This pseudogene is located downstream from the growth hormone locus on chromosome 17. This locus evolved by a series of partial duplications that have disrupted the human gene. A homologous gene in mouse encodes a testis-specific cell adhesion protein that may play a role in germ cell-Sertoli cell interactions. [provided by RefSeq, Apr 2012] See more...

Aliases for TCAM1P Gene

Aliases for TCAM1P Gene

  • Testicular Cell Adhesion Molecule 1, Pseudogene 2 3 5
  • Testicular Cell Adhesion Molecule 1 Homolog (Mouse), Pseudogene 2
  • Testicular Cell Adhesion Molecule 1 Homolog, Pseudogene 3
  • Testicular Cell Adhesion Molecule 1 Homolog (Mouse) 2
  • TCAM1 3

External Ids for TCAM1P Gene

Previous HGNC Symbols for TCAM1P Gene

  • TCAM1

Previous GeneCards Identifiers for TCAM1P Gene

  • GC17P061927

Summaries for TCAM1P Gene

Entrez Gene Summary for TCAM1P Gene

  • This pseudogene is located downstream from the growth hormone locus on chromosome 17. This locus evolved by a series of partial duplications that have disrupted the human gene. A homologous gene in mouse encodes a testis-specific cell adhesion protein that may play a role in germ cell-Sertoli cell interactions. [provided by RefSeq, Apr 2012]

GeneCards Summary for TCAM1P Gene

TCAM1P (Testicular Cell Adhesion Molecule 1, Pseudogene) is a Pseudogene.

Additional gene information for TCAM1P Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TCAM1P Gene

Genomics for TCAM1P Gene

GeneHancer (GH) Regulatory Elements for TCAM1P Gene

Promoters and enhancers for TCAM1P Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J063848 Promoter/Enhancer 1.8 Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 -0.1 -100 1.5 SP1 ZBTB40 SIX5 RBPJ SMARCE1 POLR2A CTBP1 USF2 HDAC2 ATF1 TCAM1P lnc-PSMC5-7 DDX42 FTSJ3 CEP95 POLG2 CSH2 DDX5 SMARCD2 EEF1DP7
GH17J063600 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 9.9 -248.0 -248016 2.5 PPP1R10 E2F8 ZNF785 SIN3A ZNF24 SP1 ZBTB40 SREBF1 SIX5 LCORL NONHSAG022459.2 TACO1 POLG2 FTSJ3 CEP95 SMARCD2 DDX5 DDX42 DCAF7 MAP3K3
GH17J063694 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 6.1 -150.0 -150021 10.2 E2F8 ZNF24 SP1 CTCF ZBTB6 MYC ETV6 RELA HLF MAX STRADA ENSG00000279369 LOC729683 LIMD2 lnc-CCDC47-2 piR-33059 FTSJ3 CEP95 CSH2 DDX42
GH17J062868 Enhancer 0.7 Ensembl 9.8 -981.0 -980991 0.2 MTA3 PRDM1 YBX1 ZBTB33 ZNF512B PKNOX1 BMI1 ZKSCAN1 ZNF592 ZNF207 FTSJ3 DDX42 SMARCD2 MED13 INTS2 DCAF7 ENSG00000239246 TLK2 RNU6-446P MRC2
GH17J063437 Promoter/Enhancer 1.3 EPDnew Ensembl dbSUPER 4.9 -411.2 -411216 1.1 L3MBTL2 ZFX EGR1 MTA2 MGA ZBTB10 ESRRA MBD2 NFRKB CREM CYB561 piR-51111 TCAM1P lnc-STRADA-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCAM1P on UCSC Golden Path with GeneCards custom track

Genomic Locations for TCAM1P Gene

Genomic Locations for TCAM1P Gene
chr17:63,849,292-63,864,379
(GRCh38/hg38)
Size:
15,088 bases
Orientation:
Plus strand
chr17:61,926,652-61,941,739
(GRCh37/hg19)
Size:
15,088 bases
Orientation:
Plus strand

Genomic View for TCAM1P Gene

Genes around TCAM1P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCAM1P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCAM1P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCAM1P Gene

Proteins for TCAM1P Gene

Post-translational modifications for TCAM1P Gene

No Post-translational modifications

No data available for DME Specific Peptides for TCAM1P Gene

Domains & Families for TCAM1P Gene

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TCAM1P Gene

Function for TCAM1P Gene

Phenotypes From GWAS Catalog for TCAM1P Gene

Animal Model Products

CRISPR Products

miRNA for TCAM1P Gene

miRTarBase miRNAs that target TCAM1P

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCAM1P Gene

Localization for TCAM1P Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for TCAM1P Gene

Pathways & Interactions for TCAM1P Gene

PathCards logo

SuperPathways for TCAM1P Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCAM1P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCAM1P Gene

Drugs & Compounds for TCAM1P Gene

No Compound Related Data Available

Transcripts for TCAM1P Gene

mRNA/cDNA for TCAM1P Gene

(7) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCAM1P Gene

No ASD Table

Relevant External Links for TCAM1P Gene

GeneLoc Exon Structure for
TCAM1P
ECgene alternative splicing isoforms for
TCAM1P

Expression for TCAM1P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCAM1P Gene

mRNA differential expression in normal tissues according to GTEx for TCAM1P Gene

This gene is overexpressed in Testis (x39.7).

NURSA nuclear receptor signaling pathways regulating expression of TCAM1P Gene:

TCAM1P

SOURCE GeneReport for Unigene cluster for TCAM1P Gene:

Hs.629177
genes like me logo Genes that share expression patterns with TCAM1P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCAM1P Gene

Orthologs for TCAM1P Gene

Evolution for TCAM1P Gene

ENSEMBL:
Gene Tree for TCAM1P (if available)
TreeFam:
Gene Tree for TCAM1P (if available)

No data available for Orthologs for TCAM1P Gene

Paralogs for TCAM1P Gene

No data available for Paralogs for TCAM1P Gene

Variants for TCAM1P Gene

Sequence variations from dbSNP and Humsavar for TCAM1P Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000251106 -- 63,857,102(+) T/C non_coding_transcript_variant
rs1000939449 -- 63,858,215(+) C/G intron_variant
rs1001147227 -- 63,860,208(+) A/G non_coding_transcript_variant
rs1001753606 -- 63,863,830(+) T/C non_coding_transcript_variant
rs1001809560 -- 63,856,555(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TCAM1P Gene

Variant ID Type Subtype PubMed ID
esv2716098 CNV deletion 23290073
esv3573787 CNV gain 25503493
esv3582856 CNV loss 25503493
nsv510720 CNV deletion 20534489
nsv517272 CNV gain+loss 19592680
nsv833510 CNV loss 17160897
nsv954553 CNV deletion 24416366
nsv960135 CNV duplication 23825009

Additional Variant Information for TCAM1P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCAM1P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TCAM1P Gene

Disorders for TCAM1P Gene

Additional Disease Information for TCAM1P

No disorders were found for TCAM1P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCAM1P Gene

Publications for TCAM1P Gene

  1. Testicular cell adhesion molecule 1 (TCAM1) is not essential for fertility. (PMID: 19766163) Nalam RL … Matzuk MM (Molecular and cellular endocrinology 2010) 2 3 56
  2. Structure, expression, and conserved physical linkage of mouse testicular cell adhesion molecule-1 (TCAM-1) gene. (PMID: 11195349) Sakatani S … Ono M (Genome 2000) 2 3 56
  3. The human growth hormone locus: nucleotide sequence, biology, and evolution. (PMID: 2744760) Chen EY … Seeburg PH (Genomics 1989) 2 3 56
  4. Characterization of the human TCAM1P pseudogene and its activation by a potential dual promoter-enhancer: comparison with a protein-coding mouse orthologue. (PMID: 25622893) Kurihara M … Kimura AP (FEBS letters 2015) 3 56
  5. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang ZD … Gerstein M (Genome biology 2010) 3 56

Products for TCAM1P Gene

Sources for TCAM1P Gene