The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is s... See more...

Aliases for TBK1 Gene

Aliases for TBK1 Gene

  • TANK Binding Kinase 1 2 3 5
  • Serine/Threonine-Protein Kinase TBK1 3 4
  • NF-Kappa-B-Activating Kinase 3 4
  • TANK-Binding Kinase 1 2 4
  • NAK 3 4
  • T2K 3 4
  • NF-KB-Activating Kinase 3
  • EC 2.7.11.1 4
  • EC 2.7.11 52
  • FTDALS4 3
  • IIAE8 3

External Ids for TBK1 Gene

Previous GeneCards Identifiers for TBK1 Gene

  • GC00U990677
  • GC13U900006
  • GC12P064562
  • GC12P063132
  • GC12P064845
  • GC12P061898

Summaries for TBK1 Gene

Entrez Gene Summary for TBK1 Gene

  • The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. [provided by RefSeq, Oct 2010]

CIViC Summary for TBK1 Gene

GeneCards Summary for TBK1 Gene

TBK1 (TANK Binding Kinase 1) is a Protein Coding gene. Diseases associated with TBK1 include Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4 and Encephalopathy, Acute, Infection-Induced 8. Among its related pathways are Toll-like Receptor Signaling Pathway and Ras signaling pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein kinase activity. An important paralog of this gene is IKBKE.

UniProtKB/Swiss-Prot Summary for TBK1 Gene

  • Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:10581243, PubMed:11839743, PubMed:15485837, PubMed:21138416, PubMed:25636800, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:26611359). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, TMEM173/STING and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595).

Gene Wiki entry for TBK1 Gene

Additional gene information for TBK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TBK1 Gene

Genomics for TBK1 Gene

GeneHancer (GH) Regulatory Elements for TBK1 Gene

Promoters and enhancers for TBK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TBK1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TBK1

Top Transcription factor binding sites by QIAGEN in the TBK1 gene promoter:
  • AP-1
  • AREB6
  • ATF-2
  • c-Jun
  • Nkx2-5

Genomic Locations for TBK1 Gene

Genomic Locations for TBK1 Gene
chr12:64,452,060-64,502,119
(GRCh38/hg38)
Size:
50,060 bases
Orientation:
Plus strand
chr12:64,845,660-64,895,899
(GRCh37/hg19)
Size:
50,240 bases
Orientation:
Plus strand

Genomic View for TBK1 Gene

Genes around TBK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBK1 Gene

Proteins for TBK1 Gene

  • Protein details for TBK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHD2-TBK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase TBK1
    Protein Accession:
    Q9UHD2
    Secondary Accessions:
    • A8K4S4
    • Q8IYV3
    • Q9NUJ5

    Protein attributes for TBK1 Gene

    Size:
    729 amino acids
    Molecular mass:
    83642 Da
    Quaternary structure:
    • Homodimer (PubMed:21145761). Interacts with DDX3X, TIRAP and TRAF2 (PubMed:10581243, PubMed:14530355). Part of a ternary complex consisting of TANK, TRAF2 and TBK1 (PubMed:10581243). Interacts with AZI2, TANK and TBKBP1; these interactions are mutually exclusive and mediate TBK1 activation (PubMed:14560022, PubMed:21931631, PubMed:23453972, PubMed:10581243, PubMed:29251827). Interacts with GSK3B; this interaction promotes TBK1 self-association and autophosphorylation (PubMed:21145761). Interacts with SIKE1; SIKE1 is associated with TBK1 under physiological condition and dissociated from TBK1 upon viral infection or TLR3 stimulation (PubMed:16281057). Interacts with IRF3, leading to IRF3 phosphorylation (PubMed:14703513, PubMed:25636800). Interacts with DDX58/RIG-I (PubMed:16281057). Interacts with CYLD (PubMed:18636086). Interacts with OPTN and TRAF3 (PubMed:20174559). Interacts with SRC (PubMed:19419966). Interacts with the exocyst complex subunit SEC5/EXOC2; this interaction is sufficient to trigger TBK1 activity (PubMed:17018283). Interacts with TMEM173/STING, leading to TMEM173/STING phosphorylation (PubMed:19416887, PubMed:25636800, PubMed:30842653). Interacts with IFIT3 (via N-terminus) (PubMed:21813773). Interacts with MAVS; interaction only takes place in the presence of IFIT3 and leads to MAVS phosphorylation (PubMed:21813773, PubMed:25636800, PubMed:28011935). Interacts (via protein kinase domain) with TTLL12 (via TTL domain); the interaction prevents MAVS binding to TBK1 (PubMed:28011935). Interacts with TICAM1; this interaction is enhanced in the presence of WDFY1 and leads to TICAM1 phosphorylation (PubMed:14530355, PubMed:14739303, PubMed:25736436, PubMed:25636800). Interacts with TRIM26 (PubMed:26611359). Interacts with TRIM23 (PubMed:28871090). Interacts with TTC4 and IKBKE (PubMed:29251827). Interacts with HNRNPA2B1 (PubMed:31320558).
    • (Microbial infection) Interacts with Borna disease virus (BDV) P protein leading to its phosphorylation.
    • (Microbial infection) Interacts with Ebola virus protein VP35.
    • (Microbial infection) Interacts with HCV NS3; this interaction leads to inhibition of cellular antiviral response by blocking necessary interactions between the TBK1 and its substrates IRF3 and IRF7.
    • (Microbial infection) Interacts with herpes simplex virus 1 protein ICP34.5.
    Miscellaneous:
    • In cancer cells, pathological TBK1 activation promotes oncogenic transformation by suppressing programmed cell death. Mechanistically, the RALB-SEC5/EXOC2-TBK1 signaling cascade seems to participate in both innate immune signaling and cell transformation. Additionally, TBK1 supports oncogenesis by directly phosphorylating and activating AKT1 at the exocyst (PubMed:21042276).
    SequenceCaution:
    • Sequence=BAA92129.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TBK1 Gene

neXtProt entry for TBK1 Gene

Selected DME Specific Peptides for TBK1 Gene

Q9UHD2:
  • YGTEEYLHPDMYERAVLRK
  • YHAATGSLPF
  • YNEEQIHK
  • GPRRNKE
  • HRDIKPGN

Post-translational modifications for TBK1 Gene

  • Autophosphorylation at Ser-172 activates the kinase, and is an essential step for virus-triggered signaling. Phosphorylated by IKBKB/IKKB at Ser-172. Phosphorylation requires homodimerization and ubiquitination at Lys-30 and Lys-401. Dephosphorylated at Ser-172 by PPM1B and this negatively regulates its role in mediating antiviral response.
  • 'Lys-63'-linked polyubiquitination by MIB1 after RNA virus infection, or by NRDP1 after LPS stimulation at Lys-30 and Lys-401, participates in kinase activation. 'Lys-48'-linked polyubiquitination at Lys-670 by DTX4 leads to proteasomal degradation. 'Lys-48'-linked polyubiquitination by TRAIP also leads to proteasomal degradation. 'Lys-63'-linked polyubiquitination by RNF128 at Lys-30 and Lys-401 leads to the activation of antiviral responses.
  • Ubiquitination at Lys30, Lys154, Lys401, and Lys670
  • Modification sites at PhosphoSitePlus

Domains & Families for TBK1 Gene

Gene Families for TBK1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for TBK1 Gene

Suggested Antigen Peptide Sequences for TBK1 Gene

GenScript: Design optimal peptide antigens:
  • TANK-binding kinase 1 (TBK1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UHD2

UniProtKB/Swiss-Prot:

TBK1_HUMAN :
  • Comprises A N-terminal kinase domain, a ubiquitin-like domain and a C-terminal coiled-coil region mediating homodimerization.
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Domain:
  • Comprises A N-terminal kinase domain, a ubiquitin-like domain and a C-terminal coiled-coil region mediating homodimerization.
Family:
  • Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
genes like me logo Genes that share domains with TBK1: view

Function for TBK1 Gene

Molecular function for TBK1 Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:10581243, PubMed:11839743, PubMed:15485837, PubMed:21138416, PubMed:25636800, PubMed:23453971, PubMed:23453972, PubMed:23746807, PubMed:26611359). Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (PubMed:12692549, PubMed:14703513, PubMed:18583960, PubMed:12702806, PubMed:15367631, PubMed:25636800). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (PubMed:12702806, PubMed:15367631, PubMed:25636800). In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli (PubMed:23453971, PubMed:23453972, PubMed:23746807). Plays a key role in IRF3 activation: acts by first phosphorylating innate adapter proteins MAVS, TMEM173/STING and TICAM1 on their pLxIS motif, leading to recruitment of IRF3, thereby licensing IRF3 for phosphorylation by TBK1 (PubMed:25636800, PubMed:30842653). Phosphorylated IRF3 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce expression of interferons (PubMed:25636800). Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes (PubMed:21931631). Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus (PubMed:10783893, PubMed:15489227). Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy (PubMed:21617041). Phosphorylates SMCR8 component of the C9orf72-SMCR8 complex, promoting autophagosome maturation (PubMed:27103069). Phosphorylates and activates AKT1 (PubMed:21464307). Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity (By similarity). Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C (PubMed:21270402). Phosphorylates Borna disease virus (BDV) P protein (PubMed:16155125). Plays an essential role in the TLR3- and IFN-dependent control of herpes virus HSV-1 and HSV-2 infections in the central nervous system (PubMed:22851595).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269 PubMed:10783893, ECO:0000269 PubMed:14703513, ECO:0000269 PubMed:15367631, ECO:0000269 PubMed:18583960, ECO:0000269 PubMed:21138416, ECO:0000269 PubMed:21270402, ECO:0000269 PubMed:21464307, ECO:0000269 PubMed:21617041, ECO:0000269 PubMed:25636800};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence={ECO:0000269 PubMed:10783893, ECO:0000269 PubMed:14703513, ECO:0000269 PubMed:15367631, ECO:0000269 PubMed:18583960, ECO:0000269 PubMed:21138416, ECO:0000269 PubMed:21270402, ECO:0000269 PubMed:21464307, ECO:0000269 PubMed:21617041, ECO:0000269 PubMed:25636800};.

Enzyme Numbers (IUBMB) for TBK1 Gene

Phenotypes From GWAS Catalog for TBK1 Gene

Gene Ontology (GO) - Molecular Function for TBK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004672 protein kinase activity IEA,TAS --
GO:0004674 protein serine/threonine kinase activity TAS,IBA 21042276
GO:0005515 protein binding IPI 14743216
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with TBK1: view
genes like me logo Genes that share phenotypes with TBK1: view

Human Phenotype Ontology for TBK1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TBK1 Gene

MGI Knock Outs for TBK1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBK1

No data available for Transcription Factor Targets and HOMER Transcription for TBK1 Gene

Localization for TBK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBK1 Gene

Cytoplasm. Note=Upon mitogen stimulation or triggering of the immune system, TBK1 is recruited to the exocyst by EXOC2. {ECO:0000269 PubMed:17018283}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBK1 gene
Compartment Confidence
nucleus 5
endosome 5
cytosol 5
mitochondrion 3
endoplasmic reticulum 3
plasma membrane 2
extracellular 2
cytoskeleton 2
peroxisome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TBK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IBA 21813773
GO:0005829 cytosol TAS --
GO:0010008 endosome membrane TAS --
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with TBK1: view

Pathways & Interactions for TBK1 Gene

genes like me logo Genes that share pathways with TBK1: view

SIGNOR curated interactions for TBK1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TBK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002218 activation of innate immune response IEA --
GO:0002376 immune system process IEA --
GO:0006468 protein phosphorylation IDA,IEA 27103069
GO:0006954 inflammatory response TAS 21042276
GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS 21042276
genes like me logo Genes that share ontologies with TBK1: view

Drugs & Compounds for TBK1 Gene

(4) Drugs for TBK1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0

(3) Additional Compounds for TBK1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TBK1: view

Transcripts for TBK1 Gene

mRNA/cDNA for TBK1 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBK1

Alternative Splicing Database (ASD) splice patterns (SP) for TBK1 Gene

No ASD Table

Relevant External Links for TBK1 Gene

GeneLoc Exon Structure for
TBK1

Expression for TBK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TBK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TBK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.9), Lymph node (9.1), and Lung (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TBK1 Gene



Protein tissue co-expression partners for TBK1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TBK1

SOURCE GeneReport for Unigene cluster for TBK1 Gene:

Hs.505874

mRNA Expression by UniProt/SwissProt for TBK1 Gene:

Q9UHD2-TBK1_HUMAN
Tissue specificity: Ubiquitous with higher expression in testis. Expressed in the ganglion cells, nerve fiber layer and microvasculature of the retina.

Evidence on tissue expression from TISSUES for TBK1 Gene

  • Spleen(4.5)
  • Nervous system(3.4)
  • Kidney(2.5)
  • Blood(2.4)
  • Lymph node(2.3)
  • Eye(2.2)
  • Heart(2.2)
  • Liver(2.1)
  • Muscle(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TBK1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • epiglottis
  • face
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • skull
  • tongue
  • vocal cord
Thorax:
  • bronchus
  • clavicle
  • esophagus
  • heart
  • lung
  • scapula
  • trachea
Abdomen:
  • biliary tract
  • liver
  • stomach
Limb:
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • shin
  • shoulder
  • thigh
  • toe
  • upper limb
General:
  • blood
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with TBK1: view

No data available for mRNA differential expression in normal tissues for TBK1 Gene

Orthologs for TBK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TBK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TBK1 31 30
  • 99.73 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TBK1 31 30
  • 94.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TBK1 31 30
  • 94.6 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TBK1 31
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tbk1 30
  • 86.88 (n)
mouse
(Mus musculus)
Mammalia Tbk1 17 31 30
  • 86.37 (n)
chicken
(Gallus gallus)
Aves TBK1 31 30
  • 80.29 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TBK1 31
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tbk1 30
  • 71.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14920 30
zebrafish
(Danio rerio)
Actinopterygii tbk1 31 30
  • 63.49 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ik2 31 32 30
  • 47.99 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009565 30
  • 46.21 (n)
worm
(Caenorhabditis elegans)
Secernentea Y39G8B.5 31
  • 17 (a)
ManyToMany
ikke-1 31
  • 14 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 35 (a)
OneToMany
Species where no ortholog for TBK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TBK1 Gene

ENSEMBL:
Gene Tree for TBK1 (if available)
TreeFam:
Gene Tree for TBK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TBK1: view image

Paralogs for TBK1 Gene

Paralogs for TBK1 Gene

(8) SIMAP similar genes for TBK1 Gene using alignment to 4 proteins:

  • TBK1_HUMAN
  • F5GZI4_HUMAN
  • F5H1A3_HUMAN
  • F5H206_HUMAN
genes like me logo Genes that share paralogs with TBK1: view

Variants for TBK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TBK1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
643946 Likely Pathogenic: Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 64,474,391(+) G/A SPLICE_DONOR_VARIANT
645888 Uncertain Significance: Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 64,484,458(+) G/T MISSENSE_VARIANT
647255 Uncertain Significance: Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 64,497,252(+) C/A MISSENSE_VARIANT
654729 Uncertain Significance: Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 64,484,382(+) C/T MISSENSE_VARIANT
655436 Uncertain Significance: Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 64,490,103(+) A/G MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for TBK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TBK1 Gene

Variant ID Type Subtype PubMed ID
nsv832443 CNV loss 17160897

Variation tolerance for TBK1 Gene

Residual Variation Intolerance Score: 18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.08; 38.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBK1 Gene

Human Gene Mutation Database (HGMD)
TBK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBK1 Gene

Disorders for TBK1 Gene

MalaCards: The human disease database

(30) MalaCards diseases for TBK1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
frontotemporal dementia and/or amyotrophic lateral sclerosis 4
  • ftdals4
encephalopathy, acute, infection-induced 8
  • encephalopathy, acute, infection-induced , susceptibility to, 8
frontotemporal dementia and/or amyotrophic lateral sclerosis 1
  • ftdals1
motor neuron disease
  • anterior horn cell disease
borna disease
  • enzootic encephalomyelitis
- elite association - COSMIC cancer census association via MalaCards
Search TBK1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TBK1_HUMAN
  • Glaucoma 1, open angle, P (GLC1P) [MIM:177700]: A form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. GLC1P is characterized by early onset, thin central corneas and low intraocular pressure. {ECO:0000269 PubMed:21447600, ECO:0000269 PubMed:22306015}. Note=The disease may be caused by mutations affecting the gene represented in this entry. A copy number variation on chromosome 12q14 consisting of a 300 kb duplication that includes TBK1, XPOT, RASSF3 and GNS has been found in individuals affected by glaucoma. TBK1 is the most likely candidate for the disorder (PubMed:21447600). {ECO:0000269 PubMed:21447600}.
  • Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 (FTDALS4) [MIM:616439]: A neurodegenerative disorder characterized by frontotemporal dementia and/or amyotrophic lateral sclerosis in affected individuals. There is high intrafamilial variation. Frontotemporal dementia is characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Amyotrophic lateral sclerosis is characterized by the death of motor neurons in the brain, brainstem, and spinal cord, resulting in fatal paralysis. {ECO:0000269 PubMed:25803835, ECO:0000269 PubMed:25943890}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Encephalopathy, acute, infection-induced, herpes-specific, 8 (IIAE8) [MIM:617900]: A rare, often fatal complication of herpes simplex infection, caused by virus spreading in the central nervous system. Disease manifestations include low-grade fever, severe headache, nausea, vomiting, and lethargy. Neurological features include confusion, acute memory disturbances, disorientation, behavioral changes, hemiparesis and seizures. {ECO:0000269 PubMed:22851595, ECO:0000269 PubMed:26513235}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Additional Disease Information for TBK1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TBK1: view

No data available for Genatlas for TBK1 Gene

Publications for TBK1 Gene

  1. NAK is an IkappaB kinase-activating kinase. (PMID: 10783893) Tojima Y … Nakanishi M (Nature 2000) 2 3 4 23 54
  2. NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. (PMID: 10581243) Pomerantz JL … Baltimore D (The EMBO journal 1999) 2 3 4 23 54
  3. The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. (PMID: 18636086) Friedman CS … Ting AT (EMBO reports 2008) 3 4 23 54
  4. The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. (PMID: 18583960) Soulat D … Superti-Furga G (The EMBO journal 2008) 3 4 23 54
  5. Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. (PMID: 17599067) Ikeda F … Dikic I (The EMBO journal 2007) 3 4 23 54

Products for TBK1 Gene

  • Addgene plasmids for TBK1

Sources for TBK1 Gene