Aliases for TBC1D5 Gene
External Ids for TBC1D5 Gene
Previous GeneCards Identifiers for TBC1D5 Gene
GeneCards Summary for TBC1D5 Gene
TBC1D5 (TBC1 Domain Family Member 5) is a Protein Coding gene. Diseases associated with TBC1D5 include Legionnaire Disease. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and AP-2 adaptor complex binding. An important paralog of this gene is TBC1D9.
UniProtKB/Swiss-Prot Summary for TBC1D5 Gene
May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492).