This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a seque... See more...

Aliases for TCEAL1 Gene

Aliases for TCEAL1 Gene

  • Transcription Elongation Factor A Like 1 2 3 5
  • SIIR 2 3 4
  • P21 2 2 3
  • Transcription Elongation Factor S-II Protein-Like 1 3 4
  • Transcription Elongation Factor A Protein-Like 1 3 4
  • Transcription Elongation Factor A (SII)-Like 1 2 3
  • Nuclear Phosphoprotein P21/SIIR 3 4
  • TCEA-Like Protein 1 3 4
  • WEX9 2 3
  • Pp21 2 3
  • TCEAL1 5

External Ids for TCEAL1 Gene

Previous GeneCards Identifiers for TCEAL1 Gene

  • GC0XP098185
  • GC0XP099792
  • GC0XP100916
  • GC0XP101655
  • GC0XP102690
  • GC0XP102770
  • GC0XP102883
  • GC0XP092540

Summaries for TCEAL1 Gene

Entrez Gene Summary for TCEAL1 Gene

  • This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

GeneCards Summary for TCEAL1 Gene

TCEAL1 (Transcription Elongation Factor A Like 1) is a Protein Coding gene. Diseases associated with TCEAL1 include Plasmodium Ovale Malaria. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is TCEAL8.

UniProtKB/Swiss-Prot Summary for TCEAL1 Gene

  • May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.

Gene Wiki entry for TCEAL1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCEAL1 Gene

Genomics for TCEAL1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TCEAL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ103628 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.7 696 3.2 IKZF1 ZNF600 POLR2A ZIC2 ZBTB10 YY1 SMAD5 BHLHE40 ZNF341 KLF7 LOC105373302 HSALNG0139322 TCEAL1 TCEAL3-AS1 BEX4 lnc-TCEAL3-1 TCEAL3 MORF4L2
GH0XJ103627 Promoter 0.3 EPDnew 250.7 -1.6 -1643 0.1 HSALNG0139322 TCEAL1 TCEAL3-AS1 LOC105373302 HSALNG0139319 TCEAL3 lnc-TCEAL3-1
GH0XJ103584 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE CraniofacialAtlas 12.8 -42.8 -42818 2.6 POLR2A YY1 BHLHE40 SIN3A KLF9 KDM5A TAF1 RAD51 REST ZNF350 TCEAL4 ENSG00000287619 NONHSAG055037.2 TCEAL3 TCEAL1 TCEAL3-AS1 BEX4 piR-52772-007
GH0XJ103151 Enhancer 1.1 Ensembl ENCODE 12.8 -476.3 -476303 1.6 MYC IKZF1 ZNF600 JUND ATF2 ATF3 NFIC CEBPB FEZF1 ZNF639 GPRASP1 BEX4 TMSB15B TCEAL1 ELF2P1 TCEAL3 MORF4L2 LINC00630 TCEAL4 BEX1
GH0XJ103655 Enhancer 0.9 Ensembl ENCODE 12.6 +29.0 28982 4.2 ATF2 BRCA1 CEBPB MAX ZNF217 EP300 MBD2 FOXA2 CTBP1 RFX5 MORF4L2-AS1 MORF4L2 TCEAL3 TCEAL1 TCEAL3-AS1 PLP1 BEX4 BEX2 RAB40A piR-34093-039
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCEAL1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCEAL1

Top Transcription factor binding sites by QIAGEN in the TCEAL1 gene promoter:
  • ATF
  • FOXD3
  • GATA-3
  • p53
  • POU6F1 (c2)

Genomic Locations for TCEAL1 Gene

Latest Assembly
chrX:103,628,704-103,630,953
(GRCh38/hg38)
Size:
2,250 bases
Orientation:
Plus strand

Previous Assembly
chrX:102,883,644-102,885,881
(GRCh37/hg19 by Entrez Gene)
Size:
2,238 bases
Orientation:
Plus strand

chrX:102,883,632-102,885,881
(GRCh37/hg19 by Ensembl)
Size:
2,250 bases
Orientation:
Plus strand

Genomic View for TCEAL1 Gene

Genes around TCEAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEAL1 Gene

Proteins for TCEAL1 Gene

  • Protein details for TCEAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15170-TCAL1_HUMAN
    Recommended name:
    Transcription elongation factor A protein-like 1
    Protein Accession:
    Q15170
    Secondary Accessions:
    • Q9UJQ9

    Protein attributes for TCEAL1 Gene

    Size:
    157 amino acids
    Molecular mass:
    18354 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCEAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEAL1 Gene

Post-translational modifications for TCEAL1 Gene

  • Phosphorylation of Ser-36 and Ser-37 is critical for transcriptional repression.
  • Ubiquitination at Lys136
  • Modification sites at PhosphoSitePlus

Other Protein References for TCEAL1 Gene

No data available for DME Specific Peptides for TCEAL1 Gene

Domains & Families for TCEAL1 Gene

Gene Families for TCEAL1 Gene

Protein Domains for TCEAL1 Gene

InterPro:

Suggested Antigen Peptide Sequences for TCEAL1 Gene

GenScript: Design optimal peptide antigens:
  • Transcription elongation factor S-II protein-like 1 (TCAL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15170

UniProtKB/Swiss-Prot:

TCAL1_HUMAN :
  • Belongs to the TFS-II family. TFA subfamily.
Family:
  • Belongs to the TFS-II family. TFA subfamily.
genes like me logo Genes that share domains with TCEAL1: view

Function for TCEAL1 Gene

Molecular function for TCEAL1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.
GENATLAS Biochemistry:
transcription elongation factor A-like 1,widely expressed,modulating transcription in a promoter context-dependent fashion

Gene Ontology (GO) - Molecular Function for TCEAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI --
GO:0050699 WW domain binding IBA 21873635
genes like me logo Genes that share ontologies with TCEAL1: view
genes like me logo Genes that share phenotypes with TCEAL1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCEAL1

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEAL1 Gene

Localization for TCEAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEAL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEAL1 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TCEAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 7971997
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TCEAL1: view

Pathways & Interactions for TCEAL1 Gene

PathCards logo

SuperPathways for TCEAL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCEAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010629 NOT negative regulation of gene expression TAS 7971997
genes like me logo Genes that share ontologies with TCEAL1: view

No data available for Pathways by source and SIGNOR curated interactions for TCEAL1 Gene

Drugs & Compounds for TCEAL1 Gene

(3) Drugs for TCEAL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for TCEAL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TCEAL1: view

Transcripts for TCEAL1 Gene

mRNA/cDNA for TCEAL1 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCEAL1

Alternative Splicing Database (ASD) splice patterns (SP) for TCEAL1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - -
SP6:

Relevant External Links for TCEAL1 Gene

GeneLoc Exon Structure for
TCEAL1

Expression for TCEAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCEAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCEAL1 Gene

This gene is overexpressed in Urinary Bladder (16.3), Ovary (13.1), Prostate (11.1), Testis (8.2), and Blymphocyte (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TCEAL1 Gene



Protein tissue co-expression partners for TCEAL1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCEAL1

SOURCE GeneReport for Unigene cluster for TCEAL1 Gene:

Hs.95243

mRNA Expression by UniProt/SwissProt for TCEAL1 Gene:

Q15170-TCAL1_HUMAN
Tissue specificity: Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle. Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines.

Evidence on tissue expression from TISSUES for TCEAL1 Gene

  • Nervous system(2.5)
  • Intestine(2.3)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with TCEAL1: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEAL1 Gene

Orthologs for TCEAL1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TCEAL1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TCEAL1 29 30
  • 99.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TCEAL1 29 30
  • 88.89 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TCEAL1 29 30
  • 84.28 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tceal1 29 16 30
  • 74.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tceal1 29
  • 74.21 (n)
Species where no ortholog for TCEAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for TCEAL1 Gene

ENSEMBL:
Gene Tree for TCEAL1 (if available)
TreeFam:
Gene Tree for TCEAL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCEAL1: view image
Alliance of Genome Resources:
Additional Orthologs for TCEAL1

Paralogs for TCEAL1 Gene

Paralogs for TCEAL1 Gene

(3) SIMAP similar genes for TCEAL1 Gene using alignment to 1 proteins:

  • TCAL1_HUMAN
genes like me logo Genes that share paralogs with TCEAL1: view

Variants for TCEAL1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCEAL1 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs34421776 -- p.Arg5Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TCEAL1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for TCEAL1 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCEAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEAL1
Leiden Open Variation Database (LOVD)
TCEAL1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TCEAL1 Gene

Disorders for TCEAL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCEAL1 Gene - From: COP

Disorder Aliases PubMed IDs
plasmodium ovale malaria
  • malariaby plasmodium ovale
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TCEAL1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TCEAL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCEAL1 Gene

Publications for TCEAL1 Gene

  1. A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII. (PMID: 8206389) Yeh CH … Shatkin AJ (Gene 1994) 2 3 4 22
  2. Polymorphisms in cell cycle regulatory genes, urinary arsenic profile and urothelial carcinoma. (PMID: 18640142) Chung CJ … Hsueh YM (Toxicology and applied pharmacology 2008) 3 40
  3. Polymorphisms of p53 and p21 genes in chronic obstructive pulmonary disease. (PMID: 16697770) Lee YL … Wang YC (The Journal of laboratory and clinical medicine 2006) 3 40
  4. TP53 and P21 polymorphisms: response to cisplatinum/paclitaxel-based chemotherapy in ovarian cancer. (PMID: 16364249) Santos AM … Medeiros R (Biochemical and biophysical research communications 2006) 3 40
  5. Association between TP53 and p21 genetic polymorphisms and acute side effects of radiotherapy in breast cancer patients. (PMID: 16331344) Tan XL … Chang-Claude J (Breast cancer research and treatment 2006) 3 40

Products for TCEAL1 Gene

Sources for TCEAL1 Gene