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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016]
TBP (TATA-Box Binding Protein) is a Protein Coding gene. Diseases associated with TBP include Spinocerebellar Ataxia 17 and Parkinson Disease, Late-Onset. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and RNA Polymerase I Promoter Escape. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is TBPL2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 7933101 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000987 | proximal promoter sequence-specific DNA binding | IDA | 16263792 |
GO:0000995 | RNA polymerase III general transcription initiation factor activity | IMP | 26638071 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000126 | transcription factor TFIIIB complex | IBA | 21873635 |
GO:0000790 | nuclear chromatin | IDA | 24289924 |
GO:0001939 | female pronucleus | IEA | -- |
GO:0001940 | male pronucleus | IEA | -- |
GO:0005634 | nucleus | IEA,IDA | 9841876 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
Assembly of RNA Polymerase-II Initiation Complex
.91
Transcription of mRNA
.91
|
Protein Acetylation and Deacetylation
.51
Crosstalk Between CARM1 and ESRs
.39
Transcription Ligand-Dependent Transcription of Retinoid-Target genes
.33
|
2 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
3 | RNA Polymerase III Transcription Initiation | ||
4 | HIV Life Cycle |
.91
.65
|
.45
|
5 | HIV Transcription Elongation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006352 | DNA-templated transcription, initiation | IEA | -- |
GO:0006361 | transcription initiation from RNA polymerase I promoter | TAS | -- |
GO:0006362 | transcription elongation from RNA polymerase I promoter | TAS | -- |
GO:0006363 | termination of RNA polymerase I transcription | TAS | -- |
GO:0006366 | transcription by RNA polymerase II | IDA,TAS | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | |||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||||||
SP5: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Oppossum (Monodelphis domestica) |
Mammalia | TBP 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | TBP 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | TBP 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | TBP 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Tbp 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Tbp 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | TBP 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | TBP 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | TBP 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | tbp 30 |
|
||
Str.6374 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.6667 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | tbp 30 31 |
|
OneToOne | |
sizc101n13.2 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Trf 32 |
|
|
|
Tbp 31 32 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | tbp-1 31 32 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E10099g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SPT15 30 31 33 |
|
OneToMany | |
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AGR134W 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.2191 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.4412 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os10g0432300 30 |
|
||
Os.18508 30 |
|
||||
Barley (Hordeum vulgare) |
Liliopsida | Hv.10645 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.15 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.93 30 |
|
||
Bread mold (Neurospora crassa) |
Ascomycetes | NCU04770 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | tbp1 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.10479 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.14174 30 |
|
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1042327 | Likely Benign: not specified | 170,569,705(+) | T/C | SYNONYMOUS_VARIANT | |
rs112083427 | Uncertain Significance: not provided | 170,561,964(+) | G/A | SYNONYMOUS_VARIANT | |
rs1290125655 | Uncertain Significance: Spinocerebellar ataxia type 17 | 170,561,957(+) | A/AGC | FRAMESHIFT_VARIANT | |
rs1491487452 | Benign: not specified | 170,561,963(+) | AGC/A | FRAMESHIFT_VARIANT | |
rs55736770 | Likely Benign: Spinocerebellar ataxia type 17; not specified | 170,561,952(+) | A/G | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv6208n100 | CNV | gain | 25217958 |
dgv6209n100 | CNV | gain | 25217958 |
esv2759497 | CNV | gain+loss | 17122850 |
esv3571551 | CNV | loss | 25503493 |
esv3611742 | CNV | gain | 21293372 |
nsv1015584 | CNV | gain | 25217958 |
nsv1033491 | CNV | loss | 25217958 |
nsv428158 | CNV | gain | 18775914 |
nsv605580 | CNV | gain | 21841781 |
nsv830874 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
spinocerebellar ataxia 17 |
|
|
parkinson disease, late-onset |
|
|
autosomal dominant cerebellar ataxia |
|
|
hereditary ataxia |
|
|
gastrointestinal tuberculosis |
|
|