Aliases for TBXA2R Gene
Aliases for TBXA2R Gene
External Ids for TBXA2R Gene
- HGNC: 11608
- Entrez Gene: 6915
- Ensembl: ENSG00000006638
- OMIM: 188070
- UniProtKB: P21731
Previous GeneCards Identifiers for TBXA2R Gene
- GC19M003687
- GC19M003664
- GC19M003534
- GC19M003545
- GC19M003359
Summaries for TBXA2R Gene
-
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for TBXA2R Gene
TBXA2R (Thromboxane A2 Receptor) is a Protein Coding gene. Diseases associated with TBXA2R include Bleeding Disorder, Platelet-Type, 13 and Aspirin Resistance. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and thromboxane receptor activity. An important paralog of this gene is PTGER1.
UniProtKB/Swiss-Prot for TBXA2R Gene
-
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
-
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.
Additional gene information for TBXA2R Gene
- Monarch Initiative
- Search for TBXA2R at DataMed
- Search for TBXA2R at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBXA2R Gene
Genomics for TBXA2R Gene
GeneHancer (GH) Regulatory Elements for TBXA2R Gene
Promoters and enhancers for TBXA2R Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TBXA2R on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TBXA2R gene promoter:
Regulatory Element Products
Genomic Locations for TBXA2R Gene
Genomic Locations for TBXA2R Gene
- chr19:3,594,506-3,606,851
- (GRCh38/hg38)
- Size:
- 12,346 bases
- Orientation:
- Minus strand
- chr19:3,594,504-3,606,838
- (GRCh37/hg19)
Genomic View for TBXA2R Gene
Genes around TBXA2R on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by Ensembl
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC
TBXA2R Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TBXA2R Gene
Proteins for TBXA2R Gene
-
Protein details for TBXA2R Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P21731-TA2R_HUMAN
- Recommended name:
- Thromboxane A2 receptor
- Protein Accession:
- P21731
- O75228
- Q6DK52
- Q9UCY1
- Q9UCY2
Protein attributes for TBXA2R Gene
- Size:
- 343 amino acids
- Molecular mass:
- 37431 Da
- Quaternary structure:
-
- Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with RACK1; the interaction regulates TBXA2R cell surface expression.
- SequenceCaution:
-
- Sequence=AAA58957.1; Type=Frameshift; Positions=329; Evidence={ECO:0000305};
Protein Expression for TBXA2R Gene
Post-translational modifications for TBXA2R Gene
Other Protein References for TBXA2R Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TBXA2R
-
Abcam antibodies for TBXA2R
-
Cloud-Clone Corp. Antibodies for TBXA2R
- Invitrogen Antibodies for TBXA2R
- GeneTex TBXA2R antibody for TBXA2R
-
Santa Cruz Biotechnology (SCBT) Antibodies for TBXA2R
Protein Products
-
OriGene Purified Proteins for TBXA2R
- Search Origene for MassSpec and Protein Over-expression Lysates for TBXA2R
- Origene Custom Protein Services for TBXA2R
-
Cloud-Clone Corp. Proteins for TBXA2R
- antibodies-online: Search results for 3 available TBXA2R Proteins ranked by validation data
- Compare Top TBXA2R Proteins
-
Quality Products:
- Search GeneTex for Proteins for TBXA2R
Assay Products
-
Cloud-Clone Corp. Assay Kits for TBXA2R
No data available for DME Specific Peptides for TBXA2R Gene
Domains & Families for TBXA2R Gene
Gene Families for TBXA2R Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Disease related genes
- FDA approved drug targets
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for TBXA2R Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TBXA2R Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P21731- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for TBXA2R Gene
Molecular function for TBXA2R Gene
- GENATLAS Biochemistry:
- thromboxane A2 receptor (platelet,placenta,lung,megakaryocyte), G protein coupled receptor superfamily
- UniProtKB/Swiss-Prot Function:
- Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004871 | signal transducer activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0004960 | thromboxane receptor activity | IEA | -- |
| GO:0004961 | thromboxane A2 receptor activity | TAS | 8119956 |
| GO:0005085 | guanyl-nucleotide exchange factor activity | TAS | -- |
Phenotypes for TBXA2R Gene
- MGI mutant phenotypes for TBXA2R:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for TBXA2R:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TBXA2R
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TBXA2R gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TBXA2R gene
- Search ViGene Biosciences for TBXA2R
CRISPR Products
-
OriGene CRISPR knockouts for TBXA2R
- genomics-online: gRNA clones - Search results for available TBXA2R gene related products
- Applied Biological Materials CRISPR for TBXA2R
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TBXA2R
- GenScript: Design CRISPR guide RNA sequences for TBXA2R
miRNA for TBXA2R Gene
- miRTarBase miRNAs that target TBXA2R
-
- hsa-mir-124-3p (MIRT022135)
- hsa-mir-31-5p (MIRT054726)
- hsa-mir-665 (MIRT466501)
- hsa-mir-566 (MIRT466502)
- hsa-mir-6513-5p (MIRT466503)
- hsa-mir-887-5p (MIRT466504)
- hsa-mir-3913-5p (MIRT466505)
- hsa-mir-3122 (MIRT466506)
- hsa-mir-450a-1-3p (MIRT466507)
- hsa-mir-6780a-5p (MIRT466508)
- hsa-mir-6779-5p (MIRT466509)
- hsa-mir-3689c (MIRT466510)
- hsa-mir-3689b-3p (MIRT466511)
- hsa-mir-3689a-3p (MIRT466512)
- hsa-mir-30b-3p (MIRT466513)
- hsa-mir-1273h-5p (MIRT466514)
- hsa-mir-6788-5p (MIRT466515)
- hsa-mir-30c-2-3p (MIRT466516)
- hsa-mir-30c-1-3p (MIRT466517)
- hsa-mir-6514-3p (MIRT466518)
- hsa-mir-7977 (MIRT466519)
- hsa-mir-1206 (MIRT466520)
- hsa-mir-203a-5p (MIRT466521)
- hsa-mir-6799-5p (MIRT466522)
- hsa-mir-6883-5p (MIRT466523)
- hsa-mir-6785-5p (MIRT466524)
- hsa-mir-4728-5p (MIRT466525)
- hsa-mir-149-3p (MIRT466526)
- hsa-mir-7106-5p (MIRT466527)
- hsa-mir-7160-5p (MIRT466528)
- hsa-mir-6811-3p (MIRT466529)
- hsa-mir-214-5p (MIRT466530)
- hsa-mir-6884-5p (MIRT466531)
- hsa-mir-485-5p (MIRT466532)
- hsa-mir-4679 (MIRT466533)
- hsa-mir-383-3p (MIRT466534)
- hsa-mir-4478 (MIRT466535)
- hsa-mir-4419b (MIRT466536)
- hsa-mir-3929 (MIRT466537)
- hsa-mir-3680-3p (MIRT639342)
- hsa-mir-557 (MIRT639343)
- hsa-mir-507 (MIRT639344)
- hsa-mir-450b-5p (MIRT639345)
- hsa-mir-6809-3p (MIRT639346)
- hsa-mir-6833-3p (MIRT639347)
- hsa-mir-4768-5p (MIRT639348)
- hsa-mir-4753-3p (MIRT639349)
- hsa-mir-3191-5p (MIRT639350)
- hsa-mir-6873-3p (MIRT639351)
- hsa-mir-3140-3p (MIRT639352)
- hsa-mir-130b-5p (MIRT639353)
- hsa-mir-6817-3p (MIRT639354)
- hsa-mir-7110-3p (MIRT639355)
- hsa-mir-4665-5p (MIRT684242)
- hsa-mir-1275 (MIRT684243)
- hsa-mir-6720-5p (MIRT684244)
- hsa-mir-6512-3p (MIRT684245)
- hsa-mir-5010-5p (MIRT684246)
- hsa-mir-4525 (MIRT684247)
- hsa-mir-7111-5p (MIRT684248)
- hsa-mir-6870-5p (MIRT684249)
- hsa-mir-5698 (MIRT684250)
- hsa-mir-4723-5p (MIRT684251)
- hsa-mir-625-5p (MIRT684252)
- hsa-mir-661 (MIRT684253)
- hsa-mir-4696 (MIRT684254)
- hsa-mir-637 (MIRT684255)
- hsa-mir-766-3p (MIRT684256)
- hsa-mir-6852-5p (MIRT684257)
- hsa-mir-6827-3p (MIRT684258)
- hsa-mir-340-3p (MIRT684259)
- hsa-mir-6849-3p (MIRT684260)
- hsa-mir-6501-3p (MIRT684261)
- hsa-mir-451b (MIRT684262)
- hsa-mir-508-5p (MIRT684263)
- hsa-mir-4432 (MIRT684264)
- hsa-mir-1471 (MIRT762741)
- hsa-mir-4787-3p (MIRT772342)
- hsa-mir-5089-5p (MIRT773247)
- hsa-mir-619-5p (MIRT776060)
- hsa-mir-6504-3p (MIRT776587)
- hsa-mir-6506-5p (MIRT776609)
miRNA Products
- Search ViGene Biosciences for TBXA2R
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TBXA2R
- Browse OriGene Inhibitory RNA Products For TBXA2R
- genomics-online: shRNA clones - Search results for available TBXA2R gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TBXA2R gene
Clone Products
-
OriGene ORF clones in human for TBXA2R
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TBXA2R
- VectorBuilder custom plasmid, inducible vectors for TBXA2R
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TBXA2R
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TBXA2R
- genomics-online: cdna clones - Search results for available TBXA2R gene related products
- orf clones - Search results for available TBXA2R gene related products
- Applied Biological Materials Clones for TBXA2R
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TBXA2R (Thromboxane A2 R/TBXA2R)
Cell Line Products
-
Horizon Cell Lines for TBXA2R
-
ViGene Biosciences adenoviral particle packaged cDNA for TBXA2R gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TBXA2R gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TBXA2R gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TBXA2R Gene
Localization for TBXA2R Gene
Subcellular locations from UniProtKB/Swiss-Prot for TBXA2R Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 4 |
| extracellular | 1 |
- Plasma membrane (3)
- Nuclear speckles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001669 | acrosomal vesicle | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 1825698 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TBXA2R Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors | ||
| 2 | Eicosanoid ligand-binding receptors | ||
| 3 | Signaling by GPCR | ||
| 4 | RET signaling | ||
| 5 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
Pathways by source for TBXA2R Gene
2 BioSystems pathways for TBXA2R Gene
14 Reactome pathways for TBXA2R Gene
3 PharmGKB pathways for TBXA2R Gene
3 KEGG pathways for TBXA2R Gene
1 GeneGo (Thomson Reuters) pathway for TBXA2R Gene
1 Qiagen pathway for TBXA2R Gene
Interacting Proteins for TBXA2R Gene
Selected Interacting proteins:
P21731-TA2R_HUMAN
ENSP00000393333
for TBXA2R Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006954 | inflammatory response | IEA | -- |
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | -- |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | IEA | -- |
| GO:0007584 | response to nutrient | IEA | -- |
Drugs & Compounds for TBXA2R Gene
(77) Drugs for TBXA2R Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Iloprost | Approved, Investigational | Pharma | Full agonist, Agonist, agonist | Prostacyclin (PGI2) analog, Others | 83 | |
| Ridogrel | Approved | Pharma | Target, antagonist | 0 | ||
| Aspirin | Approved, Vet_approved | Pharma | Channel blocker | 1232 | ||
| Seratrodast | Approved | Pharma | Target, antagonist | 0 | ||
| calcium | Approved | Nutra | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| GR 32191 |
|
Antagonist |
|
|||
| Thromboxane |
|
66719-58-2 | ||||
| Thromboxane A2 |
|
57576-52-0 | ||||
| AGN192093 |
|
Agonist |
|
|
||
| CTA<sub>2</sub> |
|
Full agonist, Agonist |
|
(5) Tocris Compounds for TBXA2R Gene
| Compound | Action | Cas Number |
|---|---|---|
| (+-)-Cloprostenol sodium salt | Water-soluble PGF2alpha analog and potent FP receptor agonist | 55028-72-3 |
| BMY 45778 | Non-prostanoid prostacyclin IP receptor partial agonist | 152575-66-1 |
| Iloprost | Prostacyclin (PGI2) analog | 78919-13-8 |
| Prostaglandin E2 | Major endogenous prostanoid | 363-24-6 |
| U 46619 | Potent, stable thromboxane A2 (TP) receptor agonist | 56985-40-1 |
(1) ApexBio Compounds for TBXA2R Gene
| Compound | Action | Cas Number |
|---|---|---|
| Ozagrel HCl | 78712-43-3 |
Transcripts for TBXA2R Gene
mRNA/cDNA for TBXA2R Gene
- (3) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (27) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TBXA2R Gene
CRISPR Products
-
OriGene CRISPR knockouts for TBXA2R
- genomics-online: gRNA clones - Search results for available TBXA2R gene related products
- Applied Biological Materials CRISPR for TBXA2R
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TBXA2R
- GenScript: Design CRISPR guide RNA sequences for TBXA2R
miRNA Products
- Search ViGene Biosciences for TBXA2R
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TBXA2R
- Browse OriGene Inhibitory RNA Products For TBXA2R
- genomics-online: shRNA clones - Search results for available TBXA2R gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TBXA2R gene
Clone Products
-
OriGene ORF clones in human for TBXA2R
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TBXA2R
- VectorBuilder custom plasmid, inducible vectors for TBXA2R
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TBXA2R
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TBXA2R
- genomics-online: cdna clones - Search results for available TBXA2R gene related products
- orf clones - Search results for available TBXA2R gene related products
- Applied Biological Materials Clones for TBXA2R
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for TBXA2R (Thromboxane A2 R/TBXA2R)
Expression for TBXA2R Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for TBXA2R Gene
This gene is overexpressed in Artery - Aorta (x8.3), Artery - Tibial (x7.9), and Artery - Coronary (x6.7).
This gene is overexpressed in Platelet (61.8) and Peripheral blood mononuclear cells (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBXA2R Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of TBXA2R Gene:
TBXA2RSOURCE GeneReport for Unigene cluster for TBXA2R Gene:
Hs.442530Evidence on tissue expression from TISSUES for TBXA2R Gene
- Blood(4.4)
- Heart(4.2)
- Lung(4.2)
- Liver(4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TBXA2R Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- integumentary
Regions:
Head and neck:
- face
- head
- nose
General:
- blood vessel
- coagulation system
- skin
Primer Products
-
OriGene qPCR primer pairs for TBXA2R
-
OriGene qPCR primer pairs and template standards for TBXA2R
- genomics-online: primer clones - Search results for available TBXA2R gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt for TBXA2R Gene
Orthologs for TBXA2R Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TBXA2R 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TBXA2R 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TBXA2R 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tbxa2r 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Tbxa2r 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TBXA2R 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TBXA2R 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TBXA2R 33 34 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tbxa2r 33 |
|
||
| Str.17668 33 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | ptger1c 34 |
|
ManyToMany |
- Species where no ortholog for TBXA2R was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TBXA2R Gene
(6) SIMAP similar genes for TBXA2R Gene using alignment to 5 proteins:
Variants for TBXA2R Gene
| SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs34377097 | risk-factor, Platelet-type bleeding disorder 13, susceptibility to, Bleeding disorder, platelet-type 13 (BDPLT13) [MIM:614009] | 3,600,456(-) | C/A | coding_sequence_variant, missense_variant | |
| rs387906691 | risk-factor, Platelet-type bleeding disorder 13, susceptibility to | 3,595,810(-) | C/T | coding_sequence_variant, missense_variant | |
| rs397514542 | risk-factor, Platelet-type bleeding disorder 13, susceptibility to | 3,599,913(-) | A/C | coding_sequence_variant, missense_variant | |
| rs1131882 | benign, not specified | 3,595,925(-) | G/A | coding_sequence_variant, synonymous_variant | |
| rs34486470 | benign, not specified | 3,595,008(-) | A/G | 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2717950 | CNV | deletion | 23290073 |
| esv2717952 | CNV | deletion | 23290073 |
| esv2717953 | CNV | deletion | 23290073 |
| nsv470114 | CNV | loss | 18288195 |
| nsv833713 | CNV | loss | 17160897 |
| nsv953948 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.80;
47.53% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TBXA2R Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBXA2R Gene
Disorders for TBXA2R Gene
(4) MalaCards diseases for TBXA2R Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| bleeding disorder, platelet-type, 13 |
|
|
| aspirin resistance |
|
|
| asthma |
|
|
| stroke, ischemic |
|
Search TBXA2R in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
TA2R_HUMAN- Bleeding disorder, platelet-type 13 (BDPLT13) [MIM:614009]: A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. {ECO:0000269 PubMed:7929844, ECO:0000269 PubMed:8613548}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Genatlas disease for TBXA2R Gene
bleeding diathesis with platelet unresponsiveness to thromboxane A2
Additional Disease Information for TBXA2R
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Publications for TBXA2R Gene
- Cloning and expression of cDNA for a human thromboxane A2 receptor. (PMID: 1825698) Hirata M … Narumiya S (Nature 1991) 2 3 4 22 58
- Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population. (PMID: 19403042) Park SA … Shin HD (BMB reports 2009) 3 22 44 58
- Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma. (PMID: 15898979) Kim SH … Shin HD (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005) 3 22 44 58
- Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. (PMID: 8613548) Hirata T … Narumiya S (The Journal of clinical investigation 1996) 3 4 22 58
- Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells. (PMID: 7965765) D'Angelo DD … Dorn GW (The Journal of pharmacology and experimental therapeutics 1994) 3 4 22 58
Products for TBXA2R Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- R&D Systems cDNA Clones for TBXA2R (Thromboxane A2 R/TBXA2R)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TBXA2R
- Search Origene for MassSpec and Protein Over-expression Lysates for TBXA2R
- Origene Custom Protein Services for TBXA2R
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TBXA2R
- Browse OriGene Inhibitory RNA Products For TBXA2R
- OriGene qPCR primer pairs and template standards for TBXA2R
- OriGene qPCR primer pairs for TBXA2R
- OriGene CRISPR knockouts for TBXA2R
- OriGene ORF clones in human for TBXA2R
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For TBXA2R
- GenScript: Next-day shipping of latest version cDNA ORF clones for TBXA2R in any vector
- GenScript Custom Purified and Recombinant Proteins Services for TBXA2R
- GenScript Custom Assay Services for TBXA2R
- GenScript TBXA2R - overexpressing Cell Line for Assay
- GenScript Custom overexpressing Cell Line Services for TBXA2R
- GenScript: Design CRISPR guide RNA sequences for TBXA2R
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TBXA2R
- Sino Biological Human cDNA Clone for TBXA2R
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for TBXA2R
- Novus Biologicals lysates and proteins for TBXA2R
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for TBXA2R
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for TBXA2R
- Cloud-Clone Corp. Proteins for TBXA2R
- Cloud-Clone Corp. Assay Kits for TBXA2R
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- ApexBio compounds for TBXA2R
- Cyagen custom Knockout/knockin (KOKI) mouse models for TBXA2R
- VectorBuilder custom plasmid, inducible vectors for TBXA2R
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TBXA2R
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for TBXA2R
- antibodies-online: Search results for 40 available TBXA2R Antibodies ranked by validation data
- Compare Top TBXA2R Antibodies
- antibodies-online: Search results for 16 available TBXA2R Elisa Kits ranked by validation data
- Compare Top TBXA2R Elisa Kits
- Quality Products:
- antibodies-online: Search results for 3 available TBXA2R Proteins ranked by validation data
- Compare Top TBXA2R Proteins
- Quality Products:
- GeneTex TBXA2R antibody for TBXA2R
- Search GeneTex for Proteins for TBXA2R
- ViGene Biosciences adenoviral particle packaged cDNA for TBXA2R gene
- ViGene Biosciences lentiviral particle packaged cDNA for TBXA2R gene
- ViGene Biosciences ready-to-package AAV shRNAs for TBXA2R gene
- Search ViGene Biosciences for TBXA2R
- Santa Cruz Biotechnology (SCBT) Antibodies for TBXA2R
- Search Santa Cruz Biotechnology (SCBT) for TBXA2R siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TBXA2R
- Horizon Cell Lines for TBXA2R
- genomics-online: cdna clones - Search results for available TBXA2R gene related products
- orf clones - Search results for available TBXA2R gene related products
- genomics-online: gRNA clones - Search results for available TBXA2R gene related products
- genomics-online: primer clones - Search results for available TBXA2R gene related products
- genomics-online: shRNA clones - Search results for available TBXA2R gene related products
Sources for TBXA2R Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
