Aliases for TC2N Gene

Aliases for TC2N Gene

  • Tandem C2 Domains, Nuclear 2 3 5
  • Membrane Targeting (Tandem) C2 Domain Containing 1 2 3
  • C2 Calcium-Dependent Domain Containing 1 2 3
  • Tandem C2 Domains Nuclear Protein 3 4
  • Tandem C2 Protein In Nucleus 3 4
  • C14orf47 3 4
  • MTAC2D1 3 4
  • Tac2-N 3 4
  • Membrane Targeting Tandem C2 Domain-Containing Protein 1 4
  • Chromosome 14 Open Reading Frame 47 2
  • C2CD1 3

External Ids for TC2N Gene

Previous HGNC Symbols for TC2N Gene

  • C14orf47
  • MTAC2D1

Previous GeneCards Identifiers for TC2N Gene

  • GC14M091317
  • GC14M092246
  • GC14M072426
  • GC14M091780
  • GC14M092333
  • GC14M092429
  • GC14M092451
  • GC14M091782
  • GC14M091893
  • GC14M091978
  • GC14M092234

Summaries for TC2N Gene

GeneCards Summary for TC2N Gene

TC2N (Tandem C2 Domains, Nuclear) is a Protein Coding gene. Diseases associated with TC2N include Von Willebrand Disease, Type 1. Gene Ontology (GO) annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is SYTL5.

Gene Wiki entry for TC2N Gene

Additional gene information for TC2N Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TC2N Gene

Genomics for TC2N Gene

GeneHancer (GH) Regulatory Elements for TC2N Gene

Promoters and enhancers for TC2N Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J091835 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 546.9 +31.7 31650 3.8 HNRNPK ZSCAN5C NRF1 ZFX CTCF POLR2A CLOCK ZBTB26 REST KLF4 TC2N CATSPERB HSALNG0103222 lnc-CATSPERB-2
GH14J091864 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 515.1 +1.1 1111 4.5 ZIC2 ZNF423 OSR2 EBF1 SCRT1 PRDM6 FEZF1 TBX21 ZNF24 INSM2 TC2N lnc-TC2N-2 FBLN5 ENSG00000260711 CATSPERB HSALNG0103222
GH14J091743 Enhancer 1.2 FANTOM5 Ensembl ENCODE 48.2 +122.7 122725 3.2 ZNF217 ZNF639 ZNF10 ZIC2 ATF2 CTBP1 OSR2 ESRRA WT1 FOXA2 TC2N CATSPERB FBLN5 TRIP11 PPP4R3A ATXN3 ENSG00000260711 ENSG00000275154
GH14J091753 Enhancer 1 Ensembl ENCODE 48.2 +112.1 112062 4.9 ZNF217 KLF4 TEAD1 CTBP1 OSR2 FOXA2 CEBPB BRCA1 FOS CEBPG TC2N CATSPERB PPP4R3A ATXN3 ENSG00000260711 ENSG00000275154
GH14J091830 Enhancer 0.7 ENCODE 60 +36.5 36524 1.2 OSR2 WT1 CREB1 FOXA2 BATF FOXA1 ZBTB48 IKZF3 POU2F2 SCRT1 TC2N FBLN5 TRIP11 CATSPERB HSALNG0103222 lnc-CATSPERB-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TC2N on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TC2N

Top Transcription factor binding sites by QIAGEN in the TC2N gene promoter:
  • AML1a
  • C/EBPalpha
  • FOXO4
  • Gfi-1
  • HSF2
  • Pbx1a
  • POU2F1
  • POU2F1a
  • STAT1
  • STAT5B

Genomic Locations for TC2N Gene

Genomic Locations for TC2N Gene
chr14:91,779,746-91,867,536
(GRCh38/hg38)
Size:
87,791 bases
Orientation:
Minus strand
chr14:92,246,095-92,333,880
(GRCh37/hg19)
Size:
87,786 bases
Orientation:
Minus strand

Genomic View for TC2N Gene

Genes around TC2N on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TC2N Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TC2N Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TC2N Gene

Proteins for TC2N Gene

  • Protein details for TC2N Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9U0-TAC2N_HUMAN
    Recommended name:
    Tandem C2 domains nuclear protein
    Protein Accession:
    Q8N9U0

    Protein attributes for TC2N Gene

    Size:
    490 amino acids
    Molecular mass:
    55284 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TC2N Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TC2N Gene

Post-translational modifications for TC2N Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TC2N Gene

Domains & Families for TC2N Gene

Gene Families for TC2N Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TC2N Gene

Blocks:
  • C2 domain
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TC2N Gene

GenScript: Design optimal peptide antigens:
  • Tandem C2 protein in nucleus (TAC2N_HUMAN)
genes like me logo Genes that share domains with TC2N: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TC2N Gene

Function for TC2N Gene

Phenotypes From GWAS Catalog for TC2N Gene

Gene Ontology (GO) - Molecular Function for TC2N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with TC2N: view
genes like me logo Genes that share phenotypes with TC2N: view

Animal Model Products

CRISPR Products

miRNA for TC2N Gene

miRTarBase miRNAs that target TC2N

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TC2N Gene

Localization for TC2N Gene

Subcellular locations from UniProtKB/Swiss-Prot for TC2N Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TC2N gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TC2N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TC2N: view

Pathways & Interactions for TC2N Gene

PathCards logo

SuperPathways for TC2N Gene

No Data Available

Gene Ontology (GO) - Biological Process for TC2N Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TC2N Gene

Drugs & Compounds for TC2N Gene

No Compound Related Data Available

Transcripts for TC2N Gene

mRNA/cDNA for TC2N Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TC2N Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d
SP1: - - - - - -
SP2: - - -
SP3: - -
SP4: - - - -
SP5: - -
SP6: -
SP7:
SP8:

Relevant External Links for TC2N Gene

GeneLoc Exon Structure for
TC2N

Expression for TC2N Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TC2N Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TC2N Gene

This gene is overexpressed in Pancreas (x8.8), Artery - Aorta (x5.0), and Minor Salivary Gland (x4.2).

Protein differential expression in normal tissues from HIPED for TC2N Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.5), Pancreas (17.2), and Lung (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TC2N Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TC2N

SOURCE GeneReport for Unigene cluster for TC2N Gene:

Hs.510262

Evidence on tissue expression from TISSUES for TC2N Gene

  • Blood(4.3)
genes like me logo Genes that share expression patterns with TC2N: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TC2N Gene

Orthologs for TC2N Gene

This gene was present in the common ancestor of chordates.

Orthologs for TC2N Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TC2N 31 30
  • 99.39 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TC2N 31 30
  • 92.04 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TC2N 31 30
  • 89.73 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tc2n 17 31 30
  • 88.82 (n)
rat
(Rattus norvegicus)
Mammalia Tc2n 30
  • 88.62 (n)
oppossum
(Monodelphis domestica)
Mammalia TC2N 31
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TC2N 31
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TC2N 31 30
  • 70.82 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TC2N 31
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tc2n 30
  • 65.49 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC101885722 30
  • 52.79 (n)
TC2N 31
  • 43 (a)
OneToOne
Species where no ortholog for TC2N was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TC2N Gene

ENSEMBL:
Gene Tree for TC2N (if available)
TreeFam:
Gene Tree for TC2N (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TC2N: view image

Paralogs for TC2N Gene

Pseudogenes.org Pseudogenes for TC2N Gene

genes like me logo Genes that share paralogs with TC2N: view

Variants for TC2N Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TC2N Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs2402073 - p.Lys151Thr
rs8020529 - p.Ser172Asn

Additional dbSNP identifiers (rs#s) for TC2N Gene

Structural Variations from Database of Genomic Variants (DGV) for TC2N Gene

Variant ID Type Subtype PubMed ID
esv3307793 CNV mobile element insertion 20981092
esv3406882 CNV insertion 20981092
esv3635327 CNV gain 21293372
nsv1053264 CNV loss 25217958

Variation tolerance for TC2N Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.99; 36.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TC2N Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TC2N

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TC2N Gene

Disorders for TC2N Gene

MalaCards: The human disease database

(1) MalaCards diseases for TC2N Gene - From: DISEASES

Disorder Aliases PubMed IDs
von willebrand disease, type 1
  • vwd1
- elite association - COSMIC cancer census association via MalaCards
Search TC2N in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TC2N

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TC2N: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TC2N Gene

Publications for TC2N Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Tac2-N, an atypical C-type tandem C2 protein localized in the nucleus. (PMID: 11526914) Fukuda M … Mikoshiba K (FEBS letters 2001) 2 3 54
  4. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for TC2N Gene

Sources for TC2N Gene