Aliases for TCEA2 Gene
Aliases for TCEA2 Gene
- Transcription Elongation Factor A2 2 3 5
- Transcription Elongation Factor S-II Protein 2 3 4
- Transcription Elongation Factor A (SII), 2 2 3
- Transcription Elongation Factor TFIIS.L 3 4
- Testis-Specific S-II 3 4
- Transcription Elongation Factor A Protein 2 3
- Transcription Elongation Factor TFIIS.1 3
- TFIIS 3
External Ids for TCEA2 Gene
- HGNC: 11614
- Entrez Gene: 6919
- Ensembl: ENSG00000171703
- OMIM: 604784
- UniProtKB: Q15560
Previous GeneCards Identifiers for TCEA2 Gene
- GC20P062572
- GC20P063367
- GC20P063420
- GC20P063414
- GC20P062158
- GC20P062681
- GC20P059422
- GC20P064049
- GC20P064050
- GC20P064073
- GC20P064074
Summaries for TCEA2 Gene
-
The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCEA2 Gene
TCEA2 (Transcription Elongation Factor A2) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and translation elongation factor activity. An important paralog of this gene is TCEA1.
UniProtKB/Swiss-Prot for TCEA2 Gene
-
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCEA2 Gene
Genomics for TCEA2 Gene
GeneHancer (GH) Regulatory Elements for TCEA2 Gene
Promoters and enhancers for TCEA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TCEA2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TCEA2 gene promoter:
Regulatory Element Products
Genomic Locations for TCEA2 Gene
Genomic Locations for TCEA2 Gene
- chr20:64,042,350-64,072,347
- (GRCh38/hg38)
- Size:
- 29,998 bases
- Orientation:
- Plus strand
- chr20:62,681,189-62,703,700
- (GRCh37/hg19)
Genomic View for TCEA2 Gene
Genes around TCEA2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.33 by Ensembl
- 20q13.33 by Entrez Gene
- 20q13.33 by HGNC
TCEA2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TCEA2 Gene
Proteins for TCEA2 Gene
-
Protein details for TCEA2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q15560-TCEA2_HUMAN
- Recommended name:
- Transcription elongation factor A protein 2
- Protein Accession:
- Q15560
- B3KNM1
- Q8TD37
- Q8TD38
Protein attributes for TCEA2 Gene
- Size:
- 299 amino acids
- Molecular mass:
- 33601 Da
- Quaternary structure:
-
- Interacts with the basal transcription factor GTF2B. Interacts with REXO1.
- SequenceCaution:
-
- Sequence=CAD11900.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAD11901.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for TCEA2 Gene
Post-translational modifications for TCEA2 Gene
Other Protein References for TCEA2 Gene
Antibody Products
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-
Abcam antibodies for TCEA2
-
Cloud-Clone Corp. Antibodies for TCEA2
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-
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-
Abcam proteins for TCEA2
Assay Products
No data available for DME Specific Peptides for TCEA2 Gene
Domains & Families for TCEA2 Gene
Gene Families for TCEA2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TCEA2 Gene
Suggested Antigen Peptide Sequences for TCEA2 Gene
Graphical View of Domain Structure for InterPro Entry
Q15560- Family:
-
- Belongs to the TFS-II family.
Function for TCEA2 Gene
Molecular function for TCEA2 Gene
- GENATLAS Biochemistry:
- transcription elongation factor A,RNA polymerase II,SII class,testis specific
- UniProtKB/Swiss-Prot Function:
- Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus.
Phenotypes From GWAS Catalog for TCEA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003746 | translation elongation factor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16169070 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for TCEA2 Gene
- GenomeRNAi human phenotypes for TCEA2:
Animal Model Products
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-
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-
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- Overview of 111 available TCEA2 gene related products
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miRNA for TCEA2 Gene
- miRTarBase miRNAs that target TCEA2
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Inhibitory RNA Products
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TCEA2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for TCEA2
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCEA2 Gene
Localization for TCEA2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TCEA2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 2 |
| cytosol | 2 |
- Centrosome (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0008023 | transcription elongation factor complex | NAS | 8566795 |
Pathways & Interactions for TCEA2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RNA Polymerase II Transcription Initiation And Promoter Clearance | ||
Pathways by source for TCEA2 Gene
1 Qiagen pathway for TCEA2 Gene
Interacting Proteins for TCEA2 Gene
Selected Interacting proteins:
ENSP00000343515
Q15560-TCEA2_HUMAN
for TCEA2 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006354 | DNA-templated transcription, elongation | NAS | 8566795 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006414 | translational elongation | IEA | -- |
| GO:0032784 | regulation of DNA-templated transcription, elongation | NAS | 8566795 |
No data available for SIGNOR curated interactions for TCEA2 Gene
Transcripts for TCEA2 Gene
mRNA/cDNA for TCEA2 Gene
- (8) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (244) Selected AceView cDNA sequences:
- (17) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TCEA2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TCEA2
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TCEA2
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miRNA Products
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Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TCEA2
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ViGene Biosciences ready-to-package AAV shRNAs for TCEA2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TCEA2
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TCEA2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for TCEA2 Gene
This gene is overexpressed in Plasma (43.8) and Ovary (19.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCEA2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TCEA2 Gene:
TCEA2SOURCE GeneReport for Unigene cluster for TCEA2 Gene:
Hs.505004mRNA Expression by UniProt/SwissProt for TCEA2 Gene:
Q15560-TCEA2_HUMAN
Tissue specificity:
Testis and ovary specific.
Evidence on tissue expression from TISSUES for TCEA2 Gene
- Nervous system(4.8)
- Liver(4.3)
- Skin(4.2)
Primer Products
-
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-
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Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEA2 Gene
Orthologs for TCEA2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TCEA2 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | TCEA2 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | TCEA2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tcea2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tcea2 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TCEA2 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TCEA2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TCEA2 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398066 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tcea2 34 33 |
|
OneToOne | |
| zgc56325 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | TfIIS 35 34 |
|
||
| CG8117 35 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | T24H10.1 35 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AGR011W 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DST1 33 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F09361g 33 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU02563 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.2769 34 |
|
OneToMany | |
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tfs1 33 |
|
- Species where no ortholog for TCEA2 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for TCEA2 Gene
(7) SIMAP similar genes for TCEA2 Gene using alignment to 6 proteins:
Variants for TCEA2 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs28936692 | pathogenic, Hypotrichosis-lymphedema-telangiectasia syndrome | 64,049,207(+) | C/G | genic_upstream_transcript_variant, intron_variant | |
| rs28936693 | pathogenic, Hypotrichosis-lymphedema-telangiectasia syndrome | 64,049,234(+) | A/T | genic_upstream_transcript_variant, intron_variant | |
| rs74315430 | pathogenic, Glomerulonephritis with sparse hair and telangiectases | 64,048,601(+) | G/T | genic_upstream_transcript_variant, intron_variant | |
| rs794728015 | pathogenic, Hypotrichosis-lymphedema-telangiectasia syndrome | 64,048,840(+) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs144785707 | benign, not specified | 64,049,274(+) | G/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4345n100 | CNV | gain | 25217958 |
| dgv7701n54 | CNV | loss | 21841781 |
| esv1663265 | CNV | insertion | 17803354 |
| esv2758807 | CNV | gain+loss | 17122850 |
| nsv428381 | CNV | gain+loss | 18775914 |
| nsv470564 | CNV | gain | 18288195 |
| nsv509785 | CNV | insertion | 20534489 |
| nsv586703 | CNV | loss | 21841781 |
| nsv586732 | CNV | loss | 21841781 |
| nsv953310 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.62;
31.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TCEA2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TCEA2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCEA2 Gene
Disorders for TCEA2 Gene
Additional Disease Information for TCEA2
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TCEA2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCEA2 Gene
Publications for TCEA2 Gene
- Genomic characterization of a testis-specific TFIIS (TCEA2) gene. (PMID: 9441762) Weaver ZA … Kane CM (Genomics 1997) 2 3 4 22 58
- Isolation and characterization of a cDNA encoding a new type of human transcription elongation factor S-II. (PMID: 8566795) Umehara T … Horikoshi M (Gene 1995) 2 3 4 58
- A negative elongation factor for human RNA polymerase II inhibits the anti-arrest transcript-cleavage factor TFIIS. (PMID: 16214896) Palangat M … Landick R (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 22 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for TCEA2 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 37 available TCEA2 Antibodies ranked by validation data
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Sources for TCEA2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
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