Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TCAF1 Gene

Aliases for TCAF1 Gene

  • TRPM8 Channel Associated Factor 1 2 3 5
  • Family With Sequence Similarity 115, Member A 2 3
  • TRPM8 Channel-Associated Factor 1 2 3
  • TRP Channel-Associated Factor 1 3 4
  • FAM115A 3 4
  • Protein FAM115A 3
  • KIAA0738 4

External Ids for TCAF1 Gene

Previous HGNC Symbols for TCAF1 Gene

  • FAM115A

Summaries for TCAF1 Gene

GeneCards Summary for TCAF1 Gene

TCAF1 (TRPM8 Channel Associated Factor 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ion channel binding. An important paralog of this gene is TCAF2.

UniProtKB/Swiss-Prot for TCAF1 Gene

  • Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.

Additional gene information for TCAF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCAF1 Gene

Genomics for TCAF1 Gene

GeneHancer (GH) Regulatory Elements for TCAF1 Gene

Promoters and enhancers for TCAF1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I143898 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 555.4 -1.0 -958 9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 TCAF1 ARHGEF35 CASP2 OR2A13P OR2A25 OR2A12 ARHGEF34P OR2A2 OR2F1 LOC105375549
GH07I143884 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 554.7 +16.9 16909 1.4 CTCF MXI1 PKNOX1 ZBTB7B CHAMP1 ZNF335 ZFHX2 POLR2A EGR1 VEZF1 TCAF1 LOC105375549 ARHGEF35 GC07M143854
GH07I143933 Enhancer 0.7 ENCODE 11.5 -33.2 -33207 2.9 FOXA2 RFX1 HLF MAFG CEBPG ZFHX2 ATF4 MAFF JUND ZNF316 OR2F2 ARHGEF35 OR2F1 TCAF1 OR2A7 LOC100422324
GH07I143929 Enhancer 0.5 ENCODE 11.6 -27.7 -27677 1 FOSL1 MCM3 PKNOX1 FOS BATF ARHGEF35 OR2A1 CASP2 OR2F1 TCAF1 LOC154761 OR2A5 OR2F2
GH07I143881 Promoter/Enhancer 1.3 Ensembl ENCODE 4.3 +19.9 19852 2.3 ELF3 FOXA2 ARID4B SIN3A ZNF48 RAD21 RARA CREM THAP11 MIXL1 OR2A13P TCAF1 LOC105375549 GC07M143854
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TCAF1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TCAF1 Gene

Genomic Locations for TCAF1 Gene
50,831 bases
Minus strand

Genomic View for TCAF1 Gene

Genes around TCAF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCAF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCAF1 Gene

Proteins for TCAF1 Gene

  • Protein details for TCAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TRPM8 channel-associated factor 1
    Protein Accession:
    Secondary Accessions:
    • A8K6E0
    • Q75KM8
    • Q75KM9
    • Q7L665
    • Q9BW63

    Protein attributes for TCAF1 Gene

    921 amino acids
    Molecular mass:
    102126 Da
    Quaternary structure:
    • Interacts with TRPM8 (via N-terminus and C-terminus domains); the interaction inhibits TRPM8 channel activity. Interacts with TRPV6.
    • Sequence=BAA34458.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TCAF1 Gene


neXtProt entry for TCAF1 Gene

Post-translational modifications for TCAF1 Gene

  • Ubiquitination at posLast=274274, posLast=281281, isoforms=2434, isoforms=2439, isoforms=2632, posLast=750750, posLast=817817, posLast=865865, and isoforms=912
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TCAF1 Gene

Domains & Families for TCAF1 Gene

Gene Families for TCAF1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCAF1 Gene

Suggested Antigen Peptide Sequences for TCAF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The C-terminal region is necessary for the channel activity stimulation.
  • Belongs to the TCAF family.
  • The C-terminal region is necessary for the channel activity stimulation.
  • Belongs to the TCAF family.
genes like me logo Genes that share domains with TCAF1: view

Function for TCAF1 Gene

Molecular function for TCAF1 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner.

Gene Ontology (GO) - Molecular Function for TCAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0044325 ion channel binding IPI 25559186
genes like me logo Genes that share ontologies with TCAF1: view
genes like me logo Genes that share phenotypes with TCAF1: view

Animal Model Products

miRNA for TCAF1 Gene

miRTarBase miRNAs that target TCAF1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TCAF1 Gene

Localization for TCAF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCAF1 Gene

Cell membrane. Note=Colocalizes with TRPM8 on the plasma membrane. {ECO:0000269 PubMed:25559186}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCAF1 gene
Compartment Confidence
plasma membrane 5
nucleus 3
mitochondrion 2
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TCAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA,IEA 25559186
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TCAF1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCAF1 Gene

Pathways & Interactions for TCAF1 Gene

SuperPathways for TCAF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TCAF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0030336 negative regulation of cell migration IDA 25559186
GO:0090314 positive regulation of protein targeting to membrane IMP 25559186
GO:1901529 positive regulation of anion channel activity IDA 25559186
genes like me logo Genes that share ontologies with TCAF1: view

No data available for Pathways by source and SIGNOR curated interactions for TCAF1 Gene

Drugs & Compounds for TCAF1 Gene

No Compound Related Data Available

Transcripts for TCAF1 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCAF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b
SP1: - - - - -
SP2: - - - - -
SP3: - -
SP6: - - -
SP7: -
SP8: - - - - - -

Relevant External Links for TCAF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TCAF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCAF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TCAF1 Gene

This gene is overexpressed in Breast (14.6) and Testis (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TCAF1 Gene

Protein tissue co-expression partners for TCAF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TCAF1 Gene:


mRNA Expression by UniProt/SwissProt for TCAF1 Gene:

Tissue specificity: Isoform 2 is expressed in the prostate and strongly expressed in cancerous prostate samples.

Evidence on tissue expression from TISSUES for TCAF1 Gene

  • Nervous system(4.5)
  • Liver(4.3)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with TCAF1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TCAF1 Gene

Orthologs for TCAF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TCAF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM115A 34 33
  • 99.67 (n)
(Canis familiaris)
Mammalia FAM115A 34
  • 98 (a)
LOC482730 33
  • 90.88 (n)
(Bos Taurus)
Mammalia FAM115A 34 33
  • 89.32 (n)
(Rattus norvegicus)
Mammalia Fam115a 33
  • 86.54 (n)
(Mus musculus)
Mammalia Fam115a 33 34
  • 86.51 (n)
Tcaf1 16
(Monodelphis domestica)
Mammalia -- 34
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 56 (a)
-- 34
  • 56 (a)
-- 34
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
-- 34
  • 42 (a)
(Danio rerio)
Actinopterygii si:ch211-210b2.4 34
  • 38 (a)
zgc:162193 34
  • 38 (a)
si:ch211-210b2.2 34
  • 37 (a)
si:ch211-210b2.3 34
  • 37 (a)
Species where no ortholog for TCAF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TCAF1 Gene

Gene Tree for TCAF1 (if available)
Gene Tree for TCAF1 (if available)

Paralogs for TCAF1 Gene

Paralogs for TCAF1 Gene Pseudogenes for TCAF1 Gene

genes like me logo Genes that share paralogs with TCAF1: view

Variants for TCAF1 Gene

Sequence variations from dbSNP and Humsavar for TCAF1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000019819 -- 143,853,500(-) A/G 3_prime_UTR_variant
rs1000065056 -- 143,881,913(-) G/A intron_variant
rs1000093960 -- 143,898,217(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000190689 -- 143,879,048(-) C/T intron_variant
rs1000374824 -- 143,890,980(-) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TCAF1 Gene

Variant ID Type Subtype PubMed ID
dgv11664n54 CNV gain 21841781
dgv1332e214 CNV gain 21293372
dgv251n111 CNV duplication 26073780
dgv252n111 CNV duplication 26073780
dgv3685n106 CNV duplication 24896259
dgv6700n100 CNV gain 25217958
dgv6706n100 CNV loss 25217958
dgv6712n100 CNV loss 25217958
dgv6717n100 CNV gain+loss 25217958
dgv6718n100 CNV gain 25217958
dgv6721n100 CNV gain+loss 25217958
dgv6722n100 CNV loss 25217958
dgv6724n100 CNV loss 25217958
dgv6725n100 CNV gain 25217958
dgv842n27 CNV gain 19166990
esv1682998 OTHER inversion 17803354
esv2422489 CNV duplication 17116639
esv2752147 CNV gain 17911159
esv2759570 CNV gain+loss 17122850
esv29816 CNV gain+loss 19812545
esv3584556 CNV gain 24956385
esv3615308 CNV loss 21293372
esv3615312 CNV gain 21293372
esv3891220 CNV loss 25118596
esv3891223 CNV loss 25118596
nsv1016831 CNV gain 25217958
nsv1021504 CNV loss 25217958
nsv1027488 CNV gain 25217958
nsv1076630 CNV duplication 25765185
nsv1140255 OTHER inversion 24896259
nsv1145961 CNV duplication 26484159
nsv1151347 CNV duplication 26484159
nsv1151710 CNV duplication 26484159
nsv1161631 CNV duplication 26073780
nsv1161656 CNV duplication 26073780
nsv16 OTHER inversion 15895083
nsv428188 CNV gain+loss 18775914
nsv442210 CNV gain 18776908
nsv469570 CNV gain+loss 16826518
nsv471645 CNV gain+loss 15918152
nsv522225 CNV gain 19592680
nsv608682 CNV gain 21841781
nsv608684 CNV loss 21841781
nsv608690 CNV loss 21841781
nsv608691 CNV loss 21841781
nsv7408 OTHER inversion 18451855
nsv8227 CNV gain+loss 18304495
nsv949974 CNV duplication 24416366
nsv971554 CNV duplication 23825009

Variation tolerance for TCAF1 Gene

Gene Damage Index Score: 1.62; 31.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCAF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCAF1 Gene

Disorders for TCAF1 Gene

Additional Disease Information for TCAF1

No disorders were found for TCAF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCAF1 Gene

Publications for TCAF1 Gene

  1. TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity. (PMID: 25559186) Gkika D … Prevarskaya N (The Journal of cell biology 2015) 2 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. An Interaction Landscape of Ubiquitin Signaling. (PMID: 28190767) Zhang X … Vermeulen M (Molecular cell 2017) 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TCAF1 Gene

Sources for TCAF1 Gene

Loading form....