Aliases for TCEA1 Gene
External Ids for TCEA1 Gene
Previous HGNC Symbols for TCEA1 Gene
Previous GeneCards Identifiers for TCEA1 Gene
GeneCards Summary for TCEA1 Gene
TCEA1 (Transcription Elongation Factor A1) is a Protein Coding gene. Diseases associated with TCEA1 include Cockayne Syndrome and Perforated Corneal Ulcer. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and HIV Transcription Elongation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and translation elongation factor activity. An important paralog of this gene is TCEA2.
UniProtKB/Swiss-Prot Summary for TCEA1 Gene
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.