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The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
TCEA2 (Transcription Elongation Factor A2) is a Protein Coding gene. Diseases associated with TCEA2 include Hypotrichosis-Lymphedema-Telangiectasia Syndrome and Uv-Sensitive Syndrome. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and translation elongation factor activity. An important paralog of this gene is TCEA1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003746 | translation elongation factor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 16169070 |
GO:0008270 | zinc ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0008023 | transcription elongation factor complex | NAS | 8566795 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Transcription of mRNA
.91
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006351 | transcription, DNA-templated | IEA | -- |
GO:0006354 | DNA-templated transcription, elongation | NAS | 8566795 |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006414 | translational elongation | IEA | -- |
GO:0032784 | regulation of DNA-templated transcription, elongation | NAS | 8566795 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TCEA2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TCEA2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TCEA2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tcea2 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tcea2 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TCEA2 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TCEA2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TCEA2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
African clawed frog (Xenopus laevis) |
Amphibia | LOC398066 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tcea2 30 31 |
|
OneToOne | |
zgc56325 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG8117 31 32 |
|
ManyToMany | |
TfIIS 31 32 |
|
ManyToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | T24H10.1 31 32 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGR011W 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | DST1 30 31 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F09361g 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU02563 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.2769 31 |
|
OneToMany | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tfs1 30 |
|
SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
709170 | Benign: not provided | 64,048,912(+) | C/T | MISSENSE_VARIANT | |
730441 | Likely Benign: not provided | 64,048,322(+) | G/A | SYNONYMOUS_VARIANT | |
749628 | Likely Benign: not provided | 64,049,445(+) | C/G | SYNONYMOUS_VARIANT | |
754921 | Likely Benign: not provided | 64,048,172(+) | G/A | SYNONYMOUS_VARIANT | |
765354 | Likely Benign: not provided | 64,048,307(+) | G/C | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4345n100 | CNV | gain | 25217958 |
dgv7701n54 | CNV | loss | 21841781 |
esv1663265 | CNV | insertion | 17803354 |
esv2758807 | CNV | gain+loss | 17122850 |
nsv428381 | CNV | gain+loss | 18775914 |
nsv470564 | CNV | gain | 18288195 |
nsv509785 | CNV | insertion | 20534489 |
nsv586703 | CNV | loss | 21841781 |
nsv586732 | CNV | loss | 21841781 |
nsv953310 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hypotrichosis-lymphedema-telangiectasia syndrome |
|
|
uv-sensitive syndrome |
|
|
xeroderma pigmentosum, variant type |
|
|