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Aliases for TBC1D9B Gene

Aliases for TBC1D9B Gene

  • TBC1 Domain Family Member 9B 2 3 5
  • TBC1 Domain Family, Member 9B (With GRAM Domain) 2 3
  • KIAA0676 4
  • GRAMD9B 3

External Ids for TBC1D9B Gene

Previous GeneCards Identifiers for TBC1D9B Gene

  • GC05M179222
  • GC05M179223
  • GC05M179289
  • GC05M174013

Summaries for TBC1D9B Gene

GeneCards Summary for TBC1D9B Gene

TBC1D9B (TBC1 Domain Family Member 9B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activator activity. An important paralog of this gene is TBC1D9.

UniProtKB/Swiss-Prot for TBC1D9B Gene

  • May act as a GTPase-activating protein for Rab family protein(s).

Additional gene information for TBC1D9B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TBC1D9B Gene

Genomics for TBC1D9B Gene

GeneHancer (GH) Regulatory Elements for TBC1D9B Gene

Promoters and enhancers for TBC1D9B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I179906 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 572.9 +0.2 202 2.4 ARNT ARID4B SIN3A ZNF2 ZNF121 GLIS2 ZNF143 MXD4 PPARG GLIS1 TBC1D9B GC05M179870
GH05I179817 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.1 +87.3 87300 6.5 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SQSTM1 MRNIP HNRNPH1 MAML1 ZNF354C TBC1D9B RUFY1 RNF130 LOC105377763 ZNF879
GH05I179857 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.6 +48.7 48684 2.9 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 MRNIP LOC100996419 HNRNPH1 MAML1 TBC1D9B RUFY1 ZNF354B CNOT6
GH05I179677 Promoter/Enhancer 1.6 Ensembl ENCODE 15.8 +229.3 229253 2.3 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 CANX HMGB3P22 MRNIP HNRNPH1 MAML1 ZNF354B ZNF879 CNOT6 RUFY1 TBC1D9B
GH05I180069 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 -163.1 -163120 3.6 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 POLR2B RNF130 ZFP62 MRNIP HNRNPH1 MAML1 LOC100996419 RN7SKP150 CNOT6 RUFY1 TBC1D9B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TBC1D9B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TBC1D9B gene promoter:

Genomic Locations for TBC1D9B Gene

Genomic Locations for TBC1D9B Gene
45,794 bases
Minus strand

Genomic View for TBC1D9B Gene

Genes around TBC1D9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D9B Gene

Proteins for TBC1D9B Gene

  • Protein details for TBC1D9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    TBC1 domain family member 9B
    Protein Accession:
    Secondary Accessions:
    • D3DWQ5
    • D3DWQ6
    • O75163
    • Q53EY0
    • Q6MZI2
    • Q96H49

    Protein attributes for TBC1D9B Gene

    1250 amino acids
    Molecular mass:
    140525 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH08919.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TBC1D9B Gene


neXtProt entry for TBC1D9B Gene

Post-translational modifications for TBC1D9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TBC1D9B Gene

No data available for DME Specific Peptides for TBC1D9B Gene

Domains & Families for TBC1D9B Gene

Gene Families for TBC1D9B Gene

Graphical View of Domain Structure for InterPro Entry



  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rabs switch 2 glutamine and insert in Rabs active site.
  • The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rabs switch 2 glutamine and insert in Rabs active site.
genes like me logo Genes that share domains with TBC1D9B: view

Function for TBC1D9B Gene

Molecular function for TBC1D9B Gene

UniProtKB/Swiss-Prot Function:
May act as a GTPase-activating protein for Rab family protein(s).

Phenotypes From GWAS Catalog for TBC1D9B Gene

Gene Ontology (GO) - Molecular Function for TBC1D9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 22354992
GO:0017137 Rab GTPase binding IBA --
genes like me logo Genes that share ontologies with TBC1D9B: view
genes like me logo Genes that share phenotypes with TBC1D9B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TBC1D9B Gene

Localization for TBC1D9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D9B Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBC1D9B gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TBC1D9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TBC1D9B: view

Pathways & Interactions for TBC1D9B Gene

SuperPathways for TBC1D9B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TBC1D9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0031338 regulation of vesicle fusion IBA --
GO:0090630 activation of GTPase activity IBA --
GO:1902017 NOT regulation of cilium assembly IMP 17646400
genes like me logo Genes that share ontologies with TBC1D9B: view

No data available for Pathways by source and SIGNOR curated interactions for TBC1D9B Gene

Drugs & Compounds for TBC1D9B Gene

No Compound Related Data Available

Transcripts for TBC1D9B Gene

Unigene Clusters for TBC1D9B Gene

TBC1 domain family, member 9B (with GRAM domain):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D9B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^
SP1: - - - -
SP2: - -
SP3: -
SP8: -

ExUns: 20 ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b
SP1: - -
SP2: - - -
SP3: - - -

Relevant External Links for TBC1D9B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TBC1D9B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TBC1D9B Gene

Protein differential expression in normal tissues from HIPED for TBC1D9B Gene

This gene is overexpressed in Pancreas (7.3), Lymph node (6.8), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TBC1D9B Gene

Protein tissue co-expression partners for TBC1D9B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TBC1D9B Gene:


SOURCE GeneReport for Unigene cluster for TBC1D9B Gene:


Evidence on tissue expression from TISSUES for TBC1D9B Gene

  • Nervous system(4.9)
  • Intestine(4.3)
  • Skin(4.3)
  • Liver(4.2)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with TBC1D9B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBC1D9B Gene

Orthologs for TBC1D9B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBC1D9B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TBC1D9B 33
  • 99.48 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 91 (a)
-- 34
  • 80 (a)
(Bos Taurus)
Mammalia TBC1D9B 33 34
  • 89.33 (n)
(Canis familiaris)
Mammalia TBC1D9B 33 34
  • 89.11 (n)
(Rattus norvegicus)
Mammalia Tbc1d9b 33
  • 87.49 (n)
(Mus musculus)
Mammalia Tbc1d9b 33 16 34
  • 87.45 (n)
(Monodelphis domestica)
Mammalia TBC1D9B 34
  • 81 (a)
(Gallus gallus)
Aves TBC1D9B 33 34
  • 75.82 (n)
(Anolis carolinensis)
Reptilia TBC1D9B 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tbc1d9b 33
  • 70.26 (n)
(Danio rerio)
Actinopterygii TBC1D9B 34
  • 76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BUB2 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3902 34
  • 34 (a)
Species where no ortholog for TBC1D9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TBC1D9B Gene

Gene Tree for TBC1D9B (if available)
Gene Tree for TBC1D9B (if available)

Paralogs for TBC1D9B Gene

genes like me logo Genes that share paralogs with TBC1D9B: view

Variants for TBC1D9B Gene

Sequence variations from dbSNP and Humsavar for TBC1D9B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
VAR_036196 A breast cancer sample p.Pro1086Gln
rs1000046447 -- 179,867,662(-) G/A/T intron_variant
rs1000091683 -- 179,867,940(-) T/C intron_variant
rs1000278172 -- 179,874,722(-) C/G intron_variant
rs1000309278 -- 179,874,433(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TBC1D9B Gene

Variant ID Type Subtype PubMed ID
esv2731312 CNV deletion 23290073
esv3570597 CNV loss 25503493
esv3607755 CNV loss 21293372
esv4887 CNV loss 18987735
esv990502 CNV deletion 20482838
nsv1073523 CNV deletion 25765185
nsv327239 CNV deletion 16902084
nsv469579 CNV loss 16826518
nsv823362 CNV loss 20364138

Variation tolerance for TBC1D9B Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBC1D9B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D9B Gene

Disorders for TBC1D9B Gene

Additional Disease Information for TBC1D9B

No disorders were found for TBC1D9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TBC1D9B Gene

Publications for TBC1D9B Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for TBC1D9B Gene

Sources for TBC1D9B Gene

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