Aliases for TBX2 Gene
External Ids for TBX2 Gene
- HGNC: 11597
- Entrez Gene: 6909
- Ensembl: ENSG00000121068
- OMIM: 600747
- UniProtKB: Q13207
Previous GeneCards Identifiers for TBX2 Gene
- GC17P059241
- GC17P061963
- GC17P059819
- GC17P059951
- GC17P056832
- GC17P059477
- GC17P054844
Summaries for TBX2 Gene
-
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TBX2 Gene
TBX2 (T-Box 2) is a Protein Coding gene. Diseases associated with TBX2 include Ulnar-Mammary Syndrome and Inguinal Hernia. Among its related pathways are Heart Development and Kit receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is TBX3.
UniProtKB/Swiss-Prot for TBX2 Gene
-
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBX2 Gene
Genomics for TBX2 Gene
GeneHancer (GH) Regulatory Elements for TBX2 Gene
Promoters and enhancers for TBX2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around TBX2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the TBX2 gene promoter:
Regulatory Element Products
Genomic Locations for TBX2 Gene
Genomic Locations for TBX2 Gene
- chr17:61,394,698-61,409,466
- (GRCh38/hg38)
- Size:
- 14,769 bases
- Orientation:
- Plus strand
- chr17:59,477,257-59,486,827
- (GRCh37/hg19)
Genomic View for TBX2 Gene
Genes around TBX2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q23.2 by Ensembl
- 17q23.2 by Entrez Gene
- 17q23.2 by HGNC
TBX2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TBX2 Gene
Proteins for TBX2 Gene
-
Protein details for TBX2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13207-TBX2_HUMAN
- Recommended name:
- T-box transcription factor TBX2
- Protein Accession:
- Q13207
- Q16424
- Q7Z647
Protein attributes for TBX2 Gene
- Size:
- 712 amino acids
- Molecular mass:
- 75066 Da
- Quaternary structure:
-
- Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4).
- SequenceCaution:
-
- Sequence=AAA73861.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305}; Sequence=AAH52566.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for TBX2 Gene
Post-translational modifications for TBX2 Gene
Other Protein References for TBX2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for TBX2 (TBX2)
-
Custom Antibody ServicesOriGene Antibodies for TBX2
- Novus Biologicals Antibodies for TBX2
-
Abcam antibodies for TBX2
- Invitrogen Antibodies for TBX2
- GeneTex TBX2 antibody for TBX2
-
Santa Cruz Biotechnology (SCBT) Antibodies for TBX2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TBX2
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- Search GeneTex for Proteins for TBX2
-
Abcam proteins for TBX2
Assay Products
No data available for DME Specific Peptides for TBX2 Gene
Domains & Families for TBX2 Gene
Gene Families for TBX2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for TBX2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TBX2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13207UniProtKB/Swiss-Prot:
TBX2_HUMAN :- The repression domain 1 (RD1) is necessary for its interaction with PML.
- Domain:
-
- The repression domain 1 (RD1) is necessary for its interaction with PML.
Function for TBX2 Gene
Molecular function for TBX2 Gene
- GENATLAS Biochemistry:
- murine T-box gene Tbx2 (T,brachyury) homolog,with homology to Drosophila,Trg,expressed in placenta,fetal and adult lung,kidney,adult ovary,prostate,spleen,testis,involved in developmental regulation
- UniProtKB/Swiss-Prot Function:
- Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation.
Phenotypes From GWAS Catalog for TBX2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 11111039 |
| GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 11111039 |
| GO:0003677 | DNA binding | TAS,IEA | 8530034 |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 22002537 |
Phenotypes for TBX2 Gene
- MGI mutant phenotypes for TBX2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for TBX2:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for TBX2 gene
-
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- Search ViGene Biosciences for TBX2
CRISPR Products
-
OriGene CRISPR knockouts for TBX2
- genomics-online: gRNA clones - Search results for 86 available TBX2 gene related products
- Overview of 86 available TBX2 gene related products
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Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA for TBX2 Gene
- miRTarBase miRNAs that target TBX2
-
- hsa-mir-124-3p (MIRT022554)
- hsa-mir-744-5p (MIRT037721)
- hsa-mir-4446-5p (MIRT616073)
- hsa-mir-3679-3p (MIRT616074)
- hsa-mir-6810-5p (MIRT616075)
- hsa-mir-6826-3p (MIRT616076)
- hsa-mir-4652-5p (MIRT616077)
- hsa-mir-3191-3p (MIRT616078)
- hsa-mir-3144-5p (MIRT616079)
- hsa-mir-8089 (MIRT616080)
- hsa-mir-4700-5p (MIRT616081)
- hsa-mir-4667-5p (MIRT616082)
- hsa-mir-6852-5p (MIRT616083)
- hsa-mir-6791-5p (MIRT616084)
- hsa-mir-4292 (MIRT616085)
- hsa-mir-331-3p (MIRT616086)
- hsa-mir-6810-3p (MIRT616087)
- hsa-mir-6801-3p (MIRT616088)
miRNA Products
- Search ViGene Biosciences for TBX2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TBX2
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TBX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TBX2
-
ViGene Biosciences adenoviral particle packaged cDNA for TBX2 gene
-
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-
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TBX2 Gene
Localization for TBX2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TBX2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA,IEA | 15042700 |
| GO:0005667 | transcription factor complex | IEA | -- |
Pathways & Interactions for TBX2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Inhibition of Ribosome Biogenesis by p14(ARF) | ||
| 2 | Heart Development | ||
| 3 | Kit receptor signaling pathway | ||
Pathways by source for TBX2 Gene
2 BioSystems pathways for TBX2 Gene
1 Qiagen pathway for TBX2 Gene
Interacting Proteins for TBX2 Gene
Selected Interacting proteins:
Q13207-TBX2_HUMAN
ENSP00000240328
for TBX2 Gene via
MINT
STRING
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 11111039 |
| GO:0001947 | heart looping | ISS | -- |
| GO:0003007 | heart morphogenesis | IEA | -- |
| GO:0003148 | outflow tract septum morphogenesis | IEA,ISS | -- |
| GO:0003151 | outflow tract morphogenesis | ISS,IEA | -- |
No data available for SIGNOR curated interactions for TBX2 Gene
Transcripts for TBX2 Gene
mRNA/cDNA for TBX2 Gene
- (2) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (118) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TBX2
- genomics-online: gRNA clones - Search results for 86 available TBX2 gene related products
- Overview of 86 available TBX2 gene related products
- Applied Biological Materials CRISPR for TBX2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TBX2
- GenScript: Design CRISPR guide RNA sequences for TBX2
miRNA Products
- Search ViGene Biosciences for TBX2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for TBX2
- Browse OriGene Inhibitory RNA Products For TBX2
- genomics-online: shRNA clones - Search results for 86 available TBX2 gene related products
- Overview of 86 available TBX2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TBX2 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TBX2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TBX2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TBX2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - |
Expression for TBX2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Cardiomyocytes Inner Curvature
- Cardiomyocytes Left Atrium
- Cardiomyocytes Atrioventricular Septum
- Cardiomyocytes Outflow Tract
- Atrioventricular Canal Cells Atrioventricular Canal
mRNA differential expression in normal tissues according to GTEx for TBX2 Gene
This gene is overexpressed in Lung (x5.3) and Artery - Coronary (x4.9).
This gene is overexpressed in Spinal cord (32.3) and Pancreatic juice (18.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TBX2 Gene
NURSA nuclear receptor signaling pathways regulating expression of TBX2 Gene:
TBX2SOURCE GeneReport for Unigene cluster for TBX2 Gene:
Hs.531085mRNA Expression by UniProt/SwissProt for TBX2 Gene:
Q13207-TBX2_HUMAN
Tissue specificity:
Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
Evidence on tissue expression from TISSUES for TBX2 Gene
- Nervous system(4.4)
- Liver(4.1)
- Lung(3)
- Heart(2.2)
- Eye(2.1)
- Muscle(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for TBX2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- nervous
- respiratory
- skeleton
Regions:
Head and neck:
- brain
- ear
- face
- forehead
- head
- skull
Thorax:
- aorta
- heart
- heart valve
- lung
Limb:
- digit
- finger
- foot
- hand
- lower limb
- toe
- upper limb
General:
- blood
- blood vessel
Primer Products
-
OriGene qPCR primer pairs for TBX2
-
OriGene qPCR primer pairs and template standards for TBX2
- genomics-online: primer clones - Search results for 86 available TBX2 gene related products
- Overview of 86 available TBX2 gene related products
Gene Expression Assay Products
No data available for Protein tissue co-expression partners for TBX2 Gene
Orthologs for TBX2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TBX2 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | TBX2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | TBX2 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Tbx2 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TBX2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TBX2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TBX2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tbx2 33 |
|
||
| Str.9437 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68420 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tbx2a 34 |
|
OneToMany | |
| tbx2b 33 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2629 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | bi 35 34 |
|
||
| org-1 35 |
|
|
|||
| Doc2 35 |
|
|
|||
| Doc3 35 |
|
|
|||
| Doc1 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | tbx-2 35 34 |
|
||
| tbx-9 35 |
|
|
|||
| tbx-8 35 |
|
|
|||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.7740 33 |
|
- Species where no ortholog for TBX2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for TBX2 Gene
Variants for TBX2 Gene
| SNP ID | Clin | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002796 | -- | 61,408,867(+) | C/T | 3_prime_UTR_variant | |
| rs1000197126 | -- | 61,398,231(+) | G/C | upstream_transcript_variant | |
| rs1000379778 | -- | 61,402,884(+) | G/A/C | intron_variant | |
| rs1000423 | -- | 61,398,281(+) | C/T | upstream_transcript_variant | |
| rs1000660871 | -- | 61,398,454(+) | C/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.29;
40.96% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TBX2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBX2 Gene
Disorders for TBX2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| ulnar-mammary syndrome |
|
|
| inguinal hernia |
|
|
Search TBX2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TBX2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for TBX2 Gene
Publications for TBX2 Gene
- Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene. (PMID: 8530034) Campbell C … Beatty B (Genomics 1995) 2 3 4 22 58
- Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family. (PMID: 8597636) Law DJ … Silver LM (Mammalian genome : official journal of the International Mammalian Genome Society 1995) 3 4 22 58
- Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence. (PMID: 22002537) Martin N … Bischof O (The EMBO journal 2012) 3 4 58
- The T-box transcription factor Tbx2: its role in development and possible implication in cancer. (PMID: 19960541) Abrahams A … Prince S (IUBMB life 2010) 3 22 58
- T-box 2 represses NDRG1 through an EGR1-dependent mechanism to drive the proliferation of breast cancer cells. (PMID: 20348948) Redmond KL … Mullan PB (Oncogene 2010) 3 22 58
Products for TBX2 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 76 available TBX2 Antibodies ranked by validation data
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- Overview of 86 available TBX2 gene related products
- orf clones - Search results for 86 available TBX2 gene related products
- Overview of 86 available TBX2 gene related products
- genomics-online: gRNA clones - Search results for 86 available TBX2 gene related products
- Overview of 86 available TBX2 gene related products
- genomics-online: primer clones - Search results for 86 available TBX2 gene related products
- Overview of 86 available TBX2 gene related products
- genomics-online: shRNA clones - Search results for 86 available TBX2 gene related products
- Overview of 86 available TBX2 gene related products
Sources for TBX2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
