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 2 3 4
  • Transcription Elongation Factor A (SII)-Like 2 2 3
  • TCEA-Like Protein 2 3 4
  • Transcription Elongation Factor A Protein-Like 2 3
  • MY0876G05 3
  • My048 3
  • WEX1 3

External Ids for TCEAL2 Gene

Previous GeneCards Identifiers for TCEAL2 Gene

  • GC0XP101186
  • GC0XP101267
  • GC0XP101380
  • GC0XP091188

Summaries for TCEAL2 Gene

Entrez Gene Summary for TCEAL2 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL2 Gene

TCEAL2 (Transcription Elongation Factor A Like 2) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway. An important paralog of this gene is TCEAL4.

UniProtKB/Swiss-Prot for TCEAL2 Gene

  • May be involved in transcriptional regulation.

Additional gene information for TCEAL2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEAL2 Gene

Genomics for TCEAL2 Gene

GeneHancer (GH) Regulatory Elements for TCEAL2 Gene

Promoters and enhancers for TCEAL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI102126 Promoter/Enhancer 0.7 EPDnew Ensembl 550.8 +0.3 336 0.4 TCEAL2 GC0XM102141
GH0XI102125 Promoter 0.5 EPDnew 550.8 0.0 -28 0.1 TCEAL2 MTND6P13
GH0XI102958 Enhancer 0.5 ENCODE 6.4 +833.9 833908 1.7 MITF CTCF USF1 MAX USF2 REST ZNF507 BEX4 TCEAL2 ENSG00000234050 GC0XM102944
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCEAL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCEAL2 gene promoter:

Genomic Locations for TCEAL2 Gene

Genomic Locations for TCEAL2 Gene
chrX:102,125,688-102,127,712
(GRCh38/hg38)
Size:
2,025 bases
Orientation:
Plus strand
chrX:101,380,660-101,382,684
(GRCh37/hg19)

Genomic View for TCEAL2 Gene

Genes around TCEAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL2 Gene

Proteins for TCEAL2 Gene

  • Protein details for TCEAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3H9-TCAL2_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 2
    Protein Accession:
    Q9H3H9
    Secondary Accessions:
    • B2R5C7

    Protein attributes for TCEAL2 Gene

    Size:
    227 amino acids
    Molecular mass:
    25850 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL2 Gene

Post-translational modifications for TCEAL2 Gene

  • Ubiquitination at posLast=154154
  • Modification sites at PhosphoSitePlus

Other Protein References for TCEAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEAL2 Gene

Domains & Families for TCEAL2 Gene

Gene Families for TCEAL2 Gene

Protein Domains for TCEAL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3H9

UniProtKB/Swiss-Prot:

TCAL2_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL2: view

Function for TCEAL2 Gene

Molecular function for TCEAL2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for TCEAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050699 WW domain binding IBA --
genes like me logo Genes that share ontologies with TCEAL2: view
genes like me logo Genes that share phenotypes with TCEAL2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCEAL2 Gene

Localization for TCEAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCEAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TCEAL2: view

Pathways & Interactions for TCEAL2 Gene

SuperPathways for TCEAL2 Gene

SuperPathway Contained pathways
1 Mesodermal Commitment Pathway
genes like me logo Genes that share pathways with TCEAL2: view

Pathways by source for TCEAL2 Gene

1 BioSystems pathway for TCEAL2 Gene

Gene Ontology (GO) - Biological Process for TCEAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with TCEAL2: view

No data available for SIGNOR curated interactions for TCEAL2 Gene

Drugs & Compounds for TCEAL2 Gene

No Compound Related Data Available

Transcripts for TCEAL2 Gene

mRNA/cDNA for TCEAL2 Gene

Unigene Clusters for TCEAL2 Gene

Transcription elongation factor A (SII)-like 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL2 Gene

No ASD Table

Relevant External Links for TCEAL2 Gene

GeneLoc Exon Structure for
TCEAL2
ECgene alternative splicing isoforms for
TCEAL2

Expression for TCEAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCEAL2 Gene

Protein differential expression in normal tissues from HIPED for TCEAL2 Gene

This gene is overexpressed in Bone (28.1), Fetal Brain (13.1), Ovary (11.2), Retina (6.4), and Frontal cortex (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCEAL2 Gene



Protein tissue co-expression partners for TCEAL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCEAL2 Gene:

TCEAL2

SOURCE GeneReport for Unigene cluster for TCEAL2 Gene:

Hs.401835

Evidence on tissue expression from TISSUES for TCEAL2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TCEAL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL2 Gene

Orthologs for TCEAL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCEAL2 34 33
  • 99.41 (n)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 59 (a)
OneToMany
Species where no ortholog for TCEAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TCEAL2 Gene

ENSEMBL:
Gene Tree for TCEAL2 (if available)
TreeFam:
Gene Tree for TCEAL2 (if available)

Paralogs for TCEAL2 Gene

Paralogs for TCEAL2 Gene

(4) SIMAP similar genes for TCEAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TCEAL2: view

Variants for TCEAL2 Gene

Sequence variations from dbSNP and Humsavar for TCEAL2 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1002652533 -- 102,123,699(+) T/C upstream_transcript_variant
rs1002947265 -- 102,123,855(+) A/T upstream_transcript_variant
rs1003859511 -- 102,128,128(+) G/C downstream_transcript_variant
rs1004756457 -- 102,127,132(+) A/G coding_sequence_variant, missense_variant
rs1009060999 -- 102,125,668(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TCEAL2 Gene

Variant ID Type Subtype PubMed ID
nsv469670 CNV loss 16826518

Variation tolerance for TCEAL2 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCEAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEAL2 Gene

Disorders for TCEAL2 Gene

Additional Disease Information for TCEAL2

No disorders were found for TCEAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL2 Gene

Publications for TCEAL2 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. (PMID: 28218735) Kamran M … Liu Q (Oncogenesis 2017) 3 58

Products for TCEAL2 Gene

Sources for TCEAL2 Gene

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