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Aliases for TBRG4 Gene
Aliases for TBRG4 Gene
External Ids for TBRG4 Gene
- HGNC: 17443
- Entrez Gene: 9238
- Ensembl: ENSG00000136270
- OMIM: 611325
- UniProtKB: Q969Z0
Previous GeneCards Identifiers for TBRG4 Gene
- GC07M044878
- GC07M044910
- GC07M045103
- GC07M045023
- GC07M045139
Summaries for TBRG4 Gene
GeneCards Summary for TBRG4 Gene
TBRG4 (Transforming Growth Factor Beta Regulator 4) is a Protein Coding gene. Diseases associated with TBRG4 include Waardenburg Syndrome, Type 3. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is FASTKD3.
UniProtKB/Swiss-Prot Summary for TBRG4 Gene
-
Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed:9383053).
Additional gene information for TBRG4 Gene
- HGNC(17443)
- Entrez Gene(9238)
- Ensembl(ENSG00000136270)
- OMIM(611325)
- UniProtKB(Q969Z0)
- Open Targets Platform(ENSG00000136270)
- Search for TBRG4 at DataMed
- Search for TBRG4 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TBRG4 Gene
Genomics for TBRG4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for TBRG4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around TBRG4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TBRG4
- Top Transcription factor binding sites by QIAGEN in the TBRG4 gene promoter:
-
- AML1a
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Pax-4a
- XBP-1
- Zic1
Genomic Locations for TBRG4 Gene
Genomic Locations for TBRG4 Gene
- chr7:45,100,100-45,112,047
- (GRCh38/hg38)
- Size:
- 11,948 bases
- Orientation:
- Minus strand
- chr7:45,139,699-45,151,646
- (GRCh37/hg19)
- Size:
- 11,948 bases
- Orientation:
- Minus strand
Genomic View for TBRG4 Gene
Genes around TBRG4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p13 by HGNC
- 7p13 by Entrez Gene
- 7p13 by Ensembl
TBRG4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TBRG4 Gene
Proteins for TBRG4 Gene
-
Protein details for TBRG4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q969Z0-FAKD4_HUMAN
- Recommended name:
- FAST kinase domain-containing protein 4
- Protein Accession:
- Q969Z0
- A4D2L2
- A4D2L3
- D3DVL5
- D3DVL6
- O14710
- Q53GI8
- Q8NDM4
- Q9BUC6
- Q9Y2F6
Protein attributes for TBRG4 Gene
- Size:
- 631 amino acids
- Molecular mass:
- 70738 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAB69312.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=BAA76792.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for TBRG4 Gene
Post-translational modifications for TBRG4 Gene
Other Protein References for TBRG4 Gene
Antibody Products
- G Biosciences Immunotag™ TBRG4 Antibody
- Novus Biologicals Antibodies for TBRG4
-
Abcam antibodies for TBRG4
- Invitrogen Antibodies for TBRG4 (AFLGC-TBRG4)
-
Santa Cruz Biotechnology (SCBT) Antibodies for TBRG4
- Sino Biological Antibodies for TBRG4
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for TBRG4
- Origene Custom Protein Services for TBRG4
- antibodies-online: Show 4 available TBRG4 Proteins ranked by validation data
- Compare Top TBRG4 Proteins
-
Quality Products:
-
Abcam proteins for TBRG4
No data available for DME Specific Peptides for TBRG4 Gene
Domains & Families for TBRG4 Gene
Gene Families for TBRG4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for TBRG4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TBRG4 Gene
- GenScript: Design optimal peptide antigens:
-
- Transforming growth factor beta regulator 4, isoform CRA_b (D3DVL7_HUMAN)
- Transforming growth factor beta regulator 4 (TBRG4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q969Z0UniProtKB/Swiss-Prot:
FAKD4_HUMAN :- RAP domain is required for TBRG4 function in mRNA stability and translation.
- Belongs to the FAST kinase family.
- Domain:
-
- RAP domain is required for TBRG4 function in mRNA stability and translation.
- Family:
-
- Belongs to the FAST kinase family.
Function for TBRG4 Gene
Molecular function for TBRG4 Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression (PubMed:9383053).
Phenotypes From GWAS Catalog for TBRG4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | HDA | 22658674 |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 25416956 |
Phenotypes for TBRG4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TBRG4 - Select products 50% OFF >
- * TBRG4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TBRG4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TBRG4
-
Santa Cruz Biotechnology (SCBT) CRISPR for TBRG4
miRNA for TBRG4 Gene
- miRTarBase miRNAs that target TBRG4
-
- hsa-miR-16-5p (MIRT031592)
- hsa-let-7b-5p (MIRT032352)
- hsa-miR-15b-5p (MIRT046535)
- hsa-miR-493-5p (MIRT540768)
- hsa-miR-190a-3p (MIRT540769)
- hsa-miR-4789-5p (MIRT540770)
- hsa-miR-3941 (MIRT540771)
- hsa-miR-5011-5p (MIRT540772)
- hsa-miR-603 (MIRT540773)
- hsa-miR-5580-3p (MIRT540774)
- hsa-miR-362-3p (MIRT540775)
- hsa-miR-329-3p (MIRT540776)
- hsa-miR-8485 (MIRT540777)
- hsa-miR-4789-3p (MIRT614574)
- hsa-miR-129-5p (MIRT621106)
- hsa-miR-8055 (MIRT628925)
- hsa-miR-6864-3p (MIRT628926)
- hsa-miR-3672 (MIRT628927)
- hsa-miR-4524a-3p (MIRT628928)
- hsa-miR-6805-3p (MIRT664854)
- hsa-miR-5691 (MIRT664855)
- hsa-miR-5591-3p (MIRT664856)
- hsa-miR-431-5p (MIRT664857)
- hsa-miR-3194-3p (MIRT664858)
- hsa-miR-924 (MIRT664859)
- hsa-miR-5007-5p (MIRT664860)
- hsa-miR-4797-5p (MIRT664861)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TBRG4
- Browse OriGene Inhibitory RNA Products For TBRG4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBRG4
Clone Products
- Applied Biological Materials (abm): Clones for TBRG4 - Select products 50% OFF >
- * TBRG4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG217029
- MG218467
- MR217029
- MR217029L3
- MR217029L4
- MR218467
- MR218467L3
- MR218467L4
- RC204053
- RC204053L3
- RC204053L4
- RC222933
- RC222933L3
- RC222933L4
- RC222980
- RC222980L3
- RC222980L4
- RC234639
- RG204053
- RG222933
- RG222980
- RG234639
- RR202417
- RR202417L3
- RR202417L4
- MR217029L3V
- MR217029L4V
- MR218467L3V
- MR218467L4V
- RC204053L3V
- RC204053L4V
- RC222933L3V
- RC222933L4V
- RC222980L3V
- RC222980L4V
- RR202417L3V
- RR202417L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TBRG4
- Addgene plasmids for TBRG4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TBRG4
Cell Line Products
-
Horizon Cell Lines for TBRG4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBRG4 Gene
Localization for TBRG4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TBRG4 Gene
- Mitochondrion matrix.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
- Mitochondria (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IDA | 20869947 |
| GO:0005759 | mitochondrial matrix | IEA,IDA | 28335001 |
Pathways & Interactions for TBRG4 Gene
Interacting Proteins for TBRG4 Gene
Selected Interacting proteins:
Q969Z0-FAKD4_HUMAN
ENSP00000258770
for TBRG4 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for TBRG4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | IEA | -- |
| GO:0007050 | cell cycle arrest | TAS | 9383053 |
| GO:0008284 | positive regulation of cell proliferation | TAS | 9383053 |
| GO:0016071 | mRNA metabolic process | IMP | 28335001 |
| GO:0044528 | regulation of mitochondrial mRNA stability | IMP | 28335001 |
No data available for Pathways by source and SIGNOR curated interactions for TBRG4 Gene
Transcripts for TBRG4 Gene
mRNA/cDNA for TBRG4 Gene
- 4 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 17 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000258770 2226 nts (view in UCSC)
- ENST00000361278 1917 nts (view in UCSC)
- ENST00000395655 2225 nts (view in UCSC)
- ENST00000461363 856 nts (view in UCSC)
- ENST00000471142 544 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for TBRG4 - Select products 50% OFF >
- * TBRG4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for TBRG4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for TBRG4
-
Santa Cruz Biotechnology (SCBT) CRISPR for TBRG4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for TBRG4
- Browse OriGene Inhibitory RNA Products For TBRG4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBRG4
Clone Products
- Applied Biological Materials (abm): Clones for TBRG4 - Select products 50% OFF >
- * TBRG4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG217029
- MG218467
- MR217029
- MR217029L3
- MR217029L4
- MR218467
- MR218467L3
- MR218467L4
- RC204053
- RC204053L3
- RC204053L4
- RC222933
- RC222933L3
- RC222933L4
- RC222980
- RC222980L3
- RC222980L4
- RC234639
- RG204053
- RG222933
- RG222980
- RG234639
- RR202417
- RR202417L3
- RR202417L4
- MR217029L3V
- MR217029L4V
- MR218467L3V
- MR218467L4V
- RC204053L3V
- RC204053L4V
- RC222933L3V
- RC222933L4V
- RC222980L3V
- RC222980L4V
- RR202417L3V
- RR202417L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for TBRG4
- Addgene plasmids for TBRG4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for TBRG4
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP17: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP18: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP19: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP20: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP21: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP23: | - |
| ExUns: | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13a | · | 13b | · | 13c | · | 13d | · | 13e | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP11: | - | ||||||||||||||||||||||||||||||||||||||
| SP12: | - | ||||||||||||||||||||||||||||||||||||||
| SP13: | |||||||||||||||||||||||||||||||||||||||
| SP14: | |||||||||||||||||||||||||||||||||||||||
| SP15: | |||||||||||||||||||||||||||||||||||||||
| SP16: | |||||||||||||||||||||||||||||||||||||||
| SP17: | |||||||||||||||||||||||||||||||||||||||
| SP18: | |||||||||||||||||||||||||||||||||||||||
| SP19: | - | ||||||||||||||||||||||||||||||||||||||
| SP20: | |||||||||||||||||||||||||||||||||||||||
| SP21: | - | ||||||||||||||||||||||||||||||||||||||
| SP22: | - | - | |||||||||||||||||||||||||||||||||||||
| SP23: |
Relevant External Links for TBRG4 Gene
- GeneLoc Exon Structure for
- TBRG4
Expression for TBRG4 Gene
This gene is overexpressed in Bone (33.8) and Nasal epithelium (8.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TBRG4 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TBRG4
SOURCE GeneReport for Unigene cluster for TBRG4 Gene:
Hs.231411mRNA Expression by UniProt/SwissProt for TBRG4 Gene:
Q969Z0-FAKD4_HUMAN
Tissue specificity:
Ubiquitously expressed (PubMed:12759187). Expression detected in spleen, thymus, testis, ovary, colon, heart, smooth muscle, kidney, brain, lung, liver and white adipose tissue with highest expression in smooth muscle (PubMed:20869947).
Evidence on tissue expression from TISSUES for TBRG4 Gene
- Nervous system(4.9)
- Lung(4.6)
- Kidney(4.5)
- Skin(3.5)
- Intestine(2.7)
- Blood(2.4)
- Muscle(2.3)
Primer Products
-
OriGene qPCR primer pairs for TBRG4
-
OriGene qPCR primer pairs and template standards for TBRG4
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBRG4 Gene
Orthologs for TBRG4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | TBRG4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | TBRG4 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Tbrg4 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | LOC482691 30 |
|
||
| TBRG4 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | Tbrg4 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | TBRG4 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | TBRG4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | TBRG4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | TBRG4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tbrg4 30 |
|
||
| Str.7079 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC68528 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | tbrg4 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.9270 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG13850 31 |
|
OneToOne |
- Species where no ortholog for TBRG4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for TBRG4 Gene
- ENSEMBL:
- Gene Tree for TBRG4 (if available)
- TreeFam:
- Gene Tree for TBRG4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for TBRG4: view image
Paralogs for TBRG4 Gene
Variants for TBRG4 Gene
Residual Variation Intolerance Score:
15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.47;
77.44% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for TBRG4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TBRG4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TBRG4 Gene
Disorders for TBRG4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| waardenburg syndrome, type 3 |
|
|
Search TBRG4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for TBRG4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for TBRG4 Gene
Publications for TBRG4 Gene
- Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. (PMID: 9383053) Edwards MC … Elledge SJ (Genetics 1997) 2 3 4
- FASTKD1 and FASTKD4 have opposite effects on expression of specific mitochondrial RNAs, depending upon their endonuclease-like RAP domain. (PMID: 28335001) Boehm E … Martinou JC (Nucleic acids research 2017) 3 4
- Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. (PMID: 20869947) Simarro M … Anderson P (Biochemical and biophysical research communications 2010) 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41
ExternalLinks
Products for TBRG4 Gene
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- Invitrogen Antibodies for TBRG4 (AFLGC-TBRG4)
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- antibodies-online: Show 11 available TBRG4 Antibodies ranked by validation data
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- Quality Products:
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Sources for TBRG4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
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- (15) ProtoNet
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- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
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- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
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- (53) PubMed
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- (55) TGDB
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- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
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- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
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- (115) NCBI Bookshelf
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- (122) ENCODE
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (128) SNPedia
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- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB