Aliases for TBX4 Gene
External Ids for TBX4 Gene
Previous GeneCards Identifiers for TBX4 Gene
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008]
GeneCards Summary for TBX4 Gene
TBX4 (T-Box Transcription Factor 4) is a Protein Coding gene. Diseases associated with TBX4 include Ischiocoxopodopatellar Syndrome With Or Without Pulmonary Arterial Hypertension and Amelia, Posterior, With Pelvic And Pulmonary Hypoplasia Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is TBX5.
UniProtKB/Swiss-Prot Summary for TBX4 Gene
Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs.