TBX21 Gene (Protein Coding)

T-Box Transcription Factor 21

GCID:: GC17P047733

GIFtS:: 47

Genes Participants

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the ex... See more...

Aliases for TBX21 Gene

T-Box Transcription Factor 21 ² ³ ⁵
T-Cell-Specific T-Box Transcription Factor T-Bet ³ ⁴
T-Box Transcription Factor TBX21 ³ ⁴
Transcription Factor TBLYM ³ ⁴
T-Box Protein 21 ³ ⁴

T-Box 21 ² ³
TBLYM ³ ⁴
TBET ³ ⁴
T-Box Expressed In T Cells ³
T-PET ³
T-Bet ³

External Ids for TBX21 Gene

HGNC: 11599
Entrez Gene: 30009
Ensembl: ENSG00000073861
OMIM: 604895
UniProtKB: Q9UL17

Previous GeneCards Identifiers for TBX21 Gene

GC17P045516
GC17P048291
GC17P046152
GC17P046285
GC17P043166
GC17P045810
GC17P041179

Search aliases for TBX21 gene in PubMed and other databases

Summaries for TBX21 Gene

Entrez Gene Summary for TBX21 Gene

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for TBX21 Gene

TBX21 (T-Box Transcription Factor 21) is a Protein Coding gene. Diseases associated with TBX21 include Asthma, Nasal Polyps, And Aspirin Intolerance and Asthma. Among its related pathways are Development and heterogeneity of the ILC family and Glucocorticoid receptor regulatory network. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is EOMES.

UniProtKB/Swiss-Prot Summary for TBX21 Gene

Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity).
- TBX21_HUMAN,Q9UL17

Gene Wiki entry for TBX21 Gene

Additional gene information for TBX21 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TBX21 Gene

Genomics for TBX21 Gene

GeneHancer (GH) Regulatory Elements for TBX21 Gene

Promoters and enhancers for TBX21 Gene

GeneHancer (GH) Identifier	GH Type	GH Score	GH Sources	Gene Association Score	Total Score	TSS distance (kb)	Number of Genes Away	Size (kb)	Transcription Factor Binding Sites
GH17J047728	Promoter/Enhancer	1.9	EPDnew FANTOM5 Ensembl ENCODE dbSUPER	520.7	0.0	-29	8.8	CTCF SIN3A EP300 ZIC2 ZBTB26 ZNF740 RCOR1 TRIM22 EZH2 POLR2A	TBX21 TBKBP1 OSBPL7 KPNB1 SCRN2 EFCAB13 MRPL10 SP2 RF00017-2425
GH17J047700	Enhancer	1.4	FANTOM5 ENCODE dbSUPER	10.5	-28.9	-28919	8	NRF1 PHB2 ZBTB5 ZIC2 REST ZNF263 AFF1 DNMT1 HES1 TOE1	TBKBP1 MRPL45P2 SP2 EFCAB13 ENSG00000253347 ENSG00000266601 RPS7P11 LRRC37A17P OSBPL7 ENSG00000239291
GH17J047713	Enhancer	1.5	FANTOM5 Ensembl ENCODE dbSUPER	6.2	-16.3	-16335	11	ZNF217 CTCF USF1 FOS ZIC2 REST CUX1 TSC22D4 MYC CHD1	TBKBP1 EFCAB13 TBX21 SCRN2 PNPO RF00017-2425
GH17J048036	Promoter/Enhancer	1.9	EPDnew Ensembl ENCODE CraniofacialAtlas	4.3	+304.2	304204	2.1	ZNF217 TCF12 ZFX CTCF CLOCK CTBP1 TRIM22 EZH2 ZBTB26 SIN3A	COPZ2 MIR152 ENSG00000263412 PRR15L SNX11 SCRN2 TBX21 hsa-miR-5095-226
GH17J047697	Enhancer	1.3	FANTOM5 Ensembl ENCODE dbSUPER	4.8	-34.5	-34536	1.8	ZNF217 CTCF ZBTB10 REST RAD21 TRIM22 GATAD2B SMC3 CTBP1 MYC	TBKBP1 TBX21 OSBPL7 RF00017-2425

- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TBX21 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TBX21

Top Transcription factor binding sites by QIAGEN in the TBX21 gene promoter:

AP-1
ATF-2
c-Fos
c-Jun
STAT1
STAT1alpha
STAT1beta

Genomic Locations for TBX21 Gene

chr17:47,733,236-47,746,122: (GRCh38/hg38)

Size:: 12,887 bases
Orientation:: Plus strand

chr17:45,810,610-45,823,485: (GRCh37/hg19)

Size:: 12,876 bases
Orientation:: Plus strand

Genomic View for TBX21 Gene

Genes around TBX21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:

17q21.32 by HGNC
17q21.32 by Entrez Gene
17q21.32 by Ensembl

TBX21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)

Genomic Location for TBX21 Gene — Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for TBX21 Gene

NC_000017.11

Proteins for TBX21 Gene

Protein details for TBX21 Gene (UniProtKB/Swiss-Prot)

Protein Symbol:

Q9UL17-TBX21_HUMAN

Recommended name:

T-box transcription factor TBX21

Protein Accession:

Q9UL17
Protein attributes for TBX21 Gene
Size:

535 amino acids

Molecular mass:

58328 Da
Quaternary structure:
Interacts with RUNX1, RUNX3, ITK, ABL1, RELA, CDK9 and KDM6B. The phosphorylated form (at Thr-303) interacts with NFATC2. Interacts with SMARCA4 in a KDM6B-dependent manner (By similarity). Interacts with CCTN1 (PubMed:27292648). Interacts with USP10 (PubMed:24845384). The phosphorylated form (at Tyr-530) interacts with GATA3 (PubMed:15662016).

neXtProt entry for TBX21 Gene

Protein Expression for TBX21 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for TBX21 Gene

Phosphorylations at Ser-53, Tyr-77, Ser-225 and Ser-513 are regulated by mTORC1. Phosphorylation at Tyr-530 is essential for its interaction GATA3. Phosphorylation at Tyr-220, Tyr-266 and Tyr-305 enhances its transcriptional activator activity. Phosphorylation at Thr-303 is required for its interaction with NFATC2.
- Q9UL17-TBX21_HUMAN
Ubiquitinated at Lys-314, leading to its degradation by the proteasome. Ubiquitination is essential for controlling protein stability, binding to the T-box-binding element of the IFN-gamma promoter, and for interaction with NFATC2 through induction of phosphorylation at Thr-303 (By similarity). Deubiquitinated by USP10 leading to its stabilization (PubMed:24845384).
- Q9UL17-TBX21_HUMAN
Ubiquitination at Lys314
- NX_Q9UL17 (NX_Q9UL17-1)
Modification sites at PhosphoSitePlus
- Q9UL17

Other Protein References for TBX21 Gene

ENSEMBL proteins:

ENSP00000177694

REFSEQ proteins:

NP_037483.1

Antibody Products

Miltenyi Biotec B.V. & Co. KG

G Biosciences Immunotag™ tbx21 Antibody

Creative Diagnostics Anti-TBX21 monoclonal antibody, clone FQS0412

Creative Biolabs Recombinant Anti-Human TBX21 Antibody

BioLegend

GeneTex Anti-TBX21 antibody [N1C2]

OriGene Antibodies for TBX21
- AM32239SU-N
- TA320469
- TA320470
- TA324549
- TA326655
- TA327741
- TA329696
- TA330627
- TA342329
- TA342330
Custom Antibody Services

Novus Biologicals Antibodies for TBX21

Abcam antibodies for TBX21
- T-bet / Tbx21

Invitrogen Antibodies for TBX21 (AFLGC-TBX21)

antibodies-online: Show 28 available T-Bet Antibodies ranked by validation data

Biorbyt antibodies for TBX21
- orb179078
- orb7075

Boster Bio Antibodies for TBX21
- M00404
- PA1999

ProSci Antibodies for TBX21
- T-box 21
Custom Antibody Services

Santa Cruz Biotechnology (SCBT) Antibodies for TBX21

Browse Sino Biological Antibodies

Protein Products

OriGene Purified Proteins for TBX21
- NM_013351
- NM_013351
- NM_013351
- NM_013351
- NM_019507
Search Origene for MassSpec and Protein Over-expression Lysates for TBX21
Origene Custom Protein Services for TBX21

Novus Biologicals proteins and lysates for TBX21

Browse ProSpec Recombinant Proteins

antibodies-online: Search results for available T-Bet related products ranked by validation data

Signalway Proteins for TBX21
- AP88455

Search for TBX21 Proteins at ProSci

Abcam proteins for TBX21
- T-bet / Tbx21

Assay Products

G Biosciences Immunotag™ Human TBX21 (T-box transcription factor TBX21) ELISA and Immunotag™ T-box transcription factor TBX21 ELISA Kit

Aviva Systems Biology TBX21 ELISA Kit (Human) : 96 Wells (OKEH01759) and TBX21 ELISA Kit (Human) (OKCD09430)

antibodies-online: Search results for available T-Bet related products ranked by validation data

Browse Boster Bio ELISA Kits

Signalway ELISA kits for TBX21
- EK4673
- EK16819

Abcam assays for TBX21
- T-bet / Tbx21

Browse Sino Biological Assays

No data available for DME Specific Peptides for TBX21 Gene

Domains & Families for TBX21 Gene

Gene Families for TBX21 Gene

HGNC:

T-box transcription factors

Human Protein Atlas (HPA):

Disease related genes
Predicted intracellular proteins
Transcription factors

Protein Domains for TBX21 Gene

Blocks:

Transcription factor, T-box

InterPro:

ProtoNet:

Q9UL17

Suggested Antigen Peptide Sequences for TBX21 Gene

GenScript: Design optimal peptide antigens:

Transcription factor TBLYM (TBX21_HUMAN)

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TBX21 Gene

Function for TBX21 Gene

Molecular function for TBX21 Gene

UniProtKB/Swiss-Prot Function:

Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931). Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation (By similarity). Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells (PubMed:27292648). Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program (By similarity).

TBX21_HUMAN,Q9UL17

Phenotypes From GWAS Catalog for TBX21 Gene

Gene Ontology (GO) - Molecular Function for TBX21 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	NAS	19274049
GO:0001102	RNA polymerase II activating transcription factor binding	IBA	21873635
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IC	--
GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IBA	21873635

Phenotypes for TBX21 Gene

MGI mutant phenotypes for TBX21:

inferred from 6 alleles

GenomeRNAi human phenotypes for TBX21:

Human Phenotype Ontology for TBX21 Gene

HPO Id	HPO Name	Alternative Ids	Definition	Synonyms

Animal Models for TBX21 Gene

MGI Knock Outs for TBX21:

Tbx21 ^{Tbx21<tm1Glm>}
Tbx21 ^{Tbx21<tm1Srnr>}

Animal Model Products

Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for TBX21 - Select products 50% OFF >
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OriGene CRISPR knockouts for TBX21
- GA109374
- GA206214
- KN407902
- KN517290

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TBX21

genomics-online: gRNA clones - Search results for available T-Bet gene related products

Santa Cruz Biotechnology (SCBT) CRISPR for TBX21

miRNA for TBX21 Gene

miRTarBase miRNAs that target TBX21

hsa-mir-29b-3p (MIRT007033)

Targeted motifs for TBX21 Gene

HOMER Transcription Factor Regulatory Elements motif TBX21

Consensus sequence: AGGTGTGAAM Submotif: canonical Cell Type: CD8 GEO ID: GSE33802

miRNA Products

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Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for TBX21
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Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBX21

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Search Santa Cruz Biotechnology (SCBT) for TBX21 siRNA/shRNA

Clone Products

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OriGene clones in human,mouse,rat for TBX21
- SC209713
- MC217597
- RN212710
- SC115297
- SC322597
OriGene ORF clones in human,mouse,rat for TBX21
- MG227202
- MR227202
- MR227202L3
- MR227202L4
- RC207902
- RC207902L1
- RC207902L2
- RC207902L3
- RC207902L4
- RG207902
- RR212710
- RR212710L3
- RR212710L4
- MR227202L3V
- MR227202L4V
- RC207902L1V
- RC207902L2V
- RC207902L3V
- RC207902L4V
- RR212710L3V
- RR212710L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for TBX21

Search Addgene for plasmids for TBX21

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genomics-online: cdna clones - Search results for available T-Bet gene related products
orf clones - Search results for available T-Bet gene related products

Cell Line Products

Browse ESI BIO Cell Lines and PureStem Progenitors for TBX21

Browse GeneCopoeia Cell Lines

VectorBuilder Stable cell line generation for TBX21

Horizon Cell Lines for TBX21
- TBX21 knockout cell line
- TBX21 knockout cell line

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for TBX21 Gene

Localization for TBX21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBX21 Gene

Nucleus.

Q9UL17-TBX21_HUMAN

Subcellular locations from

COMPARTMENTS

Compartment	Confidence
nucleus	5
plasma membrane	3
extracellular	3
cytosol	3
cytoskeleton	2
mitochondrion	2
endoplasmic reticulum	2
endosome	2
lysosome	2
peroxisome	1
golgi apparatus	1

Gene Ontology (GO) - Cellular Components for TBX21 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IBA,ISS	--
GO:0043025	neuronal cell body	IEA	--

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TBX21 Gene

Pathways & Interactions for TBX21 Gene

SuperPathways for TBX21 Gene

	SuperPathway	Contained pathways
1	Th17 cell differentiation	Th1 and Th2 cell differentiation .55 Th17 cell differentiation .55	Inflammatory bowel disease (IBD) .37
2	Th1 Differentiation Pathway	Th1 Differentiation Pathway .38	IL27-mediated signaling events .38
3	IL12-mediated signaling events	Immune response IL-12-induced IFN-gamma production .31	IL12-mediated signaling events .31
4	NF-kappaB Signaling	NF-kappaB Signaling -
5	Innate Lymphoid Cell Differentiation Pathways	Innate Lymphoid Cell Differentiation Pathways -

Pathways by source for TBX21 Gene

7 BioSystems pathways for TBX21 Gene

3 KEGG pathways for TBX21 Gene

1 GeneGo (Thomson Reuters) pathway for TBX21 Gene

Immune response IL-12-induced IFN-gamma production

2 R&D Systems pathways for TBX21 Gene

1 Cell Signaling Technology pathway for TBX21 Gene

NF-kappaB Signaling

Interacting Proteins for TBX21 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)

Selected Interacting proteins: Q9UL17-TBX21_HUMAN ENSP00000177694 for TBX21 Gene via UniProtKB STRING IID

Symbol	External ID(s)	Details
CREBBP	Q92793 ⁴ ¹²⁷ ENSP00000262367 ²¹	EBI-3922312, EBI-81215 STRING: ENSP00000262367 IID: # exp=1
EP300	Q09472 ⁴ ¹²⁷ ENSP00000263253 ²¹	EBI-3922312, EBI-447295 STRING: ENSP00000263253 IID: # exp=1
GATA3	P23771 ⁴ ¹²⁷ ENSP00000368632 ²¹	EBI-3922312, EBI-6664760 STRING: ENSP00000368632 IID: # exp=1 # pred=2
SP1	P08047 ⁴ ¹²⁷ ENSP00000329357 ²¹	EBI-3922312, EBI-298336 STRING: ENSP00000329357 IID: # exp=1
BCL6	ENSP00000384371 ²¹ P41182 ¹²⁷	STRING: ENSP00000384371 IID: # exp=1 # pred=1

GPS-Prot Interaction Network for TBX21

;

SIGNOR curated interactions for TBX21 Gene

Activates:

TBX21
IFNG

Inactivates:

Is activated by:

STAT1
TBX21

Is inactivated by:

GATA3

Gene Ontology (GO) - Biological Process for TBX21 Gene

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	18504404
GO:0001708	cell fate specification	IBA	21873635
GO:0001947	heart looping	IBA	21873635
GO:0006355	regulation of transcription, DNA-templated	TAS	10761931
GO:0007275	multicellular organism development	TAS	10761931

Drugs & Compounds for TBX21 Gene

(1) Drugs for TBX21 Gene - From: PharmGKB

Name	Status	Disease Links	Group	Role	Mechanism of Action	Clinical Trials
corticosteroids		MalaCards Medline Plus	Pharma			0

Drug Products

Browse Tocris compounds for TBX21

Browse compounds at ApexBio

Transcripts for TBX21 Gene

mRNA/cDNA for TBX21 Gene

1 REFSEQ mRNAs :

NM_013351.2

4 NCBI additional mRNA sequence :

2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

ENST00000177694 2583 bps (ENST00000177694.2)
ENST00000581328 718 bps (ENST00000581328.1)

CRISPR Products

Applied Biological Materials (abm): CRISPR Clones for TBX21 - Select products 50% OFF >
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* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene CRISPR knockouts for TBX21
- GA109374
- GA206214
- KN407902
- KN517290

Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TBX21

genomics-online: gRNA clones - Search results for available T-Bet gene related products

Santa Cruz Biotechnology (SCBT) CRISPR for TBX21

miRNA Products

Search GeneCopoeia for miRNA 3'UTR Target clone products for TBX21

Browse OriGene miRNA Products For TBX21

Inhibitory RNA Products

Origene shrna, sirna, and RNAi products in human, mouse, rat for TBX21
Browse OriGene Inhibitory RNA Products For TBX21

Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBX21

genomics-online: shRNA clones - Search results for available T-Bet gene related products

Search Santa Cruz Biotechnology (SCBT) for TBX21 siRNA/shRNA

Clone Products

Applied Biological Materials (abm): Clones for TBX21 - Select products 50% OFF >
* TBX21 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
* Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All

OriGene clones in human,mouse,rat for TBX21
- SC209713
- MC217597
- RN212710
- SC115297
- SC322597
OriGene ORF clones in human,mouse,rat for TBX21
- MG227202
- MR227202
- MR227202L3
- MR227202L4
- RC207902
- RC207902L1
- RC207902L2
- RC207902L3
- RC207902L4
- RG207902
- RR212710
- RR212710L3
- RR212710L4
- MR227202L3V
- MR227202L4V
- RC207902L1V
- RC207902L2V
- RC207902L3V
- RC207902L4V
- RR212710L3V
- RR212710L4V
Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling

Sino Biological Human cDNA Clone for TBX21

Search Addgene for plasmids for TBX21

Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TBX21

genomics-online: cdna clones - Search results for available T-Bet gene related products
orf clones - Search results for available T-Bet gene related products

Alternative Splicing Database (ASD) splice patterns (SP) for TBX21 Gene

No ASD Table

Relevant External Links for TBX21 Gene

GeneLoc Exon Structure for: TBX21

Expression for TBX21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TBX21 Gene

mRNA expression in normal human tissues for TBX21 Gene

mRNA expression by BioGPS for TBX21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
Blood (Hematopoietic System)
- Hematopoietic Bone Marrow

mRNA differential expression in normal tissues according to GTEx for TBX21 Gene

This gene is overexpressed in Whole Blood (x26.5) and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for TBX21 Gene

This gene is overexpressed in NK cells (22.8), Peripheral blood mononuclear cells (15.3), Brain (15.0), and CD8 Tcells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TBX21 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TBX21 Gene

Integrated proteomics: cell line protein expression from ProteomicsDB, MOPED and MaxQB for TBX21 Gene

Protein tissue co-expression partners for TBX21 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TBX21

SOURCE GeneReport for Unigene cluster for TBX21 Gene:

Hs.272409

mRNA Expression by UniProt/SwissProt for TBX21 Gene:

Q9UL17-TBX21_HUMAN

Tissue specificity: T-cell specific.

Evidence on tissue expression from TISSUES for TBX21 Gene

Blood(3.6)
Spleen(3.2)
Lymph node(2.8)
Lung(2.3)
Bone marrow(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TBX21 Gene

Germ Layers:

ectoderm
endoderm

Systems:

immune
respiratory

Regions:

Head and neck:

head
mouth
nose
pharynx

Thorax:

bronchus
lung

General:

blood
white blood cell

Primer Products

OriGene qPCR primer pairs for TBX21
- HP210499
- MP216689
OriGene qPCR primer pairs and template standards for TBX21
- HK210116

genomics-online: primer clones - Search results for available T-Bet gene related products

Gene Expression Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for TBX21

Orthologs for TBX21 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBX21 Gene

Organism	Taxonomy	Gene	Similarity	Type	Details
chimpanzee (Pan troglodytes)	Mammalia	TBX21 ³¹ ³⁰	99.75 (n)	OneToOne	17:9861810-9874735 749275 XM_001173500.2 XP_001173500.1
dog (Canis familiaris)	Mammalia	TBX21 ³¹ ³⁰	90.97 (n)	OneToOne	9:24077761-24086606 491044 XM_548164.3 XP_548164.1
cow (Bos Taurus)	Mammalia	TBX21 ³¹ ³⁰	89.97 (n)	OneToOne	19:39351741-39363523 538933 NM_001192140.1 NP_001179069.1
mouse (Mus musculus)	Mammalia	Tbx21 ¹⁷ ³¹ ³⁰	86.35 (n)		97098071 11:97098071-97115331 57765 NM_019507.2 NP_062380.2
rat (Rattus norvegicus)	Mammalia	Tbx21 ³⁰	85.98 (n)		303496 NM_001107043.1 NP_001100513.1
platypus (Ornithorhynchus anatinus)	Mammalia	TBX21 ³¹	70 (a)	OneToOne	Contig11606:16580-19726
oppossum (Monodelphis domestica)	Mammalia	-- ³¹	56 (a)	OneToMany	3:335187466-335188131
		-- ³¹	52 (a)	OneToMany	3:381765957-381766616
		-- ³¹	51 (a)	OneToMany	3:263616080-263616724
		-- ³¹	51 (a)	OneToMany	3:381810777-381811436
		-- ³¹	51 (a)	OneToMany	2:199949591-199966847
		-- ³¹	50 (a)	OneToMany	3:263606716-263607360
		-- ³¹	50 (a)	OneToMany	3:333624604-333625275
		-- ³¹	50 (a)	OneToMany	Un:102206947-102207591
		-- ³¹	50 (a)	OneToMany	3:326960602-326961267
		-- ³¹	50 (a)	OneToMany	3:327377426-327378070
lizard (Anolis carolinensis)	Reptilia	TBX21 ³¹	55 (a)	OneToOne	6:74470000-74477010
zebrafish (Danio rerio)	Actinopterygii	tbx21 ³¹	41 (a)	OneToOne	12:30297350-30318978
worm (Caenorhabditis elegans)	Secernentea	tbx-9 ³¹ ³²	28 (a)	ManyToMany	III:10339984-10341858
		tbx-37 ³¹	27 (a)	ManyToMany	III:11224800-11227125
		tbx-11 ³¹	26 (a)	ManyToMany	III:6045660-6046905
		tbx-8 ³¹ ³²	26 (a)	ManyToMany	III:10347575-10349740
		tbx-43 ³¹	25 (a)	ManyToMany	III:1765412-1770091
		tbx-38 ³¹	24 (a)	ManyToMany	III:11784076-11786052
		tbx-34 ³¹	20 (a)	ManyToMany	III:11216395-11218260
		tbx-42 ³¹	19 (a)	ManyToMany	IV:5232845-5233875
		tbx-30 ³¹	19 (a)	ManyToMany	IV:5236522-5237552
		tbx-35 ³¹	19 (a)	ManyToMany	II:5524200-5525379
		tbx-40 ³¹	15 (a)	ManyToMany	IV:15326939-15328186
		tbx-39 ³¹	14 (a)	ManyToMany	IV:15323893-15325189
sea squirt (Ciona savignyi)	Ascidiacea	CSA.7001 ³¹	15 (a)	OneToMany	reftig_107:324117-331918

Species where no ortholog for TBX21 was found in the sources mined by GeneCards:

A. gosspyii yeast (Ashbya gossypii)
Actinobacteria (Mycobacterium tuberculosis)
African clawed frog (Xenopus laevis)
African malaria mosquito (Anopheles gambiae)
Alicante grape (Vitis vinifera)
alpha proteobacteria (Wolbachia pipientis)
amoeba (Dictyostelium discoideum)
Archea (Pyrococcus horikoshii)
baker's yeast (Saccharomyces cerevisiae)
barley (Hordeum vulgare)
beta proteobacteria (Neisseria meningitidis)
bread mold (Neurospora crassa)
chicken (Gallus gallus)
Chromalveolata (Phytophthora infestans)
common water flea (Daphnia pulex)
corn (Zea mays)
E. coli (Escherichia coli)
filamentous fungi (Aspergillus nidulans)
Firmicute bacteria (Streptococcus pneumoniae)
fission yeast (Schizosaccharomyces pombe)
fruit fly (Drosophila melanogaster)
green algae (Chlamydomonas reinhardtii)
honey bee (Apis mellifera)
K. lactis yeast (Kluyveromyces lactis)
loblloly pine (Pinus taeda)
malaria parasite (Plasmodium falciparum)
medicago trunc (Medicago Truncatula)
moss (Physcomitrella patens)
orangutan (Pongo pygmaeus)
pig (Sus scrofa)
rainbow trout (Oncorhynchus mykiss)
rice (Oryza sativa)
rice blast fungus (Magnaporthe grisea)
schistosome parasite (Schistosoma mansoni)
sea anemone (Nematostella vectensis)
sea urchin (Strongylocentrotus purpuratus)
sorghum (Sorghum bicolor)
soybean (Glycine max)
stem rust fungus (Puccinia graminis)
sugarcane (Saccharum officinarum)
thale cress (Arabidopsis thaliana)
tomato (Lycopersicon esculentum)
toxoplasmosis (Toxoplasma gondii)
Trichoplax (Trichoplax adhaerens)
tropical clawed frog (Silurana tropicalis)
wheat (Triticum aestivum)

Evolution for TBX21 Gene

ENSEMBL:: Gene Tree for TBX21 (if available)
TreeFam:: Gene Tree for TBX21 (if available)
Aminode:: Evolutionary constrained regions (ECRs) for TBX21: view image

Paralogs for TBX21 Gene

EOMES ⁵
TBR1 ⁵
MGA ⁵
TBX2 ⁵
TBX5 ⁵
TBX4 ⁵
TBX1 ⁵
TBX3 ⁵
TBX19 ⁵
TBX18 ⁵
TBX10 ⁵
TBX6 ⁵
TBX15 ⁵
TBX20 ⁵
TBXT ⁵
TBX22 ⁵

(4) SIMAP similar genes for TBX21 Gene using alignment to 1 proteins:

TBX21_HUMAN

Variants for TBX21 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TBX21 Gene

SNP ID	Clinical significance and condition	Chr 17 pos	Variation	Type
733866	Likely Benign: not provided	47,743,174(+)	G/A	SYNONYMOUS_VARIANT
781304	Likely Benign: not provided	47,744,192(+)	C/T	INTRON_VARIANT
785822	Benign: not provided	47,745,267(+)	C/T	SYNONYMOUS_VARIANT
rs1567918419	Uncertain Significance: Asthma, nasal polyps, and aspirin intolerance	47,733,537(+)	G/A	MISSENSE_VARIANT
rs750645061	Uncertain Significance: Asthma, nasal polyps, and aspirin intolerance	47,745,030(+)	G/T	MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TBX21 Gene

Structural Variations from Database of Genomic Variants (DGV) for TBX21 Gene

Variant ID	Type	Subtype	PubMed ID
nsv1116224	CNV	deletion	24896259
nsv2071	CNV	deletion	18451855
nsv507841	OTHER	sequence alteration	20534489

Variation tolerance for TBX21 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)

Gene Damage Index Score: 3.49; 55.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBX21 Gene

Human Gene Mutation Database (HGMD): TBX21
SNPedia medical, phenotypic, and genealogical associations of SNPs for: TBX21

SNP Genotyping and Copy Number Assay Products

Applied Biosystems by Thermo Fisher Scientific TaqMan® Assays for TBX21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBX21 Gene

Disorders for TBX21 Gene

(24) MalaCards diseases for TBX21 Gene - From: OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder	Aliases	PubMed IDs
asthma, nasal polyps, and aspirin intolerance	asa triad	15806396
asthma	asthma, susceptibility to	19362357
genital herpes	genital herpes simplex
chronic inflammatory demyelinating polyradiculoneuropathy	chronic inflammatory demyelinating polyneuropathy
angioimmunoblastic t-cell lymphoma	aitl

- elite association - COSMIC cancer census association via MalaCards

Search TBX21 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TBX21_HUMAN

Asthma, with nasal polyps and aspirin intolerance (ANPAI) [MIM:208550]: A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities. {ECO:0000269 PubMed:15806396}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for TBX21

Genetic Association Database: (GAD)
Human Genome Epidemiology Navigator: (HuGE)
: ATLAS of Genetics and Cytogenetics in Oncology and Haematology

Search disorders for TBX21 gene in PubMed and other databases

No data available for Genatlas for TBX21 Gene

Publications for TBX21 Gene

Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. (PMID: 15806396) Akahoshi M … Shirakawa T (Human genetics 2005) ³ ⁴ ²³ ⁴¹ ⁵⁴
Association of TBX21 gene haplotypes in a Chinese population with systemic lupus erythematosus. (PMID: 20429676) You Y … Deng G (Scandinavian journal of rheumatology 2010) ³ ²³ ⁴¹ ⁵⁴
TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. (PMID: 19362357) Suttner K … Kabesch M (The Journal of allergy and clinical immunology 2009) ³ ²³ ⁴¹ ⁵⁴
Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis. (PMID: 19287198) Chae SC … Chung HT (Experimental & molecular medicine 2009) ³ ²³ ⁴¹ ⁵⁴
T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children. (PMID: 17949803) Munthe-Kaas MC … Undlien D (The Journal of allergy and clinical immunology 2008) ³ ²³ ⁴¹ ⁵⁴