This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insul... See more...

Aliases for TBC1D4 Gene

Aliases for TBC1D4 Gene

  • TBC1 Domain Family Member 4 2 3 4 5
  • Akt Substrate Of 160 KDa 2 3 4
  • AS160 2 3 4
  • KIAA0603 2 4
  • TBC (Tre-2, BUB2, CDC16) Domain-Containing Protein 3
  • TBC1 Domain Family, Member 4 2
  • DKFZp779C0666 2
  • NIDDM5 3
  • TBC1D4 5

External Ids for TBC1D4 Gene

Previous GeneCards Identifiers for TBC1D4 Gene

  • GC13M073826
  • GC13M069854
  • GC13M074795
  • GC13M073657
  • GC13M074757
  • GC13M075858
  • GC13M056556

Summaries for TBC1D4 Gene

Entrez Gene Summary for TBC1D4 Gene

  • This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

GeneCards Summary for TBC1D4 Gene

TBC1D4 (TBC1 Domain Family Member 4) is a Protein Coding gene. Diseases associated with TBC1D4 include Type 2 Diabetes 5 and Type 2 Diabetes Mellitus. Among its related pathways are Insulin resistance and Thyroid hormone signaling pathway. Gene Ontology (GO) annotations related to this gene include GTPase activator activity. An important paralog of this gene is TBC1D1.

UniProtKB/Swiss-Prot Summary for TBC1D4 Gene

  • May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.

Gene Wiki entry for TBC1D4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TBC1D4 Gene

Genomics for TBC1D4 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TBC1D4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J075479 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 255.5 +1.8 1843 4.2 BCLAF1 ZNF654 ZNF207 MYC ZNF600 IKZF1 ZNF223 ZSCAN16 POLR2A ZIC2 TBC1D4 HSALNG0097979 MN297215 COMMD6 UCHL3 ENSG00000228444 LMO7-AS1 ENSG00000225203
GH13J075323 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 25.3 +157.5 157492 4.5 MYC NCOR1 NFIC HES1 MNT TAF9B TAL1 ZNF316 NFE2 HLTF TBC1D4 lnc-COMMD6-9 HSALNG0097976
GH13J075328 Enhancer 1.1 FANTOM5 Ensembl ENCODE 24.9 +153.1 153069 2.2 CEBPA NFIC YY1 RXRA RBM22 JUND SOX5 HNF4A HMG20A RAD21 lnc-COMMD6-9 TBC1D4 lnc-UCHL3-2
GH13J075299 Enhancer 1 Ensembl ENCODE dbSUPER 18.2 +182.7 182743 1.6 SP1 BCL11A BATF ZNF24 BMI1 NR2F1 TCF7 ATF2 JUNB ZBED1 TBC1D4 HSALNG0097976 lnc-COMMD6-9
GH13J075372 Enhancer 1 Ensembl ENCODE dbSUPER 17.2 +109.8 109815 1.7 TRIM22 CTCF MAFF RAD21 SMC3 ZNF316 RBM22 MAFK ZNF384 MAFG TBC1D4 COMMD6 UCHL3 lnc-UCHL3-2 lnc-COMMD6-9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TBC1D4 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TBC1D4

Top Transcription factor binding sites by QIAGEN in the TBC1D4 gene promoter:
  • ATF6
  • E47
  • ER-alpha
  • GATA-1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • Sox9
  • Tal-1
  • ZIC2

Genomic Locations for TBC1D4 Gene

Latest Assembly
chr13:75,283,503-75,483,144
(GRCh38/hg38)
Size:
199,642 bases
Orientation:
Minus strand

Previous Assembly
chr13:75,857,639-76,056,305
(GRCh37/hg19 by Entrez Gene)
Size:
198,667 bases
Orientation:
Minus strand

chr13:75,858,808-76,056,250
(GRCh37/hg19 by Ensembl)
Size:
197,443 bases
Orientation:
Minus strand

Genomic View for TBC1D4 Gene

Genes around TBC1D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TBC1D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TBC1D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TBC1D4 Gene

Proteins for TBC1D4 Gene

  • Protein details for TBC1D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60343-TBCD4_HUMAN
    Recommended name:
    TBC1 domain family member 4
    Protein Accession:
    O60343
    Secondary Accessions:
    • A7E2X8
    • B4DU25
    • B4E235
    • B6ETN8
    • B6ETN9
    • Q5W0B9
    • Q68D14

    Protein attributes for TBC1D4 Gene

    Size:
    1298 amino acids
    Molecular mass:
    146563 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA25529.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TBC1D4 Gene

    Alternative splice isoforms for TBC1D4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TBC1D4 Gene

Post-translational modifications for TBC1D4 Gene

  • Phosphorylated by AKT1; insulin-induced. Also phosphorylated by AMPK in response to insulin. Insulin-stimulated phosphorylation is required for SLC2A4/GLUT4 translocation. Has no effect on SLC2A4/GLUT4 internalization. Physiological hyperinsulinemia increases phosphorylation in skeletal muscle. Insulin-stimulated phosphorylation is reduced by 39% in type 2 diabetic patients.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TBC1D4 Gene

Domains & Families for TBC1D4 Gene

Gene Families for TBC1D4 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted intracellular proteins
  • Transporters

Protein Domains for TBC1D4 Gene

InterPro:
Blocks:
  • Protein kinase PKN/PRK1, effector
  • Phosphotyrosine interaction domain
  • RabGAP/TBC domain

Suggested Antigen Peptide Sequences for TBC1D4 Gene

GenScript: Design optimal peptide antigens:
  • TBC1 domain family, member 4 (Q5JU47_HUMAN)
  • Akt substrate of 160 kDa (TBCD4_HUMAN)
genes like me logo Genes that share domains with TBC1D4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for TBC1D4 Gene

Function for TBC1D4 Gene

Molecular function for TBC1D4 Gene

UniProtKB/Swiss-Prot Function:
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.

Phenotypes From GWAS Catalog for TBC1D4 Gene

Gene Ontology (GO) - Molecular Function for TBC1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IBA 21873635
GO:0005515 protein binding IPI 15161933
GO:0031267 small GTPase binding IBA --
genes like me logo Genes that share ontologies with TBC1D4: view
genes like me logo Genes that share phenotypes with TBC1D4: view

Animal Models for TBC1D4 Gene

MGI Knock Outs for TBC1D4:

Animal Models for research

  • Taconic Biosciences Mouse Models for TBC1D4

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBC1D4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TBC1D4 Gene

Localization for TBC1D4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TBC1D4 Gene

Cytoplasm. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TBC1D4 gene
Compartment Confidence
cytosol 5
plasma membrane 3
nucleus 3
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
peroxisome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TBC1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0031982 vesicle IEA --
genes like me logo Genes that share ontologies with TBC1D4: view

Pathways & Interactions for TBC1D4 Gene

genes like me logo Genes that share pathways with TBC1D4: view

SIGNOR curated interactions for TBC1D4 Gene

Inactivates:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for TBC1D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0016192 vesicle-mediated transport IMP 22908308
GO:0031339 negative regulation of vesicle fusion IEA --
GO:0032869 cellular response to insulin stimulus IMP 22908308
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with TBC1D4: view

Drugs & Compounds for TBC1D4 Gene

(2) Additional Compounds for TBC1D4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TBC1D4: view

Transcripts for TBC1D4 Gene

mRNA/cDNA for TBC1D4 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TBC1D4

Alternative Splicing Database (ASD) splice patterns (SP) for TBC1D4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a ·
SP1: - - - - - -
SP2:
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8:
SP9:
SP10:
SP11:

ExUns: 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TBC1D4 Gene

GeneLoc Exon Structure for
TBC1D4

Expression for TBC1D4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TBC1D4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TBC1D4 Gene

This gene is overexpressed in Muscle - Skeletal (x6.1) and Adrenal Gland (x5.5).

Protein differential expression in normal tissues from HIPED for TBC1D4 Gene

This gene is overexpressed in Adrenal (17.2), Salivary gland (11.2), and Ovary (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TBC1D4 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TBC1D4

SOURCE GeneReport for Unigene cluster for TBC1D4 Gene:

Hs.210891

mRNA Expression by UniProt/SwissProt for TBC1D4 Gene:

O60343-TBCD4_HUMAN
Tissue specificity: Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis.

Evidence on tissue expression from TISSUES for TBC1D4 Gene

  • Liver(4.5)
  • Nervous system(4.5)
  • Muscle(3.5)
  • Heart(2.8)
  • Kidney(2.6)
  • Pancreas(2.4)
  • Skin(2.3)
  • Adrenal gland(2.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with TBC1D4: view

Primer products for research

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TBC1D4 Gene

Orthologs for TBC1D4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TBC1D4 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TBC1D4 29 30
  • 99.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TBC1D4 29 30
  • 89.57 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TBC1D4 29 30
  • 89.15 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia TBC1D4 30
  • 88 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TBC1D4 30
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tbc1d4 29
  • 84.81 (n)
Mouse
(Mus musculus)
Mammalia Tbc1d4 29 16 30
  • 84.63 (n)
OneToOne
Chicken
(Gallus gallus)
Aves TBC1D4 29 30
  • 75.95 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TBC1D4 30
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia tbc1d4 29
  • 69.68 (n)
Str.19119 29
Zebrafish
(Danio rerio)
Actinopterygii TBC1D4 30
  • 65 (a)
OneToOne
si:ch211-222g23.4 29
  • 64.22 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5191 29
Fruit Fly
(Drosophila melanogaster)
Insecta plx 30
  • 26 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GYP5 30
  • 19 (a)
ManyToMany
GYL1 30
  • 19 (a)
ManyToMany
Species where no ortholog for TBC1D4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for TBC1D4 Gene

ENSEMBL:
Gene Tree for TBC1D4 (if available)
TreeFam:
Gene Tree for TBC1D4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TBC1D4: view image
Alliance of Genome Resources:
Additional Orthologs for TBC1D4

Paralogs for TBC1D4 Gene

(1) SIMAP similar genes for TBC1D4 Gene using alignment to 2 proteins:

  • TBCD4_HUMAN
  • Q5JU47_HUMAN
genes like me logo Genes that share paralogs with TBC1D4: view

Variants for TBC1D4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TBC1D4 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs1062087 Likely Benign: not specified 75,310,080(-) C/Tp.Val819Ile
NM_014832.5(TBC1D4):c.2455G>A (p.Val819Ile)
MISSENSE
rs149821147 Benign: not specified; not provided 75,312,867(-) T/C
NM_014832.5(TBC1D4):c.2254A>G (p.Thr752Ala)
MISSENSE
rs1555310734 Uncertain Significance: not specified 75,362,274(-) G/A
NM_014832.5(TBC1D4):c.832C>T (p.Leu278Phe)
MISSENSE
rs1555327550 Uncertain Significance: not specified 75,481,761(-) G/T
NM_014832.5(TBC1D4):c.7C>A (p.Pro3Thr)
MISSENSE
rs17254379 Likely Benign: not specified 75,362,500(-) G/A
NM_014832.5(TBC1D4):c.606C>T (p.Phe202=)
SYNONYMOUS

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for TBC1D4 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for TBC1D4 Gene

Variant ID Type Subtype PubMed ID
dgv338n67 CNV loss 20364138
esv2747669 CNV deletion 23290073
esv2761803 CNV gain 21179565
esv3632746 CNV loss 21293372
esv3632747 CNV loss 21293372
nsv1145683 CNV deletion 24896259
nsv476054 CNV novel sequence insertion 20440878
nsv521444 CNV gain 19592680
nsv562346 CNV gain 21841781

Variation tolerance for TBC1D4 Gene

Residual Variation Intolerance Score: 23.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.20; 84.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TBC1D4 Gene

Human Gene Mutation Database (HGMD)
TBC1D4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TBC1D4
Leiden Open Variation Database (LOVD)
TBC1D4

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TBC1D4 Gene

Disorders for TBC1D4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TBC1D4 Gene - From: OMI, CVR, GTR, COP, and GCD

Disorder Aliases PubMed IDs
type 2 diabetes 5
  • t2d5
type 2 diabetes mellitus
  • t2d
acanthosis nigricans
  • an - acanthosis nigricans
hyperinsulinism
  • hyperinsulinemia
diabetes mellitus
  • diabetes
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TBCD4_HUMAN
  • Diabetes mellitus, non-insulin-dependent, 5 (NIDDM5) [MIM:616087]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:25043022}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.

Additional Disease Information for TBC1D4

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with TBC1D4: view

No data available for Genatlas for TBC1D4 Gene

Publications for TBC1D4 Gene

  1. Upregulation of the transcript level of GTPase activating protein KIAA0603 in T cells from patients with atopic dermatitis. (PMID: 15304337) Matsumoto Y … Oshida T (FEBS letters 2004) 2 3 4 22
  2. A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes. (PMID: 25043022) Moltke I … Hansen T (Nature 2014) 3 4 72
  3. Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity. (PMID: 19077034) Ishibashi K … Fukuda M (Genes to cells : devoted to molecular & cellular mechanisms 2009) 3 4 22
  4. Rab GTPase-activating protein AS160 is a major downstream effector of protein kinase B/Akt signaling in pancreatic beta-cells. (PMID: 18276765) Bouzakri K … Halban PA (Diabetes 2008) 3 4 22
  5. Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects. (PMID: 15919790) Karlsson HK … Wallberg-Henriksson H (Diabetes 2005) 3 4 22

Products for TBC1D4 Gene

Sources for TBC1D4 Gene