Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TCAF2 Gene

Aliases for TCAF2 Gene

  • TRPM8 Channel Associated Factor 2 2 3 5
  • Family With Sequence Similarity 139, Member A 2 3
  • Family With Sequence Similarity 115, Member C 2 3
  • TRPM8 Channel-Associated Factor 2 2 3
  • TRP Channel-Associated Factor 2 3 4
  • FAM115C 3 4
  • FAM139A 3 4
  • Protein FAM115C 3
  • GATD9 3

External Ids for TCAF2 Gene

Previous HGNC Symbols for TCAF2 Gene

  • FAM139A
  • FAM115C

Previous GeneCards Identifiers for TCAF2 Gene

  • GC07P143621
  • GC07P143622
  • GC07P143695

Summaries for TCAF2 Gene

GeneCards Summary for TCAF2 Gene

TCAF2 (TRPM8 Channel Associated Factor 2) is a Protein Coding gene. Diseases associated with TCAF2 include Retinitis Pigmentosa 11. Gene Ontology (GO) annotations related to this gene include ion channel binding. An important paralog of this gene is TCAF2C.

UniProtKB/Swiss-Prot for TCAF2 Gene

  • Isoform 2: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.

Additional gene information for TCAF2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCAF2 Gene

Genomics for TCAF2 Gene

GeneHancer (GH) Regulatory Elements for TCAF2 Gene

Promoters and enhancers for TCAF2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I143620 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 51 2 PKNOX1 LOC101928466 TCAF2 LOC101928422 ENSG00000283537
GH07I143622 Promoter 0.5 Ensembl 550.8 +1.4 1351 0.2 LOC101928422 LOC101928466 TCAF2 ENSG00000283537
GH07I143715 Promoter 0.5 EPDnew 550.2 +94.9 94853 0.1 TCAF2 PIR46266 TCAF2C
GH07I143378 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.1 -234.8 -234756 15.9 HDGF PKNOX1 FOXA2 SMAD1 ARNT MLX ARID4B SIN3A YBX1 ZNF2 ZYX CASP2 LOC154761 OR2A1 RN7SL535P EPHA1-AS1 EPHA1 TCAF2 HINT1P1 CLCN1
GH07I143262 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 13.7 -356.8 -356837 2.8 HDGF SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B LOC154761 TCAF2 CASP2 GSTK1 TMEM139 LOC105375545 LOC105375546
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCAF2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TCAF2 Gene

Genomic Locations for TCAF2 Gene
109,460 bases
Plus strand

Genomic View for TCAF2 Gene

Genes around TCAF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCAF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCAF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCAF2 Gene

Proteins for TCAF2 Gene

  • Protein details for TCAF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TRPM8 channel-associated factor 2
    Protein Accession:
    Secondary Accessions:
    • B4DK02
    • Q14D25
    • Q17RQ4
    • Q8IWQ0
    • Q8NF84

    Protein attributes for TCAF2 Gene

    919 amino acids
    Molecular mass:
    100906 Da
    Quaternary structure:
    • Isoform 2 interacts with TRPM8 (via N-terminus and C-terminus domains); the interaction inhibits TRPM8 channel activity. Interacts with TRPV6.
    • Sequence=BAC03376.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TCAF2 Gene


neXtProt entry for TCAF2 Gene

Post-translational modifications for TCAF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCAF2 Gene

Domains & Families for TCAF2 Gene

Gene Families for TCAF2 Gene

Protein Domains for TCAF2 Gene

Suggested Antigen Peptide Sequences for TCAF2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TCAF family.
  • Belongs to the TCAF family.
genes like me logo Genes that share domains with TCAF2: view

Function for TCAF2 Gene

Molecular function for TCAF2 Gene

UniProtKB/Swiss-Prot Function:
Isoform 2: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner.

Phenotypes From GWAS Catalog for TCAF2 Gene

Gene Ontology (GO) - Molecular Function for TCAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044325 ion channel binding IPI 25559186
genes like me logo Genes that share ontologies with TCAF2: view
genes like me logo Genes that share phenotypes with TCAF2: view

Animal Model Products

CRISPR Products

miRNA for TCAF2 Gene

miRTarBase miRNAs that target TCAF2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCAF2 Gene

Localization for TCAF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCAF2 Gene

Isoform 2: Cell membrane. Note=Colocalizes with TRPM8 on the plasma membrane. {ECO:0000269 PubMed:25559186}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCAF2 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TCAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 25559186
GO:0016020 membrane IEA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with TCAF2: view

Pathways & Interactions for TCAF2 Gene

SuperPathways for TCAF2 Gene

No Data Available

Interacting Proteins for TCAF2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: A6NFQ2-TCAF2_HUMAN ENSP00000349902 for TCAF2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for TCAF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0010360 negative regulation of anion channel activity IDA 25559186
GO:0030335 positive regulation of cell migration IDA 25559186
GO:0090314 positive regulation of protein targeting to membrane IMP 25559186
genes like me logo Genes that share ontologies with TCAF2: view

No data available for Pathways by source and SIGNOR curated interactions for TCAF2 Gene

Drugs & Compounds for TCAF2 Gene

No Compound Related Data Available

Transcripts for TCAF2 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCAF2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c
SP1: -
SP2: -

Relevant External Links for TCAF2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCAF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCAF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCAF2 Gene

This gene is overexpressed in Cervix (36.2), Lymph node (7.8), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TCAF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCAF2 Gene:


mRNA Expression by UniProt/SwissProt for TCAF2 Gene:

Tissue specificity: Isoform 2 is expressed in the prostate and in cancerous prostate samples.

Evidence on tissue expression from TISSUES for TCAF2 Gene

  • Spleen(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with TCAF2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCAF2 Gene

Orthologs for TCAF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCAF2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM115C 33 34
  • 98.82 (n)
(Canis familiaris)
Mammalia FAM115C 33 34
  • 83.33 (n)
(Bos Taurus)
Mammalia FAM115C 33 34
  • 82.03 (n)
(Mus musculus)
Mammalia Fam115c 33 34
  • 79.27 (n)
Tcaf2 16
(Monodelphis domestica)
Mammalia -- 34
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
-- 34
  • 55 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fam115c 33
  • 54.59 (n)
Str.16417 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1616 33
(Danio rerio)
Actinopterygii zgc:162193 33 34
  • 49.82 (n)
si:ch211-210b2.2 34
  • 36 (a)
si:ch211-210b2.3 34
  • 36 (a)
si:ch211-210b2.4 34
  • 36 (a)
Species where no ortholog for TCAF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCAF2 Gene

Gene Tree for TCAF2 (if available)
Gene Tree for TCAF2 (if available)

Paralogs for TCAF2 Gene

Paralogs for TCAF2 Gene

genes like me logo Genes that share paralogs with TCAF2: view

Variants for TCAF2 Gene

Sequence variations from dbSNP and Humsavar for TCAF2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs142539094 likely-benign, not specified 143,724,382(+) C/T coding_sequence_variant, synonymous_variant
rs1000196077 -- 143,730,658(+) A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000197200 -- 143,632,485(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000252547 -- 143,727,188(+) CCCCC/CCCC genic_downstream_transcript_variant, intron_variant
rs1000275212 -- 143,701,836(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TCAF2 Gene

Variant ID Type Subtype PubMed ID
dgv12n29 CNV gain+loss 16826518
dgv249n111 CNV duplication 26073780
dgv6699n100 CNV gain 25217958
dgv6700n100 CNV gain 25217958
dgv6701n100 CNV gain 25217958
dgv6702n100 CNV gain 25217958
dgv6703n100 CNV loss 25217958
dgv6704n100 CNV loss 25217958
dgv6705n100 CNV gain+loss 25217958
dgv6706n100 CNV loss 25217958
dgv6707n100 CNV loss 25217958
dgv6708n100 CNV loss 25217958
dgv6709n100 CNV loss 25217958
dgv6710n100 CNV loss 25217958
esv2422489 CNV duplication 17116639
esv2759570 CNV gain+loss 17122850
esv2761113 CNV gain+loss 21179565
esv2761375 CNV gain 21179565
esv29816 CNV gain+loss 19812545
esv3572224 CNV loss 25503493
esv3584556 CNV gain 24956385
esv3615306 CNV loss 21293372
esv3615307 CNV gain 21293372
esv3891219 CNV loss 25118596
esv3891221 CNV loss 25118596
esv3891222 CNV gain+loss 25118596
nsv1016831 CNV gain 25217958
nsv1017272 CNV gain 25217958
nsv1020659 CNV gain+loss 25217958
nsv1022654 CNV gain+loss 25217958
nsv1022655 CNV gain 25217958
nsv1024360 CNV gain+loss 25217958
nsv1029557 CNV gain+loss 25217958
nsv1033465 CNV gain 25217958
nsv1034865 CNV gain 25217958
nsv1076007 CNV deletion 25765185
nsv1126813 CNV deletion 24896259
nsv1133673 CNV deletion 24896259
nsv1140255 OTHER inversion 24896259
nsv1144201 CNV deletion 24896259
nsv1144202 CNV deletion 24896259
nsv1145165 CNV deletion 24896259
nsv1150104 CNV duplication 26484159
nsv1151212 CNV duplication 26484159
nsv1152402 CNV duplication 26484159
nsv1152507 CNV duplication 26484159
nsv1161631 CNV duplication 26073780
nsv16 OTHER inversion 15895083
nsv428188 CNV gain+loss 18775914
nsv442210 CNV gain 18776908
nsv514455 CNV gain+loss 21397061
nsv520055 CNV loss 19592680
nsv522225 CNV gain 19592680
nsv608682 CNV gain 21841781
nsv608683 CNV loss 21841781
nsv608684 CNV loss 21841781
nsv608685 CNV loss 21841781
nsv608686 CNV loss 21841781
nsv7408 OTHER inversion 18451855
nsv818565 CNV gain 17921354
nsv819199 CNV gain 19587683
nsv8227 CNV gain+loss 18304495
nsv824356 CNV loss 20364138

Variation tolerance for TCAF2 Gene

Gene Damage Index Score: 1.50; 29.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCAF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCAF2 Gene

Disorders for TCAF2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TCAF2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 11
  • rp11
- elite association - COSMIC cancer census association via MalaCards
Search TCAF2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TCAF2

genes like me logo Genes that share disorders with TCAF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TCAF2 Gene

Publications for TCAF2 Gene

  1. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. (PMID: 25559186) Gkika D … Prevarskaya N (The Journal of cell biology 2015) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J … Elledge SJ (Cell 2009) 3 58

Products for TCAF2 Gene

Sources for TCAF2 Gene

Loading form....