This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. [provided by RefSeq, Jul 2008] See more...

Aliases for TCEAL2 Gene

Aliases for TCEAL2 Gene

  • Transcription Elongation Factor A Like 2 2 3 5
  • Transcription Elongation Factor S-II Protein-Like 2 3 4
  • Transcription Elongation Factor A Protein-Like 2 3 4
  • Transcription Elongation Factor A (SII)-Like 2 2 3
  • TCEA-Like Protein 2 3 4
  • MY0876G05 2 3
  • My048 2 3
  • WEX1 2 3
  • TCEAL2 5

External Ids for TCEAL2 Gene

Previous GeneCards Identifiers for TCEAL2 Gene

  • GC0XP101186
  • GC0XP101267
  • GC0XP101380
  • GC0XP091188

Summaries for TCEAL2 Gene

Entrez Gene Summary for TCEAL2 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL2 Gene

TCEAL2 (Transcription Elongation Factor A Like 2) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway. An important paralog of this gene is TCEAL4.

UniProtKB/Swiss-Prot Summary for TCEAL2 Gene

Additional gene information for TCEAL2 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCEAL2 Gene

Genomics for TCEAL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TCEAL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ102125 Promoter 0.8 EPDnew Ensembl 629 +0.3 322 1.6 TOE1 TCEAL2 HSALNG0139241 GPRASP1 BEX5 TCEAL6 lnc-BEX5-1
GH0XJ102976 Enhancer 0.7 Ensembl ENCODE 7.4 +851.8 851821 4.2 GATA3 SPI1 TCF7L2 CREM ATF3 ATF1 ATF2 EGR2 BEX4 TCEAL2 lnc-RAB40AL-3 lnc-RAB40AL-1 RAB40AL BEX1
GH0XJ102958 Enhancer 0.7 Ensembl ENCODE 6.4 +834.0 833988 1.9 REST USF1 CTCF TOE1 RAD21 MAX RAD51 USF2 lnc-RAB40AL-1 BEX4 TCEAL2 RAB40AL lnc-RAB40AL-3 BEX1 LINC00630
GH0XJ101948 Enhancer 0.3 Ensembl 3.8 -176.9 -176878 0.8 SPI1 BEX5 TCEAL6 TCEAL2 ZMAT1 piR-57461-306 hsa-miR-5095-539
GH0XJ102142 Promoter 0.8 EPDnew Ensembl 0.4 +16.4 16422 1 EZH2 ENSG00000286794 LOC105373299 TCEAL6 lnc-BEX5-1 BEX5 GPRASP1 TCEAL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCEAL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCEAL2

Top Transcription factor binding sites by QIAGEN in the TCEAL2 gene promoter:
  • c-Myc
  • CREB
  • deltaCREB
  • HTF
  • Max
  • Max1
  • RFX1
  • RORalpha2
  • USF-1
  • USF1

Genomic Locations for TCEAL2 Gene

Genomic Locations for TCEAL2 Gene
chrX:102,125,679-102,140,426
(GRCh38/hg38)
Size:
14,748 bases
Orientation:
Plus strand
chrX:101,380,660-101,382,684
(GRCh37/hg19)
Size:
2,025 bases
Orientation:
Plus strand

Genomic View for TCEAL2 Gene

Genes around TCEAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL2 Gene

Proteins for TCEAL2 Gene

  • Protein details for TCEAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3H9-TCAL2_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 2
    Protein Accession:
    Q9H3H9
    Secondary Accessions:
    • B2R5C7

    Protein attributes for TCEAL2 Gene

    Size:
    227 amino acids
    Molecular mass:
    25850 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TCEAL2 Gene

Post-translational modifications for TCEAL2 Gene

  • Ubiquitination at Lys154
  • Modification sites at PhosphoSitePlus

Other Protein References for TCEAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TCEAL2 Gene

Domains & Families for TCEAL2 Gene

Gene Families for TCEAL2 Gene

Protein Domains for TCEAL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TCEAL2 Gene

GenScript: Design optimal peptide antigens:
  • Transcription elongation factor S-II protein-like 2 (TCAL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H3H9

UniProtKB/Swiss-Prot:

TCAL2_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL2: view

Function for TCEAL2 Gene

Molecular function for TCEAL2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for TCEAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050699 WW domain binding IBA 21873635
genes like me logo Genes that share ontologies with TCEAL2: view
genes like me logo Genes that share phenotypes with TCEAL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCEAL2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TCEAL2 Gene

Localization for TCEAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL2 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCEAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with TCEAL2: view

Pathways & Interactions for TCEAL2 Gene

PathCards logo

SuperPathways for TCEAL2 Gene

SuperPathway Contained pathways
1 Mesodermal Commitment Pathway
genes like me logo Genes that share pathways with TCEAL2: view

Pathways by source for TCEAL2 Gene

1 BioSystems pathway for TCEAL2 Gene

Gene Ontology (GO) - Biological Process for TCEAL2 Gene

None

No data available for SIGNOR curated interactions for TCEAL2 Gene

Drugs & Compounds for TCEAL2 Gene

No Compound Related Data Available

Transcripts for TCEAL2 Gene

mRNA/cDNA for TCEAL2 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCEAL2

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL2 Gene

No ASD Table

Relevant External Links for TCEAL2 Gene

GeneLoc Exon Structure for
TCEAL2

Expression for TCEAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCEAL2 Gene

Protein differential expression in normal tissues from HIPED for TCEAL2 Gene

This gene is overexpressed in Bone (28.1), Fetal Brain (13.1), Ovary (11.2), Retina (6.4), and Frontal cortex (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TCEAL2 Gene



Protein tissue co-expression partners for TCEAL2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCEAL2

SOURCE GeneReport for Unigene cluster for TCEAL2 Gene:

Hs.401835

Evidence on tissue expression from TISSUES for TCEAL2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TCEAL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL2 Gene

Orthologs for TCEAL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TCEAL2 30 31
  • 99.41 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 59 (a)
OneToMany
Species where no ortholog for TCEAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TCEAL2 Gene

ENSEMBL:
Gene Tree for TCEAL2 (if available)
TreeFam:
Gene Tree for TCEAL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCEAL2: view image

Paralogs for TCEAL2 Gene

Paralogs for TCEAL2 Gene

(4) SIMAP similar genes for TCEAL2 Gene using alignment to 1 proteins:

  • TCAL2_HUMAN
genes like me logo Genes that share paralogs with TCEAL2: view

Variants for TCEAL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCEAL2 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs34924423 - p.Asp19Gly
rs5944856 - p.Gly68Ala

Additional dbSNP identifiers (rs#s) for TCEAL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for TCEAL2 Gene

Variant ID Type Subtype PubMed ID
nsv469670 CNV loss 16826518

Variation tolerance for TCEAL2 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.09; 22.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCEAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEAL2 Gene

Disorders for TCEAL2 Gene

Additional Disease Information for TCEAL2

No disorders were found for TCEAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEAL2 Gene

Publications for TCEAL2 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. (PMID: 16221301) Winter EE … Ponting CP (BMC evolutionary biology 2005) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. (PMID: 29676528) Khanna R … Parnaik VK (The FEBS journal 2018) 3
  5. Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. (PMID: 28218735) Kamran M … Liu Q (Oncogenesis 2017) 3

Products for TCEAL2 Gene

Sources for TCEAL2 Gene