Aliases for TBXA2R Gene
External Ids for TBXA2R Gene
Previous GeneCards Identifiers for TBXA2R Gene
This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
GeneCards Summary for TBXA2R Gene
TBXA2R (Thromboxane A2 Receptor) is a Protein Coding gene. Diseases associated with TBXA2R include Bleeding Disorder, Platelet-Type, 13 and Bleeding Disorder, Platelet-Type, 14. Among its related pathways are Eicosanoid ligand-binding receptors and p75 NTR receptor-mediated signalling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and thromboxane receptor activity. An important paralog of this gene is PTGER1.
UniProtKB/Swiss-Prot Summary for TBXA2R Gene
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.