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This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
TBXA2R (Thromboxane A2 Receptor) is a Protein Coding gene. Diseases associated with TBXA2R include Bleeding Disorder, Platelet-Type, 13 and Phenytoin Allergy. Among its related pathways are Eicosanoid ligand-binding receptors and RET signaling. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and thromboxane receptor activity. An important paralog of this gene is PTGFR.
Prostanoid receptors are activated by the endogenous ligands prostaglandin (PG) D2, PGE2, PGF2alpha, PGH2, prostacyclin (PGI2) and thromboxane A2. Cyclooxygenase (COX) converts arachidonic acid to PGH2, from which the other prostaglandins are synthesized.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0004960 | thromboxane receptor activity | IEA | -- |
GO:0004961 | thromboxane A2 receptor activity | TAS,IBA | 21873635 |
GO:0005085 | guanyl-nucleotide exchange factor activity | TAS | -- |
GO:0005515 | protein binding | IPI | 17644091 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001669 | acrosomal vesicle | IEA | -- |
GO:0005623 | cell | IEA | -- |
GO:0005886 | plasma membrane | TAS | -- |
GO:0005887 | integral component of plasma membrane | TAS | 1825698 |
GO:0016020 | membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Eicosanoid ligand-binding receptors | ||
3 | Signaling by GPCR | ||
4 | RET signaling | ||
5 | Response to elevated platelet cytosolic Ca2+ |
.44
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006954 | inflammatory response | IEA,IBA | 21873635 |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | IBA | 21873635 |
GO:0007204 | positive regulation of cytosolic calcium ion concentration | IEA,IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Iloprost | Approved, Investigational | Pharma | Agonist, Full agonist, agonist | Prostacyclin (PGI2) analog, Others | 93 | |
Aspirin | Approved, Vet_approved | Pharma | Channel blocker | 1512 | ||
Dinoprostone | Approved | Pharma | activates the PGE2 receptor, Major endogenous prostanoid | 137 | ||
Ridogrel | Experimental | Pharma | Target, antagonist | 0 | ||
Seratrodast | Experimental | Pharma | Target, antagonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
GR 32191 |
|
Antagonist |
|
|||
Thromboxane |
|
66719-58-2 | ||||
Thromboxane A2 |
|
57576-52-0 | ||||
AGN192093 |
|
Agonist |
|
|
||
CTA<sub>2</sub> |
|
Agonist, Full agonist |
|
Compound | Action | Cas Number |
---|---|---|
(+-)-Cloprostenol sodium salt | Water-soluble PGF2alpha analog and potent FP receptor agonist | 55028-72-3 |
BMY 45778 | Non-prostanoid prostacyclin IP receptor partial agonist | 152575-66-1 |
Iloprost | Prostacyclin (PGI2) analog | 78919-13-8 |
Prostaglandin E2 | Major endogenous prostanoid | 363-24-6 |
U 46619 | Potent, stable thromboxane A2 (TP) receptor agonist | 56985-40-1 |
Compound | Action | Cas Number |
---|---|---|
Ozagrel HCl | 78712-43-3 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | TBXA2R 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TBXA2R 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TBXA2R 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tbxa2r 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Tbxa2r 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | TBXA2R 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | TBXA2R 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TBXA2R 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tbxa2r 30 |
|
||
Str.17668 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | ptger1c 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
626956 | Uncertain Significance: Impaired thromboxane A2 agonist-induced platelet aggregation | 3,600,289(-) | CGAA/C | INFRAME_DELETION | |
627136 | Likely Pathogenic: Abnormal platelet aggregation | 3,595,935(-) | T/C | SPLICE_ACCEPTOR_VARIANT | |
627148 | Uncertain Significance: Abnormal platelet aggregation | 3,595,872(-) | G/C | MISSENSE_VARIANT | |
627364 | Uncertain Significance: Impaired thromboxane A2 agonist-induced platelet aggregation | 3,599,922(-) | T/C | MISSENSE_VARIANT | |
736890 | Benign: not provided | 3,600,086(-) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2717950 | CNV | deletion | 23290073 |
esv2717952 | CNV | deletion | 23290073 |
esv2717953 | CNV | deletion | 23290073 |
nsv470114 | CNV | loss | 18288195 |
nsv833713 | CNV | loss | 17160897 |
nsv953948 | CNV | deletion | 24416366 |
Disorder | Aliases | PubMed IDs |
---|---|---|
bleeding disorder, platelet-type, 13 |
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phenytoin allergy |
|
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allergic rhinitis |
|
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bleeding disorder, platelet-type, 14 |
|
|
water-clear cell adenoma |
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