TBX21 Gene (Protein Coding)

T-Box Transcription Factor 21

GC17P047733
GIFtS:
46
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the ex... See more...

Aliases for TBX21 Gene

Aliases for TBX21 Gene

  • T-Box Transcription Factor 21 2 3 5
  • TBLYM 2 3 4
  • T-Cell-Specific T-Box Transcription Factor T-Bet 3 4
  • T-Box Transcription Factor TBX21 3 4
  • Transcription Factor TBLYM 3 4
  • T-Box Protein 21 3 4
  • T-Box 21 2 3
  • T-Bet 2 3
  • TBET 3 4
  • T-Box Expressed In T Cells 3
  • T-PET 3
  • TBX21 5

External Ids for TBX21 Gene

Previous GeneCards Identifiers for TBX21 Gene

  • GC17P045516
  • GC17P048291
  • GC17P046152
  • GC17P046285
  • GC17P043166
  • GC17P045810
  • GC17P041179

Summaries for TBX21 Gene

Entrez Gene Summary for TBX21 Gene

  • This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for TBX21 Gene

TBX21 (T-Box Transcription Factor 21) is a Protein Coding gene. Diseases associated with TBX21 include Asthma, Nasal Polyps, And Aspirin Intolerance and Asthma. Among its related pathways are Innate Lymphoid Cell Differentiation Pathways and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is EOMES.

UniProtKB/Swiss-Prot Summary for TBX21 Gene

  • Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity).

Gene Wiki entry for TBX21 Gene

Additional gene information for TBX21 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TBX21 Gene

Genomics for TBX21 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for TBX21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TBX21 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TBX21

Top Transcription factor binding sites by QIAGEN in the TBX21 gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for TBX21 Gene

Latest Assembly
chr17:47,733,236-47,746,122
(GRCh38/hg38)
Size:
12,887 bases
Orientation:
Plus strand

Previous Assembly
chr17:45,810,602-45,823,488
(GRCh37/hg19 by Entrez Gene)
Size:
12,887 bases
Orientation:
Plus strand

chr17:45,810,610-45,823,485
(GRCh37/hg19 by Ensembl)
Size:
12,876 bases
Orientation:
Plus strand

Genomic View for TBX21 Gene

Genes around TBX21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBX21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBX21 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TBX21 Gene

Proteins for TBX21 Gene

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  • Protein details for TBX21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL17-TBX21_HUMAN
    Recommended name:
    T-box transcription factor TBX21
    Protein Accession:
    Q9UL17

    Protein attributes for TBX21 Gene

    Size:
    535 amino acids
    Molecular mass:
    58328 Da
    Quaternary structure:
    • Interacts with RUNX1, RUNX3, ITK, ABL1, RELA, CDK9 and KDM6B. The phosphorylated form (at Thr-303) interacts with NFATC2. Interacts with SMARCA4 in a KDM6B-dependent manner (By similarity). Interacts with CCTN1 (PubMed:27292648). Interacts with USP10 (PubMed:24845384). The phosphorylated form (at Tyr-530) interacts with GATA3 (PubMed:15662016).

neXtProt entry for TBX21 Gene

Protein Expression for TBX21 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TBX21 Gene

  • Phosphorylations at Ser-53, Tyr-77, Ser-225 and Ser-513 are regulated by mTORC1. Phosphorylation at Tyr-530 is essential for its interaction GATA3. Phosphorylation at Tyr-220, Tyr-266 and Tyr-305 enhances its transcriptional activator activity. Phosphorylation at Thr-303 is required for its interaction with NFATC2.
  • Ubiquitinated at Lys-314, leading to its degradation by the proteasome. Ubiquitination is essential for controlling protein stability, binding to the T-box-binding element of the IFN-gamma promoter, and for interaction with NFATC2 through induction of phosphorylation at Thr-303 (By similarity). Deubiquitinated by USP10 leading to its stabilization (PubMed:24845384).
  • Ubiquitination at Lys314
  • Modification sites at PhosphoSitePlus

Other Protein References for TBX21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

No data available for DME Specific Peptides for TBX21 Gene

Domains & Families for TBX21 Gene

Gene Families for TBX21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for TBX21 Gene

InterPro:
Blocks:
  • Transcription factor, T-box

Suggested Antigen Peptide Sequences for TBX21 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor TBLYM (TBX21_HUMAN)
genes like me logo Genes that share domains with TBX21: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TBX21 Gene

Function for TBX21 Gene

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  6. Cell Lines for research

Molecular function for TBX21 Gene

UniProtKB/Swiss-Prot Function:
Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity).

Phenotypes From GWAS Catalog for TBX21 Gene

Gene Ontology (GO) - Molecular Function for TBX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 19805038
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 18504404
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TBX21: view
genes like me logo Genes that share phenotypes with TBX21: view

Human Phenotype Ontology for TBX21 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TBX21 Gene

MGI Knock Outs for TBX21:

Animal Models for research

miRNA for TBX21 Gene

miRTarBase miRNAs that target TBX21
Targeted motifs for TBX21 Gene
HOMER Transcription Factor Regulatory Elements motif TBX21
  • Consensus sequence: AGGTGTGAAM Submotif: canonical Cell Type: CD8 GEO ID: GSE33802

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBX21

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for TBX21 Gene

Localization for TBX21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBX21 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBX21 gene
Compartment Confidence
nucleus 5
plasma membrane 3
extracellular 3
cytosol 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
lysosome 2
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TBX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005634 nucleus ISS --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TBX21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TBX21 Gene

Pathways & Interactions for TBX21 Gene

genes like me logo Genes that share pathways with TBX21: view

Pathways by source for TBX21 Gene

1 GeneGo (Thomson Reuters) pathway for TBX21 Gene
  • Immune response IL-12-induced IFN-gamma production
1 Cell Signaling Technology pathway for TBX21 Gene

SIGNOR curated interactions for TBX21 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TBX21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 18504404
GO:0001708 cell fate specification IBA 21873635
GO:0001947 heart looping IBA 21873635
GO:0006355 regulation of transcription, DNA-templated TAS 10761931
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with TBX21: view

Drugs & Compounds for TBX21 Gene

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(1) Drugs for TBX21 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
corticosteroids Pharma 0
genes like me logo Genes that share compounds with TBX21: view

Transcripts for TBX21 Gene

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mRNA/cDNA for TBX21 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBX21

Alternative Splicing Database (ASD) splice patterns (SP) for TBX21 Gene

No ASD Table

Relevant External Links for TBX21 Gene

GeneLoc Exon Structure for
TBX21

Expression for TBX21 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TBX21 Gene

mRNA expression in normal human tissues for TBX21 Gene
mRNA expression by BioGPS for TBX21 GenemRNA expression by GTEx for TBX21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TBX21 Gene

This gene is overexpressed in Whole Blood (x26.5) and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for TBX21 Gene

This gene is overexpressed in NK cells (22.8), Peripheral blood mononuclear cells (15.3), Brain (15.0), and CD8 Tcells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TBX21 Gene



Protein tissue co-expression partners for TBX21 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TBX21

SOURCE GeneReport for Unigene cluster for TBX21 Gene:

Hs.272409

mRNA Expression by UniProt/SwissProt for TBX21 Gene:

Q9UL17-TBX21_HUMAN
Tissue specificity: T-cell specific.

Evidence on tissue expression from TISSUES for TBX21 Gene

  • Blood(3.6)
  • Spleen(3.5)
  • Lymph node(3.2)
  • Bone marrow(2.9)
  • Intestine(2.5)
  • Liver(2.4)
  • Lung(2.4)
  • Skin(2.3)
  • Nervous system(2.2)
  • Kidney(2.1)
  • Heart(2.1)
  • Muscle(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TBX21 Gene

Germ Layers:
  • ectoderm
  • endoderm
Systems:
  • immune
  • respiratory
Regions:
Head and neck:
  • head
  • mouth
  • nose
  • pharynx
Thorax:
  • bronchus
  • lung
General:
  • blood
  • white blood cell
genes like me logo Genes that share expression patterns with TBX21: view

Primer products for research

Orthologs for TBX21 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBX21 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia TBX21 29 30
  • 99.75 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia TBX21 29 30
  • 90.97 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia TBX21 29 30
  • 89.97 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Tbx21 29 16 30
  • 86.35 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Tbx21 29
  • 85.98 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia TBX21 30
  • 70 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia -- 30
  • 56 (a)
 OneToMany
-- 30
  • 52 (a)
 OneToMany
-- 30
  • 51 (a)
 OneToMany
-- 30
  • 51 (a)
 OneToMany
-- 30
  • 51 (a)
 OneToMany
-- 30
  • 50 (a)
 OneToMany
-- 30
  • 50 (a)
 OneToMany
-- 30
  • 50 (a)
 OneToMany
-- 30
  • 50 (a)
 OneToMany
-- 30
  • 50 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia TBX21 30
  • 55 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii tbx21 30
  • 41 (a)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea tbx-9 30 31
  • 28 (a)
 ManyToMany
tbx-37 30
  • 27 (a)
 ManyToMany
tbx-11 30
  • 26 (a)
 ManyToMany
tbx-8 30 31
  • 26 (a)
 ManyToMany
tbx-43 30
  • 25 (a)
 ManyToMany
tbx-38 30
  • 24 (a)
 ManyToMany
tbx-34 30
  • 20 (a)
 ManyToMany
tbx-42 30
  • 19 (a)
 ManyToMany
tbx-30 30
  • 19 (a)
 ManyToMany
tbx-35 30
  • 19 (a)
 ManyToMany
tbx-40 30
  • 15 (a)
 ManyToMany
tbx-39 30
  • 14 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.7001 30
  • 15 (a)
 OneToMany
Species where no ortholog for TBX21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TBX21 Gene

ENSEMBL:
Gene Tree for TBX21 (if available)
TreeFam:
Gene Tree for TBX21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TBX21: view image
Alliance of Genome Resources:
Additional Orthologs for TBX21

Paralogs for TBX21 Gene

Paralogs for TBX21 Gene

(4) SIMAP similar genes for TBX21 Gene using alignment to 1 proteins:

  • TBX21_HUMAN
genes like me logo Genes that share paralogs with TBX21: view

Variants for TBX21 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TBX21 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
992544 Uncertain Significance: Asthma, nasal polyps, and aspirin intolerance 47,744,824(+) T/C
NM_013351.2(TBX21):c.1066T>C (p.Ser356Pro) 		MISSENSE
992545 Uncertain Significance: Asthma, nasal polyps, and aspirin intolerance 47,744,915(+) G/T
NM_013351.2(TBX21):c.1157G>T (p.Trp386Leu) 		MISSENSE
rs151279999 Benign: not provided 47,745,267(+) C/T
NM_013351.2(TBX21):c.1509C>T (p.Ser503=) 		SYNONYMOUS
rs1567918419 Uncertain Significance: Asthma, nasal polyps, and aspirin intolerance 47,733,537(+) G/A
NM_013351.2(TBX21):c.83G>A (p.Gly28Asp) 		MISSENSE
rs369295345 Likely Benign: not provided 47,743,174(+) G/A
NM_013351.2(TBX21):c.750G>A (p.Ala250=) 		SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TBX21 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TBX21 Gene

Variant ID Type Subtype PubMed ID
nsv1116224 CNV deletion 24896259
nsv2071 CNV deletion 18451855
nsv507841 OTHER sequence alteration 20534489

Variation tolerance for TBX21 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.49; 55.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBX21 Gene

Human Gene Mutation Database (HGMD)
TBX21
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBX21
Leiden Open Variation Database (LOVD)
TBX21

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBX21 Gene

Disorders for TBX21 Gene

MalaCards: The human disease database

(27) MalaCards diseases for TBX21 Gene - From: OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
asthma, nasal polyps, and aspirin intolerance
  • asa triad
asthma
  • asthma, susceptibility to
genital herpes
  • genital herpes simplex
chronic inflammatory demyelinating polyradiculoneuropathy
  • chronic inflammatory demyelinating polyneuropathy
angioimmunoblastic t-cell lymphoma
  • aitl
- elite association - COSMIC cancer census association via MalaCards
Search TBX21 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TBX21_HUMAN
  • Asthma, with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]: A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities. {ECO:0000269 PubMed:15806396}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Additional Disease Information for TBX21

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TBX21: view

No data available for Genatlas for TBX21 Gene

Publications for TBX21 Gene

  1. Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. (PMID: 15806396) Akahoshi M … Shirakawa T (Human genetics 2005) 3 4 22 40 72
  2. Association of TBX21 gene haplotypes in a Chinese population with systemic lupus erythematosus. (PMID: 20429676) You Y … Deng G (Scandinavian journal of rheumatology 2010) 3 22 40
  3. Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis. (PMID: 19287198) Chae SC … Chung HT (Experimental & molecular medicine 2009) 3 22 40
  4. TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. (PMID: 19362357) Suttner K … Kabesch M (The Journal of allergy and clinical immunology 2009) 3 22 40
  5. T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children. (PMID: 17949803) Munthe-Kaas MC … Undlien D (The Journal of allergy and clinical immunology 2008) 3 22 40

ExternalLinks

View latest publications for TBX21 gene in Mastermind

Products for TBX21 Gene

Sources for TBX21 Gene