Aliases for TCEA1 Gene

Aliases for TCEA1 Gene

  • Transcription Elongation Factor A1 2 3 5
  • TFIIS 2 3 4
  • Transcription Elongation Factor S-II Protein 1 3 4
  • Transcription Elongation Factor A Protein 1 3 4
  • Transcription Elongation Factor A (SII), 1 2 3
  • Transcription Elongation Factor TFIIS.O 3 4
  • Transcription Factor IIS 2 3
  • GTF2S 3 4
  • TF2S 2 3
  • SII 2 3
  • Epididymis Secretory Sperm Binding Protein 3
  • TCEA1 5
  • TCEA 3

External Ids for TCEA1 Gene

Previous HGNC Symbols for TCEA1 Gene

  • TCEA
  • GTF2S

Previous GeneCards Identifiers for TCEA1 Gene

  • GC03P036581
  • GC08M054818
  • GC08M054582
  • GC08M054929
  • GC08M055041
  • GC08M050347
  • GC08M054879

Summaries for TCEA1 Gene

GeneCards Summary for TCEA1 Gene

TCEA1 (Transcription Elongation Factor A1) is a Protein Coding gene. Diseases associated with TCEA1 include Cockayne Syndrome and Perforated Corneal Ulcer. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and HIV Transcription Elongation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and translation elongation factor activity. An important paralog of this gene is TCEA2.

UniProtKB/Swiss-Prot Summary for TCEA1 Gene

  • Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.

Gene Wiki entry for TCEA1 Gene

Additional gene information for TCEA1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCEA1 Gene

Genomics for TCEA1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TCEA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCEA1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TCEA1

Top Transcription factor binding sites by QIAGEN in the TCEA1 gene promoter:
  • AREB6
  • COMP1
  • FOXI1
  • HFH-1
  • HFH-3
  • HNF-3beta
  • Pax-2
  • Pax-2a
  • POU2F1
  • POU2F1a

Genomic Locations for TCEA1 Gene

Genomic Locations for TCEA1 Gene
chr8:53,966,552-54,022,456
(GRCh38/hg38)
Size:
55,905 bases
Orientation:
Minus strand
chr8:54,879,112-54,935,089
(GRCh37/hg19)
Size:
55,978 bases
Orientation:
Minus strand

Genomic View for TCEA1 Gene

Genes around TCEA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCEA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCEA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCEA1 Gene

Proteins for TCEA1 Gene

  • Protein details for TCEA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23193-TCEA1_HUMAN
    Recommended name:
    Transcription elongation factor A protein 1
    Protein Accession:
    P23193
    Secondary Accessions:
    • A6NF25
    • A8K339
    • Q15563
    • Q6FG87

    Protein attributes for TCEA1 Gene

    Size:
    301 amino acids
    Molecular mass:
    33970 Da
    Quaternary structure:
    • Interacts with EAF2 (By similarity). Associates with UBR5 and forms a transcription regulatory complex made of CDK9, RNAP II, UBR5 and TFIIS/TCEA1 that can stimulate target gene transcription (e.g. gamma fibrinogen/FGG) by recruiting their promoters.
    Miscellaneous:
    • S-II binds to RNA-polymerase II in the absence of transcription.

    Three dimensional structures from OCA and Proteopedia for TCEA1 Gene

    Alternative splice isoforms for TCEA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCEA1 Gene

Post-translational modifications for TCEA1 Gene

  • Ubiquitination at Lys29, Lys55, Lys67, and Lys252
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TCEA1 Gene

Domains & Families for TCEA1 Gene

Gene Families for TCEA1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Protein Domains for TCEA1 Gene

InterPro:
Blocks:
  • Transcription elongation factor S-II, N-terminal
ProtoNet:

Suggested Antigen Peptide Sequences for TCEA1 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51251, moderately similar to Transcription elongation factor A protein 1 (B7Z4S1_HUMAN)
  • Transcription elongation factor TFIIS.o (TCEA1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P23193

UniProtKB/Swiss-Prot:

TCEA1_HUMAN :
  • Belongs to the TFS-II family.
Family:
  • Belongs to the TFS-II family.
genes like me logo Genes that share domains with TCEA1: view

Function for TCEA1 Gene

Molecular function for TCEA1 Gene

UniProtKB/Swiss-Prot Function:
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.
GENATLAS Biochemistry:
transcription elongation factor A for RNA polymerase II,SII class,widely expressed,fused with PLAG1 in translocation (3;8)(p21;q12) in salivary tumors (see PSA2)

Phenotypes From GWAS Catalog for TCEA1 Gene

Gene Ontology (GO) - Molecular Function for TCEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003746 translation elongation factor activity IEA --
GO:0005515 protein binding IPI 20178742
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TCEA1: view
genes like me logo Genes that share phenotypes with TCEA1: view

Animal Models for TCEA1 Gene

MGI Knock Outs for TCEA1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCEA1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCEA1 Gene

Localization for TCEA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCEA1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCEA1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA,TAS --
GO:0005669 transcription factor TFIID complex IDA 27193682
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with TCEA1: view

Pathways & Interactions for TCEA1 Gene

genes like me logo Genes that share pathways with TCEA1: view

Pathways by source for TCEA1 Gene

SIGNOR curated interactions for TCEA1 Gene

Activates:

Gene Ontology (GO) - Biological Process for TCEA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006283 transcription-coupled nucleotide-excision repair TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TCEA1: view

Drugs & Compounds for TCEA1 Gene

No Compound Related Data Available

Transcripts for TCEA1 Gene

mRNA/cDNA for TCEA1 Gene

2 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TCEA1

Alternative Splicing Database (ASD) splice patterns (SP) for TCEA1 Gene

No ASD Table

Relevant External Links for TCEA1 Gene

GeneLoc Exon Structure for
TCEA1

Expression for TCEA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TCEA1 Gene

Protein differential expression in normal tissues from HIPED for TCEA1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.9) and Lymph node (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TCEA1 Gene



Protein tissue co-expression partners for TCEA1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TCEA1

SOURCE GeneReport for Unigene cluster for TCEA1 Gene:

Hs.491745

Evidence on tissue expression from TISSUES for TCEA1 Gene

  • Nervous system(4.8)
  • Liver(4.5)
  • Kidney(4.5)
  • Blood(4.5)
  • Skin(2.9)
  • Heart(2.6)
  • Muscle(2.5)
  • Intestine(2.5)
  • Lung(2.4)
  • Spleen(2.4)
  • Thyroid gland(2.3)
  • Lymph node(2.2)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with TCEA1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCEA1 Gene

Orthologs for TCEA1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TCEA1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TCEA1 30 31
  • 99.89 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TCEA1 30 31
  • 93.56 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 93 (a)
OneToMany
-- 31
  • 92 (a)
OneToMany
-- 31
  • 90 (a)
OneToMany
-- 31
  • 89 (a)
OneToMany
-- 31
  • 87 (a)
OneToMany
-- 31
  • 83 (a)
OneToMany
-- 31
  • 81 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia LOC498453 30
  • 92.14 (n)
Mouse
(Mus musculus)
Mammalia Tcea1 30 17 31
  • 92 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TCEA1 30 31
  • 90.03 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TCEA1 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TCEA1 30 31
  • 82.11 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TCEA1 31
  • 87 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tcea1 30
  • 75.08 (n)
MGC76031 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.238 30
Zebrafish
(Danio rerio)
Actinopterygii tcea1 30 31
  • 74.11 (n)
OneToOne
wufj48e12 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1255 30
Fruit Fly
(Drosophila melanogaster)
Insecta TfIIS 31 32
  • 49 (a)
ManyToMany
CG8117 31 32
  • 48 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea T24H10.1 30 31 32
  • 55.51 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DST1 31
  • 28 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons TFIIS 30
  • 52.93 (n)
Rice
(Oryza sativa)
Liliopsida Os07g0229700 30
  • 45.91 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2769 31
  • 47 (a)
OneToMany
Species where no ortholog for TCEA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for TCEA1 Gene

ENSEMBL:
Gene Tree for TCEA1 (if available)
TreeFam:
Gene Tree for TCEA1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCEA1: view image

Paralogs for TCEA1 Gene

Paralogs for TCEA1 Gene

(4) SIMAP similar genes for TCEA1 Gene using alignment to 6 proteins:

  • TCEA1_HUMAN
  • B7Z4S1_HUMAN
  • E5RFI1_HUMAN
  • E5RIS7_HUMAN
  • E5RJ93_HUMAN
  • E5RK46_HUMAN

Pseudogenes.org Pseudogenes for TCEA1 Gene

genes like me logo Genes that share paralogs with TCEA1: view

Variants for TCEA1 Gene

Additional dbSNP identifiers (rs#s) for TCEA1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TCEA1 Gene

Variant ID Type Subtype PubMed ID
esv2487551 CNV deletion 19546169
esv2759617 CNV gain 17122850
esv3576573 CNV gain 25503493
nsv477561 CNV novel sequence insertion 20440878

Variation tolerance for TCEA1 Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCEA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCEA1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TCEA1 Gene

Disorders for TCEA1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TCEA1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cockayne syndrome
  • cs
perforated corneal ulcer
exudative vitreoretinopathy 1
  • evr1
uv-sensitive syndrome
  • uv sensitive syndrome
chronic closed-angle glaucoma
  • anatomical narrow angle glaucoma
- elite association - COSMIC cancer census association via MalaCards
Search TCEA1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TCEA1_HUMAN
  • Note=A chromosomal aberration involving TCEA1 may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(3;8)(p21;q12) with PLAG1. {ECO:0000269 PubMed:10029085}.

Additional Disease Information for TCEA1

genes like me logo Genes that share disorders with TCEA1: view

No data available for Genatlas for TCEA1 Gene

Publications for TCEA1 Gene

  1. Transcription elongation factor SII (TCEA) maps to human chromosome 3p22 --> p21.3. (PMID: 8812434) DiMarco SP … Warren ST (Genomics 1996) 2 3 23
  2. Characterization of the gene encoding the human transcriptional elongation factor TFIIS. (PMID: 8112616) Park H … Yoo O (Gene 1994) 2 3 4
  3. Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B. (PMID: 21127351) Cojocaru M … Coulombe B (The Journal of biological chemistry 2011) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for TCEA1 Gene

Sources for TCEA1 Gene