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Aliases for TCAIM Gene

Aliases for TCAIM Gene

  • T Cell Activation Inhibitor, Mitochondrial 2 3
  • C3orf23 2 3 4
  • T-Cell Activation Inhibitor, Mitochondrial 3 5
  • Tolerance Associated Gene-1 Protein 3 4
  • TOAG-1 3 4
  • TOAG1 3 4
  • Tolerance Associated Gene-1 2

External Ids for TCAIM Gene

Previous HGNC Symbols for TCAIM Gene

  • C3orf23

Summaries for TCAIM Gene

GeneCards Summary for TCAIM Gene

TCAIM (T Cell Activation Inhibitor, Mitochondrial) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TCAIM Gene

  • May regulate T-cell apoptosis.

Gene Wiki entry for TCAIM Gene

Additional gene information for TCAIM Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCAIM Gene

Genomics for TCAIM Gene

GeneHancer (GH) Regulatory Elements for TCAIM Gene

Promoters and enhancers for TCAIM Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I044337 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.0 950 3.6 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 LOC105377055 TCAIM ZNF660 ZNF852 ZNF35 SNRK-AS1 ZNF445 ZNF197 ENSG00000271941 ZNF502
GH03I044233 Enhancer 1.2 Ensembl ENCODE 7.8 -102.2 -102217 5.6 ATF1 PKNOX1 ARNT BRCA1 TCF12 GATA2 E2F8 ARID2 ZNF143 ATF7 ZNF660 ZNF502 ZNF197 ZKSCAN7 ZNF445 ZNF852 RNU6-367P ZNF35 SNRK-AS1 MIR138-1
GH03I044031 Enhancer 0.8 FANTOM5 ENCODE 4.2 -305.5 -305475 1.9 PKNOX1 EBF1 ATF2 IRF4 ZNF592 IKZF1 NBN MLLT1 BCLAF1 RUNX3 GC03M044031 RNU6-367P ENSG00000261786 SNRK TCAIM
GH03I044202 Enhancer 0.7 ENCODE dbSUPER 4.2 -132.3 -132332 5.7 NFIC KLF16 HLF CBFA2T3 CBFA2T2 ZNF660 ZNF197 ENSG00000271941 TCAIM TOPAZ1 PIR53341
GH03I044201 Enhancer 0.4 ENCODE dbSUPER 6.8 -136.1 -136132 1.2 ZNF197 ZNF660 TCAIM TOPAZ1 PIR53341
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCAIM on UCSC Golden Path with GeneCards custom track

Genomic Locations for TCAIM Gene

Genomic Locations for TCAIM Gene
chr3:44,338,119-44,409,451
(GRCh38/hg38)
Size:
71,333 bases
Orientation:
Plus strand
chr3:44,379,611-44,450,943
(GRCh37/hg19)

Genomic View for TCAIM Gene

Genes around TCAIM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCAIM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCAIM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCAIM Gene

Proteins for TCAIM Gene

  • Protein details for TCAIM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N3R3-TCAIM_HUMAN
    Recommended name:
    T-cell activation inhibitor, mitochondrial
    Protein Accession:
    Q8N3R3
    Secondary Accessions:
    • A8K9P1
    • Q0P5T9
    • Q495R1
    • Q495R3
    • Q4G0M4
    • Q6GMU8

    Protein attributes for TCAIM Gene

    Size:
    496 amino acids
    Molecular mass:
    57925 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TCAIM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TCAIM Gene

Post-translational modifications for TCAIM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCAIM Gene

Domains & Families for TCAIM Gene

Gene Families for TCAIM Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCAIM Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TCAIM: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TCAIM Gene

Function for TCAIM Gene

Molecular function for TCAIM Gene

UniProtKB/Swiss-Prot Function:
May regulate T-cell apoptosis.
genes like me logo Genes that share phenotypes with TCAIM: view

Animal Models for TCAIM Gene

MGI Knock Outs for TCAIM:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCAIM Gene

Localization for TCAIM Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCAIM Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCAIM gene
Compartment Confidence
mitochondrion 5
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TCAIM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with TCAIM: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCAIM Gene

Pathways & Interactions for TCAIM Gene

SuperPathways for TCAIM Gene

No Data Available

Interacting Proteins for TCAIM Gene

Gene Ontology (GO) - Biological Process for TCAIM Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TCAIM Gene

Drugs & Compounds for TCAIM Gene

No Compound Related Data Available

Transcripts for TCAIM Gene

Unigene Clusters for TCAIM Gene

T cell activation inhibitor, mitochondrial:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCAIM Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - -
SP9: - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - -
SP13: -
SP14: -

ExUns: 15b ^ 16 ^ 17a · 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for TCAIM Gene

GeneLoc Exon Structure for
TCAIM
ECgene alternative splicing isoforms for
TCAIM

Expression for TCAIM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCAIM Gene

NURSA nuclear receptor signaling pathways regulating expression of TCAIM Gene:

TCAIM

SOURCE GeneReport for Unigene cluster for TCAIM Gene:

Hs.55131

Evidence on tissue expression from TISSUES for TCAIM Gene

  • Nervous system(4.6)
  • Blood(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with TCAIM: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCAIM Gene

Orthologs for TCAIM Gene

This gene was present in the common ancestor of animals.

Orthologs for TCAIM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCAIM 33 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia TCAIM 33 34
  • 92.14 (n)
cow
(Bos Taurus)
Mammalia TCAIM 33 34
  • 89.81 (n)
rat
(Rattus norvegicus)
Mammalia Tcaim 33
  • 83 (n)
mouse
(Mus musculus)
Mammalia Tcaim 33 16 34
  • 82.53 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TCAIM 34
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TCAIM 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves C2H3ORF23 33
  • 75.32 (n)
TCAIM 34
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TCAIM 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tcaim 33
  • 67.9 (n)
Str.18228 33
zebrafish
(Danio rerio)
Actinopterygii LOC559258 33
  • 58.6 (n)
TCAIM 34
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13295 33 34
  • 44.25 (n)
CG2854 34
  • 23 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009133 33
  • 41.08 (n)
worm
(Caenorhabditis elegans)
Secernentea C35B8.3 33 34
  • 41.53 (n)
Species where no ortholog for TCAIM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TCAIM Gene

ENSEMBL:
Gene Tree for TCAIM (if available)
TreeFam:
Gene Tree for TCAIM (if available)

Paralogs for TCAIM Gene

No data available for Paralogs for TCAIM Gene

Variants for TCAIM Gene

Sequence variations from dbSNP and Humsavar for TCAIM Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000085646 -- 44,356,921(+) C/A intron_variant
rs1000102677 -- 44,351,077(+) A/G intron_variant
rs1000137924 -- 44,356,648(+) C/G intron_variant
rs1000140133 -- 44,377,915(+) A/C genic_downstream_transcript_variant, intron_variant
rs1000170770 -- 44,356,298(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TCAIM Gene

Variant ID Type Subtype PubMed ID
dgv282n21 CNV loss 19592680
dgv859e199 CNV deletion 23128226
esv1002255 CNV deletion 20482838
esv2422854 CNV deletion 19546169
esv3596033 CNV loss 21293372
nsv528038 CNV gain 19592680
nsv954475 CNV duplication 24416366

Variation tolerance for TCAIM Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.44; 42.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCAIM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCAIM

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCAIM Gene

Disorders for TCAIM Gene

Additional Disease Information for TCAIM

No disorders were found for TCAIM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCAIM Gene

Publications for TCAIM Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. B-cell-related biomarkers of tolerance are up-regulated in rejection-free kidney transplant recipients. (PMID: 23222918) Viklicky O … Reinke P (Transplantation 2013) 3 58
  5. Expansion of memory-type CD8+ T cells correlates with the failure of early immunosuppression withdrawal after cadaver liver transplantation using high-dose ATG induction and rapamycin. (PMID: 23799424) Donckier V … Goldman M (Transplantation 2013) 3 58

Products for TCAIM Gene

Sources for TCAIM Gene

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