TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008] See more...

Aliases for TBKBP1 Gene

Aliases for TBKBP1 Gene

  • TBK1 Binding Protein 1 2 3 5
  • TANK-Binding Kinase 1-Binding Protein 1 3 4
  • SINTBAD 3 4
  • TBK1-Binding Protein 1 4
  • ProSAPiP2 3
  • KIAA0775 4

External Ids for TBKBP1 Gene

Previous GeneCards Identifiers for TBKBP1 Gene

  • GC17P043127
  • GC17P045772
  • GC17P041141

Summaries for TBKBP1 Gene

Entrez Gene Summary for TBKBP1 Gene

  • TBKBP1 is an adaptor protein that binds to TBK1 (MIM 604834) and is part of the interaction network in the TNF (MIM 191160)/NFKB (see MIM 164011) pathway (Bouwmeester et al., 2004 [PubMed 14743216]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TBKBP1 Gene

TBKBP1 (TBK1 Binding Protein 1) is a Protein Coding gene. Diseases associated with TBKBP1 include Vaccinia. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and NF-kappaB Signaling. An important paralog of this gene is AZI2.

UniProtKB/Swiss-Prot Summary for TBKBP1 Gene

  • Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.

Additional gene information for TBKBP1 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TBKBP1 Gene

Genomics for TBKBP1 Gene

GeneHancer (GH) Regulatory Elements for TBKBP1 Gene

Promoters and enhancers for TBKBP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TBKBP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TBKBP1

Top Transcription factor binding sites by QIAGEN in the TBKBP1 gene promoter:
  • AhR
  • Arnt
  • c-Myb
  • HOXA5
  • Lmo2
  • LyF-1
  • NF-E2
  • NF-E2 p45
  • POU3F2
  • RREB-1

Genomic Locations for TBKBP1 Gene

Genomic Locations for TBKBP1 Gene
chr17:47,694,065-47,712,063
(GRCh38/hg38)
Size:
17,999 bases
Orientation:
Plus strand
chr17:45,771,447-45,789,429
(GRCh37/hg19)
Size:
17,983 bases
Orientation:
Plus strand

Genomic View for TBKBP1 Gene

Genes around TBKBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBKBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBKBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBKBP1 Gene

Proteins for TBKBP1 Gene

  • Protein details for TBKBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A7MCY6-TBKB1_HUMAN
    Recommended name:
    TANK-binding kinase 1-binding protein 1
    Protein Accession:
    A7MCY6
    Secondary Accessions:
    • B2RZG6
    • O94873
    • Q14DW3

    Protein attributes for TBKBP1 Gene

    Size:
    615 amino acids
    Molecular mass:
    67702 Da
    Quaternary structure:
    • Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE.
    • (Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555).
    SequenceCaution:
    • Sequence=BAA34495.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for TBKBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBKBP1 Gene

Post-translational modifications for TBKBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TBKBP1 Gene

Domains & Families for TBKBP1 Gene

Gene Families for TBKBP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TBKBP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TBKBP1 Gene

GenScript: Design optimal peptide antigens:
  • TBK1 binding protein 1, isoform CRA_a (D3DTT5_HUMAN)
  • TANK-binding kinase 1-binding protein 1 (TBKB1_HUMAN)
genes like me logo Genes that share domains with TBKBP1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TBKBP1 Gene

Function for TBKBP1 Gene

Molecular function for TBKBP1 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.

Phenotypes From GWAS Catalog for TBKBP1 Gene

Gene Ontology (GO) - Molecular Function for TBKBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with TBKBP1: view
genes like me logo Genes that share phenotypes with TBKBP1: view

Animal Models for TBKBP1 Gene

MGI Knock Outs for TBKBP1:

Animal Model Products

CRISPR Products

miRNA for TBKBP1 Gene

miRTarBase miRNAs that target TBKBP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBKBP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TBKBP1 Gene

Localization for TBKBP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBKBP1 gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TBKBP1 Gene

Pathways & Interactions for TBKBP1 Gene

genes like me logo Genes that share pathways with TBKBP1: view

Pathways by source for TBKBP1 Gene

1 BioSystems pathway for TBKBP1 Gene
1 KEGG pathway for TBKBP1 Gene
1 Cell Signaling Technology pathway for TBKBP1 Gene

Gene Ontology (GO) - Biological Process for TBKBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016032 viral process IEA --
GO:0045087 innate immune response IEA --
genes like me logo Genes that share ontologies with TBKBP1: view

No data available for SIGNOR curated interactions for TBKBP1 Gene

Drugs & Compounds for TBKBP1 Gene

No Compound Related Data Available

Transcripts for TBKBP1 Gene

mRNA/cDNA for TBKBP1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBKBP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBKBP1 Gene

No ASD Table

Relevant External Links for TBKBP1 Gene

GeneLoc Exon Structure for
TBKBP1

Expression for TBKBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TBKBP1 Gene

mRNA differential expression in normal tissues according to GTEx for TBKBP1 Gene

This gene is overexpressed in Whole Blood (x5.5).

Protein differential expression in normal tissues from HIPED for TBKBP1 Gene

This gene is overexpressed in Heart (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TBKBP1 Gene



Protein tissue co-expression partners for TBKBP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TBKBP1

SOURCE GeneReport for Unigene cluster for TBKBP1 Gene:

Hs.94790

mRNA Expression by UniProt/SwissProt for TBKBP1 Gene:

A7MCY6-TBKB1_HUMAN
Tissue specificity: Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.

Evidence on tissue expression from TISSUES for TBKBP1 Gene

  • Liver(4.1)
genes like me logo Genes that share expression patterns with TBKBP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBKBP1 Gene

Orthologs for TBKBP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TBKBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBKBP1 31 30
  • 93.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TBKBP1 31 30
  • 91.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TBKBP1 31 30
  • 89.53 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tbkbp1 17 31 30
  • 86.54 (n)
rat
(Rattus norvegicus)
Mammalia Tbkbp1 30
  • 86.27 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TBKBP1 31
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TBKBP1 31 30
  • 72.66 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBKBP1 31
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbkbp1 30
  • 63.47 (n)
zebrafish
(Danio rerio)
Actinopterygii tbkbp1 31 30
  • 58.18 (n)
OneToOne
Species where no ortholog for TBKBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBKBP1 Gene

ENSEMBL:
Gene Tree for TBKBP1 (if available)
TreeFam:
Gene Tree for TBKBP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TBKBP1: view image

Paralogs for TBKBP1 Gene

Paralogs for TBKBP1 Gene

(1) SIMAP similar genes for TBKBP1 Gene using alignment to 4 proteins:

  • TBKB1_HUMAN
  • D3DTT5_HUMAN
  • F5H1U4_HUMAN
  • J3KS71_HUMAN
genes like me logo Genes that share paralogs with TBKBP1: view

Variants for TBKBP1 Gene

Additional dbSNP identifiers (rs#s) for TBKBP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TBKBP1 Gene

Variant ID Type Subtype PubMed ID
nsv1144808 CNV deletion 24896259
nsv953919 CNV deletion 24416366
nsv9570 CNV gain 18304495

Variation tolerance for TBKBP1 Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.76; 66.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBKBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBKBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TBKBP1 Gene

Disorders for TBKBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TBKBP1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
vaccinia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TBKBP1

genes like me logo Genes that share disorders with TBKBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TBKBP1 Gene

Publications for TBKBP1 Gene

  1. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. (PMID: 14743216) Bouwmeester T … Superti-Furga G (Nature cell biology 2004) 2 3 4 54
  2. Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7. (PMID: 21931555) Unterholzner L … Bowie AG (PLoS pathogens 2011) 3 4 54
  3. ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3. (PMID: 19481056) Liebau S … Boeckers TM (Biochemical and biophysical research communications 2009) 2 3 54
  4. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. (PMID: 17568778) Ryzhakov G … Randow F (The EMBO journal 2007) 3 4 54
  5. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 54

Products for TBKBP1 Gene

Sources for TBKBP1 Gene