Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TBXA2R Gene

Aliases for TBXA2R Gene

  • Thromboxane A2 Receptor 2 3 5
  • Prostanoid TP Receptor 3 4
  • TXA2-R 3 4
  • BDPLT13 3

External Ids for TBXA2R Gene

Previous GeneCards Identifiers for TBXA2R Gene

  • GC19M003687
  • GC19M003664
  • GC19M003534
  • GC19M003545
  • GC19M003359

Summaries for TBXA2R Gene

Entrez Gene Summary for TBXA2R Gene

  • This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

GeneCards Summary for TBXA2R Gene

TBXA2R (Thromboxane A2 Receptor) is a Protein Coding gene. Diseases associated with TBXA2R include Bleeding Disorder, Platelet-Type, 13 and Aspirin Resistance. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and thromboxane receptor activity. An important paralog of this gene is PTGER1.

UniProtKB/Swiss-Prot for TBXA2R Gene

  • Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

Tocris Summary for TBXA2R Gene

  • Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.

Gene Wiki entry for TBXA2R Gene

Additional gene information for TBXA2R Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBXA2R Gene

Genomics for TBXA2R Gene

GeneHancer (GH) Regulatory Elements for TBXA2R Gene

Promoters and enhancers for TBXA2R Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I003605 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.8 -752 4.6 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF2 POLR2B ZNF766 SP3 MCM5 CACTIN-AS1 TBXA2R ZNF77 CACTIN CCDC94 ENSG00000267030 ZNF555 ENSG00000267769 APBA3 GNA11
GH19I003604 Enhancer 0.8 ENCODE dbSUPER 550.8 +1.9 1918 0.7 NR2F1 MAX EBF1 MNT ELF1 DPF2 GLIS2 TARDBP MLLT1 RUNX3 TBXA2R PIP5K1C GIPC3
GH19I003559 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +42.9 42916 8.1 HDGF PKNOX1 SMAD1 ATF1 ARNT SIN3A ZNF280A TCF12 ZNF766 GATA2 CACTIN-AS1 CCDC94 CACTIN ZNF77 TBXA2R NCLN ENSG00000267030 LOC101928631 PLIN5 ENSG00000279590
GH19I003568 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.6 +37.9 37879 0.7 ATF1 INSM2 KLF17 BRCA1 ZBTB40 ZNF766 EGR1 RCOR1 ATF7 CREM ENSG00000266959 ENSG00000279590 TBXA2R CACTIN-AS1 HMG20B MFSD12
GH19I003603 Enhancer 1 FANTOM5 ENCODE dbSUPER 9.1 +3.3 3288 1 BCOR MEIS2 CTCF PKNOX1 RXRA ZNF623 RAD21 NR2F2 ZBTB33 PRDM4 TBXA2R CACTIN GIPC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TBXA2R on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TBXA2R gene promoter:

Genomic Locations for TBXA2R Gene

Genomic Locations for TBXA2R Gene
chr19:3,594,506-3,606,851
(GRCh38/hg38)
Size:
12,346 bases
Orientation:
Minus strand
chr19:3,594,504-3,606,838
(GRCh37/hg19)

Genomic View for TBXA2R Gene

Genes around TBXA2R on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBXA2R Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBXA2R Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBXA2R Gene

Proteins for TBXA2R Gene

  • Protein details for TBXA2R Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21731-TA2R_HUMAN
    Recommended name:
    Thromboxane A2 receptor
    Protein Accession:
    P21731
    Secondary Accessions:
    • O75228
    • Q6DK52
    • Q9UCY1
    • Q9UCY2

    Protein attributes for TBXA2R Gene

    Size:
    343 amino acids
    Molecular mass:
    37431 Da
    Quaternary structure:
    • Interacts with RPGRIP1L. Interacts with PSMA3. Interacts with RACK1; the interaction regulates TBXA2R cell surface expression.
    SequenceCaution:
    • Sequence=AAA58957.1; Type=Frameshift; Positions=329; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TBXA2R Gene

    Alternative splice isoforms for TBXA2R Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBXA2R Gene

Post-translational modifications for TBXA2R Gene

  • Glycosylation at posLast=44 and isoforms=316
  • Modification sites at PhosphoSitePlus

Other Protein References for TBXA2R Gene

No data available for DME Specific Peptides for TBXA2R Gene

Domains & Families for TBXA2R Gene

Gene Families for TBXA2R Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for TBXA2R Gene

Suggested Antigen Peptide Sequences for TBXA2R Gene

Graphical View of Domain Structure for InterPro Entry

P21731

UniProtKB/Swiss-Prot:

TA2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with TBXA2R: view

Function for TBXA2R Gene

Molecular function for TBXA2R Gene

GENATLAS Biochemistry:
thromboxane A2 receptor (platelet,placenta,lung,megakaryocyte), G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.

Gene Ontology (GO) - Molecular Function for TBXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004960 thromboxane receptor activity IEA --
GO:0004961 thromboxane A2 receptor activity TAS 8119956
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with TBXA2R: view
genes like me logo Genes that share phenotypes with TBXA2R: view

Animal Models for TBXA2R Gene

MGI Knock Outs for TBXA2R:

Animal Model Products

miRNA for TBXA2R Gene

miRTarBase miRNAs that target TBXA2R

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TBXA2R (Thromboxane A2 R/TBXA2R)

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TBXA2R Gene

Localization for TBXA2R Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBXA2R Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBXA2R gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TBXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1825698
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TBXA2R: view

Pathways & Interactions for TBXA2R Gene

genes like me logo Genes that share pathways with TBXA2R: view

SIGNOR curated interactions for TBXA2R Gene

Other effect:

Gene Ontology (GO) - Biological Process for TBXA2R Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with TBXA2R: view

Drugs & Compounds for TBXA2R Gene

(77) Drugs for TBXA2R Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iloprost Approved, Investigational Pharma Full agonist, Agonist, agonist Prostacyclin (PGI2) analog, Others 83
Ridogrel Approved Pharma Target, antagonist 0
Aspirin Approved, Vet_approved Pharma Channel blocker 1232
Seratrodast Approved Pharma Target, antagonist 0
calcium Approved Nutra 0

(33) Additional Compounds for TBXA2R Gene - From: Novoseek, HMDB, and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GR 32191
Antagonist
Thromboxane
  • Thromboxane A2
66719-58-2
Thromboxane A2
  • (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-Heptenoate
  • (1S-(1alpha,3alpha,3R*),4beta(Z),5alpha)-7-(3-(3-hydroxy-1-octenyl)-2,6-dioxabicyclo(3.1.1)hept-4-yl)-5-Heptenoic acid
  • (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-hydroxy-1-octenyl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-Heptenoate
  • (5Z)-7-[(1S,3R,4S,5S)-3-[(1E,3S)-3-hydroxy-1-octenyl]-2,6-dioxabicyclo[3.1.1]hept-4-yl]-5-Heptenoic acid
  • (5Z,13E)-(15S)-9,11-epoxy-15-hydroxythromba-5,13-dienoate
57576-52-0
AGN192093
Agonist
CTA<sub>2</sub>
Full agonist, Agonist

(5) Tocris Compounds for TBXA2R Gene

Compound Action Cas Number
(+-)-Cloprostenol sodium salt Water-soluble PGF2alpha analog and potent FP receptor agonist 55028-72-3
BMY 45778 Non-prostanoid prostacyclin IP receptor partial agonist 152575-66-1
Iloprost Prostacyclin (PGI2) analog 78919-13-8
Prostaglandin E2 Major endogenous prostanoid 363-24-6
U 46619 Potent, stable thromboxane A2 (TP) receptor agonist 56985-40-1

(1) ApexBio Compounds for TBXA2R Gene

Compound Action Cas Number
Ozagrel HCl 78712-43-3
genes like me logo Genes that share compounds with TBXA2R: view

Drug Products

Transcripts for TBXA2R Gene

Unigene Clusters for TBXA2R Gene

Thromboxane A2 receptor:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • R&D Systems cDNA Clones for TBXA2R (Thromboxane A2 R/TBXA2R)

Alternative Splicing Database (ASD) splice patterns (SP) for TBXA2R Gene

No ASD Table

Relevant External Links for TBXA2R Gene

GeneLoc Exon Structure for
TBXA2R
ECgene alternative splicing isoforms for
TBXA2R

Expression for TBXA2R Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBXA2R Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TBXA2R Gene

This gene is overexpressed in Artery - Aorta (x8.3), Artery - Tibial (x7.9), and Artery - Coronary (x6.7).

Protein differential expression in normal tissues from HIPED for TBXA2R Gene

This gene is overexpressed in Platelet (61.8) and Peripheral blood mononuclear cells (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBXA2R Gene



Protein tissue co-expression partners for TBXA2R Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBXA2R Gene:

TBXA2R

SOURCE GeneReport for Unigene cluster for TBXA2R Gene:

Hs.442530

Evidence on tissue expression from TISSUES for TBXA2R Gene

  • Blood(4.4)
  • Heart(4.2)
  • Lung(4.2)
  • Liver(4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TBXA2R Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • cardiovascular
  • integumentary
Regions:
Head and neck:
  • face
  • head
  • nose
General:
  • blood vessel
  • coagulation system
  • skin
genes like me logo Genes that share expression patterns with TBXA2R: view

No data available for mRNA Expression by UniProt/SwissProt for TBXA2R Gene

Orthologs for TBXA2R Gene

This gene was present in the common ancestor of chordates.

Orthologs for TBXA2R Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBXA2R 33 34
  • 97.92 (n)
dog
(Canis familiaris)
Mammalia TBXA2R 33 34
  • 86.51 (n)
cow
(Bos Taurus)
Mammalia TBXA2R 33 34
  • 82.65 (n)
rat
(Rattus norvegicus)
Mammalia Tbxa2r 33
  • 78.12 (n)
mouse
(Mus musculus)
Mammalia Tbxa2r 33 16 34
  • 77.61 (n)
oppossum
(Monodelphis domestica)
Mammalia TBXA2R 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBXA2R 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TBXA2R 33 34
  • 66.58 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbxa2r 33
  • 55.65 (n)
Str.17668 33
zebrafish
(Danio rerio)
Actinopterygii ptger1c 34
  • 34 (a)
ManyToMany
Species where no ortholog for TBXA2R was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBXA2R Gene

ENSEMBL:
Gene Tree for TBXA2R (if available)
TreeFam:
Gene Tree for TBXA2R (if available)

Paralogs for TBXA2R Gene

Paralogs for TBXA2R Gene

(6) SIMAP similar genes for TBXA2R Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TBXA2R: view

Variants for TBXA2R Gene

Sequence variations from dbSNP and Humsavar for TBXA2R Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs34377097 risk-factor, Platelet-type bleeding disorder 13, susceptibility to, Bleeding disorder, platelet-type 13 (BDPLT13) [MIM:614009] 3,600,456(-) C/A coding_sequence_variant, missense_variant
rs387906691 risk-factor, Platelet-type bleeding disorder 13, susceptibility to 3,595,810(-) C/T coding_sequence_variant, missense_variant
rs397514542 risk-factor, Platelet-type bleeding disorder 13, susceptibility to 3,599,913(-) A/C coding_sequence_variant, missense_variant
rs1131882 benign, not specified 3,595,925(-) G/A coding_sequence_variant, synonymous_variant
rs34486470 benign, not specified 3,595,008(-) A/G 3_prime_UTR_variant, coding_sequence_variant, genic_downstream_transcript_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for TBXA2R Gene

Variant ID Type Subtype PubMed ID
esv2717950 CNV deletion 23290073
esv2717952 CNV deletion 23290073
esv2717953 CNV deletion 23290073
nsv470114 CNV loss 18288195
nsv833713 CNV loss 17160897
nsv953948 CNV deletion 24416366

Variation tolerance for TBXA2R Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBXA2R Gene

Human Gene Mutation Database (HGMD)
TBXA2R
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBXA2R

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBXA2R Gene

Disorders for TBXA2R Gene

MalaCards: The human disease database

(4) MalaCards diseases for TBXA2R Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
bleeding disorder, platelet-type, 13
  • bleeding disorder, platelet-type, 13, susceptibility to
aspirin resistance
  • aspirin antithrombotic effect of
asthma
  • asthma, susceptibility to
stroke, ischemic
  • cerebrovascular accident
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TA2R_HUMAN
  • Bleeding disorder, platelet-type 13 (BDPLT13) [MIM:614009]: A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. {ECO:0000269 PubMed:7929844, ECO:0000269 PubMed:8613548}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Genatlas disease for TBXA2R Gene

bleeding diathesis with platelet unresponsiveness to thromboxane A2

Additional Disease Information for TBXA2R

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TBXA2R: view

Publications for TBXA2R Gene

  1. Cloning and expression of cDNA for a human thromboxane A2 receptor. (PMID: 1825698) Hirata M … Narumiya S (Nature 1991) 2 3 4 22 58
  2. Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population. (PMID: 19403042) Park SA … Shin HD (BMB reports 2009) 3 22 44 58
  3. Association of thromboxane A2 receptor gene polymorphism with the phenotype of acetyl salicylic acid-intolerant asthma. (PMID: 15898979) Kim SH … Shin HD (Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2005) 3 22 44 58
  4. Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. (PMID: 8613548) Hirata T … Narumiya S (The Journal of clinical investigation 1996) 3 4 22 58
  5. Cloning and pharmacologic characterization of a thromboxane A2 receptor from K562 (human chronic myelogenous leukemia) cells. (PMID: 7965765) D'Angelo DD … Dorn GW (The Journal of pharmacology and experimental therapeutics 1994) 3 4 22 58

Products for TBXA2R Gene

Sources for TBXA2R Gene

Content
Loading form....